Abstract:
:The diversity reflected by >100 different neural cell types fundamentally contributes to brain function and a central idea is that neuronal identity can be inferred from genetic information. Recent large-scale transcriptomic assays seem to confirm this hypothesis, but a lack of morphological information has limited the identification of several known cell types. In this study, we used single-cell RNA-seq in morphologically identified parvalbumin interneurons (PV-INs), and studied their transcriptomic states in the morphological, physiological, and developmental domains. Overall, we find high transcriptomic similarity among PV-INs, with few genes showing divergent expression between morphologically different types. Furthermore, PV-INs show a uniform synaptic cell adhesion molecule (CAM) profile, suggesting that CAM expression in mature PV cells does not reflect wiring specificity after development. Together, our results suggest that while PV-INs differ in anatomy and in vivo activity, their continuous transcriptomic and homogenous biophysical landscapes are not predictive of these distinct identities.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Que L,Lukacsovich D,Luo W,Földy Cdoi
10.1038/s41467-020-20328-4subject
Has Abstractpub_date
2021-01-04 00:00:00pages
108issue
1issn
2041-1723pii
10.1038/s41467-020-20328-4journal_volume
12pub_type
杂志文章abstract::Animals promote their survival by avoiding rapidly approaching objects that indicate threats. In mice, looming-evoked defensive responses are triggered by the superior colliculus (SC) which receives direct retinal inputs. However, the specific neural circuits that begin in the retina and mediate this important behavio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14908
更新日期:2017-03-31 00:00:00
abstract::Hybridomas, fusions of primary mouse B cells and myelomas, are stable, rapidly-proliferating cell lines widely utilized for antibody screening and production. Antibody specificity of a hybridoma clone is determined by the immunoglobulin sequence of the primary B cell. Here we report a platform for rapid reprogramming ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12535
更新日期:2016-08-17 00:00:00
abstract::Gene regulation and metabolism are two fundamental processes that coordinate the self-renewal and differentiation of neural precursor cells (NPCs) in the developing mammalian brain. However, little is known about how metabolic signals instruct gene expression to control NPC homeostasis. Here, we show that methylglyoxa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15941-2
更新日期:2020-04-24 00:00:00
abstract::Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,083 controls, we identify two SNPs with genome-wide significance...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7691
更新日期:2015-04-07 00:00:00
abstract::Mountain glaciers are known to be strongly affected by global climate change. Here we compute temporally consistent changes in glacier area, surface elevation and ice mass over the entire European Alps between 2000 and 2014. We apply remote sensing techniques on an extensive database of optical and radar imagery cover...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16818-0
更新日期:2020-06-25 00:00:00
abstract::The rate of interictal high frequency oscillations (HFOs) is a promising biomarker of the seizure onset zone, though little is known about its consistency over hours to days. Here we test whether the highest HFO-rate channels are consistent across different 10-min segments of EEG during sleep. An automated HFO detecto...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04549-2
更新日期:2018-06-01 00:00:00
abstract::Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its accuracy and general robustness to misspecified reference sets. We ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03621-1
更新日期:2018-05-08 00:00:00
abstract::Exploitation of drug-drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug-drug synergy mediated by allosteric cross-talk in chromatin, whereby the binding of ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14860
更新日期:2017-03-30 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-13126-0
更新日期:2019-11-08 00:00:00
abstract::Previous studies have demonstrated that aneuploidy in human embryos is surprisingly frequent with 50-80% of cleavage-stage human embryos carrying an abnormal chromosome number. Here we combine non-invasive time-lapse imaging with karyotypic reconstruction of all blastomeres in four-cell human embryos to address the hy...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2249
更新日期:2012-01-01 00:00:00
abstract::The high Aβ42/Aβ40 production ratio is a hallmark of familial Alzheimer's disease, which can be caused by mutations in the amyloid precursor protein (APP). The C-terminus of Aβ is generated by γ-secretase cleavage within the transmembrane domain of APP (APPTM), a process that is primed by an initial ε-cleavage at eith...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4037
更新日期:2014-01-01 00:00:00
abstract::Apicomplexans are obligate intracellular parasites that scavenge essential nutrients from their hosts via transporter proteins on their plasma membrane. The identities of the transporters that mediate amino acid uptake into apicomplexans are unknown. Here we demonstrate that members of an apicomplexan-specific protein...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14455
更新日期:2017-02-16 00:00:00
abstract::Application of force on biomolecules has been instrumental in understanding biofunctional behaviour from single molecules to complex collections of cells. Current approaches, for example, those based on atomic force microscopy or magnetic or optical tweezers, are powerful but limited in their applicability as integrat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6284
更新日期:2014-10-21 00:00:00
abstract::Polyborylated organic compounds have been emerging as versatile building blocks in chemical synthesis. Here we report a selective cobalt-catalyzed deoxygenative 1,1,3-triborylation reaction of allylic ethers with pinacolborane to prepare 1,1,3-triborylalkane compounds. With naturally abundant and/or synthetic cinnamic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19039-7
更新日期:2020-10-15 00:00:00
abstract::Despite the lack of a layered neocortex and fundamental differences in endbrain organization in birds compared with mammals, intelligent species evolved from both vertebrate classes. Among birds, corvids show exceptional cognitive flexibility. Here we explore the neuronal foundation of corvid cognition by recording si...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3878
更新日期:2013-01-01 00:00:00
abstract::HIV-1-infected people who take drugs that suppress viremia to undetectable levels are protected from developing AIDS. Nonetheless, HIV-1 establishes proviruses in long-lived CD4+ memory T cells, and perhaps other cell types, that preclude elimination of the virus even after years of continuous antiviral therapy. Here ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07753-2
更新日期:2018-12-13 00:00:00
abstract::Catalytic C-H activation and hydroamination represent two important strategies for eco-friendly chemical synthesis with high atom efficiency and reduced waste production. Combining both C-H activation and hydroamination in a cascade process, preferably with a single catalyst, would allow rapid access to valuable nitro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11506
更新日期:2016-06-20 00:00:00
abstract::Drought comprehensively affects different interlinked aspects of the terrestrial water cycle, which have so far been mostly investigated without direct comparison. Resolving the partitioning of water deficit during drought into blue-water runoff and green-water evapotranspiration fluxes is critical, as anomalies in th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06013-7
更新日期:2018-09-06 00:00:00
abstract::Human social networks are overwhelmingly homophilous: individuals tend to befriend others who are similar to them in terms of a range of physical attributes (e.g., age, gender). Do similarities among friends reflect deeper similarities in how we perceive, interpret, and respond to the world? To test whether friendship...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02722-7
更新日期:2018-01-30 00:00:00
abstract::Sustainable food production in the context of climate change necessitates diversification of agriculture and a more efficient utilization of plant genetic resources. Fonio millet (Digitaria exilis) is an orphan African cereal crop with a great potential for dryland agriculture. Here, we establish high-quality genomic ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18329-4
更新日期:2020-09-08 00:00:00
abstract::Macrophages regulate host responses to implants through their dynamic adhesion, release, and activation. Herein, we employ bisphosphonate (BP)-coated gold nanoparticle template (BNP) to direct the swift and convertible formation of Mg2+-functional Mg2+-BP nanoparticle (NP) on the BP-AuNP surface via reversible Mg2+-BP...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09733-6
更新日期:2019-04-12 00:00:00
abstract::The dynamics of many natural and artificial systems are well described as random walks on a network: the stochastic behaviour of molecules, traffic patterns on the internet, fluctuations in stock prices and so on. The vast literature on random walks provides many tools for computing properties such as steady-state pro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6121
更新日期:2014-10-14 00:00:00
abstract::Flexible organic memory devices are one of the integral components for future flexible organic electronics. However, high-density all-organic memory cell arrays on malleable substrates without cross-talk have not been demonstrated because of difficulties in their fabrication and relatively poor performances to date. H...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3707
更新日期:2013-01-01 00:00:00
abstract::Insulin resistance is closely associated with obesity and is one of the earliest symptoms of type-2 diabetes. Endothelial cells are involved in the pathogenesis of insulin resistance through their role in insulin delivery and adipose tissue angiogenesis. Here we show that Ecscr (endothelial cell surface expressed chem...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3389
更新日期:2013-01-01 00:00:00
abstract::Prostate development depends on balanced cell proliferation and differentiation, and acetylated KLF5 is known to alter epithelial proliferation. It remains elusive whether post-translational modifications of transcription factors can differentially determine adult stem/progenitor cell fate. Here we report that, in hum...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14737-8
更新日期:2020-02-21 00:00:00
abstract::Assembly of infectious influenza A viruses (IAV) is a complex process involving transport from the nucleus to the plasma membrane. Rab11A-containing recycling endosomes have been identified as a platform for intracellular transport of viral RNA (vRNA). Here, using high spatiotemporal resolution light-sheet microscopy ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13838-3
更新日期:2020-01-07 00:00:00
abstract::The brain identifies potentially salient features within continuous information streams to process hierarchical temporal events. This requires the compression of information streams, for which effective computational principles are yet to be explored. Backpropagating action potentials can induce synaptic plasticity in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15367-w
更新日期:2020-03-25 00:00:00
abstract::The Nrf2 transcription factor controls the expression of genes involved in the antioxidant defense system. Here, we identified Nrf2 as a novel regulator of desmosomes in the epidermis through the regulation of microRNAs. On Nrf2 activation, expression of miR-29a and miR-29b increases in cultured human keratinocytes an...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6099
更新日期:2014-10-06 00:00:00
abstract::Much of the world's Li deposits occurs as basinal brines in magmatic orogens, particularly in continental volcanic arcs. However, the exact origin of Li enrichment in arc magmatic systems is not clear. Here, we show that, globally, primitive arc magmas have Li contents and Li/Y ratios similar to mid-ocean ridge basalt...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19106-z
更新日期:2020-10-20 00:00:00
abstract::Increased lipogenesis has been linked to an increased cancer risk and poor prognosis; however, the underlying mechanisms remain obscure. Here we show that phosphatidic acid phosphatase (PAP) lipin-1, which generates diglyceride precursors necessary for the synthesis of glycerolipids, interacts with and is a direct sub...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19694-w
更新日期:2020-11-17 00:00:00