Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice.

abstract：:Spectrally-selective monitoring of ultraviolet radiations (UVR) is of paramount importance across diverse fields, including effective monitoring of excessive solar exposure. Current UV sensors cannot differentiate between UVA, B, and C, each of which has a remarkably different impact on human health. Here we show spec...

journal_title：Nature communications

authors： Zou W,González A,Jampaiah D,Ramanathan R,Taha M,Walia S,Sriram S,Bhaskaran M,Dominguez-Vera JM,Bansal V

更新日期：2018-09-25 00:00:00

abstract：:Photocatalytic formation of hydrocarbons using solar energy via artificial photosynthesis is a highly desirable renewable-energy source for replacing conventional fossil fuels. Using an L-cysteine-based hydrothermal process, here we synthesize a carbon-doped SnS2 (SnS2-C) metal dichalcogenide nanostructure, which exhi...

journal_title：Nature communications

authors： Shown I,Samireddi S,Chang YC,Putikam R,Chang PH,Sabbah A,Fu FY,Chen WF,Wu CI,Yu TY,Chung PW,Lin MC,Chen LC,Chen KH

更新日期：2018-01-12 00:00:00

abstract：:Cellular protein-RNA complexes assemble on nascent transcripts, but methods to observe transcription and protein binding in real time and at physiological concentrations are not available. Here, we report a single-molecule approach based on zero-mode waveguides that simultaneously tracks transcription progress and the...

journal_title：Nature communications

authors： Duss O,Stepanyuk GA,Grot A,O'Leary SE,Puglisi JD,Williamson JR

更新日期：2018-11-30 00:00:00

abstract：:Prostate development depends on balanced cell proliferation and differentiation, and acetylated KLF5 is known to alter epithelial proliferation. It remains elusive whether post-translational modifications of transcription factors can differentially determine adult stem/progenitor cell fate. Here we report that, in hum...

journal_title：Nature communications

authors： Zhang B,Ci X,Tao R,Ni JJ,Xuan X,King JL,Xia S,Li Y,Frierson HF,Lee DK,Xu J,Osunkoya AO,Dong JT

更新日期：2020-02-21 00:00:00

abstract：:Deformation twins are three-dimensional domains, traditionally viewed as ellipsoids because of their two-dimensional lenticular sections. In this work, we performed statistical analysis of twin shapes viewing along three orthogonal directions: the 'dark side' (DS) view along the twin shear direction (η1), the twinning...

journal_title：Nature communications

authors： Liu Y,Tang PZ,Gong MY,McCabe RJ,Wang J,Tomé CN

更新日期：2019-07-25 00:00:00

abstract：:Vibrio cholerae, responsible for acute gastroenteritis secretes a large multifunctional-autoprocessing repeat-in-toxin (MARTX) toxin linked to evasion of host immune system, facilitating colonization of small intestine. Unlike other effector domains of the multifunctional toxin that target cytoskeleton, the function o...

journal_title：Nature communications

authors： Agarwal S,Kim H,Chan RB,Agarwal S,Williamson R,Cho W,Paolo GD,Satchell KJ

更新日期：2015-10-26 00:00:00

abstract：:Although chemically very simple, Fe2O3 is known to undergo a series of enigmatic structural, electronic and magnetic transformations at high pressures and high temperatures. So far, these transformations have neither been correctly described nor understood because of the lack of structural data. Here we report a syste...

journal_title：Nature communications

authors： Bykova E,Dubrovinsky L,Dubrovinskaia N,Bykov M,McCammon C,Ovsyannikov SV,Liermann HP,Kupenko I,Chumakov AI,Rüffer R,Hanfland M,Prakapenka V

更新日期：2016-02-11 00:00:00

abstract：:Due to the high versatility of chiral cyanohydrins, the catalytic asymmetric cyanation reaction of carbonyl compounds has attracted widespread interest. However, efficient protocols that function at a preparative scale with low catalyst loading are still rare. Here, asymmetric counteranion-directed Lewis acid organoca...

journal_title：Nature communications

authors： Zhang Z,Bae HY,Guin J,Rabalakos C,van Gemmeren M,Leutzsch M,Klussmann M,List B

更新日期：2016-08-17 00:00:00

abstract：:UV vision is prevalent, but we know little about its utility in common general tasks, as in resolving habitat structure. Here we visualize vegetated habitats using a multispectral camera with channels mimicking bird photoreceptor sensitivities across the UV-visible spectrum. We find that the contrast between upper and...

journal_title：Nature communications

authors： Tedore C,Nilsson DE

更新日期：2019-01-22 00:00:00

abstract：:High-performance Li-ion batteries require materials with well-designed and controlled structures on nanometre and micrometre scales. Electrochemical properties can be enhanced by reducing crystallite size and by manipulating structure and morphology. Here we show a method for preparing hierarchically structured Li4Ti5...

journal_title：Nature communications

authors： Odziomek M,Chaput F,Rutkowska A,Świerczek K,Olszewska D,Sitarz M,Lerouge F,Parola S

更新日期：2017-05-26 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Fryirs KA,Brierley GJ,Dixon T

更新日期：2019-11-08 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Barlow JT,Bogatyrev SR,Ismagilov RF

更新日期：2020-07-06 00:00:00

abstract：:Mitochondrial DNA (mtDNA) deletions are associated with mitochondrial disease, and also accumulate during normal human ageing. The mechanisms underlying mtDNA deletions remain unknown although several models have been proposed. Here we use deep sequencing to characterize abundant mtDNA deletions in patients with mutat...

journal_title：Nature communications

authors： Persson Ö,Muthukumar Y,Basu S,Jenninger L,Uhler JP,Berglund AK,McFarland R,Taylor RW,Gustafsson CM,Larsson E,Falkenberg M

更新日期：2019-02-15 00:00:00

abstract：:Adoptive immunotherapy using chimeric antigen receptor (CAR) expressing T cells targeting the CD19 B lineage receptor has demonstrated marked success in relapsed pre-B-cell acute lymphoblastic leukaemia (ALL). Persisting CAR-T cells generate sustained pressure against CD19 that may drive unique mechanisms of resistanc...

journal_title：Nature communications

authors： Jacoby E,Nguyen SM,Fountaine TJ,Welp K,Gryder B,Qin H,Yang Y,Chien CD,Seif AE,Lei H,Song YK,Khan J,Lee DW,Mackall CL,Gardner RA,Jensen MC,Shern JF,Fry TJ

更新日期：2016-07-27 00:00:00

abstract：:Strain engineering is widely used in material science to tune the (opto-)electronic properties of materials and enhance the performance of devices. Two-dimensional atomic crystals are a versatile playground to study the influence of strain, as they can sustain very large deformations without breaking. Various optical ...

journal_title：Nature communications

authors： Mennel L,Furchi MM,Wachter S,Paur M,Polyushkin DK,Mueller T

更新日期：2018-02-06 00:00:00

abstract：:In nature, electrical signalling occurs with ions and protons, rather than electrons. Artificial devices that can control and monitor ionic and protonic currents are thus an ideal means for interfacing with biological systems. Here we report the first demonstration of a biopolymer protonic field-effect transistor with...

journal_title：Nature communications

authors： Zhong C,Deng Y,Roudsari AF,Kapetanovic A,Anantram MP,Rolandi M

更新日期：2011-09-20 00:00:00

abstract：:Formation of domain walls in ferroelectrics is not energetically favourable in low-dimensional systems. Instead, vortex-type structures are formed that are driven by depolarization fields occurring in such systems. Consequently, polarization vortices have only been experimentally found in systems in which these fields...

journal_title：Nature communications

authors： Peters JJP,Apachitei G,Beanland R,Alexe M,Sanchez AM

更新日期：2016-11-16 00:00:00

abstract：:Ever since its discovery around a decade ago, all-optical magnetization switching (AOS) using femtosecond laser pulses has shown potential for future data storage and logic devices. In particular, single pulse helicity independent AOS in certain ferrimagnetic alloys and multilayers is highly efficient and ultrafast. H...

journal_title：Nature communications

authors： van Hees YLW,van de Meugheuvel P,Koopmans B,Lavrijsen R

更新日期：2020-07-31 00:00:00

abstract：:Increased vascular permeability contributes to many diseases, including acute respiratory distress syndrome, cancer and inflammation. Most past work on vascular barrier function has focused on soluble regulators, such as tumour-necrosis factor-α. Here we show that lung vascular permeability is controlled mechanically ...

journal_title：Nature communications

authors： Mammoto A,Mammoto T,Kanapathipillai M,Wing Yung C,Jiang E,Jiang A,Lofgren K,Gee EP,Ingber DE

更新日期：2013-01-01 00:00:00

abstract：:Tuning the thermodynamic state of a material has a tremendous impact on its performance. In the case of polymers placed in proximity of a solid wall, this is possible by annealing above the glass transition temperature, Tg, which induces the formation of an adsorbed layer. Whether heating to higher temperatures would ...

journal_title：Nature communications

authors： Monnier X,Napolitano S,Cangialosi D

更新日期：2020-08-28 00:00:00

abstract：:Many bacteria can exchange genetic material through horizontal gene transfer (HGT) mediated by plasmids and plasmid-borne transposable elements. Here, we study the population structure and dynamics of over 10,000 bacterial plasmids, by quantifying their genetic similarities and reconstructing a network based on their ...

journal_title：Nature communications

authors： Acman M,van Dorp L,Santini JM,Balloux F

更新日期：2020-05-15 00:00:00

abstract：:Gamma-ray 'glows' are long duration (seconds to tens of minutes) X-ray and gamma-ray emission coming from thunderclouds. Measurements suggest the presence of relativistic runaway electron avalanches (RREA), the same process underlying terrestrial gamma-ray flashes. Here we demonstrate that glows are relatively a commo...

journal_title：Nature communications

authors： Kelley NA,Smith DM,Dwyer JR,Splitt M,Lazarus S,Martinez-McKinney F,Hazelton B,Grefenstette B,Lowell A,Rassoul HK

更新日期：2015-08-12 00:00:00

abstract：:Noble metal nanoparticles stabilized by organic ligands are important for applications in assembly, site-specific bioconjugate labelling and sensing, drug delivery and medical therapy, molecular recognition and molecular electronics, and catalysis. Here we report crystal structures and theoretical analysis of three Ag...

journal_title：Nature communications

authors： Yang H,Wang Y,Huang H,Gell L,Lehtovaara L,Malola S,Häkkinen H,Zheng N

更新日期：2013-01-01 00:00:00

abstract：:How genomic and transcriptomic alterations affect the functional proteome in lung cancer is not fully understood. Here, we integrate DNA copy number, somatic mutations, RNA-sequencing, and expression proteomics in a cohort of 108 squamous cell lung cancer (SCC) patients. We identify three proteomic subtypes, two of wh...

journal_title：Nature communications

authors： Stewart PA,Welsh EA,Slebos RJC,Fang B,Izumi V,Chambers M,Zhang G,Cen L,Pettersson F,Zhang Y,Chen Z,Cheng CH,Thapa R,Thompson Z,Fellows KM,Francis JM,Saller JJ,Mesa T,Zhang C,Yoder S,DeNicola GM,Beg AA,Boyle TA

更新日期：2019-08-08 00:00:00

abstract：:Despite the maximized metal dispersion offered by single-atom catalysts, further improvement of intrinsic activity can be hindered by the lack of neighboring metal atoms in these systems. Here we report the use of isolated Pt1 atoms on ceria as "seeds" to develop a Pt-O-Pt ensemble, which is well-represented by a Pt8O...

journal_title：Nature communications

authors： Wang H,Liu JX,Allard LF,Lee S,Liu J,Li H,Wang J,Wang J,Oh SH,Li W,Flytzani-Stephanopoulos M,Shen M,Goldsmith BR,Yang M

更新日期：2019-08-23 00:00:00

abstract：:During mitosis, duplicated sister chromatids attach to microtubules emanating from opposing sides of the bipolar spindle through large protein complexes called kinetochores. In the absence of stable kinetochore-microtubule attachments, a cell surveillance mechanism known as the spindle assembly checkpoint (SAC) produc...

journal_title：Nature communications

authors： Tauchman EC,Boehm FJ,DeLuca JG

更新日期：2015-12-01 00:00:00

abstract：:Influenza is a leading cause of respiratory mortality and morbidity. While inflammation is essential for fighting infection, a balance of anti-viral defense and host tolerance is necessary for recovery. Circadian rhythms have been shown to modulate inflammation. However, the importance of diurnal variability in the ti...

journal_title：Nature communications

authors： Sengupta S,Tang SY,Devine JC,Anderson ST,Nayak S,Zhang SL,Valenzuela A,Fisher DG,Grant GR,López CB,FitzGerald GA

更新日期：2019-09-11 00:00:00

abstract：:The bacteria-derived clustered regularly interspaced short palindromic repeat (CRISPR)-Cas systems are powerful tools for genome engineering. Recently, in addition to Cas protein engineering, the improvement of guide RNAs are also performed, contributing to broadening the research area of CRISPR-Cas9 systems. Here we ...

journal_title：Nature communications

authors： Kweon J,Jang AH,Kim DE,Yang JW,Yoon M,Rim Shin H,Kim JS,Kim Y

更新日期：2017-11-23 00:00:00

abstract：:The dynamics of many natural and artificial systems are well described as random walks on a network: the stochastic behaviour of molecules, traffic patterns on the internet, fluctuations in stock prices and so on. The vast literature on random walks provides many tools for computing properties such as steady-state pro...

journal_title：Nature communications

authors： Perkins TJ,Foxall E,Glass L,Edwards R

更新日期：2014-10-14 00:00:00

abstract：:The midge, Belgica antarctica, is the only insect endemic to Antarctica, and thus it offers a powerful model for probing responses to extreme temperatures, freeze tolerance, dehydration, osmotic stress, ultraviolet radiation and other forms of environmental stress. Here we present the first genome assembly of an extre...

journal_title：Nature communications

authors： Kelley JL,Peyton JT,Fiston-Lavier AS,Teets NM,Yee MC,Johnston JS,Bustamante CD,Lee RE,Denlinger DL

更新日期：2014-08-12 00:00:00