Abstract:
:Accurate estimates of the BOLD hemodynamic response function (HRF) are crucial for the interpretation and analysis of event-related functional MRI data. To date, however, there have been no comprehensive measurements of the HRF in white matter (WM) despite increasing evidence that BOLD signals in WM change after a stimulus. We performed an event-related cognitive task (Stroop color-word interference) to measure the HRF in selected human WM pathways. The task was chosen in order to produce robust, distributed centers of activity throughout the cortex. To measure the HRF in WM, fiber tracts were reconstructed between each pair of activated cortical areas. We observed clear task-specific HRFs with reduced magnitudes, delayed onsets and prolonged initial dips in WM tracts compared with activated grey matter, thus calling for significant changes to current standard models for accurately characterizing the HRFs in WM and for modifications of standard methods of analysis of functional imaging data.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Li M,Newton AT,Anderson AW,Ding Z,Gore JCdoi
10.1038/s41467-019-09076-2subject
Has Abstractpub_date
2019-03-08 00:00:00pages
1140issue
1issn
2041-1723pii
10.1038/s41467-019-09076-2journal_volume
10pub_type
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