High capacity in G protein-coupled receptor signaling.

abstract：:The human brain has the capacity to rapidly change state, and in epilepsy these state changes can be catastrophic, resulting in loss of consciousness, injury and even death. Theoretical interpretations considering the brain as a dynamical system suggest that prior to a seizure, recorded brain signals may exhibit criti...

journal_title：Nature communications

authors： Maturana MI,Meisel C,Dell K,Karoly PJ,D'Souza W,Grayden DB,Burkitt AN,Jiruska P,Kudlacek J,Hlinka J,Cook MJ,Kuhlmann L,Freestone DR

更新日期：2020-05-01 00:00:00

abstract：:As a key variance partitioning tool, linear mixed models (LMMs) using genome-based restricted maximum likelihood (GREML) allow both fixed and random effects. Classic LMMs assume independence between random effects, which can be violated, causing bias. Here we introduce a generalized GREML, named CORE GREML, that expli...

journal_title：Nature communications

authors： Zhou X,Im HK,Lee SH

更新日期：2020-08-21 00:00:00

abstract：:Given the limited availability of serological testing to date, the seroprevalence of SARS-CoV-2-specific antibodies in different populations has remained unclear. Here, we report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seroreactivity was 0.26% in 387 hospitalized patients admitted...

journal_title：Nature communications

authors： Ng DL,Goldgof GM,Shy BR,Levine AG,Balcerek J,Bapat SP,Prostko J,Rodgers M,Coller K,Pearce S,Franz S,Du L,Stone M,Pillai SK,Sotomayor-Gonzalez A,Servellita V,Martin CSS,Granados A,Glasner DR,Han LM,Truong K,Akagi

更新日期：2020-09-17 00:00:00

abstract：:The high pathogenicity of the Ebola virus reflects multiple concurrent processes on infection. Among other important determinants, Ebola fusogenic glycoprotein (GP) has been associated with the detachment of infected cells and eventually leads to vascular leakage and haemorrhagic fever. Here we report that the membran...

journal_title：Nature communications

authors： Hacke M,Björkholm P,Hellwig A,Himmels P,Ruiz de Almodóvar C,Brügger B,Wieland F,Ernst AM

更新日期：2015-07-09 00:00:00

abstract：:Age, as a threshold of floral competence acquisition, prevents precocious flowering when there is insufficient biomass, and ensures flowering independent of environmental conditions; however, the underlying regulatory mechanisms are largely unknown. In this study, silencing the expression of a nuclear factor gene, CmN...

journal_title：Nature communications

authors： Wei Q,Ma C,Xu Y,Wang T,Chen Y,Lü J,Zhang L,Jiang CZ,Hong B,Gao J

更新日期：2017-10-10 00:00:00

abstract：:Evolution of supramolecular chirality from self-assembly of achiral compounds and control over its handedness is closely related to the evolution of life and development of supramolecular materials with desired handedness. Here we report a system where the entire process of induction, control and locking of supramolec...

journal_title：Nature communications

authors： Kim J,Lee J,Kim WY,Kim H,Lee S,Lee HC,Lee YS,Seo M,Kim SY

更新日期：2015-04-23 00:00:00

abstract：:Mountain glaciers are known to be strongly affected by global climate change. Here we compute temporally consistent changes in glacier area, surface elevation and ice mass over the entire European Alps between 2000 and 2014. We apply remote sensing techniques on an extensive database of optical and radar imagery cover...

journal_title：Nature communications

authors： Sommer C,Malz P,Seehaus TC,Lippl S,Zemp M,Braun MH

更新日期：2020-06-25 00:00:00

abstract：:Two waves of DNA methylation reprogramming occur during mammalian embryogenesis; during preimplantation development and during primordial germ cell (PGC) formation. However, it is currently unclear how evolutionarily conserved these processes are. Here we characterise the DNA methylomes of zebrafish PGCs at four devel...

journal_title：Nature communications

authors： Skvortsova K,Tarbashevich K,Stehling M,Lister R,Irimia M,Raz E,Bogdanovic O

更新日期：2019-07-11 00:00:00

abstract：:Vortices play a crucial role in determining the properties of superconductors as well as their applications. Therefore, characterization and manipulation of vortices, especially at the single-vortex level, is of great importance. Among many techniques to study single vortices, scanning tunnelling microscopy (STM) stan...

journal_title：Nature communications

authors： Ge JY,Gladilin VN,Tempere J,Xue C,Devreese JT,Van de Vondel J,Zhou Y,Moshchalkov VV

更新日期：2016-12-09 00:00:00

abstract：:Viruses provide top-down control on microbial communities, yet their direct study in natural environments was hindered by culture limitations. The advance of bioinformatics enables cultivation-independent study of viruses. Many studies assemble new viral genomes and study viral diversity using marker genes from free v...

journal_title：Nature communications

authors： Sieradzki ET,Ignacio-Espinoza JC,Needham DM,Fichot EB,Fuhrman JA

更新日期：2019-03-12 00:00:00

abstract：:Active biofluid management is central to the realization of wearable bioanalytical platforms that are poised to autonomously provide frequent, real-time, and accurate measures of biomarkers in epidermally-retrievable biofluids (e.g., sweat). Accordingly, here, a programmable epidermal microfluidic valving system is de...

journal_title：Nature communications

authors： Lin H,Tan J,Zhu J,Lin S,Zhao Y,Yu W,Hojaiji H,Wang B,Yang S,Cheng X,Wang Z,Tang E,Yeung C,Emaminejad S

更新日期：2020-09-02 00:00:00

abstract：:Eastern Beringia is one of the few Western Arctic regions where full Holocene climate reconstructions are possible. However, most full Holocene reconstructions in Eastern Beringia are based either on pollen or midges, which show conflicting early Holocene summer temperature histories. This discrepancy precludes unders...

journal_title：Nature communications

authors： Porter TJ,Schoenemann SW,Davies LJ,Steig EJ,Bandara S,Froese DG

更新日期：2019-04-09 00:00:00

abstract：:Transition-metal-catalyzed alkene hydrosilylation is one of the most important homogeneous catalytic reactions, and the development of methods that use base metals, especially iron, as catalysts for this transformation is a growing area of research. However, the limited number of ligand scaffolds applicable for base-m...

journal_title：Nature communications

authors： Hu MY,He Q,Fan SJ,Wang ZC,Liu LY,Mu YJ,Peng Q,Zhu SF

更新日期：2018-01-15 00:00:00

abstract：:Tunable metasurfaces enable dynamical control of the key constitutive properties of light at a subwavelength scale. To date, electrically tunable metasurfaces at near-infrared wavelengths have been realized using free carrier modulation, and switching of thermo-optical, liquid crystal and phase change media. However, ...

journal_title：Nature communications

authors： Wu PC,Pala RA,Kafaie Shirmanesh G,Cheng WH,Sokhoyan R,Grajower M,Alam MZ,Lee D,Atwater HA

更新日期：2019-08-13 00:00:00

abstract：:Potassium-ion batteries are a compelling technology for large scale energy storage due to their low-cost and good rate performance. However, the development of potassium-ion batteries remains in its infancy, mainly hindered by the lack of suitable cathode materials. Here we show that a previously known frustrated magn...

journal_title：Nature communications

authors： Ji B,Yao W,Zheng Y,Kidkhunthod P,Zhou X,Tunmee S,Sattayaporn S,Cheng HM,He H,Tang Y

更新日期：2020-03-06 00:00:00

abstract：:Building a population-specific catalogue of single nucleotide variants (SNVs), indels and structural variants (SVs) with frequencies, termed a national pan-genome, is critical for further advancing clinical and public health genetics in large cohorts. Here we report a Danish pan-genome obtained from sequencing 10 trio...

journal_title：Nature communications

authors： Besenbacher S,Liu S,Izarzugaza JM,Grove J,Belling K,Bork-Jensen J,Huang S,Als TD,Li S,Yadav R,Rubio-García A,Lescai F,Demontis D,Rao J,Ye W,Mailund T,Friborg RM,Pedersen CN,Xu R,Sun J,Liu H,Wang O,Cheng X,Fl

更新日期：2015-01-19 00:00:00

abstract：:On-surface chemical reactions hold the potential for manufacturing nanoscale structures directly onto surfaces by linking carbon atoms in a single-step reaction. To fabricate more complex and functionalized structures, the control of the on-surface chemical reactions must be developed significantly. Here, we present a...

journal_title：Nature communications

authors： Kawai S,Haapasilta V,Lindner BD,Tahara K,Spijker P,Buitendijk JA,Pawlak R,Meier T,Tobe Y,Foster AS,Meyer E

更新日期：2016-09-13 00:00:00

abstract：:Increasing incidence of inflammatory bowel disorders demands a better understanding of the molecular mechanisms underlying its multifactorial aetiology. Here we demonstrate that mice deficient for REGγ, a proteasome activator, show significantly attenuated intestinal inflammation and colitis-associated cancer in dextr...

journal_title：Nature communications

authors： Xu J,Zhou L,Ji L,Chen F,Fortmann K,Zhang K,Liu Q,Li K,Wang W,Wang H,Xie W,Wang Q,Liu J,Zheng B,Zhang P,Huang S,Shi T,Zhang B,Dang Y,Chen J,O'Malley BW,Moses RE,Wang P,Li L,Xiao J,Hoffmann A,Li X

更新日期：2016-02-22 00:00:00

abstract：:UV vision is prevalent, but we know little about its utility in common general tasks, as in resolving habitat structure. Here we visualize vegetated habitats using a multispectral camera with channels mimicking bird photoreceptor sensitivities across the UV-visible spectrum. We find that the contrast between upper and...

journal_title：Nature communications

authors： Tedore C,Nilsson DE

更新日期：2019-01-22 00:00:00

abstract：:In Drosophila melanogaster the single male chromosome X undergoes an average twofold transcriptional upregulation for balancing the transcriptional output between sexes. Previous literature hypothesised that a global change in chromosome structure may accompany this process. However, recent studies based on Hi-C faile...

journal_title：Nature communications

authors： Pal K,Forcato M,Jost D,Sexton T,Vaillant C,Salviato E,Mazza EMC,Lugli E,Cavalli G,Ferrari F

更新日期：2019-11-25 00:00:00

abstract：:The initiation of heterogeneity within a population of phenotypically identical progenitors is a critical event for the onset of morphogenesis and differentiation patterning. Gap junction communication within multicellular systems produces complex networks of intercellular connectivity that result in heterogeneous dis...

journal_title：Nature communications

authors： Glen CM,McDevitt TC,Kemp ML

更新日期：2018-10-05 00:00:00

abstract：:Many phenomena occurring in strongly correlated quantum systems still await conclusive explanations. The absence of isolated free quarks in nature is an example. It is attributed to quark confinement, whose origin is not yet understood. The phase diagram for nuclear matter at general temperatures and densities, studie...

journal_title：Nature communications

authors： Tagliacozzo L,Celi A,Orland P,Mitchell MW,Lewenstein M

更新日期：2013-01-01 00:00:00

abstract：:The development of atomic-scale structures revealing novel transport phenomena is a major goal of nanotechnology. Examples include chains of atoms that form while stretching a transition metal contact or the predicted formation of magnetic order in these chains, the existence of which is still debated. Here we report ...

journal_title：Nature communications

authors： Strigl F,Espy C,Bückle M,Scheer E,Pietsch T

更新日期：2015-02-04 00:00:00

abstract：:With the rapidly growing global air traffic, the impacts of the black carbon (BC) in the aviation exhaust on climate, environment and public health are likely rising. The particle number and size distribution are crucial metrics for toxicological analysis and aerosol-cloud interactions. Here, a size-resolved BC partic...

journal_title：Nature communications

authors： Zhang X,Chen X,Wang J

更新日期：2019-02-01 00:00:00

abstract：:Pterosaurs, the first vertebrates to evolve active flight, lived between 210 and 66 million years ago. They were important components of Mesozoic ecosystems, and reconstructing pterosaur diets is vital for understanding their origins, their roles within Mesozoic food webs and the impact of other flying vertebrates (i....

journal_title：Nature communications

authors： Bestwick J,Unwin DM,Butler RJ,Purnell MA

更新日期：2020-10-28 00:00:00

abstract：:Nitrogen fixation by cyanobacteria supplies critical bioavailable nitrogen to marine ecosystems worldwide; however, field and lab data have demonstrated it to be limited by iron, phosphorus and/or CO2. To address unknown future interactions among these factors, we grew the nitrogen-fixing cyanobacterium Trichodesmium ...

journal_title：Nature communications

authors： Walworth NG,Fu FX,Webb EA,Saito MA,Moran D,Mcllvin MR,Lee MD,Hutchins DA

更新日期：2016-06-27 00:00:00

abstract：:Modulation of CD8 coreceptor levels can profoundly affect T-cell sensitivity to antigen. Here we show that the heritable downregulation of CD8 during type 2 polarization of murine CD8(+) effector T cells in vitro and in vivo is associated with CpG methylation of several regions of the Cd8a locus. These epigenetic modi...

journal_title：Nature communications

authors： Harland KL,Day EB,Apte SH,Russ BE,Doherty PC,Turner SJ,Kelso A

更新日期：2014-03-28 00:00:00

abstract：:By providing broad resistance to environmental biocides, transporters from the small multidrug resistance (SMR) family drive the spread of multidrug resistance cassettes among bacterial populations. A fundamental understanding of substrate selectivity by SMR transporters is needed to identify the types of selective pr...

journal_title：Nature communications

authors： Kermani AA,Macdonald CB,Burata OE,Ben Koff B,Koide A,Denbaum E,Koide S,Stockbridge RB

更新日期：2020-11-27 00:00:00

abstract：:The Barbier reaction, a widely utilized reaction for carbon-carbon bond formation, has played important roles in modern organic chemistry for more than a century. Here, we show its successful introduction to polymer chemistry. Through one-pot Barbier polyaddition (both A2+B2 type and AB type) of monomers containing an...

journal_title：Nature communications

authors： Sun XL,Liu DM,Tian D,Zhang XY,Wu W,Wan WM

更新日期：2017-10-31 00:00:00

abstract：:Accurate estimates of the BOLD hemodynamic response function (HRF) are crucial for the interpretation and analysis of event-related functional MRI data. To date, however, there have been no comprehensive measurements of the HRF in white matter (WM) despite increasing evidence that BOLD signals in WM change after a sti...

journal_title：Nature communications

authors： Li M,Newton AT,Anderson AW,Ding Z,Gore JC

更新日期：2019-03-08 00:00:00