Long-range ordered vorticity patterns in living tissue induced by cell division.

Abstract:

:In healthy blood vessels with a laminar blood flow, the endothelial cell division rate is low, only sufficient to replace apoptotic cells. The division rate significantly increases during embryonic development and under halted or turbulent flow. Cells in barrier tissue are connected and their motility is highly correlated. Here we investigate the long-range dynamics induced by cell division in an endothelial monolayer under non-flow conditions, mimicking the conditions during vessel formation or around blood clots. Cell divisions induce long-range, well-ordered vortex patterns extending several cell diameters away from the division site, in spite of the system's low Reynolds number. Our experimental results are reproduced by a hydrodynamic continuum model simulating division as a local pressure increase corresponding to a local tension decrease. Such long-range physical communication may be crucial for embryonic development and for healing tissue, for instance around blood clots.

journal_name

Nat Commun

journal_title

Nature communications

authors

Rossen NS,Tarp JM,Mathiesen J,Jensen MH,Oddershede LB

doi

10.1038/ncomms6720

subject

Has Abstract

pub_date

2014-12-08 00:00:00

pages

5720

issn

2041-1723

pii

ncomms6720

journal_volume

5

pub_type

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