Beam electrons as a source of Hα flare ribbons.

abstract：:Multiphoton absorption processes enable many technologically important applications, such as in vivo imaging, photodynamic therapy and optical limiting, and so on. Specifically, higher-order nonlinear absorption such as five-photon absorption offers significant advantages of greater spatial confinement, increased pene...

journal_title：Nature communications

authors： Chen W,Bhaumik S,Veldhuis SA,Xing G,Xu Q,Grätzel M,Mhaisalkar S,Mathews N,Sum TC

更新日期：2017-05-12 00:00:00

abstract：:Cell identity is specified in the early mammalian embryo by the generation of precursors for two cell lineages: the pluripotent inner cell mass and differentiating trophectoderm. Here we identify Angiomotin as a key regulator of this process. We show that the loss of Angiomotin, together with Angiomotin-like 2, leads ...

journal_title：Nature communications

authors： Leung CY,Zernicka-Goetz M

更新日期：2013-01-01 00:00:00

abstract：:Inflammasomes regulate innate immune responses by facilitating maturation of inflammatory cytokines, interleukin (IL)-1β and IL-18. NACHT, LRR and PYD domains-containing protein 7 (NALP7) is one inflammasome constituent, but little is known about its cellular handling. Here we show a mechanism for NALP7 protein stabil...

journal_title：Nature communications

authors： Bednash JS,Weathington N,Londino J,Rojas M,Gulick DL,Fort R,Han S,McKelvey AC,Chen BB,Mallampalli RK

更新日期：2017-05-11 00:00:00

abstract：:Regulatory T (Treg) cells derived from the thymus (tTreg) and periphery (pTreg) have central and distinct functions in immunosuppression, but mechanisms for the generation and activation of Treg subsets in vivo are unclear. Here, we show that mechanistic target of rapamycin (mTOR) unexpectedly supports the homeostasis...

journal_title：Nature communications

authors： Chapman NM,Zeng H,Nguyen TM,Wang Y,Vogel P,Dhungana Y,Liu X,Neale G,Locasale JW,Chi H

更新日期：2018-05-29 00:00:00

abstract：:Control over interactions with biomolecules holds the key to applications of graphene in biotechnology. One such application is nanopore sequencing, where a DNA molecule is electrophoretically driven through a graphene nanopore. Here we investigate how interactions of single-stranded DNA and a graphene membrane can be...

journal_title：Nature communications

authors： Shankla M,Aksimentiev A

更新日期：2014-10-09 00:00:00

abstract：:Human mesenchymal stromal cells (hMSCs) are a promising source for engineered cell-based therapies in which genetic engineering could enhance therapeutic efficacy and install novel cellular functions. Here, we describe an optimized Cas9-AAV6-based genome editing tool platform for site-specific mutagenesis and integrat...

journal_title：Nature communications

authors： Srifa W,Kosaric N,Amorin A,Jadi O,Park Y,Mantri S,Camarena J,Gurtner GC,Porteus M

更新日期：2020-05-18 00:00:00

abstract：:Proteins are versatile natural building blocks with highly complex and multifunctional architectures, and self-assembled protein structures have been created by the introduction of covalent, noncovalent, or metal-coordination bonding. Here, we report the robust, selective, and reversible metal coordination properties ...

journal_title：Nature communications

authors： Yang M,Song WJ

更新日期：2019-12-05 00:00:00

abstract：:Linking microbial metabolomics and carbon sequestration in the ocean via refractory organic molecules has been hampered by the chemical complexity of dissolved organic matter (DOM). Here, using bioassay experiments and ultra-high resolution metabolic profiling, we demonstrate that marine bacteria rapidly utilize simpl...

journal_title：Nature communications

authors： Lechtenfeld OJ,Hertkorn N,Shen Y,Witt M,Benner R

更新日期：2015-03-31 00:00:00

abstract：:The human Immunodeficiency Centromeric Instability Facial Anomalies (ICF) 4 syndrome is a severe disease with increased mortality caused by mutation in the LSH gene. Although LSH belongs to a family of chromatin remodeling proteins, it remains unknown how LSH mediates its function on chromatin in vivo. Here, we use ch...

journal_title：Nature communications

authors： Ni K,Ren J,Xu X,He Y,Finney R,Braun SMG,Hathaway NA,Crabtree GR,Muegge K

更新日期：2020-11-06 00:00:00

abstract：:Identification of lymph node (LN) metastasis is essential for staging of solid tumors, and as a result, surgeons focus on harvesting significant numbers of LNs during ablative procedures for pathological evaluation. Isolating those LNs most likely to harbor metastatic disease can allow for a more rigorous evaluation o...

journal_title：Nature communications

authors： Nishio N,van den Berg NS,van Keulen S,Martin BA,Fakurnejad S,Teraphongphom N,Chirita SU,Oberhelman NJ,Lu G,Horton CE,Kaplan MJ,Divi V,Colevas AD,Rosenthal EL

更新日期：2019-11-06 00:00:00

abstract：:Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteoblast suppression. ...

journal_title：Nature communications

authors： Garcia-Gomez A,Li T,de la Calle-Fabregat C,Rodríguez-Ubreva J,Ciudad L,Català-Moll F,Godoy-Tena G,Martín-Sánchez M,San-Segundo L,Muntión S,Morales X,Ortiz-de-Solórzano C,Oyarzabal J,San José-Enériz E,Esteller M,Agirre X,P

更新日期：2021-01-18 00:00:00

abstract：:After stroke, peripheral immune cells are activated and these systemic responses may amplify brain damage, but how the injured brain sends out signals to trigger systemic inflammation remains unclear. Here we show that a brain-to-cervical lymph node (CLN) pathway is involved. In rats subjected to focal cerebral ischem...

journal_title：Nature communications

authors： Esposito E,Ahn BJ,Shi J,Nakamura Y,Park JH,Mandeville ET,Yu Z,Chan SJ,Desai R,Hayakawa A,Ji X,Lo EH,Hayakawa K

更新日期：2019-11-22 00:00:00

abstract：:The Montreal Protocol has succeeded in limiting major ozone-depleting substance emissions, and consequently stratospheric ozone concentrations are expected to recover this century. However, there is a large uncertainty in the rate of regional ozone recovery in the Northern Hemisphere. Here we identify a Eurasia-North ...

journal_title：Nature communications

authors： Zhang J,Tian W,Xie F,Chipperfield MP,Feng W,Son SW,Abraham NL,Archibald AT,Bekki S,Butchart N,Deushi M,Dhomse S,Han Y,Jöckel P,Kinnison D,Kirner O,Michou M,Morgenstern O,O'Connor FM,Pitari G,Plummer DA,Revell LE

更新日期：2018-01-15 00:00:00

abstract：:Expression of oestrogen receptor (ESR1) determines whether a breast cancer patient receives endocrine therapy, but does not guarantee patient response. The molecular factors that define endocrine response in ESR1-positive breast cancer patients remain poorly understood. Here we characterize the DNA methylome of endocr...

journal_title：Nature communications

authors： Stone A,Zotenko E,Locke WJ,Korbie D,Millar EK,Pidsley R,Stirzaker C,Graham P,Trau M,Musgrove EA,Nicholson RI,Gee JM,Clark SJ

更新日期：2015-07-14 00:00:00

abstract：:This corrects the article DOI: 10.1038/ncomms14778. ...

journal_title：Nature communications

authors： Li B,Bian K,Lane JMD,Salerno KM,Grest GS,Ao T,Hickman R,Wise J,Wang Z,Fan H

更新日期：2017-05-24 00:00:00

abstract：:To avoid dangerous climate change, new technologies must remove billions of tonnes of CO2 from the atmosphere every year by mid-century. Here we detail a land-based enhanced weathering cycle utilizing magnesite (MgCO3) feedstock to repeatedly capture CO2 from the atmosphere. In this process, MgCO3 is calcined, produci...

journal_title：Nature communications

authors： McQueen N,Kelemen P,Dipple G,Renforth P,Wilcox J

更新日期：2020-07-03 00:00:00

abstract：:Connection of tubules into larger networks is the key process for the development of circulatory systems. In Drosophila development, tip cells of the tracheal system lead the migration of each branch and connect tubules by adhering to each other and simultaneously changing into a torus-shape. We show that as adhesion ...

journal_title：Nature communications

authors： Kato K,Dong B,Wada H,Tanaka-Matakatsu M,Yagi Y,Hayashi S

更新日期：2016-04-12 00:00:00

abstract：:Telomerase elongates the telomeric G-strand to prevent telomere shortening through conventional DNA replication. However, synthesis of the complementary C-strand by DNA polymerase α is also required to maintain telomere length. Polymerase α cannot perform this role without the ssDNA binding complex CST (CTC1-STN1-TEN1...

journal_title：Nature communications

authors： Feng X,Hsu SJ,Bhattacharjee A,Wang Y,Diao J,Price CM

更新日期：2018-07-19 00:00:00

abstract：:A long-standing and profound problem in astronomy is the difficulty in obtaining deep near-infrared observations due to the extreme brightness and variability of the night sky at these wavelengths. A solution to this problem is crucial if we are to obtain the deepest possible observations of the early Universe, as red...

journal_title：Nature communications

authors： Bland-Hawthorn J,Ellis SC,Leon-Saval SG,Haynes R,Roth MM,Löhmannsröben HG,Horton AJ,Cuby JG,Birks TA,Lawrence JS,Gillingham P,Ryder SD,Trinh C

更新日期：2011-12-06 00:00:00

abstract：:Treatments that stimulate neuronal excitability enhance motor performance after stroke. cAMP-response-element binding protein (CREB) is a transcription factor that plays a key role in neuronal excitability. Increasing the levels of CREB with a viral vector in a small pool of motor neurons enhances motor recovery after...

journal_title：Nature communications

authors： Caracciolo L,Marosi M,Mazzitelli J,Latifi S,Sano Y,Galvan L,Kawaguchi R,Holley S,Levine MS,Coppola G,Portera-Cailliau C,Silva AJ,Carmichael ST

更新日期：2018-06-08 00:00:00

abstract：:CRISPR-Cas9 is a promising technology for genome editing. Here we use Cas9 nuclease-induced double-strand break DNA (DSB) at the UROS locus to model and correct congenital erythropoietic porphyria. We demonstrate that homology-directed repair is rare compared with NHEJ pathway leading to on-target indels and causing u...

journal_title：Nature communications

authors： Cullot G,Boutin J,Toutain J,Prat F,Pennamen P,Rooryck C,Teichmann M,Rousseau E,Lamrissi-Garcia I,Guyonnet-Duperat V,Bibeyran A,Lalanne M,Prouzet-Mauléon V,Turcq B,Ged C,Blouin JM,Richard E,Dabernat S,Moreau-Gaudry F,

更新日期：2019-03-08 00:00:00

abstract：:Plasmonics on metal-dielectric interfaces was widely seen as the main route for miniaturization of components and interconnect of photonic circuits. However recently, ultra-confined surface phonon-polaritonics in high-index chalcogenide films of nanometric thickness has emerged as an important alternative to plasmonic...

journal_title：Nature communications

authors： Dubrovkin AM,Qiang B,Salim T,Nam D,Zheludev NI,Wang QJ

更新日期：2020-04-20 00:00:00

abstract：:Homeowners around the world elevate houses to manage flood risks. Deciding how high to elevate a house poses a nontrivial decision problem. The U.S. Federal Emergency Management Agency (FEMA) recommends elevating existing houses to the Base Flood Elevation (the elevation of the 100-year flood) plus a freeboard. This r...

journal_title：Nature communications

authors： Zarekarizi M,Srikrishnan V,Keller K

更新日期：2020-10-26 00:00:00

abstract：:Tauopathies are neurodegenerative diseases characterized by intracellular amyloid deposits of tau protein. Missense mutations in the tau gene (MAPT) correlate with aggregation propensity and cause dominantly inherited tauopathies, but their biophysical mechanism driving amyloid formation is poorly understood. Many dis...

journal_title：Nature communications

authors： Chen D,Drombosky KW,Hou Z,Sari L,Kashmer OM,Ryder BD,Perez VA,Woodard DR,Lin MM,Diamond MI,Joachimiak LA

更新日期：2019-06-07 00:00:00

abstract：:Nanocrystal quantum dots are attractive materials for applications as nanoscale light sources. One impediment to these applications is fluctuations of single-dot emission intensity, known as blinking. Recent progress in colloidal synthesis has produced nonblinking nanocrystals; however, the physics underlying blinking...

journal_title：Nature communications

authors： Galland C,Ghosh Y,Steinbrück A,Hollingsworth JA,Htoon H,Klimov VI

更新日期：2012-06-19 00:00:00

abstract：:FDA proactively invests in tools to support innovation of emerging technologies, such as infectious disease next generation sequencing (ID-NGS). Here, we introduce FDA-ARGOS quality-controlled reference genomes as a public database for diagnostic purposes and demonstrate its utility on the example of two use cases. We...

journal_title：Nature communications

authors： Sichtig H,Minogue T,Yan Y,Stefan C,Hall A,Tallon L,Sadzewicz L,Nadendla S,Klimke W,Hatcher E,Shumway M,Aldea DL,Allen J,Koehler J,Slezak T,Lovell S,Schoepp R,Scherf U

更新日期：2019-07-25 00:00:00

abstract：:The maintenance of sensory hair cell stereocilia is critical for lifelong hearing; however, mechanisms of structural homeostasis remain poorly understood. Conflicting models propose that stereocilia F-actin cores are either continually renewed every 24-48 h via a treadmill or are stable, exceptionally long-lived struc...

journal_title：Nature communications

authors： Drummond MC,Barzik M,Bird JE,Zhang DS,Lechene CP,Corey DP,Cunningham LL,Friedman TB

更新日期：2015-04-21 00:00:00

abstract：:Main group elements usually assume a typical oxidation state while forming compounds with other species. Group I elements are usually in the +1 state in inorganic materials. Our recent work reveals that pressure may make the inner shell 5p electrons of Cs reactive, causing Cs to expand beyond the +1 oxidation state. H...

journal_title：Nature communications

authors： Botana J,Miao MS

更新日期：2014-09-10 00:00:00

abstract：:Phase-coherent transfer of optical frequencies over a long distance is required for diverse photonic applications, including optical clock dissemination and physical constants measurement. Several demonstrations were made successfully over fiber networks, but not much work has been done yet through the open air where ...

journal_title：Nature communications

authors： Kang HJ,Yang J,Chun BJ,Jang H,Kim BS,Kim YJ,Kim SW

更新日期：2019-09-30 00:00:00

abstract：:The high Aβ42/Aβ40 production ratio is a hallmark of familial Alzheimer's disease, which can be caused by mutations in the amyloid precursor protein (APP). The C-terminus of Aβ is generated by γ-secretase cleavage within the transmembrane domain of APP (APPTM), a process that is primed by an initial ε-cleavage at eith...

journal_title：Nature communications

authors： Chen W,Gamache E,Rosenman DJ,Xie J,Lopez MM,Li YM,Wang C

更新日期：2014-01-01 00:00:00