Cationic amino acid transporters play key roles in the survival and transmission of apicomplexan parasites.

abstract：:Domain walls can be driven by current at very high speeds in nanowires formed from ultra-thin, perpendicularly magnetized cobalt layers and cobalt/nickel multilayers deposited on platinum underlayers due to a chiral spin torque. An important feature of this torque is a magnetic chiral exchange field that each domain w...

journal_title：Nature communications

authors： Ryu KS,Yang SH,Thomas L,Parkin SS

更新日期：2014-05-23 00:00:00

abstract：:Mutations disrupting regulatory T (Treg) cell function can cause IPEX and IPEX-related disorders, but whether established disease can be reversed by correcting these mutations is unclear. Treg-specific deletion of the chromatin remodeling factor Brg1 impairs Treg cell activation and causes fatal autoimmunity in mice. ...

journal_title：Nature communications

authors： Li Y,Chen Y,Mao S,Kaundal R,Jing Z,Chen Q,Wang X,Xia J,Liu D,Sun J,Wang H,Chi T

更新日期：2020-06-03 00:00:00

abstract：:Real-time imaging of moving organs and tissues at microscopic resolutions represents a major challenge in studying the complex biology of live animals. Here we present a technique based on a novel stabilizer setup combined with a gating acquisition algorithm for the imaging of a beating murine heart at the single-cell...

journal_title：Nature communications

authors： Lee S,Vinegoni C,Feruglio PF,Fexon L,Gorbatov R,Pivoravov M,Sbarbati A,Nahrendorf M,Weissleder R

更新日期：2012-01-01 00:00:00

abstract：:The ice- and organic-rich permafrost of the northeast Siberian Arctic lowlands (NESAL) has been projected to remain stable beyond 2100, even under pessimistic climate warming scenarios. However, the numerical models used for these projections lack processes which induce widespread landscape change termed thermokarst, ...

journal_title：Nature communications

authors： Nitzbon J,Westermann S,Langer M,Martin LCP,Strauss J,Laboor S,Boike J

更新日期：2020-05-04 00:00:00

abstract：:Aerobic methane oxidation is catalyzed by particulate methane monooxygenase (pMMO), a copper-dependent, membrane metalloenzyme composed of subunits PmoA, PmoB, and PmoC. Characterization of the copper active site has been limited by challenges in spectroscopic analysis stemming from the presence of multiple copper bin...

journal_title：Nature communications

authors： Ro SY,Schachner LF,Koo CW,Purohit R,Remis JP,Kenney GE,Liauw BW,Thomas PM,Patrie SM,Kelleher NL,Rosenzweig AC

更新日期：2019-06-17 00:00:00

abstract：:Detection of Identical-By-Descent (IBD) segments provides a fundamental measure of genetic relatedness and plays a key role in a wide range of analyses. We develop FastSMC, an IBD detection algorithm that combines a fast heuristic search with accurate coalescent-based likelihood calculations. FastSMC enables biobank-s...

journal_title：Nature communications

authors： Nait Saada J,Kalantzis G,Shyr D,Cooper F,Robinson M,Gusev A,Palamara PF

更新日期：2020-11-30 00:00:00

abstract：:Although environmental selection and spatial separation have been shown to shape the distribution and abundance of marine microorganisms, the effects of advection (physical transport) have not been directly tested. Here we examine 25 samples covering all major water masses of the Southern Ocean to determine the effect...

journal_title：Nature communications

authors： Wilkins D,van Sebille E,Rintoul SR,Lauro FM,Cavicchioli R

更新日期：2013-01-01 00:00:00

abstract：:Microbial production of isoprene from renewable feedstock is a promising alternative to traditional petroleum-based processes. Currently, efforts to improve isoprenoid production in Saccharomyces cerevisiae mainly focus on cytoplasmic engineering, whereas comprehensive engineering of multiple subcellular compartments ...

journal_title：Nature communications

authors： Lv X,Wang F,Zhou P,Ye L,Xie W,Xu H,Yu H

更新日期：2016-09-21 00:00:00

abstract：:The original version of this Article omitted a declaration from the Competing Interests statement, which should have included the following: 'A patent has been applied for by Emory University with F.E.L, I.S. and D.C. N. as named inventors. The patent application number is PCT/US2016/036650'. This has now been correct...

journal_title：Nature communications

authors： Nguyen DC,Garimalla S,Xiao H,Kyu S,Albizua I,Galipeau J,Chiang KY,Waller EK,Wu R,Gibson G,Roberson J,Lund FE,Randall TD,Sanz I,Lee FE

更新日期：2019-01-17 00:00:00

abstract：:The time-dependent response of structural materials dominates our aging infrastructure's life expectancy and has important resilience implications. For calcium-silicate-hydrates, the glue of cement, nanoscale mechanisms underlying time-dependent phenomena are complex and remain poorly understood. This complexity origi...

journal_title：Nature communications

authors： Morshedifard A,Masoumi S,Abdolhosseini Qomi MJ

更新日期：2018-05-03 00:00:00

abstract：:Two-dimensional metallic transition metal dichalcogenides are emerging as prototypes for uncovering fundamental physical phenomena, such as superconductivity and charge-density waves, as well as for engineering-related applications. However, the batch production of such envisioned transition metal dichalcogenides rema...

journal_title：Nature communications

authors： Shi J,Wang X,Zhang S,Xiao L,Huan Y,Gong Y,Zhang Z,Li Y,Zhou X,Hong M,Fang Q,Zhang Q,Liu X,Gu L,Liu Z,Zhang Y

更新日期：2017-10-16 00:00:00

abstract：:Since the 1970s, it has been known that black-hole (and other) horizons are truly thermodynamic. More generally, surfaces which are not horizons have also been conjectured to behave thermodynamically. Initially, for surfaces microscopically expanded from a horizon to so-called stretched horizons, and more recently, fo...

journal_title：Nature communications

authors： Wang ZW,Braunstein SL

更新日期：2018-07-30 00:00:00

abstract：:During meiosis, homologous chromosomes synapse and recombine at sites marked by the binding of the mismatch repair protein MLH1. In hexaploid wheat, the Ph1 locus has a major effect on whether crossover occurs between homologues or between related homoeologues. Here we report that--in wheat-rye hybrids where homologue...

journal_title：Nature communications

authors： Martín AC,Shaw P,Phillips D,Reader S,Moore G

更新日期：2014-08-06 00:00:00

abstract：:In the original version of this Article, equation three contained a sign error whereby the term RT was added when it should have been subtracted. This has now been corrected in the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Jung C,Bandilla P,von Reutern M,Schnepf M,Rieder S,Unnerstall U,Gaul U

更新日期：2019-02-05 00:00:00

abstract：:Acetic acid is an important bulk chemical that is currently produced via methanol carbonylation using fossil based CO. Synthesis of acetic acid from the renewable and cheap CO2 is of great importance, but state of the art routes encounter difficulties, especially in reaction selectivity and activity. Here we report a ...

journal_title：Nature communications

authors： Qian Q,Zhang J,Cui M,Han B

更新日期：2016-05-11 00:00:00

abstract：:Modulation of CD8 coreceptor levels can profoundly affect T-cell sensitivity to antigen. Here we show that the heritable downregulation of CD8 during type 2 polarization of murine CD8(+) effector T cells in vitro and in vivo is associated with CpG methylation of several regions of the Cd8a locus. These epigenetic modi...

journal_title：Nature communications

authors： Harland KL,Day EB,Apte SH,Russ BE,Doherty PC,Turner SJ,Kelso A

更新日期：2014-03-28 00:00:00

abstract：:The dual role played by symmetry in many-body physics manifests itself through two fundamental mechanisms: spontaneous symmetry breaking and topological symmetry protection. These two concepts, ubiquitous in both condensed matter and high energy physics, have been applied successfully in the last decades to unravel a ...

journal_title：Nature communications

authors： González-Cuadra D,Bermudez A,Grzybowski PR,Lewenstein M,Dauphin A

更新日期：2019-06-19 00:00:00

abstract：:The three-dimensional architecture of the genome affects genomic functions. Multiple genome architectures at different length scales, including chromatin loops, domains, compartments, and lamina- and nucleolus-associated regions, have been discovered. However, how these structures are arranged in the same cell and how...

journal_title：Nature communications

authors： Liu M,Lu Y,Yang B,Chen Y,Radda JSD,Hu M,Katz SG,Wang S

更新日期：2020-06-09 00:00:00

abstract：:Hybridomas, fusions of primary mouse B cells and myelomas, are stable, rapidly-proliferating cell lines widely utilized for antibody screening and production. Antibody specificity of a hybridoma clone is determined by the immunoglobulin sequence of the primary B cell. Here we report a platform for rapid reprogramming ...

journal_title：Nature communications

authors： Pogson M,Parola C,Kelton WJ,Heuberger P,Reddy ST

更新日期：2016-08-17 00:00:00

abstract：:Functional blood vessel growth depends on generation of distinct but coordinated responses from endothelial cells. Bone morphogenetic proteins (BMP), part of the TGFβ superfamily, bind receptors to induce phosphorylation and nuclear translocation of SMAD transcription factors (R-SMAD1/5/8) and regulate vessel growth. ...

journal_title：Nature communications

authors： Mouillesseaux KP,Wiley DS,Saunders LM,Wylie LA,Kushner EJ,Chong DC,Citrin KM,Barber AT,Park Y,Kim JD,Samsa LA,Kim J,Liu J,Jin SW,Bautch VL

更新日期：2016-11-11 00:00:00

abstract：:The biological pump transports organic carbon produced by photosynthesis to the meso- and bathypelagic zones, the latter removing carbon from exchanging with the atmosphere over centennial time scales. Organisms living in both zones are supported by a passive flux of particles, and carbon transported to the deep-sea t...

journal_title：Nature communications

authors： Hernández-León S,Koppelmann R,Fraile-Nuez E,Bode A,Mompeán C,Irigoien X,Olivar MP,Echevarría F,Fernández de Puelles ML,González-Gordillo JI,Cózar A,Acuña JL,Agustí S,Duarte CM

更新日期：2020-11-27 00:00:00

abstract：:Recent years have witnessed the growing interest in the remote functionalization of alkenes for it offers a strategy to activate the challenging C-H bonds distant from the initiation point via alkene isomerization/functionalization. However, the catalytic enantioselective isomerization/functionalization with one singl...

journal_title：Nature communications

authors： Chen X,Cheng Z,Guo J,Lu Z

更新日期：2018-09-26 00:00:00

abstract：:Mass extinctions have profoundly impacted the evolution of life through not only reducing taxonomic diversity but also reshaping ecosystems and biogeographic patterns. In particular, they are considered to have driven increased biogeographic cosmopolitanism, but quantitative tests of this hypothesis are rare and have ...

journal_title：Nature communications

authors： Button DJ,Lloyd GT,Ezcurra MD,Butler RJ

更新日期：2017-10-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Kremer M,Petrides I,Meyer E,Heinrich M,Zilberberg O,Szameit A

更新日期：2020-04-08 00:00:00

abstract：:Base editing tools with diversified editing scopes and minimized RNA off-target activities are required for broad applications. Nevertheless, current Streptococcus pyogenes Cas9 (SpCas9)-based adenine base editors (ABEs) with minimized RNA off-target activities display constrained editing scopes with efficient editing...

journal_title：Nature communications

authors： Li S,Yuan B,Cao J,Chen J,Chen J,Qiu J,Zhao XM,Wang X,Qiu Z,Cheng TL

更新日期：2020-11-17 00:00:00

abstract：:Botulinum neurotoxins are known to have seven serotypes (BoNT/A-G). Here we report a new BoNT serotype, tentatively named BoNT/X, which has the lowest sequence identity with other BoNTs and is not recognized by antisera against known BoNTs. Similar to BoNT/B/D/F/G, BoNT/X cleaves vesicle-associated membrane proteins (...

journal_title：Nature communications

authors： Zhang S,Masuyer G,Zhang J,Shen Y,Lundin D,Henriksson L,Miyashita SI,Martínez-Carranza M,Dong M,Stenmark P

更新日期：2017-08-03 00:00:00

abstract：:Precise manipulation and control of coherent lattice oscillations via nanostructuring and phonon-wave interference has the potential to significantly impact a broad array of technologies and research areas. Resolving the dynamics of individual phonons in defect-laden materials presents an enormous challenge, however, ...

journal_title：Nature communications

authors： Cremons DR,Plemmons DA,Flannigan DJ

更新日期：2016-04-15 00:00:00

abstract：:China has enacted a series of policies since 2015 to substitute electricity for in-home combustion for rural residential heating. The Electric Heating Policy (EHP) has contributed to significant improvements in air quality, benefiting hundreds of millions of people. This shift, however, has resulted in a sharp increas...

journal_title：Nature communications

authors： Wang J,Zhong H,Yang Z,Wang M,Kammen DM,Liu Z,Ma Z,Xia Q,Kang C

更新日期：2020-11-27 00:00:00

abstract：:Microglia and peripheral monocytes contribute to hypersensitivity in rodent models of neuropathic pain. However, the precise respective function of microglia and peripheral monocytes has not been investigated in these models. To address this question, here we combined transgenic mice and pharmacological tools to speci...

journal_title：Nature communications

authors： Peng J,Gu N,Zhou L,B Eyo U,Murugan M,Gan WB,Wu LJ

更新日期：2016-06-28 00:00:00

abstract：:In cavity quantum electrodynamics (QED), the interaction between an atomic transition and the cavity field is measured by the vacuum Rabi frequency Ω(0). The analogous term 'circuit QED' has been introduced for Josephson junctions, because superconducting circuits behave as artificial atoms coupled to the bosonic fiel...

journal_title：Nature communications

authors： Nataf P,Ciuti C

更新日期：2010-09-07 00:00:00