Long-range ordered vorticity patterns in living tissue induced by cell division.

abstract：:The original version of this Article contained an error in the spelling of the author Woochul Song, which was incorrectly given as Woochul C. Song. This has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Shen YX,Song W,Barden DR,Ren T,Lang C,Feroz H,Henderson CB,Saboe PO,Tsai D,Yan H,Butler PJ,Bazan GC,Phillip WA,Hickey RJ,Cremer PS,Vashisth H,Kumar M

更新日期：2018-08-14 00:00:00

abstract：:Development of acute experimental autoimmune encephalomyelitis (EAE) depends on Th17 cells expressing the nuclear factor NR4A2. However, in mice lacking NR4A2 in T cells, a late-onset disease is still inducible, despite a great reduction in acute inflammation. We here reveal that development of this late onset disease...

journal_title：Nature communications

authors： Raveney BJ,Oki S,Hohjoh H,Nakamura M,Sato W,Murata M,Yamamura T

更新日期：2015-10-05 00:00:00

abstract：:The competition between bimolecular nucleophilic substitution and base-induced elimination is of fundamental importance for the synthesis of pure samples in organic chemistry. Many factors that influence this competition have been identified over the years, but the underlying atomistic dynamics have remained difficult...

journal_title：Nature communications

authors： Carrascosa E,Meyer J,Zhang J,Stei M,Michaelsen T,Hase WL,Yang L,Wester R

更新日期：2017-06-21 00:00:00

abstract：:DNA methylation maintenance by DNMT1 is an essential process in mammals but molecular mechanisms connecting DNA methylation patterns and enzyme activity remain elusive. Here, we systematically analyzed the specificity of DNMT1, revealing a pronounced influence of the DNA sequences flanking the target CpG site on DNMT1...

journal_title：Nature communications

authors： Adam S,Anteneh H,Hornisch M,Wagner V,Lu J,Radde NE,Bashtrykov P,Song J,Jeltsch A

更新日期：2020-07-24 00:00:00

abstract：:A skullcap found in the Salkhit Valley in northeast Mongolia is, to our knowledge, the only Pleistocene hominin fossil found in the country. It was initially described as an individual with possible archaic affinities, but its ancestry has been debated since the discovery. Here, we determine the age of the Salkhit sku...

journal_title：Nature communications

authors： Devièse T,Massilani D,Yi S,Comeskey D,Nagel S,Nickel B,Ribechini E,Lee J,Tseveendorj D,Gunchinsuren B,Meyer M,Pääbo S,Higham T

更新日期：2019-01-30 00:00:00

abstract：:Expansion of Hevea brasiliensis rubber plantations is a resurgent driver of deforestation, carbon emissions, and biodiversity loss in Southeast Asia. Southeast Asian rubber extent is massive, equivalent to 67% of oil palm, with rapid further expansion predicted. Results-based carbon finance could dis-incentivise fores...

journal_title：Nature communications

authors： Warren-Thomas EM,Edwards DP,Bebber DP,Chhang P,Diment AN,Evans TD,Lambrick FH,Maxwell JF,Nut M,O'Kelly HJ,Theilade I,Dolman PM

更新日期：2018-03-02 00:00:00

abstract：:HIV persists in latently infected CD4+ T cells during antiretroviral therapy (ART). Immune checkpoint molecules, including PD-1, are preferentially expressed at the surface of persistently infected cells. However, whether PD-1 plays a functional role in HIV latency and reservoir persistence remains unknown. Using CD4+...

journal_title：Nature communications

authors： Fromentin R,DaFonseca S,Costiniuk CT,El-Far M,Procopio FA,Hecht FM,Hoh R,Deeks SG,Hazuda DJ,Lewin SR,Routy JP,Sékaly RP,Chomont N

更新日期：2019-02-18 00:00:00

abstract：:Disordered proteins, such as those central to Alzheimer's and Parkinson's, are particularly intractable for structure-targeted therapeutic design. Here we demonstrate the capacity of a synthetic foldamer to capture structure in a disease relevant peptide. Oligoquinoline amides have a defined fold with a solvent-exclud...

journal_title：Nature communications

authors： Kumar S,Birol M,Schlamadinger DE,Wojcik SP,Rhoades E,Miranker AD

更新日期：2016-04-25 00:00:00

abstract：:Vegetation impacts on ecosystem functioning are mediated by mycorrhizas, plant-fungal associations formed by most plant species. Ecosystems dominated by distinct mycorrhizal types differ strongly in their biogeochemistry. Quantitative analyses of mycorrhizal impacts on ecosystem functioning are hindered by the scarcit...

journal_title：Nature communications

authors： Soudzilovskaia NA,van Bodegom PM,Terrer C,Zelfde MV,McCallum I,Luke McCormack M,Fisher JB,Brundrett MC,de Sá NC,Tedersoo L

更新日期：2019-11-07 00:00:00

abstract：:Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we study the complete spectrum of mtDNA changes, including deletions, copy-number variation and point ...

journal_title：Nature communications

authors： Dölle C,Flønes I,Nido GS,Miletic H,Osuagwu N,Kristoffersen S,Lilleng PK,Larsen JP,Tysnes OB,Haugarvoll K,Bindoff LA,Tzoulis C

更新日期：2016-11-22 00:00:00

abstract：:The Paris Agreement set a goal to keep global warming well below 2 °C and pursue efforts to limit it to 1.5 °C. Understanding how 0.5 °C less warming reduces impacts and risks is key for climate policies. Here, we show that both areal and population exposures to dangerous extreme precipitation events (e.g., once in 10...

journal_title：Nature communications

authors： Zhang W,Zhou T,Zou L,Zhang L,Chen X

更新日期：2018-08-08 00:00:00

abstract：:Emerging evidence suggests that caveolin-1 (Cav1) is associated with pulmonary arterial hypertension. MURC (also called Cavin-4) is a member of the cavin family, which regulates caveolar formation and functions together with caveolins. Here, we show that hypoxia increased Murc mRNA expression in the mouse lung, and th...

journal_title：Nature communications

authors： Nakanishi N,Ogata T,Naito D,Miyagawa K,Taniguchi T,Hamaoka T,Maruyama N,Kasahara T,Nishi M,Matoba S,Ueyama T

更新日期：2016-08-22 00:00:00

abstract：:A variant at amino acid 47 in human TP53 exists predominantly in individuals of African descent. P47S human and mouse cells show increased cancer risk due to defective ferroptosis. Here, we show that this ferroptotic defect causes iron accumulation in P47S macrophages. This high iron content alters macrophage cytokine...

journal_title：Nature communications

authors： Singh KS,Leu JI,Barnoud T,Vonteddu P,Gnanapradeepan K,Lin C,Liu Q,Barton JC,Kossenkov AV,George DL,Murphy ME,Dotiwala F

更新日期：2020-01-24 00:00:00

abstract：:Sclerosing stromal tumor (SST) of the ovary is a rare type of sex cord-stromal tumor (SCST), whose genetic underpinning is currently unknown. Here, using whole-exome, targeted capture and RNA-sequencing, we report recurrent FHL2-GLI2 fusion genes in 65% (17/26) of SSTs and other GLI2 rearrangements in additional 15% (...

journal_title：Nature communications

authors： Kim SH,Da Cruz Paula A,Basili T,Dopeso H,Bi R,Pareja F,da Silva EM,Gularte-Mérida R,Sun Z,Fujisawa S,Smith CG,Ferrando L,Martins Sebastião AP,Bykov Y,Li A,Silveira C,Ashley CW,Stylianou A,Selenica P,Samore WR,Jung

更新日期：2020-01-02 00:00:00

abstract：:Herein, we report on a significant discovery, namely, the quantitative discharging of reduced graphite forms, such as graphite intercalation compounds, graphenide dispersions and graphenides deposited on surfaces with the simple solvent benzonitrile. Because of its comparatively low reduction potential, benzonitrile i...

journal_title：Nature communications

authors： Vecera P,Holzwarth J,Edelthalhammer KF,Mundloch U,Peterlik H,Hauke F,Hirsch A

更新日期：2016-08-10 00:00:00

abstract：:In fragmented forests, tree diversity declines near edges but the ecological processes underlying this loss of diversity remain poorly understood. Theory predicts that top-down regulation of seedling recruitment by insect herbivores and fungal pathogens contributes to maintaining tree diversity in forests, but it is u...

journal_title：Nature communications

authors： Krishnadas M,Bagchi R,Sridhara S,Comita LS

更新日期：2018-10-30 00:00:00

abstract：:Malignant pleural effusion (MPE) is a frequent metastatic manifestation of human cancers. While we previously identified KRAS mutations as molecular culprits of MPE formation, the underlying mechanism remained unknown. Here, we determine that non-canonical IKKα-RelB pathway activation of KRAS-mutant tumor cells mediat...

journal_title：Nature communications

authors： Marazioti A,Lilis I,Vreka M,Apostolopoulou H,Kalogeropoulou A,Giopanou I,Giotopoulou GA,Krontira AC,Iliopoulou M,Kanellakis NI,Agalioti T,Giannou AD,Jones-Paris C,Iwakura Y,Kardamakis D,Blackwell TS,Taraviras S,Spella M

更新日期：2018-02-14 00:00:00

abstract：:While engineering the phase and structure of electrocatalysts could regulate the performance of many typical electrochemical processes, its importance to the carbon dioxide electroreduction has been largely unexplored. Herein, a series of phase and structure engineered copper-tin dioxide catalysts have been created an...

journal_title：Nature communications

authors： Wang P,Qiao M,Shao Q,Pi Y,Zhu X,Li Y,Huang X

更新日期：2018-11-22 00:00:00

abstract：:Two-Photon Microscopy has become an invaluable tool for biological and medical research, providing high sensitivity, molecular specificity, inherent three-dimensional sub-cellular resolution and deep tissue penetration. In terms of imaging speeds, however, mechanical scanners still limit the acquisition rates to typic...

journal_title：Nature communications

authors： Karpf S,Riche CT,Di Carlo D,Goel A,Zeiger WA,Suresh A,Portera-Cailliau C,Jalali B

更新日期：2020-04-28 00:00:00

abstract：:Metallic nanostructures exhibit a multitude of optical resonances associated with localized surface plasmon excitations. Recent observations of plasmonic phenomena at the sub-nanometre to atomic scale have stimulated the development of various sophisticated theoretical approaches for their description. Here instead we...

journal_title：Nature communications

authors： Mortensen NA,Raza S,Wubs M,Søndergaard T,Bozhevolnyi SI

更新日期：2014-05-02 00:00:00

abstract：:The size of the membrane-bound nucleus scales with cell size in a wide range of cell types but the mechanisms determining overall nuclear size remain largely unknown. Here we investigate the role of fission yeast inner nuclear membrane proteins in determining nuclear size, and propose that the Lap2-Emerin-Man1 domain ...

journal_title：Nature communications

authors： Kume K,Cantwell H,Burrell A,Nurse P

更新日期：2019-04-23 00:00:00

abstract：:Autophosphorylation of amino-acid residues is part of the folding process of various protein kinases. Conventional chemical screening of mature kinases has missed inhibitors that selectively interfere with the folding process. Here we report a cell-based assay that evaluates inhibition of a kinase at a transitional st...

journal_title：Nature communications

authors： Kii I,Sumida Y,Goto T,Sonamoto R,Okuno Y,Yoshida S,Kato-Sumida T,Koike Y,Abe M,Nonaka Y,Ikura T,Ito N,Shibuya H,Hosoya T,Hagiwara M

更新日期：2016-04-22 00:00:00

abstract：:Venomous animals are thought to inject the same combination of toxins for both predation and defence, presumably exploiting conserved target pharmacology across prey and predators. Remarkably, cone snails can rapidly switch between distinct venoms in response to predatory or defensive stimuli. Here, we show that the d...

journal_title：Nature communications

authors： Dutertre S,Jin AH,Vetter I,Hamilton B,Sunagar K,Lavergne V,Dutertre V,Fry BG,Antunes A,Venter DJ,Alewood PF,Lewis RJ

更新日期：2014-03-24 00:00:00

abstract：:Most tumor cells take up more glucose than normal cells. Splicing dysregulation is one of the molecular hallmarks of cancer. However, the role of splicing factor in glucose metabolism and tumor development remains poorly defined. Here, we show that upon glucose intake, the splicing factor SRSF5 is specifically induced...

journal_title：Nature communications

authors： Chen Y,Huang Q,Liu W,Zhu Q,Cui CP,Xu L,Guo X,Wang P,Liu J,Dong G,Wei W,Liu CH,Feng Z,He F,Zhang L

更新日期：2018-06-25 00:00:00

abstract：:Stimuli-responsive hydrogel actuators have promising applications in various fields. However, the typical hydrogel actuation relies on the swelling and de-swelling process caused by osmotic-pressure changes, which is slow and normally requires the presence of water environment. Herein, we report a light-powered in-air...

journal_title：Nature communications

authors： Li M,Wang X,Dong B,Sitti M

更新日期：2020-08-10 00:00:00

abstract：:Insulin resistance is closely associated with obesity and is one of the earliest symptoms of type-2 diabetes. Endothelial cells are involved in the pathogenesis of insulin resistance through their role in insulin delivery and adipose tissue angiogenesis. Here we show that Ecscr (endothelial cell surface expressed chem...

journal_title：Nature communications

authors： Akakabe Y,Koide M,Kitamura Y,Matsuo K,Ueyama T,Matoba S,Yamada H,Miyata K,Oike Y,Ikeda K

更新日期：2013-01-01 00:00:00

abstract：:In bacteria, transcription complexes stalled on DNA represent a major source of roadblocks for the DNA replication machinery that must be removed in order to prevent damaging collisions. Gram-positive bacteria contain a transcription factor HelD that is able to remove and recycle stalled complexes, but it was not know...

journal_title：Nature communications

authors： Newing TP,Oakley AJ,Miller M,Dawson CJ,Brown SHJ,Bouwer JC,Tolun G,Lewis PJ

更新日期：2020-12-18 00:00:00

abstract：:Heat shock protein-90 (Hsp90) is an essential molecular chaperone in eukaryotes involved in maintaining the stability and activity of numerous signalling proteins, also known as clients. Hsp90 ATPase activity is essential for its chaperone function and it is regulated by co-chaperones. Here we show that the tumour sup...

journal_title：Nature communications

authors： Woodford MR,Dunn DM,Blanden AR,Capriotti D,Loiselle D,Prodromou C,Panaretou B,Hughes PF,Smith A,Ackerman W,Haystead TA,Loh SN,Bourboulia D,Schmidt LS,Marston Linehan W,Bratslavsky G,Mollapour M

更新日期：2016-06-29 00:00:00

abstract：:Spinal motor neurons (MNs) control diverse motor tasks including respiration, posture and locomotion that are disrupted by neurodegenerative diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy. Methods directing MN differentiation from stem cells have been developed to enable disease modelling i...

journal_title：Nature communications

authors： Adams KL,Rousso DL,Umbach JA,Novitch BG

更新日期：2015-04-14 00:00:00

abstract：:Direct reprogramming of fibroblasts into cardiomyocytes by forced expression of cardiomyogenic factors, GMT (GATA4, Mef2C, Tbx5) or GHMT (GATA4, Hand2, Mef2C, Tbx5), has recently been demonstrated, suggesting a novel therapeutic strategy for cardiac repair. However, current approaches are inefficient. Here we demonstr...

journal_title：Nature communications

authors： Zhao Y,Londono P,Cao Y,Sharpe EJ,Proenza C,O'Rourke R,Jones KL,Jeong MY,Walker LA,Buttrick PM,McKinsey TA,Song K

更新日期：2015-09-10 00:00:00