Environmental enrichment ameliorates perinatal brain injury and promotes functional white matter recovery.

Abstract:

:Hypoxic damage to the developing brain due to preterm birth causes many anatomical changes, including damage to the periventricular white matter. This results in the loss of glial cells, significant disruptions in myelination, and thereby cognitive and behavioral disabilities seen throughout life. Encouragingly, these neurological morbidities can be improved by environmental factors; however, the underlying cellular mechanisms remain unknown. We found that early and continuous environmental enrichment selectively enhances endogenous repair of the developing white matter by promoting oligodendroglial maturation, myelination, and functional recovery after perinatal brain injury. These effects require increased exposure to socialization, physical activity, and cognitive enhancement of surroundings-a complete enriched environment. Using RNA-sequencing, we identified oligodendroglial-specific responses to hypoxic brain injury, and uncovered molecular mechanisms involved in enrichment-induced recovery. Together, these results indicate that myelin plasticity induced by modulation of the neonatal environment can be targeted as a therapeutic strategy for preterm birth.

journal_name

Nat Commun

journal_title

Nature communications

authors

Forbes TA,Goldstein EZ,Dupree JL,Jablonska B,Scafidi J,Adams KL,Imamura Y,Hashimoto-Torii K,Gallo V

doi

10.1038/s41467-020-14762-7

subject

Has Abstract

pub_date

2020-02-19 00:00:00

pages

964

issue

1

issn

2041-1723

pii

10.1038/s41467-020-14762-7

journal_volume

11

pub_type

杂志文章
  • Overlooked electrolyte destabilization by manganese (II) in lithium-ion batteries.

    abstract::Transition-metal dissolution from cathode materials, manganese in particular, has been held responsible for severe capacity fading in lithium-ion batteries, with the deposition of the transition-metal cations on anode surface, in elemental form or as chelated-complexes, as the main contributor for such degradations. I...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-11439-8

    authors: Wang C,Xing L,Vatamanu J,Chen Z,Lan G,Li W,Xu K

    更新日期:2019-07-31 00:00:00

  • White light emission from a single organic molecule with dual phosphorescence at room temperature.

    abstract::The development of single molecule white light emitters is extremely challenging for pure phosphorescent metal-free system at room temperature. Here we report a single pure organic phosphor, namely 4-chlorobenzoyldibenzothiophene, emitting white room temperature phosphorescence with Commission Internationale de l'Écla...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-00362-5

    authors: He Z,Zhao W,Lam JWY,Peng Q,Ma H,Liang G,Shuai Z,Tang BZ

    更新日期:2017-09-04 00:00:00

  • Prophage-triggered membrane vesicle formation through peptidoglycan damage in Bacillus subtilis.

    abstract::Bacteria release membrane vesicles (MVs) that play important roles in various biological processes. However, the mechanisms of MV formation in Gram-positive bacteria are unclear, as these cells possess a single cytoplasmic membrane that is surrounded by a thick cell wall. Here we use live cell imaging and electron cry...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-00492-w

    authors: Toyofuku M,Cárcamo-Oyarce G,Yamamoto T,Eisenstein F,Hsiao CC,Kurosawa M,Gademann K,Pilhofer M,Nomura N,Eberl L

    更新日期:2017-09-07 00:00:00

  • Synthesis of molecular metallic barium superhydride: pseudocubic BaH12.

    abstract::Following the discovery of high-temperature superconductivity in the La-H system, we studied the formation of new chemical compounds in the barium-hydrogen system at pressures from 75 to 173 GPa. Using in situ generation of hydrogen from NH3BH3, we synthesized previously unknown superhydride BaH12 with a pseudocubic (...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-20103-5

    authors: Chen W,Semenok DV,Kvashnin AG,Huang X,Kruglov IA,Galasso M,Song H,Duan D,Goncharov AF,Prakapenka VB,Oganov AR,Cui T

    更新日期:2021-01-11 00:00:00

  • Observation of the polaronic character of excitons in a two-dimensional semiconducting magnet CrI3.

    abstract::Exciton dynamics can be strongly affected by lattice vibrations through electron-phonon coupling. This is rarely explored in two-dimensional magnetic semiconductors. Focusing on bilayer CrI3, we first show the presence of strong electron-phonon coupling through temperature-dependent photoluminescence and absorption sp...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-18627-x

    authors: Jin W,Kim HH,Ye Z,Ye G,Rojas L,Luo X,Yang B,Yin F,Horng JSA,Tian S,Fu Y,Xu G,Deng H,Lei H,Tsen AW,Sun K,He R,Zhao L

    更新日期:2020-09-22 00:00:00

  • Publisher Correction: Aerodynamic generation of electric fields in turbulence laden with charged inertial particles.

    abstract::The original version of this Article contained an error in the last sentence of the second paragraph of the 'Atmospheric rarefaction effects' section of the Results, which incorrectly read 'The other one emulates the rarefied, CO2-rich Martian atmosphere (μ♂ = 1.3 × 10-5 N s m-2) at 6.9 mbar and 210 K, which gives ρ♂ ...

    journal_title:Nature communications

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41467-018-04545-6

    authors: Di Renzo M,Urzay J

    更新日期:2018-05-21 00:00:00

  • Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol).

    abstract::Nano-sized metal particles are attracting much interest in industrial and biomedical applications due to the recent progress and development of nanotechnology, and the surface-modifications by appropriate polymers are key techniques to stably express their characteristics. Herein, we applied cyclic poly(ethylene glyco...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-19947-8

    authors: Wang Y,Quinsaat JEQ,Ono T,Maeki M,Tokeshi M,Isono T,Tajima K,Satoh T,Sato SI,Miura Y,Yamamoto T

    更新日期:2020-11-30 00:00:00

  • Mass extinctions drove increased global faunal cosmopolitanism on the supercontinent Pangaea.

    abstract::Mass extinctions have profoundly impacted the evolution of life through not only reducing taxonomic diversity but also reshaping ecosystems and biogeographic patterns. In particular, they are considered to have driven increased biogeographic cosmopolitanism, but quantitative tests of this hypothesis are rare and have ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-00827-7

    authors: Button DJ,Lloyd GT,Ezcurra MD,Butler RJ

    更新日期:2017-10-10 00:00:00

  • Initial pulse of Siberian Traps sills as the trigger of the end-Permian mass extinction.

    abstract::Mass extinction events are short-lived and characterized by catastrophic biosphere collapse and subsequent reorganization. Their abrupt nature necessitates a similarly short-lived trigger, and large igneous province magmatism is often implicated. However, large igneous provinces are long-lived compared to mass extinct...

    journal_title:Nature communications

    pub_type: 历史文章,杂志文章

    doi:10.1038/s41467-017-00083-9

    authors: Burgess SD,Muirhead JD,Bowring SA

    更新日期:2017-07-31 00:00:00

  • Replication of flexible polymer membranes with geometry-controllable nano-apertures via a hierarchical mould-based dewetting.

    abstract::Membranes with nano-apertures are versatile templates that possess a wide range of electronic, optical and biomedical applications. However, such membranes have been limited to silicon-based inorganic materials to utilize standard semiconductor processes. Here we report a new type of flexible and free-standing polymer...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms4137

    authors: Cho H,Kim J,Park H,Won Bang J,Seop Hyun M,Bae Y,Ha L,Yoon Kim D,Min Kang S,Jung Park T,Seo S,Choi M,Suh KY

    更新日期:2014-01-01 00:00:00

  • CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells.

    abstract::Telomerase elongates the telomeric G-strand to prevent telomere shortening through conventional DNA replication. However, synthesis of the complementary C-strand by DNA polymerase α is also required to maintain telomere length. Polymerase α cannot perform this role without the ssDNA binding complex CST (CTC1-STN1-TEN1...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-05154-z

    authors: Feng X,Hsu SJ,Bhattacharjee A,Wang Y,Diao J,Price CM

    更新日期:2018-07-19 00:00:00

  • Dynamical observations on the crack tip zone and stress corrosion of two-dimensional MoS2.

    abstract::Whether and how fracture mechanics needs to be modified for small length scales and in systems of reduced dimensionality remains an open debate. Here, employing in situ transmission electron microscopy, atomic structures and dislocation dynamics in the crack tip zone of a propagating crack in two-dimensional (2D) mono...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms14116

    authors: Ly TH,Zhao J,Cichocka MO,Li LJ,Lee YH

    更新日期:2017-01-18 00:00:00

  • Surpassing the single-atom catalytic activity limit through paired Pt-O-Pt ensemble built from isolated Pt1 atoms.

    abstract::Despite the maximized metal dispersion offered by single-atom catalysts, further improvement of intrinsic activity can be hindered by the lack of neighboring metal atoms in these systems. Here we report the use of isolated Pt1 atoms on ceria as "seeds" to develop a Pt-O-Pt ensemble, which is well-represented by a Pt8O...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-11856-9

    authors: Wang H,Liu JX,Allard LF,Lee S,Liu J,Li H,Wang J,Wang J,Oh SH,Li W,Flytzani-Stephanopoulos M,Shen M,Goldsmith BR,Yang M

    更新日期:2019-08-23 00:00:00

  • TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice.

    abstract::Pachytene piRNAs are the most abundant piRNAs in mammalian adult testes. They are generated from long precursor transcripts by the primary piRNA biogenesis pathway but the factors involved in pachytene piRNA precursors processing are poorly understood. Here we show that the Tudor domain-containing 5 (TDRD5) protein is...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-02622-w

    authors: Ding D,Liu J,Midic U,Wu Y,Dong K,Melnick A,Latham KE,Chen C

    更新日期:2018-01-09 00:00:00

  • Identifying causal gateways and mediators in complex spatio-temporal systems.

    abstract::Identifying regions important for spreading and mediating perturbations is crucial to assess the susceptibilities of spatio-temporal complex systems such as the Earth's climate to volcanic eruptions, extreme events or geoengineering. Here a data-driven approach is introduced based on a dimension reduction, causal reco...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms9502

    authors: Runge J,Petoukhov V,Donges JF,Hlinka J,Jajcay N,Vejmelka M,Hartman D,Marwan N,Paluš M,Kurths J

    更新日期:2015-10-07 00:00:00

  • A transient self-assembling self-replicator.

    abstract::Developing physical models of complex dynamic systems showing emergent behaviour is key to informing on persistence and replication in biology, how living matter emerges from chemistry, and how to design systems with new properties. Herein we report a fully synthetic small molecule system in which a surfactant replica...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-04670-2

    authors: Colomer I,Morrow SM,Fletcher SP

    更新日期:2018-06-08 00:00:00

  • Fire air pollution reduces global terrestrial productivity.

    abstract::Fire emissions generate air pollutants ozone (O3) and aerosols that influence the land carbon cycle. Surface O3 damages vegetation photosynthesis through stomatal uptake, while aerosols influence photosynthesis by increasing diffuse radiation. Here we combine several state-of-the-art models and multiple measurement da...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-07921-4

    authors: Yue X,Unger N

    更新日期:2018-12-21 00:00:00

  • Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs.

    abstract::Pioneer transcription factors can engage nucleosomal DNA, which leads to local chromatin remodeling and to the establishment of transcriptional competence. However, the impact of enhancer priming by pioneer factors on the temporal control of gene expression and on mitotic memory remains unclear. Here we employ quantit...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-07613-z

    authors: Dufourt J,Trullo A,Hunter J,Fernandez C,Lazaro J,Dejean M,Morales L,Nait-Amer S,Schulz KN,Harrison MM,Favard C,Radulescu O,Lagha M

    更新日期:2018-12-05 00:00:00

  • Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting.

    abstract::Cell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep in the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system to direct macrophages carrying an oncolytic ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms9009

    authors: Muthana M,Kennerley AJ,Hughes R,Fagnano E,Richardson J,Paul M,Murdoch C,Wright F,Payne C,Lythgoe MF,Farrow N,Dobson J,Conner J,Wild JM,Lewis C

    更新日期:2015-08-18 00:00:00

  • Faster phonological processing and right occipito-temporal coupling in deaf adults signal poor cochlear implant outcome.

    abstract::The outcome of adult cochlear implantation is predicted positively by the involvement of visual cortex in speech processing, and negatively by the cross-modal recruitment of the right temporal cortex during and after deafness. How these two neurofunctional predictors concur to modulate cochlear implant (CI) performanc...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms14872

    authors: Lazard DS,Giraud AL

    更新日期:2017-03-28 00:00:00

  • Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank.

    abstract::Although snoring is common in the general population, its aetiology has been largely understudied. Here we report a genetic study on snoring (n ~ 408,000; snorers ~ 152,000) using data from the UK Biobank. We identify 42 genome-wide significant loci, with an SNP-based heritability estimate of ~10% on the liability sca...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-14625-1

    authors: Campos AI,García-Marín LM,Byrne EM,Martin NG,Cuéllar-Partida G,Rentería ME

    更新日期:2020-02-14 00:00:00

  • A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance.

    abstract::Copper resistance is a key virulence trait of the uropathogen Proteus mirabilis. Here we show that P. mirabilis ScsC (PmScsC) contributes to this defence mechanism by enabling swarming in the presence of copper. We also demonstrate that PmScsC is a thioredoxin-like disulfide isomerase but, unlike other characterized p...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms16065

    authors: Furlong EJ,Lo AW,Kurth F,Premkumar L,Totsika M,Achard MES,Halili MA,Heras B,Whitten AE,Choudhury HG,Schembri MA,Martin JL

    更新日期:2017-07-19 00:00:00

  • Consistent population declines but idiosyncratic range shifts in Alpine orchids under global change.

    abstract::Mountains are plant biodiversity hotspots considered particularly vulnerable to multiple environmental changes. Here, we quantify population changes and range-shift dynamics along elevational gradients over the last three decades for c. two-thirds of the orchid species of the European Alps. Local extinctions were more...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-19680-2

    authors: Geppert C,Perazza G,Wilson RJ,Bertolli A,Prosser F,Melchiori G,Marini L

    更新日期:2020-11-17 00:00:00

  • Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features.

    abstract::The CCCTC-binding zinc-finger protein (CTCF)-mediated network of long-range chromatin interactions is important for genome organization and function. Although this network has been considered largely invariant, we find that it exhibits extensive cell-type-specific interactions that contribute to cell identity. Here, w...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-06664-6

    authors: Kai Y,Andricovich J,Zeng Z,Zhu J,Tzatsos A,Peng W

    更新日期:2018-10-11 00:00:00

  • PPARγ is an E3 ligase that induces the degradation of NFκB/p65.

    abstract::Nuclear factor-κB (NFκB) and peroxisome proliferator activated receptor-γ (PPARγ) are both transcription factors that perform distinct but overlapping roles in cellular regulation. Here we report that PPARγ acts as an E3 ubiquitin ligase, physically interacting with p65 to induce its ubiquitination and degradation. Th...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms2270

    authors: Hou Y,Moreau F,Chadee K

    更新日期:2012-01-01 00:00:00

  • Pooled CRISPR interference screening enables genome-scale functional genomics study in bacteria with superior performance.

    abstract::To fully exploit the microbial genome resources, a high-throughput experimental platform is needed to associate genes with phenotypes at the genome level. We present here a novel method that enables investigation of the cellular consequences of repressing individual transcripts based on the CRISPR interference (CRISPR...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-04899-x

    authors: Wang T,Guan C,Guo J,Liu B,Wu Y,Xie Z,Zhang C,Xing XH

    更新日期:2018-06-26 00:00:00

  • Printable enzyme-embedded materials for methane to methanol conversion.

    abstract::An industrial process for the selective activation of methane under mild conditions would be highly valuable for controlling emissions to the environment and for utilizing vast new sources of natural gas. The only selective catalysts for methane activation and conversion to methanol under mild conditions are methane m...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms11900

    authors: Blanchette CD,Knipe JM,Stolaroff JK,DeOtte JR,Oakdale JS,Maiti A,Lenhardt JM,Sirajuddin S,Rosenzweig AC,Baker SE

    更新日期:2016-06-15 00:00:00

  • All-optical polariton transistor.

    abstract::Although optical technology provides the best solution for the transmission of information, all-optical devices must satisfy several qualitative criteria to be used as logic elements. In particular, cascadability is difficult to obtain in optical systems, and it is assured only if the output of one stage is in the cor...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms2734

    authors: Ballarini D,De Giorgi M,Cancellieri E,Houdré R,Giacobino E,Cingolani R,Bramati A,Gigli G,Sanvitto D

    更新日期:2013-01-01 00:00:00

  • Scaling law for excitons in 2D perovskite quantum wells.

    abstract::Ruddlesden-Popper halide perovskites are 2D solution-processed quantum wells with a general formula A2A'n-1M n X3n+1, where optoelectronic properties can be tuned by varying the perovskite layer thickness (n-value), and have recently emerged as efficient semiconductors with technologically relevant stability. However,...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-04659-x

    authors: Blancon JC,Stier AV,Tsai H,Nie W,Stoumpos CC,Traoré B,Pedesseau L,Kepenekian M,Katsutani F,Noe GT,Kono J,Tretiak S,Crooker SA,Katan C,Kanatzidis MG,Crochet JJ,Even J,Mohite AD

    更新日期:2018-06-08 00:00:00

  • Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform.

    abstract::The mammary gland is a highly vascularized tissue capable of expansion and regression during development and disease. To enable mechanistic insight into the coordinated morphogenic crosstalk between the epithelium and vasculature, we introduce a 3D microfluidic platform that juxtaposes a human mammary duct in proximit...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-17102-x

    authors: Kutys ML,Polacheck WJ,Welch MK,Gagnon KA,Koorman T,Kim S,Li L,McClatchey AI,Chen CS

    更新日期:2020-07-06 00:00:00