Abstract:
:Since the 1970s, it has been known that black-hole (and other) horizons are truly thermodynamic. More generally, surfaces which are not horizons have also been conjectured to behave thermodynamically. Initially, for surfaces microscopically expanded from a horizon to so-called stretched horizons, and more recently, for more general ordinary surfaces in the emergent gravity program. To test these conjectures we ask whether such surfaces satisfy an analogue to the first law of thermodynamics (as do horizons). For static asymptotically flat spacetimes we find that such a first law holds on horizons. We prove that this law remains an excellent approximation for stretched horizons, but counter-intuitively this result illustrates the insufficiency of the laws of black-hole mechanics alone from implying truly thermodynamic behavior. For surfaces away from horizons in the emergent gravity program the first law fails (except for spherically symmetric scenarios), thus undermining the key thermodynamic assumption of this program.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Wang ZW,Braunstein SLdoi
10.1038/s41467-018-05433-9subject
Has Abstractpub_date
2018-07-30 00:00:00pages
2977issue
1issn
2041-1723pii
10.1038/s41467-018-05433-9journal_volume
9pub_type
杂志文章abstract::How electronic charge is distributed over a molecule determines to a large extent its chemical properties. Here, we demonstrate how the electrostatic force field, originating from the inhomogeneous charge distribution in a molecule, can be measured with submolecular resolution. We exploit the fact that distortions typ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11560
更新日期:2016-05-27 00:00:00
abstract::Catalytic C-H activation and hydroamination represent two important strategies for eco-friendly chemical synthesis with high atom efficiency and reduced waste production. Combining both C-H activation and hydroamination in a cascade process, preferably with a single catalyst, would allow rapid access to valuable nitro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11506
更新日期:2016-06-20 00:00:00
abstract::The synergistic interaction among different components in complex catalysts is one of the crucial factors in determining catalytic performance. Here we report the interactions among the three components in controlling the catalytic performance of Cu-ZnO-ZrO2 (CZZ) catalyst for CO2 hydrogenation to methanol. The in sit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09072-6
更新日期:2019-03-11 00:00:00
abstract::Large Igneous Provinces (LIPs) are associated with the largest climate perturbations in Earth's history. The North Atlantic Igneous Province (NAIP) and Paleocene-Eocene Thermal Maximum (PETM) constitute an exemplar of this association. As yet we have no means to reconstruct the pacing of LIP greenhouse gas emissions f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12957-1
更新日期:2019-12-05 00:00:00
abstract::Post-transcriptional regulation of cellular mRNA is essential for protein synthesis. Here we describe the importance of mRNA translational repression and mRNA subcellular location for protein expression during B lymphocyte activation and the DNA damage response. Cytoplasmic RNA granules are formed upon cell activation...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00454-2
更新日期:2017-09-13 00:00:00
abstract::The emergence of antimicrobial-resistant bacteria is an increasingly serious threat to global health, necessitating the development of innovative antimicrobials. Here we report the development of a series of CRISPR-Cas13a-based antibacterial nucleocapsids, termed CapsidCas13a(s), capable of sequence-specific killing o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16731-6
更新日期:2020-06-10 00:00:00
abstract::Upgrading C1 chemicals (for example, CO, CO/H2, MeOH and CO2) with C-C bond formation is essential for the synthesis of bulk chemicals. In general, these industrially important processes (for example, Fischer Tropsch) proceed at drastic reaction conditions (>250 °C; high pressure) and suffer from low selectivity, whic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12075
更新日期:2016-07-05 00:00:00
abstract::Myxofibrosarcoma (MFS) is a common adult soft tissue sarcoma characterized by an infiltrative growth pattern and a high local recurrence rate. Here we report the genetic and epigenetic landscape of MFS based on the results of whole-exome sequencing (N = 41), RNA sequencing (N = 29), and methylation analysis (N = 41), ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03891-9
更新日期:2018-07-17 00:00:00
abstract::Spatial correlations in environmental stochasticity can synchronize populations over wide areas, a phenomenon known as the Moran effect. The Moran effect has been confirmed in field, laboratory and theoretical investigations. Little is known, however, about the Moran effect in a common ecological case, when environmen...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6993
更新日期:2015-01-09 00:00:00
abstract::Self-sustaining oscillations are essential for diverse physiological functions such as the cell cycle, insulin secretion and circadian rhythms. Synthetic oscillators using biochemical feedback circuits have been generated in cell culture. These synthetic systems provide important insight into design principles for bio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9587
更新日期:2015-11-30 00:00:00
abstract::The ter region of the bacterial chromosome, where replication terminates, is the last to be segregated before cell division in Escherichia coli. Delayed segregation is controlled by the MatP protein, which binds to specific sites (matS) within ter, and interacts with other proteins such as ZapB. Here, we investigate t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17606-6
更新日期:2020-07-30 00:00:00
abstract::Band-inverted electron-hole bilayers support quantum spin Hall insulator and exciton condensate phases. Interest in quantum spin Hall effect in these systems has recently put them in the spotlight. We investigate such a bilayer in an external magnetic field. We show that the interlayer correlations lead to formation o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10462
更新日期:2016-01-25 00:00:00
abstract::Macrophages play crucial roles in host defence and tissue homoeostasis, processes in which both environmental stimuli and intracellularly generated metabolites influence activation of macrophages. Activated macrophages are classified into M1 and M2 macrophages. It remains unclear how intracellular nutrition sufficienc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13130
更新日期:2016-10-12 00:00:00
abstract::Dynamic changes in histone modifications under various physiological cues play important roles in gene transcription and cancer. Identification of new histone marks critical for cancer development is of particular importance. Here we show that, in a glucose-dependent manner, E3 ubiquitin ligase NEDD4 ubiquitinates his...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14799
更新日期:2017-03-16 00:00:00
abstract::The original version of this Article contained an error in Fig. 2f, in which the phospholipid was incorrectly labelled 'PE' rather than the correct 'PC'. This has now been corrected in the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-019-08907-6
更新日期:2019-02-19 00:00:00
abstract::Clock genes are expressed throughout the body, although how they oscillate in unrestrained animals is not known. Here, we show an in vivo imaging technique that enables long-term simultaneous imaging of multiple tissues. We use dual-focal 3D tracking and signal-intensity calibration to follow gene expression in a targ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11705
更新日期:2016-06-10 00:00:00
abstract::Humans survive and thrive through social exchange. Yet, social dependency also comes at a cost. Perceived social isolation, or loneliness, affects physical and mental health, cognitive performance, overall life expectancy, and increases vulnerability to Alzheimer's disease-related dementias. Despite severe consequence...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20039-w
更新日期:2020-12-15 00:00:00
abstract::A crumpled sheet of paper displays an intricate pattern of creases and point-like singular structures, termed d-cones. It is typically assumed that elongated creases form when ridges connecting two d-cones fold beyond the material yielding threshold, and scarring is thus a by-product of the folding dynamics that seek ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8232
更新日期:2015-06-11 00:00:00
abstract::Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the proteolytic activities of the metalloprotease SPRTN or the proteasome in a replication-coupled manner; however, additional proteolytic mechanisms...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15170-7
更新日期:2020-03-12 00:00:00
abstract::Stem rust is an important disease of wheat that can be controlled using resistance genes. The gene SuSr-D1 identified in cultivar 'Canthatch' suppresses stem rust resistance. SuSr-D1 mutants are resistant to several races of stem rust that are virulent on wild-type plants. Here we identify SuSr-D1 by sequencing flow-s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14937-2
更新日期:2020-02-28 00:00:00
abstract::Many voltage-gated potassium channels open in response to membrane depolarization and then inactivate within milliseconds. Neurons use these channels to tune their excitability. In Shaker K(+) channels, inactivation is caused by the cytoplasmic amino terminus, termed the inactivation gate. Despite having four such gat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5050
更新日期:2014-06-09 00:00:00
abstract::The amazing structural variety of cells is matched only by their functional diversity, and reflects the complex interplay between biochemical and mechanical regulation. How both regulatory layers generate specifically shaped cellular domains is not fully understood. Here, we report how cell growth domains are shaped i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9400
更新日期:2015-10-12 00:00:00
abstract::Covalently locking interacting proteins in situ is an attractive strategy for addressing the challenge of identifying weak and transient protein interactions, yet it is demanding to execute chemical reactions in live systems in a biocompatible, specific, and autonomous manner. Harnessing proximity-enabled reactivity o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02409-z
更新日期:2017-12-21 00:00:00
abstract::A disturbance of reactive oxygen species (ROS) homeostasis may cause the pathogenesis of many diseases. Inspired by natural photosynthesis, this work proposes a photo-driven H2-evolving liposomal nanoplatform (Lip NP) that comprises an upconversion nanoparticle (UCNP) that is conjugated with gold nanoparticles (AuNPs)...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14413-x
更新日期:2020-01-27 00:00:00
abstract::Humans typically make near-optimal sensorimotor judgements but show systematic biases when making more cognitive judgements. Here we test the hypothesis that, while humans are sensitive to the noise present during early sensory encoding, the "optimality gap" arises because they are blind to noise introduced by later c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09330-7
更新日期:2019-04-12 00:00:00
abstract::Functional depletion of the alternative splicing factors Muscleblind-like (MBNL 1 and 2) is at the basis of the neuromuscular disease myotonic dystrophy type 1 (DM1). We previously showed the efficacy of miRNA downregulation in Drosophila DM1 model. Here, we screen for miRNAs that regulate MBNL1 and MBNL2 in HeLa cell...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04892-4
更新日期:2018-06-26 00:00:00
abstract::Many volcanoes erupt compositionally homogeneous magmas over timescales ranging from decades to millennia. This monotonous activity is thought to reflect a high degree of chemical homogeneity in their magmatic systems, leading to predictable eruptive behaviour. We combine petrological analyses of erupted crystals with...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17590-x
更新日期:2020-07-28 00:00:00
abstract::The worldwide prevalence of infections caused by antibiotic-resistant Gram-negative bacteria poses a serious threat to public health due to the limited therapeutic alternatives. Cationic peptides represent a large family of antibiotics and have attracted interest due to their diverse chemical structures and potential ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05781-6
更新日期:2018-08-16 00:00:00
abstract::BRCA1 mutation carriers have a higher risk of developing triple-negative breast cancer (TNBC), which is a refractory disease due to its non-responsiveness to current clinical targeted therapies. Using the Sleeping Beauty transposon system in Brca1-deficient mice, we identified 169 putative cancer drivers, among which ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16936-9
更新日期:2020-06-26 00:00:00
abstract::Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1R) mediate distinct cellular and physiological functions. Here, we demonstrate how domain differences between IR and IGF1R contribute to the distinct functions of these receptors using chimeric and site-mutated receptors. Receptors with t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14892
更新日期:2017-03-27 00:00:00