Quadruple bonding between iron and boron in the BFe(CO)3- complex.

abstract：:The bacteria-derived clustered regularly interspaced short palindromic repeat (CRISPR)-Cas systems are powerful tools for genome engineering. Recently, in addition to Cas protein engineering, the improvement of guide RNAs are also performed, contributing to broadening the research area of CRISPR-Cas9 systems. Here we ...

journal_title：Nature communications

authors： Kweon J,Jang AH,Kim DE,Yang JW,Yoon M,Rim Shin H,Kim JS,Kim Y

更新日期：2017-11-23 00:00:00

abstract：:Volcanoes are increasingly recognized as agents and recorders of global climate variability, although deciphering the linkages between planetary climate and volcanism is still in its infancy. The growth and emergence of subaqueous volcanoes produce passage zones, which are stratigraphic surfaces marking major transiti...

journal_title：Nature communications

authors： Russell JK,Edwards BR,Porritt LA

更新日期：2013-01-01 00:00:00

abstract：:Mitochondrial quality control is essential in highly structured cells such as neurons and muscles. In skeletal muscle the mitochondrial fission proteins are reduced in different physiopathological conditions including ageing sarcopenia, cancer cachexia and chemotherapy-induced muscle wasting. However, whether mitochon...

journal_title：Nature communications

authors： Favaro G,Romanello V,Varanita T,Andrea Desbats M,Morbidoni V,Tezze C,Albiero M,Canato M,Gherardi G,De Stefani D,Mammucari C,Blaauw B,Boncompagni S,Protasi F,Reggiani C,Scorrano L,Salviati L,Sandri M

更新日期：2019-06-12 00:00:00

abstract：:Genetic mutations predispose the serine protease inhibitor α1-antitrypsin to misfolding and polymerisation within hepatocytes, causing liver disease and chronic obstructive pulmonary disease. This misfolding occurs via a transiently populated intermediate state, but our structural understanding of this process is limi...

journal_title：Nature communications

authors： Jagger AM,Waudby CA,Irving JA,Christodoulou J,Lomas DA

更新日期：2020-12-11 00:00:00

abstract：:Parkinson's disease-associated kinase LRRK2 has been linked to IFN type II (IFN-γ) response in infections and to dopaminergic neuronal loss. However, whether and how LRRK2 synergizes with IFN-γ remains unclear. In this study, we employed dopaminergic neurons and microglia differentiated from patient-derived induced pl...

journal_title：Nature communications

authors： Panagiotakopoulou V,Ivanyuk D,De Cicco S,Haq W,Arsić A,Yu C,Messelodi D,Oldrati M,Schöndorf DC,Perez MJ,Cassatella RP,Jakobi M,Schneiderhan-Marra N,Gasser T,Nikić-Spiegel I,Deleidi M

更新日期：2020-10-14 00:00:00

abstract：:Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1R) mediate distinct cellular and physiological functions. Here, we demonstrate how domain differences between IR and IGF1R contribute to the distinct functions of these receptors using chimeric and site-mutated receptors. Receptors with t...

journal_title：Nature communications

authors： Cai W,Sakaguchi M,Kleinridders A,Gonzalez-Del Pino G,Dreyfuss JM,O'Neill BT,Ramirez AK,Pan H,Winnay JN,Boucher J,Eck MJ,Kahn CR

更新日期：2017-03-27 00:00:00

abstract：:The expression and stabilization of recombinant proteins is fundamental to basic and applied biology. Here we have engineered a thermostable protein nanoparticle (tES) to improve both expression and stabilization of recombinant proteins using this technology. tES provides steric accommodation and charge complementatio...

journal_title：Nature communications

authors： Deshpande S,Masurkar ND,Girish VM,Desai M,Chakraborty G,Chan JM,Drum CL

更新日期：2017-11-13 00:00:00

abstract：:The hydroxyl radical (OH) removes most atmospheric pollutants from air. The loss frequency of OH radicals due to the combined effect of all gas-phase OH reactive species is a measureable quantity termed total OH reactivity. Here we present total OH reactivity observations in pristine Amazon rainforest air, as a functi...

journal_title：Nature communications

authors： Nölscher AC,Yañez-Serrano AM,Wolff S,de Araujo AC,Lavrič JV,Kesselmeier J,Williams J

更新日期：2016-01-22 00:00:00

abstract：:The diversity reflected by >100 different neural cell types fundamentally contributes to brain function and a central idea is that neuronal identity can be inferred from genetic information. Recent large-scale transcriptomic assays seem to confirm this hypothesis, but a lack of morphological information has limited th...

journal_title：Nature communications

authors： Que L,Lukacsovich D,Luo W,Földy C

更新日期：2021-01-04 00:00:00

abstract：:Auxin is a key coordinative signal required for many aspects of plant development and its levels are controlled by auxin metabolism and intercellular auxin transport. Here we find that a member of PIN auxin transporter family, PIN8 is expressed in male gametophyte of Arabidopsis thaliana and has a crucial role in poll...

journal_title：Nature communications

authors： Ding Z,Wang B,Moreno I,Dupláková N,Simon S,Carraro N,Reemmer J,Pěnčík A,Chen X,Tejos R,Skůpa P,Pollmann S,Mravec J,Petrášek J,Zažímalová E,Honys D,Rolčík J,Murphy A,Orellana A,Geisler M,Friml J

更新日期：2012-07-03 00:00:00

abstract：:The original version of this Article contained an error in the third sentence of the penultimate paragraph of the 'Definition of the harmonic phase' section of the Results, which incorrectly read 'In the Coulomb phase the tensor S αβ (q) has one zero and two degenerate eigenvalues and it may be represented by an infin...

journal_title：Nature communications

authors： Bramwell ST

更新日期：2018-04-16 00:00:00

abstract：:Thermal melanism theory states that dark-colored ectotherm organisms are at an advantage at low temperature due to increased warming. This theory is generally supported for ectotherm animals, however, the function of colors in the fungal kingdom is largely unknown. Here, we test whether the color lightness of mushroom...

journal_title：Nature communications

authors： Krah FS,Büntgen U,Schaefer H,Müller J,Andrew C,Boddy L,Diez J,Egli S,Freckleton R,Gange AC,Halvorsen R,Heegaard E,Heideroth A,Heibl C,Heilmann-Clausen J,Høiland K,Kar R,Kauserud H,Kirk PM,Kuyper TW,Krisai-Greilhub

更新日期：2019-06-28 00:00:00

abstract：:Homologous recombination-mediated gene targeting has greatly contributed to genetic analysis in a wide range of species, but is highly inefficient in human cells because of overwhelmingly frequent random integration events, whose molecular mechanism remains elusive. Here we show that DNA polymerase θ, despite its mino...

journal_title：Nature communications

authors： Saito S,Maeda R,Adachi N

更新日期：2017-07-11 00:00:00

abstract：:The extraction and combustion of fossil natural gas, consisting primarily of methane, generates vast amounts of greenhouse gases that contribute to climate change. However, as a result of recent research efforts, "solar methane" can now be produced through the photocatalytic conversion of carbon dioxide and water to m...

journal_title：Nature communications

authors： Ulmer U,Dingle T,Duchesne PN,Morris RH,Tavasoli A,Wood T,Ozin GA

更新日期：2019-07-18 00:00:00

abstract：:Understanding catalysts strain dynamic behaviours is crucial for the development of cost-effective, efficient, stable and long-lasting catalysts. Here, we reveal in situ three-dimensional strain evolution of single gold nanocrystals during a catalytic CO oxidation reaction under operando conditions with coherent X-ray...

journal_title：Nature communications

authors： Passos AR,Rochet A,Manente LM,Suzana AF,Harder R,Cha W,Meneau F

更新日期：2020-09-18 00:00:00

abstract：:Intramolecular photostabilization via triple-state quenching was recently revived as a tool to impart synthetic organic fluorophores with 'self-healing' properties. To date, utilization of such fluorophore derivatives is rare due to their elaborate multi-step synthesis. Here we present a general strategy to covalently...

journal_title：Nature communications

authors： van der Velde JH,Oelerich J,Huang J,Smit JH,Aminian Jazi A,Galiani S,Kolmakov K,Guoridis G,Eggeling C,Herrmann A,Roelfes G,Cordes T

更新日期：2016-01-11 00:00:00

abstract：:Cellular microRNAs (miRNAs) have been shown to regulate hepatitis C virus (HCV) replication, yet a systematic interrogation of the repertoire of miRNAs impacting HCV life cycle is lacking. Here we apply integrative functional genomics strategies to elucidate global HCV-miRNA interactions. Through genome-wide miRNA mim...

journal_title：Nature communications

authors： Li Q,Lowey B,Sodroski C,Krishnamurthy S,Alao H,Cha H,Chiu S,El-Diwany R,Ghany MG,Liang TJ

更新日期：2017-11-27 00:00:00

abstract：:The development of transistors with high gain is essential for applications ranging from switching elements and drivers to transducers for chemical and biological sensing. Organic transistors have become well-established based on their distinct advantages, including ease of fabrication, synthetic freedom for chemical ...

journal_title：Nature communications

authors： Khodagholy D,Rivnay J,Sessolo M,Gurfinkel M,Leleux P,Jimison LH,Stavrinidou E,Herve T,Sanaur S,Owens RM,Malliaras GG

更新日期：2013-01-01 00:00:00

abstract：:Cryptosporidiosis in an enteric infection caused by Cryptosporidium parasites and is a major cause of acute infant diarrhea in the developing world. A major bottleneck to research progress is the lack of methods to cryopreserve Cryptosporidium oocysts, thus requiring routine propagation in laboratory animals. Here, we...

journal_title：Nature communications

authors： Jaskiewicz JJ,Sandlin RD,Swei AA,Widmer G,Toner M,Tzipori S

更新日期：2018-07-23 00:00:00

abstract：:Epilepsy is a common brain disorder throughout history. Epilepsy-related ligand-receptor complex, LGI1-ADAM22, regulates synaptic transmission and has emerged as a determinant of brain excitability, as their mutations and acquired LGI1 autoantibodies cause epileptic disorders in human. Here, we report the crystal stru...

journal_title：Nature communications

authors： Yamagata A,Miyazaki Y,Yokoi N,Shigematsu H,Sato Y,Goto-Ito S,Maeda A,Goto T,Sanbo M,Hirabayashi M,Shirouzu M,Fukata Y,Fukata M,Fukai S

更新日期：2018-04-18 00:00:00

abstract：:In the original version of this Article, equation three contained a sign error whereby the term RT was added when it should have been subtracted. This has now been corrected in the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Jung C,Bandilla P,von Reutern M,Schnepf M,Rieder S,Unnerstall U,Gaul U

更新日期：2019-02-05 00:00:00

abstract：:Bacterial autotransporters comprise a 12-stranded membrane-embedded β-barrel domain, which must be folded in a process that entraps segments of an N-terminal passenger domain. This first stage of autotransporter folding determines whether subsequent translocation can deliver the N-terminal domain to its functional for...

journal_title：Nature communications

authors： Leyton DL,Johnson MD,Thapa R,Huysmans GH,Dunstan RA,Celik N,Shen HH,Loo D,Belousoff MJ,Purcell AW,Henderson IR,Beddoe T,Rossjohn J,Martin LL,Strugnell RA,Lithgow T

更新日期：2014-06-26 00:00:00

abstract：:Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite burden in Plasmodium falciparum infections, and antimalarial control is highly dependent on ART combination therapies (ACTs). Decreased sensitivity to ARTs is emerging, making it critically important to understand the mechan...

journal_title：Nature communications

authors： Bridgford JL,Xie SC,Cobbold SA,Pasaje CFA,Herrmann S,Yang T,Gillett DL,Dick LR,Ralph SA,Dogovski C,Spillman NJ,Tilley L

更新日期：2018-09-18 00:00:00

abstract：:Puberty is regulated by epigenetic mechanisms and is highly sensitive to metabolic and nutritional cues. However, the epigenetic pathways mediating the effects of nutrition and obesity on pubertal timing are unknown. Here, we identify Sirtuin 1 (SIRT1), a fuel-sensing deacetylase, as a molecule that restrains female p...

journal_title：Nature communications

authors： Vazquez MJ,Toro CA,Castellano JM,Ruiz-Pino F,Roa J,Beiroa D,Heras V,Velasco I,Dieguez C,Pinilla L,Gaytan F,Nogueiras R,Bosch MA,Rønnekleiv OK,Lomniczi A,Ojeda SR,Tena-Sempere M

更新日期：2018-10-10 00:00:00

abstract：:Enhancers are DNA sequences that enable complex temporal and tissue-specific regulation of genes in higher eukaryotes. Although it is not entirely clear how enhancer-promoter interactions can increase gene expression, this proximity has been observed in multiple systems at multiple loci and is thought to be essential ...

journal_title：Nature communications

authors： Crump NT,Ballabio E,Godfrey L,Thorne R,Repapi E,Kerry J,Tapia M,Hua P,Lagerholm C,Filippakopoulos P,Davies JOJ,Milne TA

更新日期：2021-01-11 00:00:00

abstract：:Surface plasmons (SPs) of metals enable the tight focusing and strong absorption of light to realize an efficient utilization of photons at nanoscale. In particular, the SP-generated hot carriers have emerged as a promising way to efficiently drive photochemical and photoelectric processes under moderate conditions. I...

journal_title：Nature communications

authors： Huang SC,Wang X,Zhao QQ,Zhu JF,Li CW,He YH,Hu S,Sartin MM,Yan S,Ren B

更新日期：2020-08-24 00:00:00

abstract：:Cancer proteogenomics promises new insights into cancer biology and treatment efficacy by integrating genomics, transcriptomics and protein profiling including modifications by mass spectrometry (MS). A critical limitation is sample input requirements that exceed many sources of clinically important material. Here we ...

journal_title：Nature communications

authors： Satpathy S,Jaehnig EJ,Krug K,Kim BJ,Saltzman AB,Chan DW,Holloway KR,Anurag M,Huang C,Singh P,Gao A,Namai N,Dou Y,Wen B,Vasaikar SV,Mutch D,Watson MA,Ma C,Ademuyiwa FO,Rimawi MF,Schiff R,Hoog J,Jacobs S,Malov

更新日期：2020-01-27 00:00:00

abstract：:Mutant Huntingtin (mtHtt) causes neurodegeneration in Huntington's disease (HD) by evoking defects in the mitochondria, but the underlying mechanisms remains elusive. Our proteomic analysis identifies valosin-containing protein (VCP) as an mtHtt-binding protein on the mitochondria. Here we show that VCP is selectively...

journal_title：Nature communications

authors： Guo X,Sun X,Hu D,Wang YJ,Fujioka H,Vyas R,Chakrapani S,Joshi AU,Luo Y,Mochly-Rosen D,Qi X

更新日期：2016-08-26 00:00:00

abstract：:In contrast to processive molecular motors, skeletal myosins form a large motor ensemble for contraction of muscles against high loads. Despite numerous information on the molecular properties of skeletal myosin, its ensemble effects on collective force generation have not been rigorously clarified. Here we show 4 nm ...

journal_title：Nature communications

authors： Kaya M,Tani Y,Washio T,Hisada T,Higuchi H

更新日期：2017-07-06 00:00:00

abstract：:Acetic acid is an important bulk chemical that is currently produced via methanol carbonylation using fossil based CO. Synthesis of acetic acid from the renewable and cheap CO2 is of great importance, but state of the art routes encounter difficulties, especially in reaction selectivity and activity. Here we report a ...

journal_title：Nature communications

authors： Qian Q,Zhang J,Cui M,Han B

更新日期：2016-05-11 00:00:00