Abstract：
:Hypoxic damage to the developing brain due to preterm birth causes many anatomical changes, including damage to the periventricular white matter. This results in the loss of glial cells, significant disruptions in myelination, and thereby cognitive and behavioral disabilities seen throughout life. Encouragingly, these neurological morbidities can be improved by environmental factors; however, the underlying cellular mechanisms remain unknown. We found that early and continuous environmental enrichment selectively enhances endogenous repair of the developing white matter by promoting oligodendroglial maturation, myelination, and functional recovery after perinatal brain injury. These effects require increased exposure to socialization, physical activity, and cognitive enhancement of surroundings-a complete enriched environment. Using RNA-sequencing, we identified oligodendroglial-specific responses to hypoxic brain injury, and uncovered molecular mechanisms involved in enrichment-induced recovery. Together, these results indicate that myelin plasticity induced by modulation of the neonatal environment can be targeted as a therapeutic strategy for preterm birth.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Forbes TA,Goldstein EZ,Dupree JL,Jablonska B,Scafidi J,Adams KL,Imamura Y,Hashimoto-Torii K,Gallo Vdoi
10.1038/s41467-020-14762-7subject
Has Abstractpub_date
2020-02-19 00:00:00pages
964issue
1issn
2041-1723pii
10.1038/s41467-020-14762-7journal_volume
11pub_type
杂志文章abstract：:Respiration by soil bacteria and fungi is one of the largest fluxes of carbon (C) from the land surface. Although this flux is a direct product of microbial metabolism, controls over metabolism and their responses to global change are a major uncertainty in the global C cycle. Here, we explore an in silico approach to...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-11488-z
更新日期：2019-08-08 00:00:00
abstract：:Exciton dynamics can be strongly affected by lattice vibrations through electron-phonon coupling. This is rarely explored in two-dimensional magnetic semiconductors. Focusing on bilayer CrI3, we first show the presence of strong electron-phonon coupling through temperature-dependent photoluminescence and absorption sp...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-18627-x
更新日期：2020-09-22 00:00:00
abstract：:Extremely metal-poor galaxies with metallicity below 10% of the solar value in the local universe are the best analogues to investigating the interstellar medium at a quasi-primitive environment in the early universe. In spite of the ongoing formation of stars in these galaxies, the presence of molecular gas (which is...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms13789
更新日期：2016-12-09 00:00:00
abstract：:Non-collinear spin transport is at the heart of spin or magnetization control in spintronics devices. The use of nanoscale conductors exhibiting quantum effects in transport could provide new paths for that purpose. Here we study non-collinear spin transport in a quantum dot. We use a device made out of a single-wall ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10451
更新日期：2016-01-27 00:00:00
abstract：:Intensive studies have recently been performed on graphene-based photodetectors, but most of them are based on field effect transistor structures containing mechanically exfoliated graphene, not suitable for practical large-scale device applications. Here we report high-efficient photodetector behaviours of chemical v...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4249
更新日期：2014-01-01 00:00:00
abstract：:Plant hormone cytokinins are perceived by a subfamily of sensor histidine kinases (HKs), which via a two-component phosphorelay cascade activate transcriptional responses in the nucleus. Subcellular localization of the receptors proposed the endoplasmic reticulum (ER) membrane as a principal cytokinin perception site,...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-17949-0
更新日期：2020-08-27 00:00:00
abstract：:Natural systems frequently exploit intricate multiscale and multiphasic structures to achieve functionalities beyond those of man-made systems. Although understanding the chemical make-up of these systems is essential, the passive and active mechanics within biological systems are crucial when considering the many nat...
journal_title：Nature communications
pub_type： 杂志文章,评审
doi：10.1038/ncomms8418
更新日期：2015-07-06 00:00:00
abstract：:Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. TOP1 is also a major driver of endogenous genome instability, particularly when its catalytic intermediate-a covalent TOP1-DNA adduct known as a TOP1 cleavage complex (TOP1cc)-is stabilised. TOP1ccs are high...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15000-w
更新日期：2020-03-09 00:00:00
abstract：:Chemical modifications on DNA molecules, such as 5-methylcytosine and 5-hydroxymethylcytosine, play important roles in the mammalian brain. A novel DNA adenine modification, N(6)-methyladenine (6mA), has recently been found in mammalian cells. However, the presence and function(s) of 6mA in the mammalian brain remain ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-01195-y
更新日期：2017-10-24 00:00:00
abstract：:Spectral domain optical coherence tomography (OCT) is a widely employed, minimally invasive bio-medical imaging technique, which requires a broadband light source, typically implemented by super-luminescent diodes. Recent advances in soliton based photonic integrated frequency combs (soliton microcombs) have enabled t...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20404-9
更新日期：2021-01-18 00:00:00
abstract：:This corrects the article DOI: 10.1038/ncomms14454. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/ncomms16007
更新日期：2017-06-23 00:00:00
abstract：:Specialized cells in the medial entorhinal cortex (mEC), such as speed cells, head direction (HD) cells, and grid cells, are thought to support spatial navigation. To determine whether these computations are dependent on local circuits, we record neuronal activity in mEC layers II and III and optogenetically perturb l...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06104-5
更新日期：2018-09-12 00:00:00
abstract：:Artificial particle ices are model systems of constrained, interacting particles. They have been introduced theoretically to study ice-manifolds emergent from frustration, along with domain wall and grain boundary dynamics, doping, pinning-depinning, controlled transport of topological defects, avalanches, and memory ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06631-1
更新日期：2018-10-08 00:00:00
abstract：:Van Allen radiation belts are typically two zones of energetic particles encircling the Earth separated by the slot region. How the outer radiation belt electrons are accelerated to relativistic energies remains an unanswered question. Recent studies have presented compelling evidence for the local acceleration by ver...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10096
更新日期：2015-12-22 00:00:00
abstract：:High-harmonic generation (HHG) in gases has been the main enabling technology of attosecond science since its discovery. Recently, HHG from solids has been demonstrated, opening a lively area of research. In contrast, harmonic generation from liquids has so far remained restricted to low harmonics in the visible regim...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06040-4
更新日期：2018-09-13 00:00:00
abstract：:Neurofilaments are intermediate filaments assembled from the subunits neurofilament-low, neurofilament-medium and neurofilament-high. In axons, parallel neurofilaments form a nematic liquid-crystal hydrogel with network structure arising from interactions between the neurofilaments' C-terminal sidearms. Here we report...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms3224
更新日期：2013-01-01 00:00:00
abstract：:Pair production can be triggered by high-intensity lasers via the Breit-Wheeler process. However, the straightforward laser-laser colliding for copious numbers of pair creation requires light intensities several orders of magnitude higher than possible with the ongoing laser facilities. Despite the numerous proposed a...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms13686
更新日期：2016-12-14 00:00:00
abstract：:Bone mineral density (BMD) is a measure of osteoporosis and is useful in evaluating the risk of fracture. In a genome-wide association study of BMD among 20,100 Icelanders, with follow-up in 10,091 subjects of European and East-Asian descent, we found a new BMD locus that harbours the PTCH1 gene, represented by rs2837...
journal_title：Nature communications
pub_type： 杂志文章,meta分析
doi：10.1038/ncomms10129
更新日期：2016-01-06 00:00:00
abstract：:Microbial fatty acid-derived fuels have emerged as promising alternatives to petroleum-based transportation fuels. Here we report a modular engineering approach that systematically removed metabolic pathway bottlenecks and led to significant titre improvements in a multi-gene fatty acid metabolic pathway. On the basis...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms2425
更新日期：2013-01-01 00:00:00
abstract：:Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We find 11 genome-wide-sign...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5926
更新日期：2014-10-29 00:00:00
abstract：:In eukaryotic cells, organellar proteome biogenesis is pivotal for cellular function. Chloroplasts contain a complex proteome, the biogenesis of which includes post-translational import of nuclear-encoded proteins. However, the mechanisms determining when and how nascent chloroplast-targeted proteins are sorted in the...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms7843
更新日期：2015-04-16 00:00:00
abstract：:Cerebral cavernous malformations (CCMs) are vascular abnormalities that primarily occur in adulthood and cause cerebral hemorrhage, stroke, and seizures. CCMs are thought to be initiated by endothelial cell (EC) loss of any one of the three Ccm genes: CCM1 (KRIT1), CCM2 (OSM), or CCM3 (PDCD10). Here we report that mic...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20774-0
更新日期：2021-01-25 00:00:00
abstract：:Axially chiral compounds play an important role in areas such as asymmetric catalysis. The tyrosine click-like reaction is an efficient approach for synthesis of urazoles with potential applications in pharmaceutical and asymmetric catalysis. Here we discover a class of urazole with axial chirality by restricted rotat...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10677
更新日期：2016-02-11 00:00:00
abstract：:Explosive energy release is a common phenomenon occurring in magnetized plasma systems ranging from laboratories, Earth's magnetosphere, the solar corona and astrophysical environments. Its physical explanation is usually attributed to magnetic reconnection in a thin current sheet. Here we report the important role of...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1753
更新日期：2012-03-20 00:00:00
abstract：:Transposable elements constitute a substantial portion of eukaryotic genomes and contribute to genomic variation, function, and evolution. Miniature inverted-repeat transposable elements (MITEs), as DNA transposons, are widely distributed in plant and animal genomes. Previous studies have suggested that retrotransposo...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms14651
更新日期：2017-03-03 00:00:00
abstract：:Changes in cellular metabolism are associated with the activation of diverse immune subsets. These changes are fuelled by nutrients including glucose, amino acids and fatty acids, and are closely linked to immune cell fate and function. An emerging concept is that nutrients are not equally available to all immune cell...
journal_title：Nature communications
pub_type： 杂志文章,评审
doi：10.1038/s41467-019-10015-4
更新日期：2019-05-09 00:00:00
abstract：:The sensory cortex participates in emotional memory but its role is poorly understood. Here we show that inactivation of the higher order auditory cortex Te2 in rats during early memory consolidation impairs remote first- and second-order fear memories but not the association between two neutral cues. Furthermore, Te2...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9886
更新日期：2015-12-01 00:00:00
abstract：:Microcephaly is a cortical malformation disorder characterized by an abnormally small brain. Recent studies have revealed severe cases of microcephaly resulting from human mutations in the NDE1 gene, which is involved in the regulation of cytoplasmic dynein. Here using in utero electroporation of NDE1 short hairpin RN...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12551
更新日期：2016-08-24 00:00:00
abstract：:One primary reason that makes single-cell RNA-seq analysis challenging is dropouts, where the data only captures a small fraction of the transcriptome of each cell. Almost all computational algorithms developed for single-cell RNA-seq adopted gene selection, dimension reduction or imputation to address the dropouts. H...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-14976-9
更新日期：2020-03-03 00:00:00
abstract：:Endogenous opioid peptides and prescription opioid drugs modulate pain, anxiety and stress by activating opioid receptors, currently classified into four subtypes. Here we demonstrate that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines, is a broad-spectrum scavenger of opioid peptides. Ph...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-16664-0
更新日期：2020-06-19 00:00:00
