Abstract:
:Identifying genes regulating the pace of epigenetic ageing represents a new frontier in genome-wide association studies (GWASs). Here using 1,796 brain samples from 1,163 individuals, we carry out a GWAS of two DNA methylation-based biomarkers of brain age: the epigenetic ageing rate and estimated proportion of neurons. Locus 17q11.2 is significantly associated (P=4.5 × 10-9) with the ageing rate across five brain regions and harbours a cis-expression quantitative trait locus for EFCAB5 (P=3.4 × 10-20). Locus 1p36.12 is significantly associated (P=2.2 × 10-8) with epigenetic ageing of the prefrontal cortex, independent of the proportion of neurons. Our GWAS of the proportion of neurons identified two genome-wide significant loci (10q26 and 12p13.31) and resulted in a gene set that overlaps significantly with sets found by GWAS of age-related macular degeneration (P=1.4 × 10-12), ulcerative colitis (P<1.0 × 10-20), type 2 diabetes (P=2.8 × 10-13), hip/waist circumference in men (P=1.1 × 10-9), schizophrenia (P=1.6 × 10-9), cognitive decline (P=5.3 × 10-4) and Parkinson's disease (P=8.6 × 10-3).
journal_name
Nat Communjournal_title
Nature communicationsauthors
Lu AT,Hannon E,Levine ME,Crimmins EM,Lunnon K,Mill J,Geschwind DH,Horvath Sdoi
10.1038/ncomms15353subject
Has Abstractpub_date
2017-05-18 00:00:00pages
15353issn
2041-1723pii
ncomms15353journal_volume
8pub_type
杂志文章abstract::Cytidine base editors (CBEs) and adenine base editors (ABEs), composed of a cytidine deaminase or an evolved adenine deaminase fused to Cas9 nickase, enable the conversion of C·G to T·A or A·T to G·C base pair in organisms, respectively. Here, we show that BE3 and ABE7.10 systems can achieve a targeted mutation effici...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05232-2
更新日期:2018-07-13 00:00:00
abstract::In bacteria, transcription complexes stalled on DNA represent a major source of roadblocks for the DNA replication machinery that must be removed in order to prevent damaging collisions. Gram-positive bacteria contain a transcription factor HelD that is able to remove and recycle stalled complexes, but it was not know...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20157-5
更新日期:2020-12-18 00:00:00
abstract::Quintulene, a non-graphitic cycloarene with fivefold symmetry, has remained synthetically elusive due to its high molecular strain originating from its curved structure. Here we report the construction of extended quintulene, which was unambiguously characterized by mass and NMR spectroscopy. The extended quintulene r...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17691-7
更新日期:2020-08-07 00:00:00
abstract:: ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06969-6
更新日期:2018-10-24 00:00:00
abstract::Iminium catalysis, involving the transformation of iminium ions to enamines, has been extensively studied in the context of a number of organic processes. However, the reverse of this process involving conversion of enamines to iminium species has not been realized. Here, we describe a new transformation-'oxidative en...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1214
更新日期:2011-01-01 00:00:00
abstract::Recent crystal structures of G-protein-coupled receptors (GPCRs) have revealed ordered internal water molecules, raising questions about the functional role of those waters for receptor activation that could not be answered by the static structures. Here, we used molecular dynamics simulations to monitor--at atomic an...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5733
更新日期:2014-09-09 00:00:00
abstract::The endoplasmic reticulum-mitochondria encounter structure (ERMES) connects the mitochondrial outer membrane with the ER. Multiple functions have been linked to ERMES, including maintenance of mitochondrial morphology, protein assembly and phospholipid homeostasis. Since the mitochondrial distribution and morphology p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13021
更新日期:2016-10-10 00:00:00
abstract::Intratumor heterogeneity (ITH) and tumor evolution have been well described for clear cell renal cell carcinomas (ccRCC), but they are less studied for other kidney cancer subtypes. Here we investigate ITH and clonal evolution of papillary renal cell carcinoma (pRCC) and rarer kidney cancer subtypes, integrating whole...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16546-5
更新日期:2020-06-18 00:00:00
abstract::We study spin transport in a fully hBN encapsulated monolayer-graphene van der Waals heterostructure at room temperature. A top-layer of bilayer-hBN is used as a tunnel barrier for spin-injection and detection in graphene with ferromagnetic cobalt electrodes. We report surprisingly large and bias-induced (differential...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00317-w
更新日期:2017-08-15 00:00:00
abstract::Induction of endogenous adult stem cells by administering soluble molecules provides an advantageous approach for tissue damage repair, which could be a clinically applicable and cost-effective alternative to transplantation of embryonic or pluripotent stem cell-derived tissues for the treatment of acute organ failure...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01341-6
更新日期:2017-10-27 00:00:00
abstract::Microvilli on T cells have been proposed to survey surfaces of antigen-presenting cells (APC) or facilitate adhesion under flow; however, whether they serve essential functions during T cell activation remains unclear. Here we show that antigen-specific T cells deposit membrane particles derived from microvilli onto t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06090-8
更新日期:2018-09-07 00:00:00
abstract::Gene transfer agents (GTAs) are thought to be ancient bacteriophages that have been co-opted into serving their host and can now transfer any gene between bacteria. Production of GTAs is controlled by several global regulators through unclear mechanisms. In Rhodobacter capsulatus, gene rcc01865 encodes a putative regu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08526-1
更新日期:2019-02-05 00:00:00
abstract::Animal propulsors such as wings and fins bend during motion and these bending patterns are believed to contribute to the high efficiency of animal movements compared with those of man-made designs. However, efforts to implement flexible designs have been met with contradictory performance results. Consequently, there ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4293
更新日期:2014-01-01 00:00:00
abstract::Solid substrates often induce non-uniform strain and doping in graphene monolayer, therefore altering the intrinsic properties of graphene, reducing its charge carrier mobilities and, consequently, the overall electrical performance. Here, we exploit confocal Raman spectroscopy to study graphene directly free-floating...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14637-x
更新日期:2020-02-14 00:00:00
abstract::The recently discovered histone post-translational modification crotonylation connects cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly understood. We characterize histone crotonylation in intestinal epithelia and find that histone H3 crotonylation at lysine 18 is a surpr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02651-5
更新日期:2018-01-09 00:00:00
abstract::Global climate change has intensified the need to assess the capacity for natural populations to adapt to abrupt shifts in the environment. Reductions in seawater pH constitute a conspicuous global change stressor that is affecting marine ecosystems globally. Here, we quantify the phenotypic and genetic modifications ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13767-1
更新日期:2019-12-20 00:00:00
abstract::Transport of nanoscale energy in the form of excitons is at the core of photosynthesis and the operation of a wide range of nanostructured optoelectronic devices such as solar cells, light-emitting diodes and excitonic transistors. Of particular importance is the relationship between exciton transport and nanoscale di...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4646
更新日期:2014-04-16 00:00:00
abstract::HIV-1 envelope (Env) mimetics are candidate components of prophylactic vaccines and potential therapeutics. Here we use a synthetic V3-glycopeptide ("Man9-V3") for structural studies of an HIV Env third variable loop (V3)-glycan directed, broadly neutralizing antibody (bnAb) lineage ("DH270"), to visualize the epitope...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03565-6
更新日期:2018-03-16 00:00:00
abstract::Mitochondrial Ca(2+) uptake through the recently discovered Mitochondrial Calcium Uniporter (MCU) is controlled by its gatekeeper Mitochondrial Calcium Uptake 1 (MICU1). However, the physiological and pathological role of MICU1 remains unclear. Here we show that MICU1 is vital for adaptation to postnatal life and for ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10955
更新日期:2016-03-09 00:00:00
abstract::Fear conditioning is a form of associative learning that is known to involve different brain areas, notably the amygdala, the prefrontal cortex and the periaqueductal grey (PAG). Here, we describe the functional role of pathways that link the cerebellum with the fear network. We found that the cerebellar fastigial nuc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18953-0
更新日期:2020-10-15 00:00:00
abstract::Considerable interest has been devoted to converting mechanical energy into electricity using polymer nanofibres. In particular, piezoelectric nanofibres produced by electrospinning have shown remarkable mechanical energy-to-electricity conversion ability. However, there is little data for the acoustic-to-electric con...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11108
更新日期:2016-03-23 00:00:00
abstract::Biodiversity changes are lagging behind current climate warming. The underlying determinants of this climatic debt are unknown and yet critical to understand the impacts of climate change on the present biota and improve forecasts of biodiversity changes. Here we assess determinants of climatic debt accumulated in Fre...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12643
更新日期:2016-08-26 00:00:00
abstract::Propagation behaviors of electromagnetic waves are governed by the equifrequency surface of the medium. Up to now, ordinary materials, including the medium exist in nature and the man-made metamaterials, always have an equifrequency surface (ellipsoid or hyperboloid) centered at zero k-point. Here we propose a new typ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04490-4
更新日期:2018-05-25 00:00:00
abstract::The observations of solar flare onsets show rapid increase of hard and soft X-rays, ultra-violet emission with large Doppler blue shifts associated with plasma upflows, and Hα hydrogen emission with red shifts up to 1-4 Å. Modern radiative hydrodynamic models account well for blue-shifted emission, but struggle to rep...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15905
更新日期:2017-06-27 00:00:00
abstract::Tumors are mixtures of different compartments. While global gene expression analysis profiles the average expression of all compartments in a sample, identifying the specific contribution of each compartment remains a challenge. With the increasing recognition of the importance of non-neoplastic components, the abilit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12517-7
更新日期:2019-10-18 00:00:00
abstract::A specific bone vessel subtype, strongly positive for CD31 and endomucin (CD31hiEmcnhi), is identified as coupling angiogenesis and osteogenesis. The abundance of type CD31hiEmcnhi vessels decrease during ageing. Here we show that expression of the miR-497∼195 cluster is high in CD31hiEmcnhi endothelium but gradually ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms16003
更新日期:2017-07-07 00:00:00
abstract::Drop motility at liquid surfaces is attracting growing interest because of its potential applications in microfluidics and artificial cell design. Here we report the unique highly ordered pattern that sets in when a millimeter-size drop of dichloromethane spreads on an aqueous substrate under the influence of surface ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03201-3
更新日期:2018-02-26 00:00:00
abstract::Heparin-like oligosaccharides mediate numerous important biological interactions, of which many are implicated in various diseases. Synthetic improvements are central to the development of such oligosaccharides as therapeutics and, in addition, there are no methods to elucidate the pharmacokinetics of structurally def...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3016
更新日期:2013-01-01 00:00:00
abstract::Histone deacetylase inhibitors (HDACi) are approved for treating certain haematological malignancies, however, recent evidence also illustrates they are modulators of the immune system. In experimental models, HDACi are particularly potent against malignancies originating from the B-lymphocyte lineage. Here we examine...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7838
更新日期:2015-04-27 00:00:00
abstract::Protein biopharmaceuticals are highly successful, but their utility is compromised by their propensity to aggregate during manufacture and storage. As aggregation can be triggered by non-native states, whose population is not necessarily related to thermodynamic stability, prediction of poorly-behaving biologics is di...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15667-1
更新日期:2020-04-14 00:00:00