DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer.

abstract：:Modern science has developed well-defined and versatile sets of chemicals to perform many specific tasks, yet the diversity of these reagents is so large that it can be impractical for any one lab to stock everything they might need. At the same time, isssues of stability or limited supply mean these chemicals can be ...

journal_title：Nature communications

authors： Zalesskiy SS,Kitson PJ,Frei P,Bubliauskas A,Cronin L

更新日期：2019-12-02 00:00:00

abstract：:Nociceptors rely on cap-dependent translation to rapidly induce protein synthesis in response to pro-inflammatory signals. Comparatively little is known regarding the role of the regulatory factors bound to the 3' end of mRNA in nociceptor sensitization. Poly(A)-binding protein (PABP) stimulates translation initiation...

journal_title：Nature communications

authors： Barragán-Iglesias P,Lou TF,Bhat VD,Megat S,Burton MD,Price TJ,Campbell ZT

更新日期：2018-01-02 00:00:00

abstract：:Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several enzymes required for cholesterol, fatty acid, triacylglycerol and phospholipid synthesis. In vertebrates, SREBP activation is mainly contr...

journal_title：Nature communications

authors： Bertolio R,Napoletano F,Mano M,Maurer-Stroh S,Fantuz M,Zannini A,Bicciato S,Sorrentino G,Del Sal G

更新日期：2019-03-22 00:00:00

abstract：:O-GlcNAcylation has been implicated in the tumorigenesis of various tissue origins, but its function in liver tumorigenesis is not clear. Here, we demonstrate that O-GlcNAcylation can enhance the expression, stability and function of Yes-associated protein (YAP), the downstream transcriptional regulator of the Hippo p...

journal_title：Nature communications

authors： Zhang X,Qiao Y,Wu Q,Chen Y,Zou S,Liu X,Zhu G,Zhao Y,Chen Y,Yu Y,Pan Q,Wang J,Sun F

更新日期：2017-05-05 00:00:00

abstract：:Propagation behaviors of electromagnetic waves are governed by the equifrequency surface of the medium. Up to now, ordinary materials, including the medium exist in nature and the man-made metamaterials, always have an equifrequency surface (ellipsoid or hyperboloid) centered at zero k-point. Here we propose a new typ...

journal_title：Nature communications

authors： Chen WJ,Hou B,Zhang ZQ,Pendry JB,Chan CT

更新日期：2018-05-25 00:00:00

abstract：:Light propagating in tissue attains a spectrum that varies with location due to wavelength-dependent fluence attenuation, an effect that causes spectral corruption. Spectral corruption has limited the quantification accuracy of optical and optoacoustic spectroscopic methods, and impeded the goal of imaging blood oxyge...

journal_title：Nature communications

authors： Tzoumas S,Nunes A,Olefir I,Stangl S,Symvoulidis P,Glasl S,Bayer C,Multhoff G,Ntziachristos V

更新日期：2016-06-30 00:00:00

abstract：:The coupling of ordered electronic phases with lattice, spin, and orbital degrees of freedom are of central interest in strongly correlated systems. Their interplay has been intensively studied from femtosecond to picosecond time scales, while their dynamics beyond nanoseconds are usually assumed to follow lattice coo...

journal_title：Nature communications

authors： Zhu Y,Hoffman J,Rowland CE,Park H,Walko DA,Freeland JW,Ryan PJ,Schaller RD,Bhattacharya A,Wen H

更新日期：2018-05-04 00:00:00

abstract：:Structural degradation and low conductivity of transition-metal oxides lead to severe capacity fading in lithium-ion batteries. Recent efforts to solve this issue have mainly focused on using nanocomposites or hybrids by integrating nanosized metal oxides with conducting additives. Here we design specific hierarchical...

journal_title：Nature communications

authors： Tan G,Wu F,Yuan Y,Chen R,Zhao T,Yao Y,Qian J,Liu J,Ye Y,Shahbazian-Yassar R,Lu J,Amine K

更新日期：2016-06-03 00:00:00

abstract：:The developing CA3 hippocampus is comprised by highly connected hub neurons that are particularly effective in achieving network synchronization. Functional hub neurons were shown to be exclusively GABAergic, suggesting that the contribution of glutamatergic neurons to physiological synchronization processes at early ...

journal_title：Nature communications

authors： Marissal T,Bonifazi P,Picardo MA,Nardou R,Petit LF,Baude A,Fishell GJ,Ben-Ari Y,Cossart R

更新日期：2012-01-01 00:00:00

abstract：:With the rapidly growing global air traffic, the impacts of the black carbon (BC) in the aviation exhaust on climate, environment and public health are likely rising. The particle number and size distribution are crucial metrics for toxicological analysis and aerosol-cloud interactions. Here, a size-resolved BC partic...

journal_title：Nature communications

authors： Zhang X,Chen X,Wang J

更新日期：2019-02-01 00:00:00

abstract：:Interferon gamma (IFNγ)-producing CD8(+) T cells (Tc1) play important roles in immunological disease. We now report that CD3/CD28-mediated stimulation of CD8(+) T cells to generate Tc1 cells, not only increases IFNγ production but also boosts the generation of reactive oxygen species (ROS) and augments expression of C...

journal_title：Nature communications

authors： Bai A,Moss A,Rothweiler S,Serena Longhi M,Wu Y,Junger WG,Robson SC

更新日期：2015-11-09 00:00:00

abstract：:Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme that regulates plasma membrane (PM) fluidity. Here we report that SMPDL3b excess, as observed in podocytes in diabetic kidney disease (DKD), impairs insulin receptor isoform B-dependent pro-survival insulin signaling by interfering with insu...

journal_title：Nature communications

authors： Mitrofanova A,Mallela SK,Ducasa GM,Yoo TH,Rosenfeld-Gur E,Zelnik ID,Molina J,Varona Santos J,Ge M,Sloan A,Kim JJ,Pedigo C,Bryn J,Volosenco I,Faul C,Zeidan YH,Garcia Hernandez C,Mendez AJ,Leibiger I,Burke GW,Futerm

更新日期：2019-06-19 00:00:00

abstract：:Voltage control of magnetism in ferromagnetic semiconductor has emerged as an appealing solution to significantly reduce the power dissipation and variability beyond current CMOS technology. However, it has been proven to be very challenging to achieve a candidate with high Curie temperature (Tc), controllable ferroma...

journal_title：Nature communications

authors： Nie T,Tang J,Kou X,Gen Y,Lee S,Zhu X,He Q,Chang LT,Murata K,Fan Y,Wang KL

更新日期：2016-10-20 00:00:00

abstract：:A reliable description of any spatial pattern in species richness requires accurate knowledge about species geographical distribution. However, sampling bias may generate artefactual absences within species range and compromise our capacity to describe biodiversity patterns. Here, we analysed the spatial distribution ...

journal_title：Nature communications

authors： Menegotto A,Rangel TF

更新日期：2018-11-09 00:00:00

abstract：:In Arabidopsis thaliana, CONSTANS (CO) plays an essential role in the regulation of photoperiodic flowering under long-day conditions. CO protein is stable only in the afternoon of long days, when it induces the expression of FLOWERING LOCUS T (FT), which promotes flowering. The blue-light photoreceptor FLAVIN-BINDING...

journal_title：Nature communications

authors： Lee BD,Kim MR,Kang MY,Cha JY,Han SH,Nawkar GM,Sakuraba Y,Lee SY,Imaizumi T,McClung CR,Kim WY,Paek NC

更新日期：2017-12-22 00:00:00

abstract：:Graphene nanoscrolls are Archimedean-type spirals formed by rolling single-layer graphene sheets. Their unique structure makes them conceptually interesting and understanding their formation gives important information on the manipulation and characteristics of various carbon nanostructures. Here we report a 100% effi...

journal_title：Nature communications

authors： Sharifi T,Gracia-Espino E,Barzegar HR,Jia X,Nitze F,Hu G,Nordblad P,Tai CW,Wågberg T

更新日期：2013-01-01 00:00:00

abstract：:The yeast Saccharomyces cerevisiae has been an essential component of human civilization because of its long global history of use in food and beverage fermentation. However, the diversity and evolutionary history of the domesticated populations of the yeast remain elusive. We show here that China/Far East Asia is lik...

journal_title：Nature communications

authors： Duan SF,Han PJ,Wang QM,Liu WQ,Shi JY,Li K,Zhang XL,Bai FY

更新日期：2018-07-12 00:00:00

abstract：:RNA silencing inhibits mRNA translation. While mRNA translation accounts for the majority of cellular energy expenditure, it is unclear if RNA silencing regulates energy homeostasis. Here, we report that hepatic Argonaute 2 (Ago2)-mediated RNA silencing regulates both intrinsic energy production and consumption and di...

journal_title：Nature communications

authors： Zhang C,Seo J,Murakami K,Salem ESB,Bernhard E,Borra VJ,Choi K,Yuan CL,Chan CC,Chen X,Huang T,Weirauch MT,Divanovic S,Qi NR,Thomas HE,Mercer CA,Siomi H,Nakamura T

更新日期：2018-09-10 00:00:00

abstract：:DNA-based nanopores are synthetic biomolecular membrane pores, whose geometry and chemical functionality can be tuned using the tools of DNA nanotechnology, making them promising molecular devices for applications in single-molecule biosensing and synthetic biology. Here we introduce a large DNA membrane channel with ...

journal_title：Nature communications

authors： Krishnan S,Ziegler D,Arnaut V,Martin TG,Kapsner K,Henneberg K,Bausch AR,Dietz H,Simmel FC

更新日期：2016-09-23 00:00:00

abstract：:Primitive carbonaceous chondrites contain a large array of organic compounds dominated by insoluble organic matter (IOM). A striking feature of this IOM is the systematic enrichment in deuterium compared with the solar hydrogen reservoir. This enrichment has been taken as a sign of low-temperature ion-molecule or gas-...

journal_title：Nature communications

authors： Laurent B,Roskosz M,Remusat L,Robert F,Leroux H,Vezin H,Depecker C,Nuns N,Lefebvre JM

更新日期：2015-10-13 00:00:00

abstract：:Tumour vessels have been studied extensively as they are critical sites for drug delivery, anti-angiogenic therapies and immunotherapy. As a preclinical tool, intravital microscopy (IVM) allows for in vivo real-time direct observation of vessels at the cellular level. However, to date there are no reports of intravita...

journal_title：Nature communications

authors： Fisher DT,Muhitch JB,Kim M,Doyen KC,Bogner PN,Evans SS,Skitzki JJ

更新日期：2016-02-17 00:00:00

abstract：:An incorrect version of the Supplementary Information was inadvertently published with this Article. The HTML has now been updated to include the correct version of the Supplementary Information. ...

journal_title：Nature communications

authors： Palmer EM,Heggy E,Kofman W

更新日期：2017-11-23 00:00:00

abstract：:Nano-sized metal particles are attracting much interest in industrial and biomedical applications due to the recent progress and development of nanotechnology, and the surface-modifications by appropriate polymers are key techniques to stably express their characteristics. Herein, we applied cyclic poly(ethylene glyco...

journal_title：Nature communications

authors： Wang Y,Quinsaat JEQ,Ono T,Maeki M,Tokeshi M,Isono T,Tajima K,Satoh T,Sato SI,Miura Y,Yamamoto T

更新日期：2020-11-30 00:00:00

abstract：:Transcranial electrical stimulation has widespread clinical and research applications, yet its effect on ongoing neural activity in humans is not well established. Previous reports argue that transcranial alternating current stimulation (tACS) can entrain and enhance neural rhythms related to memory, but the evidence ...

journal_title：Nature communications

authors： Lafon B,Henin S,Huang Y,Friedman D,Melloni L,Thesen T,Doyle W,Buzsáki G,Devinsky O,Parra LC,A Liu A

更新日期：2017-10-31 00:00:00

abstract：:Meso/micro-porous solids, such as zeolites, are complex materials used in an impressive range of applications. Here we photo-polymerized ethylene using non-catalytic high-pressure techniques at 0.5-1.5 GPa under ultraviolet (351-364 nm) irradiation on a sub-nanometre scale in the channels of a pure SiO2 zeolite, silic...

journal_title：Nature communications

authors： Santoro M,Gorelli FA,Bini R,Haines J,van der Lee A

更新日期：2013-01-01 00:00:00

abstract：:Neurotechnology attempts to develop supernumerary limbs, but can the human brain deal with the complexity to control an extra limb and yield advantages from it? Here, we analyzed the neuromechanics and manipulation abilities of two polydactyly subjects who each possess six fingers on their hands. Anatomical MRI of the...

journal_title：Nature communications

authors： Mehring C,Akselrod M,Bashford L,Mace M,Choi H,Blüher M,Buschhoff AS,Pistohl T,Salomon R,Cheah A,Blanke O,Serino A,Burdet E

更新日期：2019-06-03 00:00:00

abstract：:Alterations in the methylation of promoters of cancer-related genes are promising biomarkers for the early detection of disease. Compared with single methylation alteration, assessing combined methylation alterations can provide higher association with specific cancer. Here we use cationic conjugated polymer-based flu...

journal_title：Nature communications

authors： Yang Q,Dong Y,Wu W,Zhu C,Chong H,Lu J,Yu D,Liu L,Lv F,Wang S

更新日期：2012-01-01 00:00:00

abstract：:Recently, coherent control of the optical response of thin films in standing waves has attracted considerable attention, ranging from applications in excitation-selective spectroscopy and nonlinear optics to all-optical image processing. Here, we show that integration of metamaterial and optical fibre technologies all...

journal_title：Nature communications

authors： Xomalis A,Demirtzioglou I,Plum E,Jung Y,Nalla V,Lacava C,MacDonald KF,Petropoulos P,Richardson DJ,Zheludev NI

更新日期：2018-01-12 00:00:00

abstract：:Shear-wave anisotropy in Earth's mantle helps constrain the lattice-preferred orientation of anisotropic minerals due to viscous flow. Previous studies at the Japan Trench subduction zone using land-based seismic networks identified strong anisotropy in the mantle wedge, reflecting viscous flow induced by the subducti...

journal_title：Nature communications

authors： Uchida N,Nakajima J,Wang K,Takagi R,Yoshida K,Nakayama T,Hino R,Okada T,Asano Y

更新日期：2020-11-10 00:00:00

abstract：:Sinc-shaped Nyquist pulses possess a rectangular spectrum, enabling data to be encoded in a minimum spectral bandwidth and satisfying by essence the Nyquist criterion of zero inter-symbol interference (ISI). This property makes them very attractive for communication systems since data transmission rates can be maximiz...

journal_title：Nature communications

authors： Soto MA,Alem M,Amin Shoaie M,Vedadi A,Brès CS,Thévenaz L,Schneider T

更新日期：2013-01-01 00:00:00