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SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood.

Abstract：

:Given the limited availability of serological testing to date, the seroprevalence of SARS-CoV-2-specific antibodies in different populations has remained unclear. Here, we report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seroreactivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors in early April 2020. We additionally describe the longitudinal dynamics of immunoglobulin-G (IgG), immunoglobulin-M (IgM), and in vitro neutralizing antibody titers in COVID-19 patients. The median time to seroconversion ranged from 10.3-11.0 days for these 3 assays. Neutralizing antibodies rose in tandem with immunoglobulin titers following symptom onset, and positive percent agreement between detection of IgG and neutralizing titers was >93%. These findings emphasize the importance of using highly accurate tests for surveillance studies in low-prevalence populations, and provide evidence that seroreactivity using SARS-CoV-2 anti-nucleocapsid protein IgG and anti-spike IgM assays are generally predictive of in vitro neutralizing capacity.

journal_name

Nat Commun

journal_title

Nature communications

authors

Ng DL,Goldgof GM,Shy BR,Levine AG,Balcerek J,Bapat SP,Prostko J,Rodgers M,Coller K,Pearce S,Franz S,Du L,Stone M,Pillai SK,Sotomayor-Gonzalez A,Servellita V,Martin CSS,Granados A,Glasner DR,Han LM,Truong K,Akagi

doi

10.1038/s41467-020-18468-8

subject

Has Abstract

pub_date

2020-09-17 00:00:00

pages

4698

issue

1

issn

2041-1723

pii

10.1038/s41467-020-18468-8

journal_volume

11

pub_type

杂志文章

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