Abstract:
:A central question in stem cell biology is the relationship between stem cells and their niche. Although previous reports have uncovered how signaling molecules released by niche cells support stem cell function, the role of the extra-cellular matrix (ECM) within the niche is unclear. Here, we show that upon activation, skeletal muscle stem cells (satellite cells) induce local remodeling of the ECM and the deposition of laminin-α1 and laminin-α5 into the basal lamina of the satellite cell niche. Genetic ablation of laminin-α1, disruption of integrin-α6 signaling or blocking matrix metalloproteinase activity impairs satellite cell expansion and self-renewal. Collectively, our findings establish that remodeling of the ECM is an integral process of stem cell activity to support propagation and self-renewal, and may explain the effect laminin-α1-containing supports have on embryonic and adult stem cells, as well as the regenerative activity of exogenous laminin-111 therapy.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Rayagiri SS,Ranaldi D,Raven A,Mohamad Azhar NIF,Lefebvre O,Zammit PS,Borycki AGdoi
10.1038/s41467-018-03425-3subject
Has Abstractpub_date
2018-03-14 00:00:00pages
1075issue
1issn
2041-1723pii
10.1038/s41467-018-03425-3journal_volume
9pub_type
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