Shuttling a single charge across a one-dimensional array of silicon quantum dots.

abstract：:The ability to simultaneously image multiple biomolecules in biologically relevant three-dimensional (3D) cell culture environments would contribute greatly to the understanding of complex cellular mechanisms and cell-material interactions. Here, we present a computational framework for label-free quantitative volumet...

journal_title：Nature communications

authors： Kallepitis C,Bergholt MS,Mazo MM,Leonardo V,Skaalure SC,Maynard SA,Stevens MM

更新日期：2017-03-22 00:00:00

abstract：:Stem rust is an important disease of wheat that can be controlled using resistance genes. The gene SuSr-D1 identified in cultivar 'Canthatch' suppresses stem rust resistance. SuSr-D1 mutants are resistant to several races of stem rust that are virulent on wild-type plants. Here we identify SuSr-D1 by sequencing flow-s...

journal_title：Nature communications

authors： Hiebert CW,Moscou MJ,Hewitt T,Steuernagel B,Hernández-Pinzón I,Green P,Pujol V,Zhang P,Rouse MN,Jin Y,McIntosh RA,Upadhyaya N,Zhang J,Bhavani S,Vrána J,Karafiátová M,Huang L,Fetch T,Doležel J,Wulff BBH,Lagudah E,

更新日期：2020-02-28 00:00:00

abstract：:Neuroendocrine prostate cancer (NEPC) is an aggressive malignancy with no effective targeted therapies. The oncogenic MUC1-C protein is overexpressed in castration-resistant prostate cancer (CRPC) and NEPC, but its specific role is unknown. Here, we demonstrate that upregulation of MUC1-C in androgen-dependent PC cell...

journal_title：Nature communications

authors： Yasumizu Y,Rajabi H,Jin C,Hata T,Pitroda S,Long MD,Hagiwara M,Li W,Hu Q,Liu S,Yamashita N,Fushimi A,Kui L,Samur M,Yamamoto M,Zhang Y,Zhang N,Hong D,Maeda T,Kosaka T,Wong KK,Oya M,Kufe D

更新日期：2020-01-17 00:00:00

abstract：:Proteogenomics enable the discovery of novel peptides (from unannotated genomic protein-coding loci) and single amino acid variant peptides (derived from single-nucleotide polymorphisms and mutations). Increasing the reliability of these identifications is crucial to ensure their usefulness for genome annotation and p...

journal_title：Nature communications

authors： Zhu Y,Orre LM,Johansson HJ,Huss M,Boekel J,Vesterlund M,Fernandez-Woodbridge A,Branca RMM,Lehtiö J

更新日期：2018-03-02 00:00:00

abstract：:In Arabidopsis thaliana, CONSTANS (CO) plays an essential role in the regulation of photoperiodic flowering under long-day conditions. CO protein is stable only in the afternoon of long days, when it induces the expression of FLOWERING LOCUS T (FT), which promotes flowering. The blue-light photoreceptor FLAVIN-BINDING...

journal_title：Nature communications

authors： Lee BD,Kim MR,Kang MY,Cha JY,Han SH,Nawkar GM,Sakuraba Y,Lee SY,Imaizumi T,McClung CR,Kim WY,Paek NC

更新日期：2017-12-22 00:00:00

abstract：:To fully exploit the microbial genome resources, a high-throughput experimental platform is needed to associate genes with phenotypes at the genome level. We present here a novel method that enables investigation of the cellular consequences of repressing individual transcripts based on the CRISPR interference (CRISPR...

journal_title：Nature communications

authors： Wang T,Guan C,Guo J,Liu B,Wu Y,Xie Z,Zhang C,Xing XH

更新日期：2018-06-26 00:00:00

abstract：:Detection of microbial components such as lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) on macrophages induces a robust pro-inflammatory response that is dependent on metabolic reprogramming. These innate metabolic changes have been compared to aerobic glycolysis in tumour cells. However, the mechanisms by w...

journal_title：Nature communications

authors： Balic JJ,Albargy H,Luu K,Kirby FJ,Jayasekara WSN,Mansell F,Garama DJ,De Nardo D,Baschuk N,Louis C,Humphries F,Fitzgerald K,Latz E,Gough DJ,Mansell A

更新日期：2020-07-30 00:00:00

abstract：:Actin-based vesicular trafficking of Cdc42, leading to a polarized concentration of the GTPase, has been implicated in cell polarization, but it was recently debated whether this mechanism allows stable maintenance of cell polarity. Here we show that endocytosis and exocytosis are spatially segregated in the polar pla...

journal_title：Nature communications

authors： Slaughter BD,Unruh JR,Das A,Smith SE,Rubinstein B,Li R

更新日期：2013-01-01 00:00:00

abstract：:Optogenetics enables manipulation of biological processes with light at high spatio-temporal resolution to control the behavior of cells, networks, or even whole animals. In contrast to the performance of excitatory rhodopsins, the effectiveness of inhibitory optogenetic tools is still insufficient. Here we report a t...

journal_title：Nature communications

authors： Bernal Sierra YA,Rost BR,Pofahl M,Fernandes AM,Kopton RA,Moser S,Holtkamp D,Masala N,Beed P,Tukker JJ,Oldani S,Bönigk W,Kohl P,Baier H,Schneider-Warme F,Hegemann P,Beck H,Seifert R,Schmitz D

更新日期：2018-11-05 00:00:00

abstract：:Alcohol consumption is a consistent protective factor for the development of autoimmune diseases such as rheumatoid arthritis (RA). The underlying mechanism for this tolerance-inducing effect of alcohol, however, is unknown. Here we show that alcohol and its metabolite acetate alter the functional state of T follicula...

journal_title：Nature communications

authors： Azizov V,Dietel K,Steffen F,Dürholz K,Meidenbauer J,Lucas S,Frech M,Omata Y,Tajik N,Knipfer L,Kolenbrander A,Seubert S,Lapuente D,Sokolova MV,Hofmann J,Tenbusch M,Ramming A,Steffen U,Nimmerjahn F,Linker R,Wirtz S

更新日期：2020-04-24 00:00:00

abstract：:Different thresholds of Wnt signalling are thought to drive stem cell maintenance, regeneration, differentiation and cancer. However, the principle that oncogenic Wnt signalling could be specifically targeted remains controversial. Here we examine the requirement of BCL9/9l, constituents of the Wnt-enhanceosome, for i...

journal_title：Nature communications

authors： Gay DM,Ridgway RA,Müller M,Hodder MC,Hedley A,Clark W,Leach JD,Jackstadt R,Nixon C,Huels DJ,Campbell AD,Bird TG,Sansom OJ

更新日期：2019-02-13 00:00:00

abstract：:Schwann cells (SCs) generate the myelin wrapping of peripheral nerve axons and are promising candidates for cell therapy. However, to date a renewable source of SCs is lacking. In this study, we show the conversion of skin fibroblasts into induced Schwann cells (iSCs) by driving the expression of two transcription fac...

journal_title：Nature communications

authors： Mazzara PG,Massimino L,Pellegatta M,Ronchi G,Ricca A,Iannielli A,Giannelli SG,Cursi M,Cancellieri C,Sessa A,Del Carro U,Quattrini A,Geuna S,Gritti A,Taveggia C,Broccoli V

更新日期：2017-02-07 00:00:00

abstract：:Most biochemical reactions in living cells rely on diffusive search for target molecules or regions in a heterogeneous overcrowded cytoplasmic medium. Rapid rearrangements of the medium constantly change the effective diffusivity felt locally by a diffusing particle and thus impact the distribution of the first-passag...

journal_title：Nature communications

authors： Lanoiselée Y,Moutal N,Grebenkov DS

更新日期：2018-10-23 00:00:00

abstract：:Male pattern baldness (MPB) is a sex-limited, age-related, complex trait. We study MPB genetics in 205,327 European males from the UK Biobank. Here we show that MPB is strongly heritable and polygenic, with pedigree-heritability of 0.62 (SE = 0.03) estimated from close relatives, and SNP-heritability of 0.39 (SE = 0.0...

journal_title：Nature communications

authors： Yap CX,Sidorenko J,Wu Y,Kemper KE,Yang J,Wray NR,Robinson MR,Visscher PM

更新日期：2018-12-20 00:00:00

abstract：:Genetic heterogeneity between and within tumours is a major factor determining cancer progression and therapy response. Here we examined DNA sequence and DNA copy-number heterogeneity in colorectal cancer (CRC) by targeted high-depth sequencing of 100 most frequently altered genes. In 97 samples, with primary tumours ...

journal_title：Nature communications

authors： Mamlouk S,Childs LH,Aust D,Heim D,Melching F,Oliveira C,Wolf T,Durek P,Schumacher D,Bläker H,von Winterfeld M,Gastl B,Möhr K,Menne A,Zeugner S,Redmer T,Lenze D,Tierling S,Möbs M,Weichert W,Folprecht G,Blanc E,

更新日期：2017-01-25 00:00:00

abstract：:The hydroxyl radical (OH) removes most atmospheric pollutants from air. The loss frequency of OH radicals due to the combined effect of all gas-phase OH reactive species is a measureable quantity termed total OH reactivity. Here we present total OH reactivity observations in pristine Amazon rainforest air, as a functi...

journal_title：Nature communications

authors： Nölscher AC,Yañez-Serrano AM,Wolff S,de Araujo AC,Lavrič JV,Kesselmeier J,Williams J

更新日期：2016-01-22 00:00:00

abstract：:Large Igneous Provinces (LIPs) are associated with the largest climate perturbations in Earth's history. The North Atlantic Igneous Province (NAIP) and Paleocene-Eocene Thermal Maximum (PETM) constitute an exemplar of this association. As yet we have no means to reconstruct the pacing of LIP greenhouse gas emissions f...

journal_title：Nature communications

authors： Jones SM,Hoggett M,Greene SE,Dunkley Jones T

更新日期：2019-12-05 00:00:00

abstract：:Muscle-resident PDGFRβ(+) cells, which include pericytes and PW1(+) interstitial cells (PICs), play a dual role in muscular dystrophy. They can either undergo myogenesis to promote muscle regeneration or differentiate into adipocytes and other cells to compromise regeneration. How the differentiation and fate determin...

journal_title：Nature communications

authors： Yao Y,Norris EH,Mason CE,Strickland S

更新日期：2016-05-03 00:00:00

abstract：:Plant diseases caused by fungi and oomycetes pose an increasing threat to food security and ecosystem health worldwide. These filamentous pathogens, while taxonomically distinct, modulate host defense responses by secreting effectors, which are typically identified based on the presence of signal peptides. Here we sho...

journal_title：Nature communications

authors： Liu T,Song T,Zhang X,Yuan H,Su L,Li W,Xu J,Liu S,Chen L,Chen T,Zhang M,Gu L,Zhang B,Dou D

更新日期：2014-08-26 00:00:00

abstract：:Holocene summer temperature reconstructions from northern Europe based on sedimentary pollen records suggest an onset of peak summer warmth around 9,000 years ago. However, pollen-based temperature reconstructions are largely driven by changes in the proportions of tree taxa, and thus the early-Holocene warming signal...

journal_title：Nature communications

authors： Väliranta M,Salonen JS,Heikkilä M,Amon L,Helmens K,Klimaschewski A,Kuhry P,Kultti S,Poska A,Shala S,Veski S,Birks HH

更新日期：2015-04-10 00:00:00

abstract：:Replication and transcription of genomic DNA requires partial disassembly of nucleosomes to allow progression of polymerases. This presents both an opportunity to remodel the underlying chromatin and a danger of losing epigenetic information. Centromeric transcription is required for stable incorporation of the centro...

journal_title：Nature communications

authors： Bobkov GOM,Huang A,van den Berg SJW,Mitra S,Anselm E,Lazou V,Schunter S,Feederle R,Imhof A,Lusser A,Jansen LET,Heun P

更新日期：2020-06-10 00:00:00

abstract：:How electronic charge is distributed over a molecule determines to a large extent its chemical properties. Here, we demonstrate how the electrostatic force field, originating from the inhomogeneous charge distribution in a molecule, can be measured with submolecular resolution. We exploit the fact that distortions typ...

journal_title：Nature communications

authors： Hapala P,Švec M,Stetsovych O,van der Heijden NJ,Ondráček M,van der Lit J,Mutombo P,Swart I,Jelínek P

更新日期：2016-05-27 00:00:00

abstract：:Explaining trait differences between individuals is a core and challenging aim of life sciences. Here, we introduce a powerful framework for complete decomposition of trait variation into its underlying genetic causes in diploid model organisms. We sequence and systematically pair the recombinant gametes of two interc...

journal_title：Nature communications

authors： Hallin J,Märtens K,Young AI,Zackrisson M,Salinas F,Parts L,Warringer J,Liti G

更新日期：2016-11-02 00:00:00

abstract：:The fields of soft polymers and macromolecular sciences have enjoyed a unique combination of metals and organic frameworks in the name of metallopolymers or organometallic polymers. When metallopolymers carry charged groups, they form a class of metal-containing polyelectrolytes or metallo-polyelectrolytes. This revie...

journal_title：Nature communications

authors： Zhu T,Sha Y,Yan J,Pageni P,Rahman MA,Yan Y,Tang C

更新日期：2018-10-18 00:00:00

abstract：:The intrinsically disordered scaffold proteins AFF1/4 and the transcription elongation factors ELL1/2 are core components of the super elongation complex required for HIV-1 proviral transcription. Here we report the 2.0-Å resolution crystal structure of the human ELL2 C-terminal domain bound to its 50-residue binding ...

journal_title：Nature communications

authors： Qi S,Li Z,Schulze-Gahmen U,Stjepanovic G,Zhou Q,Hurley JH

更新日期：2017-01-30 00:00:00

abstract：:Regaining the function of an impaired limb is highly desirable in paralyzed individuals. One possible avenue to achieve this goal is to bridge the interrupted pathway between preserved neural structures and muscles using a brain-computer interface. Here, we demonstrate that monkeys with subcortical stroke were able to...

journal_title：Nature communications

authors： Kato K,Sawada M,Nishimura Y

更新日期：2019-10-16 00:00:00

abstract：:Digital polymers with precisely ordered units acting as the coded 0- or 1-bit, are introduced as a promising option for molecular data storage. However, the pursuit of better performance in terms of high storage capacity and useful functions never stops. Herein, we propose a concept of an information-coded 2D digital ...

journal_title：Nature communications

authors： Huang Z,Shi Q,Guo J,Meng F,Zhang Y,Lu Y,Qian Z,Li X,Zhou N,Zhang Z,Zhu X

更新日期：2019-04-23 00:00:00

abstract：:Macrophages play crucial roles in host defence and tissue homoeostasis, processes in which both environmental stimuli and intracellularly generated metabolites influence activation of macrophages. Activated macrophages are classified into M1 and M2 macrophages. It remains unclear how intracellular nutrition sufficienc...

journal_title：Nature communications

authors： Kimura T,Nada S,Takegahara N,Okuno T,Nojima S,Kang S,Ito D,Morimoto K,Hosokawa T,Hayama Y,Mitsui Y,Sakurai N,Sarashina-Kida H,Nishide M,Maeda Y,Takamatsu H,Okuzaki D,Yamada M,Okada M,Kumanogoh A

更新日期：2016-10-12 00:00:00

abstract：:Plant hormone cytokinins are perceived by a subfamily of sensor histidine kinases (HKs), which via a two-component phosphorelay cascade activate transcriptional responses in the nucleus. Subcellular localization of the receptors proposed the endoplasmic reticulum (ER) membrane as a principal cytokinin perception site,...

journal_title：Nature communications

authors： Kubiasová K,Montesinos JC,Šamajová O,Nisler J,Mik V,Semerádová H,Plíhalová L,Novák O,Marhavý P,Cavallari N,Zalabák D,Berka K,Doležal K,Galuszka P,Šamaj J,Strnad M,Benková E,Plíhal O,Spíchal L

更新日期：2020-08-27 00:00:00

abstract：:The discovery of charge- and spin-density-wave (CDW/SDW) orders in superconducting cuprates has altered our perspective on the nature of high-temperature superconductivity (SC). However, it has proven difficult to fully elucidate the relationship between the density wave orders and SC. Here, using resonant soft X-ray ...

journal_title：Nature communications

authors： Wen JJ,Huang H,Lee SJ,Jang H,Knight J,Lee YS,Fujita M,Suzuki KM,Asano S,Kivelson SA,Kao CC,Lee JS

更新日期：2019-07-22 00:00:00