Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment.

abstract：:Glucose-induced insulin secretion is an essential function of pancreatic β-cells that is partially lost in individuals affected by Type 2 diabetes. This unique property of β-cells is acquired through a poorly understood postnatal maturation process involving major modifications in gene expression programs. Here we sho...

journal_title：Nature communications

authors： Jacovetti C,Matkovich SJ,Rodriguez-Trejo A,Guay C,Regazzi R

更新日期：2015-09-02 00:00:00

abstract：:The Spitzenkörper (SPK) constitutes a collection of secretory vesicles and polarity-related proteins intimately associated with polarized growth of fungal hyphae. Many SPK-localized proteins are known, but their assembly and dynamics remain poorly understood. Here, we identify protein-protein interaction cascades lead...

journal_title：Nature communications

authors： Zheng P,Nguyen TA,Wong JY,Lee M,Nguyen TA,Fan JS,Yang D,Jedd G

更新日期：2020-06-05 00:00:00

abstract：:Collective cell migration mediates multiple tissue morphogenesis processes. Yet how multi-dimensional mesenchymal cell movements are coordinated remains mostly unknown. Here we report that coordinated mesenchymal cell migration during chicken feather elongation is accompanied by dynamic changes of bioelectric currents...

journal_title：Nature communications

authors： Li A,Cho JH,Reid B,Tseng CC,He L,Tan P,Yeh CY,Wu P,Li Y,Widelitz RB,Zhou Y,Zhao M,Chow RH,Chuong CM

更新日期：2018-12-18 00:00:00

abstract：:Perovskite solar cells have received worldwide interests due to swiftly improved efficiency but the poor stability of the perovskite component hampers the device fabrication under normal condition. Herein, we develop a reliable nonstoichiometric acid-base reaction route to stable perovskite films by intermediate chemi...

journal_title：Nature communications

authors： Long M,Zhang T,Chai Y,Ng CF,Mak TC,Xu J,Yan K

更新日期：2016-11-15 00:00:00

abstract：:A cloak that can hide living creatures from sight is a common feature of mythology but still remains unrealized as a practical device. To preserve the wave phase, the previous cloaking solution proposed by Pendry and colleagues required transformation of the electromagnetic space around the hidden object in such a way...

journal_title：Nature communications

authors： Chen H,Zheng B,Shen L,Wang H,Zhang X,Zheludev NI,Zhang B

更新日期：2013-01-01 00:00:00

abstract：:Fatty acids (FAs) are not only essential components of cellular energy storage and structure, but play crucial roles in signalling. Here we present a toolkit of photoswitchable FA analogues (FAAzos) that incorporate an azobenzene photoswitch along the FA chain. By modifying the FAAzos to resemble capsaicin, we prepare...

journal_title：Nature communications

authors： Frank JA,Moroni M,Moshourab R,Sumser M,Lewin GR,Trauner D

更新日期：2015-05-22 00:00:00

abstract：:Drop motility at liquid surfaces is attracting growing interest because of its potential applications in microfluidics and artificial cell design. Here we report the unique highly ordered pattern that sets in when a millimeter-size drop of dichloromethane spreads on an aqueous substrate under the influence of surface ...

journal_title：Nature communications

authors： Wodlei F,Sebilleau J,Magnaudet J,Pimienta V

更新日期：2018-02-26 00:00:00

abstract：:Zika virus is a mosquito-borne flavivirus closely related to dengue virus that can cause severe disease in humans, including microcephaly in newborns and Guillain-Barré syndrome in adults. Specific treatments and vaccines for Zika virus are not currently available. Here, we isolate and characterize four monoclonal ant...

journal_title：Nature communications

authors： Bailey MJ,Duehr J,Dulin H,Broecker F,Brown JA,Arumemi FO,Bermúdez González MC,Leyva-Grado VH,Evans MJ,Simon V,Lim JK,Krammer F,Hai R,Palese P,Tan GS

更新日期：2018-11-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Tebo AG,Gautier A

更新日期：2019-08-14 00:00:00

abstract：:Diversity-oriented synthesis (DOS) can provide a collection of diverse and complex drug-like small molecules, which is critical in the development of new chemical probes for biological research of undruggable targets. However, the design and synthesis of small-molecule libraries with improved biological relevance as w...

journal_title：Nature communications

authors： Kim J,Jung J,Koo J,Cho W,Lee WS,Kim C,Park W,Park SB

更新日期：2016-10-24 00:00:00

abstract：:Optic atrophy 1 (OPA1) is a mitochondrial inner membrane protein that has an important role in mitochondrial fusion and structural integrity. Dysfunctional OPA1 mutations cause atrophy of the optic nerve leading to blindness. Here, we show that OPA1 has an important role in the innate immune system. Using conditional ...

journal_title：Nature communications

authors： Amini P,Stojkov D,Felser A,Jackson CB,Courage C,Schaller A,Gelman L,Soriano ME,Nuoffer JM,Scorrano L,Benarafa C,Yousefi S,Simon HU

更新日期：2018-07-27 00:00:00

abstract：:The continued convergence of electronics and photonics on the chip scale can benefit from the voltage control of optical polarization for applications in communications, signal processing and sensing. It is challenging, however, to electrically manipulate the polarization state of light in planar optical waveguides. H...

journal_title：Nature communications

authors： Xu Q,Chen L,Wood MG,Sun P,Reano RM

更新日期：2014-11-12 00:00:00

abstract：:Disordered proteins, such as those central to Alzheimer's and Parkinson's, are particularly intractable for structure-targeted therapeutic design. Here we demonstrate the capacity of a synthetic foldamer to capture structure in a disease relevant peptide. Oligoquinoline amides have a defined fold with a solvent-exclud...

journal_title：Nature communications

authors： Kumar S,Birol M,Schlamadinger DE,Wojcik SP,Rhoades E,Miranker AD

更新日期：2016-04-25 00:00:00

abstract：:CD8+ T cells provide a critical defence from pathogens at mucosal epithelia including the female reproductive tract (FRT). Mucosal immunisation is considered essential to initiate this response, however this is difficult to reconcile with evidence that antigen delivered to skin can recruit protective CD8+ T cells to m...

journal_title：Nature communications

authors： Zaric M,Becker PD,Hervouet C,Kalcheva P,Doszpoly A,Blattman N,A O' Neill L,Yus BI,Cocita C,Kwon SY,Baker AH,Lord GM,Klavinskis LS

更新日期：2019-05-17 00:00:00

abstract：:The emergence of personalized and stratified medicine requires label-free, low-cost diagnostic technology capable of monitoring multiple disease biomarkers in parallel. Silicon photonic biosensors combine high-sensitivity analysis with scalable, low-cost manufacturing, but they tend to measure only a single biomarker ...

journal_title：Nature communications

authors： Juan-Colás J,Parkin A,Dunn KE,Scullion MG,Krauss TF,Johnson SD

更新日期：2016-09-14 00:00:00

abstract：:Pseudo-topotactic conversion of carbon nanotubes into one-dimensional carbon nanowires is a challenging but feasible path to obtain desired diameters and morphologies. Here, a previously predicted but experimentally unobserved carbon allotrope, T-carbon, has been produced from pseudo-topotactic conversion of a multi-w...

journal_title：Nature communications

authors： Zhang J,Wang R,Zhu X,Pan A,Han C,Li X,Dan Zhao,Ma C,Wang W,Su H,Niu C

更新日期：2017-09-25 00:00:00

abstract：:Heterostructures formed by stacking layered materials require atomically clean interfaces. However, contaminants are usually trapped between the layers, aggregating into randomly located blisters, incompatible with scalable fabrication processes. Here we report a process to remove blisters from fully formed heterostru...

journal_title：Nature communications

authors： Purdie DG,Pugno NM,Taniguchi T,Watanabe K,Ferrari AC,Lombardo A

更新日期：2018-12-19 00:00:00

abstract：:Urinary sodium and potassium excretion are associated with blood pressure (BP) and cardiovascular disease (CVD). The exact biological link between these traits is yet to be elucidated. Here, we identify 50 loci for sodium and 13 for potassium excretion in a large-scale genome-wide association study (GWAS) on urinary s...

journal_title：Nature communications

authors： Pazoki R,Evangelou E,Mosen-Ansorena D,Pinto RC,Karaman I,Blakeley P,Gill D,Zuber V,Elliott P,Tzoulaki I,Dehghan A

更新日期：2019-08-13 00:00:00

abstract：:The intestinal microbiome is a unique ecosystem and an essential mediator of metabolism and obesity in mammals. However, studies investigating the impact of the diet on the establishment of the gut microbiome early in life are generally lacking, and most notably so in primate models. Here we report that a high-fat mat...

journal_title：Nature communications

authors： Ma J,Prince AL,Bader D,Hu M,Ganu R,Baquero K,Blundell P,Alan Harris R,Frias AE,Grove KL,Aagaard KM

更新日期：2014-05-20 00:00:00

abstract：:The activation of a neuronal ensemble in the central nucleus of the amygdala (CeA) during alcohol withdrawal has been hypothesized to induce high levels of alcohol drinking in dependent rats. In the present study we describe that the CeA neuronal ensemble that is activated by withdrawal from chronic alcohol exposure c...

journal_title：Nature communications

authors： de Guglielmo G,Kallupi M,Pomrenze MB,Crawford E,Simpson S,Schweitzer P,Koob GF,Messing RO,George O

更新日期：2019-03-18 00:00:00

abstract：:An industrial process for the selective activation of methane under mild conditions would be highly valuable for controlling emissions to the environment and for utilizing vast new sources of natural gas. The only selective catalysts for methane activation and conversion to methanol under mild conditions are methane m...

journal_title：Nature communications

authors： Blanchette CD,Knipe JM,Stolaroff JK,DeOtte JR,Oakdale JS,Maiti A,Lenhardt JM,Sirajuddin S,Rosenzweig AC,Baker SE

更新日期：2016-06-15 00:00:00

abstract：:Sclerosing stromal tumor (SST) of the ovary is a rare type of sex cord-stromal tumor (SCST), whose genetic underpinning is currently unknown. Here, using whole-exome, targeted capture and RNA-sequencing, we report recurrent FHL2-GLI2 fusion genes in 65% (17/26) of SSTs and other GLI2 rearrangements in additional 15% (...

journal_title：Nature communications

authors： Kim SH,Da Cruz Paula A,Basili T,Dopeso H,Bi R,Pareja F,da Silva EM,Gularte-Mérida R,Sun Z,Fujisawa S,Smith CG,Ferrando L,Martins Sebastião AP,Bykov Y,Li A,Silveira C,Ashley CW,Stylianou A,Selenica P,Samore WR,Jung

更新日期：2020-01-02 00:00:00

abstract：:Ultrafast photoinduced electron transfer preceding energy equilibration still poses many experimental and conceptual challenges to the optimization of photoconversion since an atomic-scale description has so far been beyond reach. Here we combine femtosecond transient optical absorption spectroscopy with ultrafast X-r...

journal_title：Nature communications

authors： Canton SE,Kjær KS,Vankó G,van Driel TB,Adachi S,Bordage A,Bressler C,Chabera P,Christensen M,Dohn AO,Galler A,Gawelda W,Gosztola D,Haldrup K,Harlang T,Liu Y,Møller KB,Németh Z,Nozawa S,Pápai M,Sato T,Sato T,Su

更新日期：2015-03-02 00:00:00

abstract：:Marine reserves are viewed as flagship tools to protect exploited species and to contribute to the effective management of coastal fisheries. Yet, the extent to which marine reserves are globally interconnected and able to effectively seed areas, where fisheries are most critical for food and livelihood security is la...

journal_title：Nature communications

authors： Andrello M,Guilhaumon F,Albouy C,Parravicini V,Scholtens J,Verley P,Barange M,Sumaila UR,Manel S,Mouillot D

更新日期：2017-07-10 00:00:00

abstract：:In response to brain injury, microglia rapidly extend processes that isolate lesion sites and protect the brain from further injury. Here we report that microglia carrying a pathogenic mutation in the Parkinson's disease (PD)-associated gene, G2019S-LRRK2 (GS-Tg microglia), show retarded ADP-induced motility and delay...

journal_title：Nature communications

authors： Choi I,Kim B,Byun JW,Baik SH,Huh YH,Kim JH,Mook-Jung I,Song WK,Shin JH,Seo H,Suh YH,Jou I,Park SM,Kang HC,Joe EH

更新日期：2015-09-14 00:00:00

abstract：:We propose the concept of universal fiducials based on a set of pre-made semi-synthetic antibodies (sABs) generated by customized phage display selections against the fusion protein BRIL, an engineered variant of apocytochrome b562a. These sABs can bind to BRIL fused either into the loops or termini of different GPCRs...

journal_title：Nature communications

authors： Mukherjee S,Erramilli SK,Ammirati M,Alvarez FJD,Fennell KF,Purdy MD,Skrobek BM,Radziwon K,Coukos J,Kang Y,Dutka P,Gao X,Qiu X,Yeager M,Eric Xu H,Han S,Kossiakoff AA

更新日期：2020-03-27 00:00:00

abstract：:The ever-increasing demand for flexible electronics calls for the development of low-voltage and high-mobility organic thin-film transistors (OTFTs) that can be integrated into emerging display and labeling technologies. Polymer dielectrics with comprehensive and balanced dielectric properties (i.e., a good balance be...

journal_title：Nature communications

authors： Ji D,Li T,Zou Y,Chu M,Zhou K,Liu J,Tian G,Zhang Z,Zhang X,Li L,Wu D,Dong H,Miao Q,Fuchs H,Hu W

更新日期：2018-06-14 00:00:00

abstract：:Although optical technology provides the best solution for the transmission of information, all-optical devices must satisfy several qualitative criteria to be used as logic elements. In particular, cascadability is difficult to obtain in optical systems, and it is assured only if the output of one stage is in the cor...

journal_title：Nature communications

authors： Ballarini D,De Giorgi M,Cancellieri E,Houdré R,Giacobino E,Cingolani R,Bramati A,Gigli G,Sanvitto D

更新日期：2013-01-01 00:00:00

abstract：:Cell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep in the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system to direct macrophages carrying an oncolytic ...

journal_title：Nature communications

authors： Muthana M,Kennerley AJ,Hughes R,Fagnano E,Richardson J,Paul M,Murdoch C,Wright F,Payne C,Lythgoe MF,Farrow N,Dobson J,Conner J,Wild JM,Lewis C

更新日期：2015-08-18 00:00:00

abstract：:Although chemically very simple, Fe2O3 is known to undergo a series of enigmatic structural, electronic and magnetic transformations at high pressures and high temperatures. So far, these transformations have neither been correctly described nor understood because of the lack of structural data. Here we report a syste...

journal_title：Nature communications

authors： Bykova E,Dubrovinsky L,Dubrovinskaia N,Bykov M,McCammon C,Ovsyannikov SV,Liermann HP,Kupenko I,Chumakov AI,Rüffer R,Hanfland M,Prakapenka V

更新日期：2016-02-11 00:00:00