Abstract:
:Modern science has developed well-defined and versatile sets of chemicals to perform many specific tasks, yet the diversity of these reagents is so large that it can be impractical for any one lab to stock everything they might need. At the same time, isssues of stability or limited supply mean these chemicals can be very expensive to purchase from specialist retailers. Here, we address this problem by developing a cartridge -oriented approach to reactionware-based chemical generators which can easily and reliably produce specific reagents from low-cost precursors, requiring minimal expertise and time to operate, potentially in low infrastructure environments. We developed these chemical generators for four specific targets; transition metal catalyst precursor tris(dibenzylideneacetone)dipalladium(0) [Pd2(dba)3], oxidising agent Dess-Martin periodinane (DMP), protein photolinking reagent succinimidyl 4,4'-azipentanoate (NHS-diazirine), and the polyoxometalate cluster {P8W48}. The cartridge synthesis of these materials provides high-quality target compounds in good yields which are suitable for subsequent utilization.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Zalesskiy SS,Kitson PJ,Frei P,Bubliauskas A,Cronin Ldoi
10.1038/s41467-019-13328-6subject
Has Abstractpub_date
2019-12-02 00:00:00pages
5496issue
1issn
2041-1723pii
10.1038/s41467-019-13328-6journal_volume
10pub_type
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