Magneto-nanosensor platform for probing low-affinity protein-protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction.

abstract：:Extrachromosomal telomeric circles are commonly invoked as important players in telomere maintenance, but their origin has remained elusive. Using electron microscopy analysis on purified telomeres we show that, apart from known structures, telomeric repeats accumulate internal loops (i-loops) that occur in the proxim...

journal_title：Nature communications

authors： Mazzucco G,Huda A,Galli M,Piccini D,Giannattasio M,Pessina F,Doksani Y

更新日期：2020-10-20 00:00:00

abstract：:Supercooling of aqueous solutions is a fundamentally and practically important physical phenomenon with numerous applications in biopreservation and beyond. Under normal conditions, heterogeneous nucleation mechanisms critically prohibit the simultaneous long-term (> 1 week), large volume (> 1 ml), and low temperature...

journal_title：Nature communications

authors： Huang H,Yarmush ML,Usta OB

更新日期：2018-08-10 00:00:00

abstract：:Large single-crystal graphene is highly desired and important for the applications of graphene in electronics, as grain boundaries between graphene grains markedly degrade its quality and properties. Here we report the growth of millimetre-sized hexagonal single-crystal graphene and graphene films joined from such gra...

journal_title：Nature communications

authors： Gao L,Ren W,Xu H,Jin L,Wang Z,Ma T,Ma LP,Zhang Z,Fu Q,Peng LM,Bao X,Cheng HM

更新日期：2012-02-28 00:00:00

abstract：:Conventional epitaxy of semiconductor films requires a compatible single crystalline substrate and precisely controlled growth conditions, which limit the price competitiveness and versatility of the process. We demonstrate substrate-tolerant nano-heteroepitaxy (NHE) of high-quality formamidinium-lead-tri-iodide (FAPb...

journal_title：Nature communications

authors： Lee JW,Tan S,Han TH,Wang R,Zhang L,Park C,Yoon M,Choi C,Xu M,Liao ME,Lee SJ,Nuryyeva S,Zhu C,Huynh K,Goorsky MS,Huang Y,Pan X,Yang Y

更新日期：2020-11-02 00:00:00

abstract：:Molecular machines carry out their function by equilibrium mechanical motions in environments that are far from thermodynamic equilibrium. The mechanically equilibrated character of the trajectories of the macromolecule has allowed development of a powerful theoretical description, reminiscent of Onsager's trajectory ...

journal_title：Nature communications

authors： Astumian RD

更新日期：2019-08-23 00:00:00

abstract：:Osteoarthritis (OA), primarily characterized by articular cartilage destruction, is the most common form of age-related degenerative whole-joint disease. No disease-modifying treatments for OA are currently available. Although OA is primarily characterized by cartilage destruction, our understanding of the processes c...

journal_title：Nature communications

authors： Park DR,Kim J,Kim GM,Lee H,Kim M,Hwang D,Lee H,Kim HS,Kim W,Park MC,Shim H,Lee SY

更新日期：2020-08-28 00:00:00

abstract：:Identifying regions important for spreading and mediating perturbations is crucial to assess the susceptibilities of spatio-temporal complex systems such as the Earth's climate to volcanic eruptions, extreme events or geoengineering. Here a data-driven approach is introduced based on a dimension reduction, causal reco...

journal_title：Nature communications

authors： Runge J,Petoukhov V,Donges JF,Hlinka J,Jajcay N,Vejmelka M,Hartman D,Marwan N,Paluš M,Kurths J

更新日期：2015-10-07 00:00:00

abstract：:Surface and subsurface are commonly considered as separate entities because of the difference in the bonding environment and are often investigated separately due to the experimental challenges in differentiating the surface and subsurface effects. Using in-situ atomic-scale transmission electron microscopy to resolve...

journal_title：Nature communications

authors： Sun X,Zhu W,Wu D,Li C,Wang J,Zhu Y,Chen X,Boscoboinik JA,Sharma R,Zhou G

更新日期：2020-01-16 00:00:00

abstract：:Previous research has focused on feeding circuits residing in the hindbrain and midbrain that govern homeostatic or hedonic control of food intake. However, the feeding circuits controlling emotional or cognitive aspects of food intake are largely unknown. Here we use chemical genetics and optogenetic techniques to di...

journal_title：Nature communications

authors： Sweeney P,Yang Y

更新日期：2015-12-15 00:00:00

abstract：:The 'phonon-glass electron-crystal' concept has triggered most of the progress that has been achieved in inorganic thermoelectrics in the past two decades. Organic thermoelectric materials, unlike their inorganic counterparts, exhibit molecular diversity, flexible mechanical properties and easy fabrication, and are mo...

journal_title：Nature communications

authors： Liu J,van der Zee B,Alessandri R,Sami S,Dong J,Nugraha MI,Barker AJ,Rousseva S,Qiu L,Qiu X,Klasen N,Chiechi RC,Baran D,Caironi M,Anthopoulos TD,Portale G,Havenith RWA,Marrink SJ,Hummelen JC,Koster LJA

更新日期：2020-11-10 00:00:00

abstract：:Erythropoietin regulates erythropoiesis in a hypoxia-inducible manner. Here we generate inherited super-anaemic mice (ISAM) as a mouse model of adult-onset anaemia caused by erythropoietin deficiency. ISAM express erythropoietin in the liver but lack erythropoietin production in the kidney. Around weaning age, when th...

journal_title：Nature communications

authors： Yamazaki S,Souma T,Hirano I,Pan X,Minegishi N,Suzuki N,Yamamoto M

更新日期：2013-01-01 00:00:00

abstract：:Despite significant advances in the fabrication and applications of graphene-like materials, it remains a challenge to prepare single-layered metallic materials, which have great potential applications in physics, chemistry and material science. Here we report the fabrication of poly(vinylpyrrolidone)-supported single...

journal_title：Nature communications

authors： Duan H,Yan N,Yu R,Chang CR,Zhou G,Hu HS,Rong H,Niu Z,Mao J,Asakura H,Tanaka T,Dyson PJ,Li J,Li Y

更新日期：2014-01-01 00:00:00

abstract：:Cambodia harbours a variety of aboriginal (and presumably ancient) populations that have largely been ignored in studies of genetic diversity. Here we investigate the matrilineal gene pool of 1,054 Cambodians from 14 geographic populations. Using mitochondrial whole-genome sequencing, we identify eight new mitochondri...

journal_title：Nature communications

authors： Zhang X,Qi X,Yang Z,Serey B,Sovannary T,Bunnath L,Seang Aun H,Samnom H,Zhang H,Lin Q,van Oven M,Shi H,Su B

更新日期：2013-01-01 00:00:00

abstract：:While main group elements have four valence orbitals accessible for bonding, quadruple bonding to main group elements is extremely rare. Here we report that main group element boron is able to form quadruple bonding interactions with iron in the BFe(CO)3- anion complex, which has been revealed by quantum chemical inve...

journal_title：Nature communications

authors： Chi C,Wang JQ,Hu HS,Zhang YY,Li WL,Meng L,Luo M,Zhou M,Li J

更新日期：2019-10-17 00:00:00

abstract：:The control of water-intake behavior is critical for life because an excessive water intake induces pathological conditions, such as hyponatremia or water intoxication. However, the brain mechanisms controlling water intake currently remain unclear. We previously reported that thirst-driving neurons (water neurons) in...

journal_title：Nature communications

authors： Matsuda T,Hiyama TY,Kobayashi K,Kobayashi K,Noda M

更新日期：2020-11-10 00:00:00

abstract：:During mitosis, duplicated sister chromatids attach to microtubules emanating from opposing sides of the bipolar spindle through large protein complexes called kinetochores. In the absence of stable kinetochore-microtubule attachments, a cell surveillance mechanism known as the spindle assembly checkpoint (SAC) produc...

journal_title：Nature communications

authors： Tauchman EC,Boehm FJ,DeLuca JG

更新日期：2015-12-01 00:00:00

abstract：:Electronic structure heterogeneities are ubiquitous in two-dimensional graphene and profoundly impact the transport properties of this material. Here we show the mapping of discrete electronic domains within a single graphene sheet using scanning transmission X-ray microscopy in conjunction with ab initio density func...

journal_title：Nature communications

authors： Schultz BJ,Patridge CJ,Lee V,Jaye C,Lysaght PS,Smith C,Barnett J,Fischer DA,Prendergast D,Banerjee S

更新日期：2011-06-28 00:00:00

abstract：:Theory, simulations and experimental results have suggested an important role of internal friction in the kinetics of protein folding. Recent experiments on spectrin domains provided the first evidence for a pronounced contribution of internal friction in proteins that fold on the millisecond timescale. However, it ha...

journal_title：Nature communications

authors： Borgia A,Wensley BG,Soranno A,Nettels D,Borgia MB,Hoffmann A,Pfeil SH,Lipman EA,Clarke J,Schuler B

更新日期：2012-01-01 00:00:00

abstract：:The observations of solar flare onsets show rapid increase of hard and soft X-rays, ultra-violet emission with large Doppler blue shifts associated with plasma upflows, and Hα hydrogen emission with red shifts up to 1-4 Å. Modern radiative hydrodynamic models account well for blue-shifted emission, but struggle to rep...

journal_title：Nature communications

authors： Druett M,Scullion E,Zharkova V,Matthews S,Zharkov S,Rouppe Van der Voort L

更新日期：2017-06-27 00:00:00

abstract：:Intestinal microfold cells are the primary pathway for translocation of secretory IgA (SIgA)-pathogen complexes to gut-associated lymphoid tissue. Uptake of SIgA/commensals complexes is important for priming adaptive immunity in the mucosa. This study aims to explore the effect of SIgA retrograde transport of immune c...

journal_title：Nature communications

authors： Rochereau N,Roblin X,Michaud E,Gayet R,Chanut B,Jospin F,Corthésy B,Paul S

更新日期：2021-01-11 00:00:00

abstract：:Natriuretic peptides (NPs) are important hormones that regulate multiple cellular functions including cardiovascular physiology. In the heart, two natriuretic peptide receptors NPR1 and NPR2 act as membrane guanylyl cyclases to produce 3',5'-cyclic guanosine monophosphate (cGMP). Although both receptors protect from c...

journal_title：Nature communications

authors： Subramanian H,Froese A,Jönsson P,Schmidt H,Gorelik J,Nikolaev VO

更新日期：2018-06-22 00:00:00

abstract：:Acute graft-versus-host disease (GVHD) remains a major obstacle for the wider usage of allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is an effective therapy for hematopoietic malignancy. Here we show that caspase-11, the cytosolic receptor for bacterial endotoxin (lipopolysaccharide: LPS), enha...

journal_title：Nature communications

authors： Lu Y,Meng R,Wang X,Xu Y,Tang Y,Wu J,Xue Q,Yu S,Duan M,Shan D,Wang Q,Wang H,Billiar TR,Xiao X,Chen F,Lu B

更新日期：2019-09-06 00:00:00

abstract：:Many small-interfering (si)RNAs are toxic to cancer cells through a 6mer seed sequence (positions 2-7 of the guide strand). Here we performed an siRNA screen with all 4096 6mer seeds revealing a preference for guanine in positions 1 and 2 and a high overall G or C content in the seed of the most toxic siRNAs for four ...

journal_title：Nature communications

authors： Gao QQ,Putzbach WE,Murmann AE,Chen S,Sarshad AA,Peter JM,Bartom ET,Hafner M,Peter ME

更新日期：2018-10-29 00:00:00

abstract：:Disassembly of apoptotic cells into smaller fragments (a form of extracellular vesicle called apoptotic bodies) can facilitate removal of apoptotic debris and intercellular communication. However, the mechanism underpinning this process is unclear. While observing monocytes undergoing apoptosis by time-lapse microscop...

journal_title：Nature communications

authors： Atkin-Smith GK,Tixeira R,Paone S,Mathivanan S,Collins C,Liem M,Goodall KJ,Ravichandran KS,Hulett MD,Poon IK

更新日期：2015-06-15 00:00:00

abstract：:Rapid and, in many cases, unprecedented Arctic climate changes are having far-reaching impacts on natural and human systems. Despite state-of-the-art climate models capturing the rapid nature of Arctic climate change, termed Arctic amplification, they significantly disagree on its magnitude. Using a regional, process-...

journal_title：Nature communications

authors： Boeke RC,Taylor PC

更新日期：2018-11-27 00:00:00

abstract：:Stress is a major cause of poor health and mortality in humans and other social mammals. Close social bonds buffer stress, however much of the underlying physiological mechanism remains unknown. Here, we test two key hypotheses: bond partner effects occur only during stress (social buffering) or generally throughout d...

journal_title：Nature communications

authors： Wittig RM,Crockford C,Weltring A,Langergraber KE,Deschner T,Zuberbühler K

更新日期：2016-11-01 00:00:00

abstract：:Kevin J. Cao and Richard H. Kramer, who developed extended release with beta cyclodextrin, were inadvertently omitted from the author list and author contributions section of this Article. These errors have now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Berry MH,Holt A,Levitz J,Broichhagen J,Gaub BM,Visel M,Stanley C,Aghi K,Kim YJ,Cao K,Kramer RH,Trauner D,Flannery J,Isacoff EY

更新日期：2018-03-13 00:00:00

abstract：:Mutations in many centriolar protein-encoding genes cause primary microcephaly. Using super-resolution and electron microscopy, we find that the human microcephaly protein, RTTN, is recruited to the proximal end of the procentriole at early S phase, and is located at the inner luminal walls of centrioles. Further stud...

journal_title：Nature communications

authors： Chen HY,Wu CT,Tang CC,Lin YN,Wang WJ,Tang TK

更新日期：2017-08-15 00:00:00

abstract：:Glucocorticoids are among the most commonly used anti-inflammatory agents. Despite the enormous efforts in elucidating the glucocorticoid-mediated anti-inflammatory actions, how glucocorticoids tightly control overactive inflammatory response is not fully understood. Here we show that glucocorticoids suppress bacteria...

journal_title：Nature communications

authors： Miyata M,Lee JY,Susuki-Miyata S,Wang WY,Xu H,Kai H,Kobayashi KS,Flavell RA,Li JD

更新日期：2015-01-14 00:00:00

abstract：:Plasmid-borne colistin resistance mediated by mcr-1 may contribute to the dissemination of pan-resistant Gram-negative bacteria. Here, we show that mcr-1 confers resistance to colistin-induced lysis and bacterial cell death, but provides minimal protection from the ability of colistin to disrupt the Gram-negative oute...

journal_title：Nature communications

authors： MacNair CR,Stokes JM,Carfrae LA,Fiebig-Comyn AA,Coombes BK,Mulvey MR,Brown ED

更新日期：2018-01-31 00:00:00