Abstract:
:In Arabidopsis thaliana, CONSTANS (CO) plays an essential role in the regulation of photoperiodic flowering under long-day conditions. CO protein is stable only in the afternoon of long days, when it induces the expression of FLOWERING LOCUS T (FT), which promotes flowering. The blue-light photoreceptor FLAVIN-BINDING, KELCH REPEAT, F-BOX1 (FKF1) interacts with CO and stabilizes it by an unknown mechanism. Here, we provide genetic and biochemical evidence that FKF1 inhibits CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1)-dependent CO degradation. Light-activated FKF1 has no apparent effect on COP1 stability but can interact with and negatively regulate COP1. We show that FKF1 can inhibit COP1 homo-dimerization. Mutation of the coiled-coil domain in COP1, which prevents dimer formation, impairs COP1 function in coordinating flowering time. Based on these results, we propose a model whereby the light- and day length-dependent interaction between FKF1 and COP1 controls CO stability to regulate flowering time.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Lee BD,Kim MR,Kang MY,Cha JY,Han SH,Nawkar GM,Sakuraba Y,Lee SY,Imaizumi T,McClung CR,Kim WY,Paek NCdoi
10.1038/s41467-017-02476-2subject
Has Abstractpub_date
2017-12-22 00:00:00pages
2259issue
1issn
2041-1723pii
10.1038/s41467-017-02476-2journal_volume
8pub_type
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