Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate.

abstract：:Heterostructured material systems devoid of ferroic components are presumed not to display ordering associated with ferroelectricity. In heterostructures composed of transition metal oxides, however, the disruption introduced by an interface can affect the balance of the competing interactions among electronic spins, ...

journal_title：Nature communications

authors： Rogdakis K,Seo JW,Viskadourakis Z,Wang Y,Qune LF,Choi E,Burton JD,Tsymbal EY,Lee J,Panagopoulos C

更新日期：2012-01-01 00:00:00

abstract：:Bacterial contamination of biological channels, catheters or water resources is a major threat to public health, which can be amplified by the ability of bacteria to swim upstream. The mechanisms of this 'rheotaxis', the reorientation with respect to flow gradients, are still poorly understood. Here, we follow individ...

journal_title：Nature communications

authors： Mathijssen AJTM,Figueroa-Morales N,Junot G,Clément É,Lindner A,Zöttl A

更新日期：2019-07-31 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is characterized by muscle degeneration and progressive weakness. There is considerable inter-patient variability in disease onset and progression, which can confound the results of clinical trials. Here we show that a common null polymorphism (R577X) in ACTN3 results in significantly...

journal_title：Nature communications

authors： Hogarth MW,Houweling PJ,Thomas KC,Gordish-Dressman H,Bello L,Cooperative International Neuromuscular Research Group (CINRG).,Pegoraro E,Hoffman EP,Head SI,North KN

更新日期：2017-01-31 00:00:00

abstract：:Ever since the discovery of dye self-assemblies in nature, there have been tremendous efforts to exploit biomimetic supramolecular assemblies for tailored artificial photon processing materials. This feature necessarily has resulted in an increasing demand for understanding exciton dynamics in the dye self-assemblies....

journal_title：Nature communications

authors： Sung J,Kim P,Fimmel B,Würthner F,Kim D

更新日期：2015-10-23 00:00:00

abstract：:5S rRNA is an indispensable component of cytoplasmic ribosomes in all species. The functions of 5S rRNA and the reasons for its evolutionary preservation as an independent molecule remain unclear. Here we used ribosome engineering to investigate whether 5S rRNA autonomy is critical for ribosome function and cell survi...

journal_title：Nature communications

authors： Huang S,Aleksashin NA,Loveland AB,Klepacki D,Reier K,Kefi A,Szal T,Remme J,Jaeger L,Vázquez-Laslop N,Korostelev AA,Mankin AS

更新日期：2020-06-09 00:00:00

abstract：:A conspicuous 60° bend of the Hawaiian-Emperor Chain in the north-western Pacific Ocean has variously been interpreted as the result of an abrupt Pacific plate motion change in the Eocene (∼47 Ma), a rapid southward drift of the Hawaiian hotspot before the formation of the bend, or a combination of these two causes. P...

journal_title：Nature communications

authors： Torsvik TH,Doubrovine PV,Steinberger B,Gaina C,Spakman W,Domeier M

更新日期：2017-06-05 00:00:00

abstract：:Recently, coherent control of the optical response of thin films in standing waves has attracted considerable attention, ranging from applications in excitation-selective spectroscopy and nonlinear optics to all-optical image processing. Here, we show that integration of metamaterial and optical fibre technologies all...

journal_title：Nature communications

authors： Xomalis A,Demirtzioglou I,Plum E,Jung Y,Nalla V,Lacava C,MacDonald KF,Petropoulos P,Richardson DJ,Zheludev NI

更新日期：2018-01-12 00:00:00

abstract：:Optogenetics revolutionizes basic research in neuroscience and cell biology and bears potential for medical applications. We develop mutants leading to a unifying concept for the construction of various channelrhodopsins with fast closing kinetics. Due to different absorption maxima these channelrhodopsins allow fast ...

journal_title：Nature communications

authors： Mager T,Lopez de la Morena D,Senn V,Schlotte J,D Errico A,Feldbauer K,Wrobel C,Jung S,Bodensiek K,Rankovic V,Browne L,Huet A,Jüttner J,Wood PG,Letzkus JJ,Moser T,Bamberg E

更新日期：2018-05-01 00:00:00

abstract：:While plasmonic designs have dominated recent trends in structural color, schemes using localized surface plasmon resonances and surface plasmon polaritons that simultaneously achieve high color vibrancy at ultrahigh resolution have been elusive because of tradeoffs between size and performance. Herein we demonstrate ...

journal_title：Nature communications

authors： Lee JS,Park JY,Kim YH,Jeon S,Ouellette O,Sargent EH,Kim DH,Hyun JK

更新日期：2019-10-21 00:00:00

abstract：:Chronic myeloid leukaemia (CML) is a myeloproliferative disorder characterized by the genetic translocation t(9;22)(q34;q11.2) encoding for the BCR-ABL fusion oncogene. However, many molecular mechanisms of the disease progression still remain poorly understood. A growing body of evidence suggests that the epigenetic ...

journal_title：Nature communications

authors： Amabile G,Di Ruscio A,Müller F,Welner RS,Yang H,Ebralidze AK,Zhang H,Levantini E,Qi L,Martinelli G,Brummelkamp T,Le Beau MM,Figueroa ME,Bock C,Tenen DG

更新日期：2015-05-22 00:00:00

abstract：:A synthetic biology method based on heterologous biosynthesis coupled with genome mining is a promising approach for increasing the opportunities to rationally access natural product with novel structures and biological activities through total biosynthesis and combinatorial biosynthesis. Here, we demonstrate the adva...

journal_title：Nature communications

authors： Tsukada K,Shinki S,Kaneko A,Murakami K,Irie K,Murai M,Miyoshi H,Dan S,Kawaji K,Hayashi H,Kodama EN,Hori A,Salim E,Kuraishi T,Hirata N,Kanda Y,Asai T

更新日期：2020-04-14 00:00:00

abstract：:Bright solitons are non-dispersive wave solutions, arising in a diverse range of nonlinear, one-dimensional systems, including atomic Bose-Einstein condensates with attractive interactions. In reality, cold-atom experiments can only approach the idealized one-dimensional limit necessary for the realization of true sol...

journal_title：Nature communications

authors： Marchant AL,Billam TP,Wiles TP,Yu MM,Gardiner SA,Cornish SL

更新日期：2013-01-01 00:00:00

abstract：:Many-body entanglement is at the heart of the Kondo effect, which has its hallmark in quantum dots as a zero-bias conductance peak at low temperatures. It signals the emergence of a conducting singlet state formed by a localized dot degree of freedom and conduction electrons. Carbon nanotubes offer the possibility to ...

journal_title：Nature communications

authors： Niklas M,Smirnov S,Mantelli D,Margańska M,Nguyen NV,Wernsdorfer W,Cleuziou JP,Grifoni M

更新日期：2016-08-16 00:00:00

abstract：:Main group elements usually assume a typical oxidation state while forming compounds with other species. Group I elements are usually in the +1 state in inorganic materials. Our recent work reveals that pressure may make the inner shell 5p electrons of Cs reactive, causing Cs to expand beyond the +1 oxidation state. H...

journal_title：Nature communications

authors： Botana J,Miao MS

更新日期：2014-09-10 00:00:00

abstract：:Programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1) interaction plays a crucial role in tumor-associated immune escape. Here, we verify that triple-negative breast cancer (TNBC) has higher PD-L1 expression than other subtypes. We then discover that nucleophosmin (NPM1) binds to PD-L1 promoter...

journal_title：Nature communications

authors： Qin G,Wang X,Ye S,Li Y,Chen M,Wang S,Qin T,Zhang C,Li Y,Long Q,Hu H,Shi D,Li J,Zhang K,Zhai Q,Tang Y,Kang T,Lan P,Xie F,Lu J,Deng W

更新日期：2020-04-03 00:00:00

abstract：:Surface-supported isolated atoms in single-atom catalysts (SACs) are usually stabilized by diverse defects. The fabrication of high-metal-loading and thermally stable SACs remains a formidable challenge due to the difficulty of creating high densities of underpinning stable defects. Here we report that isolated Pt ato...

journal_title：Nature communications

authors： Lang R,Xi W,Liu JC,Cui YT,Li T,Lee AF,Chen F,Chen Y,Li L,Li L,Lin J,Miao S,Liu X,Wang AQ,Wang X,Luo J,Qiao B,Li J,Zhang T

更新日期：2019-01-16 00:00:00

abstract：:The appearance of detritus shed from mountain ranges along the northern margin of the Tibetan Plateau heralds the Cenozoic development of high topography. Current estimates of the age of the basal conglomerate in the Qaidam basin place this event in Paleocene-Eocene. Here we present new magnetostratigraphy and mammali...

journal_title：Nature communications

authors： Wang W,Zheng W,Zhang P,Li Q,Kirby E,Yuan D,Zheng D,Liu C,Wang Z,Zhang H,Pang J

更新日期：2017-06-21 00:00:00

abstract：:In cancer metastasis, various environmental stressors attack the disseminating cells. The successful colonization of cancer cells in secondary sites therefore requires the ability of the cells to avoid the consequences of such exposure to the stressors. Here we show that orthotopic transplantation of a CD44 variant is...

journal_title：Nature communications

authors： Yae T,Tsuchihashi K,Ishimoto T,Motohara T,Yoshikawa M,Yoshida GJ,Wada T,Masuko T,Mogushi K,Tanaka H,Osawa T,Kanki Y,Minami T,Aburatani H,Ohmura M,Kubo A,Suematsu M,Takahashi K,Saya H,Nagano O

更新日期：2012-06-06 00:00:00

abstract：:Deregulation of transcription factors (TFs) is an important driver of tumorigenesis, but non-invasive assays for assessing transcription factor activity are lacking. Here we develop and validate a minimally invasive method for assessing TF activity based on cell-free DNA sequencing and nucleosome footprint analysis. W...

journal_title：Nature communications

authors： Ulz P,Perakis S,Zhou Q,Moser T,Belic J,Lazzeri I,Wölfler A,Zebisch A,Gerger A,Pristauz G,Petru E,White B,Roberts CES,John JS,Schimek MG,Geigl JB,Bauernhofer T,Sill H,Bock C,Heitzer E,Speicher MR

更新日期：2019-10-11 00:00:00

abstract：:Many cancer cells display enhanced glycolysis and suppressed mitochondrial metabolism. This phenomenon, known as the Warburg effect, is critical for tumor development. However, how cancer cells coordinate glucose metabolism through glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle is largely unknown. We ...

journal_title：Nature communications

authors： Nie H,Ju H,Fan J,Shi X,Cheng Y,Cang X,Zheng Z,Duan X,Yi W

更新日期：2020-01-07 00:00:00

abstract：:Semiconductor III-V photonic crystal (PC) laser is regarded as a promising ultra-compact light source with unique advantages of ultralow energy consumption and small footprint for the next generation of Si-based on-chip optical interconnects. However, the significant material dissimilarities between III-V materials an...

journal_title：Nature communications

authors： Zhou T,Tang M,Xiang G,Xiang B,Hark S,Martin M,Baron T,Pan S,Park JS,Liu Z,Chen S,Zhang Z,Liu H

更新日期：2020-02-20 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) participates in inflammation; however, its role in leukocyte rolling is still unclear. Here we use intravital microscopy in inflamed mouse cremaster muscle venules and human endothelial cells to show that S1P contributes to P-selectin-dependent leukocyte rolling through endothelial S1P re...

journal_title：Nature communications

authors： Nussbaum C,Bannenberg S,Keul P,Gräler MH,Gonçalves-de-Albuquerque CF,Korhonen H,von Wnuck Lipinski K,Heusch G,de Castro Faria Neto HC,Rohwedder I,Göthert JR,Prasad VP,Haufe G,Lange-Sperandio B,Offermanns S,Sperandio M,Lev

更新日期：2015-04-02 00:00:00

abstract：:Amongst the many spectacular properties of hybrid lead halide perovskites, their defect tolerance is regarded as the key enabler for a spectrum of high-performance optoelectronic devices that propel perovskites to prominence. However, the plateauing efficiency enhancement of perovskite devices calls into question the ...

journal_title：Nature communications

authors： Righetto M,Lim SS,Giovanni D,Lim JWM,Zhang Q,Ramesh S,Tay YKE,Sum TC

更新日期：2020-06-01 00:00:00

abstract：:Human hnRNP A2/B1 is an RNA-binding protein that plays important roles in many biological processes, including maturation, transport, and metabolism of mRNA, and gene regulation of long noncoding RNAs. hnRNP A2/B1 was reported to control the microRNAs sorting to exosomes and promote primary microRNA processing as a po...

journal_title：Nature communications

authors： Wu B,Su S,Patil DP,Liu H,Gan J,Jaffrey SR,Ma J

更新日期：2018-01-29 00:00:00

abstract：:Significant advances have been made towards fault-tolerant operation of silicon spin qubits, with single qubit fidelities exceeding 99.9%, several demonstrations of two-qubit gates based on exchange coupling, and the achievement of coherent single spin-photon coupling. Coupling arbitrary pairs of spatially separated q...

journal_title：Nature communications

authors： Mills AR,Zajac DM,Gullans MJ,Schupp FJ,Hazard TM,Petta JR

更新日期：2019-03-05 00:00:00

abstract：:In nature, protein subunits on the capsids of many icosahedral viruses form rotational patterns, and mathematicians also incorporate asymmetric patterns into faces of polyhedra. Chemists have constructed molecular polyhedra with vacant or highly symmetric faces, but very little is known about constructing polyhedra wi...

journal_title：Nature communications

authors： Wang X,Wang Y,Yang H,Fang H,Chen R,Sun Y,Zheng N,Tan K,Lu X,Tian Z,Cao X

更新日期：2016-08-24 00:00:00

abstract：:Fullerene peapods, which are carbon nanotubes encapsulating fullerene molecules, can offer enhanced functionality with respect to empty nanotubes. Their prospective applications include, for example, data storage devices, single-electron transistors and spin-qubit arrays for quantum computing. However, the present inc...

journal_title：Nature communications

authors： Utko P,Ferone R,Krive IV,Shekhter RI,Jonson M,Monthioux M,Noé L,Nygård J

更新日期：2010-07-13 00:00:00

abstract：:Synchronous oscillations of thousands of cellular clocks in the suprachiasmatic nucleus (SCN), the circadian centre, are coordinated by precisely timed cell-cell communication, the principle of which is largely unknown. Here we show that the amount of RGS16 (regulator of G protein signalling 16), a protein known to in...

journal_title：Nature communications

authors： Doi M,Ishida A,Miyake A,Sato M,Komatsu R,Yamazaki F,Kimura I,Tsuchiya S,Kori H,Seo K,Yamaguchi Y,Matsuo M,Fustin JM,Tanaka R,Santo Y,Yamada H,Takahashi Y,Araki M,Nakao K,Aizawa S,Kobayashi M,Obrietan K,Tsujimo

更新日期：2011-01-01 00:00:00

abstract：:Transcriptional regulation by chromatin is a highly dynamic process directed through the recruitment and coordinated action of epigenetic modifiers and readers of these modifications. Using an unbiased proteomic approach to find interactors of H3K36me3, a modification enriched on active chromatin, here we identify PWW...

journal_title：Nature communications

authors： Zhang T,Wei G,Millard CJ,Fischer R,Konietzny R,Kessler BM,Schwabe JWR,Brockdorff N

更新日期：2018-09-18 00:00:00

abstract：:The Clp protease complex degrades a multitude of substrates, which are engaged by a AAA+ chaperone such as ClpX and subsequently digested by the dynamic, barrel-shaped ClpP protease. Acyldepsipeptides (ADEPs) are natural product-derived antibiotics that activate ClpP for chaperone-independent protein digestion. Here w...

journal_title：Nature communications

authors： Gersch M,Famulla K,Dahmen M,Göbl C,Malik I,Richter K,Korotkov VS,Sass P,Rübsamen-Schaeff H,Madl T,Brötz-Oesterhelt H,Sieber SA

更新日期：2015-02-19 00:00:00