Abstract:
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journal_name
Nat Communjournal_title
Nature communicationsauthors
Palmer EM,Heggy E,Kofman Wdoi
10.1038/s41467-017-01617-xsubject
Has Abstractpub_date
2017-11-23 00:00:00pages
1839issue
1issn
2041-1723pii
10.1038/s41467-017-01617-xjournal_volume
8pub_type
杂志文章,已发布勘误abstract::Insulin-like growth factors (IGFs) induce proliferation of various cell types and play important roles in somatic growth and cancer development. Phosphorylation of insulin receptor substrate (IRS)-1/2 by IGF-I receptor tyrosine kinase is essential for IGF action. Here we identify Nedd4 as an IRS-2 ubiquitin ligase. Ne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7780
更新日期:2015-04-16 00:00:00
abstract::A disturbance of reactive oxygen species (ROS) homeostasis may cause the pathogenesis of many diseases. Inspired by natural photosynthesis, this work proposes a photo-driven H2-evolving liposomal nanoplatform (Lip NP) that comprises an upconversion nanoparticle (UCNP) that is conjugated with gold nanoparticles (AuNPs)...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14413-x
更新日期:2020-01-27 00:00:00
abstract::Adult stem cells commonly give rise to transit-amplifying progenitors, whose progeny differentiate into distinct cell types. It is unclear if stem cell niche signals coordinate fate decisions within the progenitor pool. Here we use quantitative analysis of Wnt, Hh, and Notch signalling reporters and the cell fate mark...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01322-9
更新日期:2017-11-01 00:00:00
abstract::Cells couple growth with division and regulate size in response to nutrient availability. In rod-shaped fission yeast, cell-size control occurs at mitotic commitment. An important regulator is the DYRK-family kinase Pom1, which forms gradients from cell poles and inhibits the mitotic activator Cdr2, itself localized a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9445
更新日期:2015-10-07 00:00:00
abstract::Crystalline solids are generally known as excellent heat conductors, amorphous materials or glasses as thermal insulators. It has thus come as a surprise that certain crystal structures defy this paradigm. A prominent example are type-I clathrates and other materials with guest-host structures. They sustain low-energy...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08685-1
更新日期:2019-02-21 00:00:00
abstract::Haematopoietic stem cells (HSCs) are produced during embryogenesis from the floor of the dorsal aorta. The localization of HSCs is dependent on the presence of instructive signals on the ventral side of the vessel. The nature of the extrinsic molecular signals that control the aortic haematopoietic niche is currently ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6588
更新日期:2014-11-27 00:00:00
abstract::Constitutive activation of Wnt/β-catenin inhibits oligodendrocyte myelination. Tcf7l2/Tcf4, a β-catenin transcriptional partner, is required for oligodendrocyte differentiation. How Tcf7l2 modifies β-catenin signalling and controls myelination remains elusive. Here we define a stage-specific Tcf7l2-regulated transcrip...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10883
更新日期:2016-03-09 00:00:00
abstract::C-Analogues of the canonical N-nucleosides have considerable importance in medicinal chemistry and are promising building blocks of xenobiotic nucleic acids (XNA) in synthetic biology. Although well established for synthesis of N-nucleosides, biocatalytic methods are lacking in C-nucleoside synthetic chemistry. Here, ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20035-0
更新日期:2020-12-08 00:00:00
abstract::Blue/deep-blue emission is crucial for organic optoelectronics but remains a formidable challenge in organic afterglow due to the difficulties in populating and stabilizing the high-energy triplet excited states. Here, a facile strategy to realize the efficient deep-blue organic afterglow is proposed via host molecule...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18572-9
更新日期:2020-09-23 00:00:00
abstract::Tenuazonic acid (TeA) is a well-known mycotoxin produced by various plant pathogenic fungi. However, its biosynthetic gene has been unknown to date. Here we identify the TeA biosynthetic gene from Magnaporthe oryzae by finding two TeA-inducing conditions of a low-producing strain. We demonstrate that TeA is synthesize...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9758
更新日期:2015-10-27 00:00:00
abstract::Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of bodily fluids. Here we show that protein sensors in combination with a nanopore, acting as an electrical transducer, can accurately quantify metabolites in real time...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06534-1
更新日期:2018-10-05 00:00:00
abstract::Deep subwavelength integration of high-definition plasmonic nanostructures is of key importance in the development of future optical nanocircuitry for high-speed communication, quantum computation and lab-on-a-chip applications. To date, the experimental realization of proposed extended plasmonic networks consisting o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1143
更新日期:2010-01-01 00:00:00
abstract::Research on surface plasmon resonance coupling of metallic nanostructures is an important area in the field of plasmonics because distinctive collective optical properties can be realized that are different from the individual constituents. Here we report the localized surface plasmon resonance of hybrid metal-organic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03453-z
更新日期:2018-03-08 00:00:00
abstract::The original version of this Article contained an error in Eq. 1. The arrows between the symbols "T" and "B", and "B" and "T", were written "↔" but should have been "→", and incorrectly read: IEBIC=IEBAC+ISEE+I(e↔h)+IEBICT↔B+IESEEB↔T The correct from of the Eq. 1 is as follows:IEBIC=IEBAC+ISEE+I(e↔h)+IEBICT→B+IESEEB→T...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-02844-6
更新日期:2018-01-24 00:00:00
abstract::Analyzing scattered wave to recognize object is of fundamental significance in wave physics. Recently-emerged deep learning technique achieved great success in interpreting wave field such as in ultrasound non-destructive testing and disease diagnosis, but conventionally need time-consuming computer postprocessing or ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19693-x
更新日期:2020-12-09 00:00:00
abstract::The potential of the folic acid biosynthesis pathway as a target for the development of antibiotics has been clinically validated. However, many pathogens have developed resistance to these antibiotics, prompting a re-evaluation of potential drug targets within the pathway. The ydaH gene of Alcanivorax borkumensis enc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7874
更新日期:2015-04-20 00:00:00
abstract::Familial hemiplegic migraine is an episodic neurological disorder characterized by transient sensory and motor symptoms and signs. Mutations of the ion pump α2-Na/K ATPase cause familial hemiplegic migraine, but the mechanisms by which α2-Na/K ATPase mutations lead to the migraine phenotype remain incompletely underst...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19915-2
更新日期:2020-12-02 00:00:00
abstract::In healthy blood vessels with a laminar blood flow, the endothelial cell division rate is low, only sufficient to replace apoptotic cells. The division rate significantly increases during embryonic development and under halted or turbulent flow. Cells in barrier tissue are connected and their motility is highly correl...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6720
更新日期:2014-12-08 00:00:00
abstract::Sensitive detection of protein interactions and post-translational modifications of native proteins is a challenge for research and diagnostic purposes. A method for this, which could be used in point-of-care devices and high-throughput screening, should be reliable, cost effective and robust. To achieve this, here we...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8294
更新日期:2015-06-12 00:00:00
abstract::The high pathogenicity of the Ebola virus reflects multiple concurrent processes on infection. Among other important determinants, Ebola fusogenic glycoprotein (GP) has been associated with the detachment of infected cells and eventually leads to vascular leakage and haemorrhagic fever. Here we report that the membran...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8688
更新日期:2015-07-09 00:00:00
abstract::Many cities globally are seeking strategies to counter the consequences of both a hotter and drier climate. While urban heat mitigation strategies have been shown to have beneficial effects on health, energy consumption, and greenhouse gas emissions, their implications for water conservation have not been widely exami...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01346-1
更新日期:2017-10-20 00:00:00
abstract::The need for active and stable oxidation catalysts is driven by the demands in production of valuable chemicals, remediation of hydrocarbon pollutants and energy sustainability. Traditional approaches focus on oxygen-activating oxides as support which provides the oxygen activation at the catalyst-support peripheral i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18017-3
更新日期:2020-08-21 00:00:00
abstract::Highly pure semiconducting single-walled carbon nanotubes (SWNTs) are essential for the next generation of electronic devices, such as field-effect transistors and photovoltaic applications; however, contamination by metallic SWNTs reduces the efficiency of their associated devices. Here we report a simple and efficie...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6041
更新日期:2014-10-03 00:00:00
abstract::The aging myopathy manifests itself with diastolic dysfunction and preserved ejection fraction. We raised the possibility that, in a mouse model of physiological aging, defects in electromechanical properties of cardiomyocytes are important determinants of the diastolic characteristics of the myocardium, independently...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9803
更新日期:2015-11-06 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-020-15500-9
更新日期:2020-03-31 00:00:00
abstract::The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of proinflammatory cytokines and mitochondrial dysfunction. Senescent cells contribute to age-related tissue degeneration. Here we show that...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15691
更新日期:2017-06-13 00:00:00
abstract::Large-area light-emitting diodes (LEDs) fabricated by mass-production techniques are needed for low-cost flat-panel lighting. Nevertheless, it is still challenging to fabricate efficient large-area LEDs using organic small molecules (OLEDs), quantum dots (QLEDs), polymers (PLEDs), and recently-developed hybrid perovsk...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20433-4
更新日期:2021-01-08 00:00:00
abstract::Cancer is caused by the accumulation of multiple genetic mutations, but their cooperative effects are poorly understood. Using a genome-wide analysis of all the somatic mutations in colorectal cancer patients in a large-scale molecular interaction network, here we find that a giant cluster of mutation-propagating modu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01171-6
更新日期:2017-11-02 00:00:00
abstract::To date, the vast preponderance of somatic variants observed in the cancer genome have been rare variants, and it is common in practice to encounter in a new tumor variants that have not been observed previously. Here we focus on probability estimation for encountering such hitherto unseen variants. We draw upon stati...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13402-z
更新日期:2019-12-03 00:00:00
abstract::The word 'holography' means a drawing that contains all of the information for light-both amplitude and wavefront. However, because of the insufficient bandwidth of current electronics, the direct measurement of the wavefront of light has not yet been achieved. Though reference-field-assisted interferometric methods h...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13359
更新日期:2016-10-31 00:00:00