Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells.

abstract：:The significant degradation that fossilized biomolecules may experience during burial makes it challenging to assess the biogenicity of organic microstructures in ancient rocks. Here we investigate the molecular signatures of 1.88 Ga Gunflint organic microfossils as a function of their diagenetic history. Synchrotron-...

journal_title：Nature communications

authors： Alleon J,Bernard S,Le Guillou C,Marin-Carbonne J,Pont S,Beyssac O,McKeegan KD,Robert F

更新日期：2016-06-17 00:00:00

abstract：:DNA methylation plays important roles in prokaryotes, and their genomic landscapes-prokaryotic epigenomes-have recently begun to be disclosed. However, our knowledge of prokaryotic methylation systems is focused on those of culturable microbes, which are rare in nature. Here, we used single-molecule real-time and circ...

journal_title：Nature communications

authors： Hiraoka S,Okazaki Y,Anda M,Toyoda A,Nakano SI,Iwasaki W

更新日期：2019-01-11 00:00:00

abstract：:The antiquity and global abundance of the enzyme, RuBisCO, attests to the crucial and longstanding role it has played in the biogeochemical cycles of Earth over billions of years. The counterproductive oxygenase activity of RuBisCO has persisted over billions of years of evolution, despite its competition with the car...

journal_title：Nature communications

authors： Shih PM,Occhialini A,Cameron JC,Andralojc PJ,Parry MA,Kerfeld CA

更新日期：2016-01-21 00:00:00

abstract：:Whispering-gallery-mode resonators have been extensively used in conjunction with different materials for the development of a variety of photonic devices. Among the latter, hybrid structures, consisting of dielectric microspheres and colloidal core/shell semiconductor nanocrystals as gain media, have attracted intere...

journal_title：Nature communications

authors： Grivas C,Li C,Andreakou P,Wang P,Ding M,Brambilla G,Manna L,Lagoudakis P

更新日期：2013-01-01 00:00:00

abstract：:Aerobic methane oxidation is catalyzed by particulate methane monooxygenase (pMMO), a copper-dependent, membrane metalloenzyme composed of subunits PmoA, PmoB, and PmoC. Characterization of the copper active site has been limited by challenges in spectroscopic analysis stemming from the presence of multiple copper bin...

journal_title：Nature communications

authors： Ro SY,Schachner LF,Koo CW,Purohit R,Remis JP,Kenney GE,Liauw BW,Thomas PM,Patrie SM,Kelleher NL,Rosenzweig AC

更新日期：2019-06-17 00:00:00

abstract：:G protein-coupled receptors (GPCRs) constitute the largest family of cell surface receptors. They can exist and act as dimers, but the requirement of dimers for agonist-induced signal initiation and structural dynamics remains largely unknown. Frizzled 6 (FZD6) is a member of Class F GPCRs, which bind WNT proteins to ...

journal_title：Nature communications

authors： Petersen J,Wright SC,Rodríguez D,Matricon P,Lahav N,Vromen A,Friedler A,Strömqvist J,Wennmalm S,Carlsson J,Schulte G

更新日期：2017-08-09 00:00:00

abstract：:Face recognition is highly proficient in humans and other social primates; it emerges in infancy, but the development of the neural mechanisms supporting this behaviour is largely unknown. We use blood-volume functional MRI to monitor longitudinally the responsiveness to faces, scrambled faces, and objects in macaque ...

journal_title：Nature communications

authors： Livingstone MS,Vincent JL,Arcaro MJ,Srihasam K,Schade PF,Savage T

更新日期：2017-03-31 00:00:00

abstract：:Signaling molecules that regulate neurodevelopmental processes in the early postnatal subventricular zone (SVZ) are critical for proper brain development yet remain poorly characterized. Here, we report that Endothelin-1 (ET-1), a molecular component of the postnatal SVZ, promotes radial glial cell maintenance and pro...

journal_title：Nature communications

authors： Adams KL,Riparini G,Banerjee P,Breur M,Bugiani M,Gallo V

更新日期：2020-05-01 00:00:00

abstract：:Standard optical tweezers rely on optical forces arising when a focused laser beam interacts with a microscopic particle: scattering forces, pushing the particle along the beam direction, and gradient forces, attracting it towards the high-intensity focal spot. Importantly, the incoming laser beam is not affected by t...

journal_title：Nature communications

authors： Kalantarifard F,Elahi P,Makey G,Maragò OM,Ilday FÖ,Volpe G

更新日期：2019-06-18 00:00:00

abstract：:Due to the generally delocalized nature of molecular valence orbitals, valence-shell spectroscopies do not usually allow to specifically target a selected atom in a molecule. However, in X-ray electron spectroscopy, the photoelectron momentum is large and the recoil angular momentum transferred to the molecule is larg...

journal_title：Nature communications

authors： Miron C,Miao Q,Nicolas C,Bozek JD,Andrałojć W,Patanen M,Simões G,Travnikova O,Ågren H,Gel'mukhanov F

更新日期：2014-05-09 00:00:00

abstract：:Stability is now a critical factor in the commercialization of organic photovoltaic (OPV) devices. Both extrinsic stability to oxygen and water and intrinsic stability to light and heat in inert conditions must be achieved. Triplet states are known to be problematic in both cases, leading to singlet oxygen production ...

journal_title：Nature communications

authors： Ramirez I,Privitera A,Karuthedath S,Jungbluth A,Benduhn J,Sperlich A,Spoltore D,Vandewal K,Laquai F,Riede M

更新日期：2021-01-20 00:00:00

abstract：:A recent review concluded that earthworm presence increases CO₂ emissions by 33% but does not affect soil organic carbon stocks. However, the findings are controversial and raise new questions. Here we hypothesize that neither an increase in CO₂ emission nor in stabilized carbon would entirely reflect the earthworms' ...

journal_title：Nature communications

authors： Zhang W,Hendrix PF,Dame LE,Burke RA,Wu J,Neher DA,Li J,Shao Y,Fu S

更新日期：2013-01-01 00:00:00

abstract：:Aberrant metabolism of cancer cells is well appreciated, but the identification of cancer subsets with specific metabolic vulnerabilities remains challenging. We conducted a chemical biology screen and identified a subset of neuroendocrine tumors displaying a striking pattern of sensitivity to inhibition of the choles...

journal_title：Nature communications

authors： Mahoney CE,Pirman D,Chubukov V,Sleger T,Hayes S,Fan ZP,Allen EL,Chen Y,Huang L,Liu M,Zhang Y,McDonald G,Narayanaswamy R,Choe S,Chen Y,Gross S,Cianchetta G,Padyana AK,Murray S,Liu W,Marks KM,Murtie J,Dorsch M,

更新日期：2019-01-09 00:00:00

abstract：:Oxygen contamination is a problem which inevitably occurs during severe plastic deformation of metallic powders by exposure to air. Although this contamination can change the morphology and properties of the consolidated materials, there is a lack of detailed information about the behavior of oxygen in nanocrystalline...

journal_title：Nature communications

authors： Guo J,Haberfehlner G,Rosalie J,Li L,Duarte MJ,Kothleitner G,Dehm G,He Y,Pippan R,Zhang Z

更新日期：2018-03-05 00:00:00

abstract：:Machines that simultaneously process and store multistate data at one and the same location can provide a new class of fast, powerful and efficient general-purpose computers. We demonstrate the central element of an all-optical calculator, a photonic abacus, which provides multistate compute-and-store operation by int...

journal_title：Nature communications

authors： Feldmann J,Stegmaier M,Gruhler N,Ríos C,Bhaskaran H,Wright CD,Pernice WHP

更新日期：2017-11-02 00:00:00

abstract：:The three-dimensional architecture of the genome affects genomic functions. Multiple genome architectures at different length scales, including chromatin loops, domains, compartments, and lamina- and nucleolus-associated regions, have been discovered. However, how these structures are arranged in the same cell and how...

journal_title：Nature communications

authors： Liu M,Lu Y,Yang B,Chen Y,Radda JSD,Hu M,Katz SG,Wang S

更新日期：2020-06-09 00:00:00

abstract：:Redox-regulated effector systems that counteract oxidative stress are essential for all forms of life. Here we uncover a new paradigm for sensing oxidative stress centred on the hydrophobic core of a sensor protein. RsrA is an archetypal zinc-binding anti-sigma factor that responds to disulfide stress in the cytoplasm...

journal_title：Nature communications

authors： Rajasekar KV,Zdanowski K,Yan J,Hopper JT,Francis ML,Seepersad C,Sharp C,Pecqueur L,Werner JM,Robinson CV,Mohammed S,Potts JR,Kleanthous C

更新日期：2016-07-19 00:00:00

abstract：:Nanoscale coordination polymers (NCPs) are self-assembled from metal ions and organic bridging ligands, and can overcome many drawbacks of existing drug delivery systems by virtue of tunable compositions, sizes and shapes, high drug loadings, ease of surface modification and intrinsic biodegradability. Here we report ...

journal_title：Nature communications

authors： Liu D,Poon C,Lu K,He C,Lin W

更新日期：2014-06-25 00:00:00

abstract：:Chronic nonalcoholic steatohepatitis (NASH) is a metabolic disorder that often leads to liver fibrosis, a condition with limited therapy options. Adiponectin is an adipocytokine that regulates glucose and lipid metabolism via binding to its receptors AdipoR1 and AdipoR2, and AdipoRs signaling is reported to enhance fa...

journal_title：Nature communications

authors： Xu H,Zhao Q,Song N,Yan Z,Lin R,Wu S,Jiang L,Hong S,Xie J,Zhou H,Wang R,Jiang X

更新日期：2020-11-16 00:00:00

abstract：:Pioneer transcription factors can engage nucleosomal DNA, which leads to local chromatin remodeling and to the establishment of transcriptional competence. However, the impact of enhancer priming by pioneer factors on the temporal control of gene expression and on mitotic memory remains unclear. Here we employ quantit...

journal_title：Nature communications

authors： Dufourt J,Trullo A,Hunter J,Fernandez C,Lazaro J,Dejean M,Morales L,Nait-Amer S,Schulz KN,Harrison MM,Favard C,Radulescu O,Lagha M

更新日期：2018-12-05 00:00:00

abstract：:Akin to single-site homogeneous catalysis, a long sought-after goal is to achieve reaction site precision in heterogeneous catalysis for chemical control over patterns of activity, selectivity and stability. Herein, we report on metal phosphides as a class of material capable of realizing these attributes and unlock t...

journal_title：Nature communications

authors： Xu YF,Duchesne PN,Wang L,Tavasoli A,Jelle AA,Xia M,Liao JF,Kuang DB,Ozin GA

更新日期：2020-10-13 00:00:00

abstract：:Microelectromechanical systems (MEMS) enable many modern-day technologies, including actuators, motion sensors, drug delivery systems, projection displays, etc. Currently, MEMS fabrication techniques are primarily based on silicon micromachining processes, resulting in rigid and low aspect ratio structures. In this st...

journal_title：Nature communications

authors： Khudiyev T,Clayton J,Levy E,Chocat N,Gumennik A,Stolyarov AM,Joannopoulos J,Fink Y

更新日期：2017-11-10 00:00:00

abstract：:Although the chemistry of uranium-ligand multiple bonding is burgeoning, analogous complexes involving other actinides such as thorium remain rare and there are not yet any terminal thorium nitrides outside of cryogenic matrix isolation conditions. Here, we report evidence that reduction of a thorium-azide produces a ...

journal_title：Nature communications

authors： Du J,Alvarez-Lamsfus C,Wildman EP,Wooles AJ,Maron L,Liddle ST

更新日期：2019-09-13 00:00:00

abstract：:The contrast and sensitivity of in vivo fluorescence imaging has been revolutionized by molecular fluorophores operating in the second near-infrared window (NIR-II; 1000-1700 nm), but an ongoing challenge is the solvatochromism-caused quenching in aqueous solution for the long-wavelength absorbing fluorophores. Herein...

journal_title：Nature communications

authors： Wang S,Fan Y,Li D,Sun C,Lei Z,Lu L,Wang T,Zhang F

更新日期：2019-03-05 00:00:00

abstract：:Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme that regulates plasma membrane (PM) fluidity. Here we report that SMPDL3b excess, as observed in podocytes in diabetic kidney disease (DKD), impairs insulin receptor isoform B-dependent pro-survival insulin signaling by interfering with insu...

journal_title：Nature communications

authors： Mitrofanova A,Mallela SK,Ducasa GM,Yoo TH,Rosenfeld-Gur E,Zelnik ID,Molina J,Varona Santos J,Ge M,Sloan A,Kim JJ,Pedigo C,Bryn J,Volosenco I,Faul C,Zeidan YH,Garcia Hernandez C,Mendez AJ,Leibiger I,Burke GW,Futerm

更新日期：2019-06-19 00:00:00

abstract：:Investigating the susceptibility of oestrogen receptor-positive (ER(pos)) normal human breast epithelial cells (HBECs) for clinical purposes or basic research awaits a proficient cell-based assay. Here we set out to identify markers for isolating ER(pos) cells and to expand what appear to be post-mitotic primary cells...

journal_title：Nature communications

authors： Fridriksdottir AJ,Kim J,Villadsen R,Klitgaard MC,Hopkinson BM,Petersen OW,Rønnov-Jessen L

更新日期：2015-11-13 00:00:00

abstract：:Cell biologists generally consider that microtubules and actin play complementary roles in long- and short-distance transport in animal cells. On the contrary, using melanosomes of melanocytes as a model, we recently discovered that the motor protein myosin-Va works with dynamic actin tracks to drive long-range organe...

journal_title：Nature communications

authors： Alzahofi N,Welz T,Robinson CL,Page EL,Briggs DA,Stainthorp AK,Reekes J,Elbe DA,Straub F,Kallemeijn WW,Tate EW,Goff PS,Sviderskaya EV,Cantero M,Montoliu L,Nedelec F,Miles AK,Bailly M,Kerkhoff E,Hume AN

更新日期：2020-07-13 00:00:00

abstract：:We propose the concept of universal fiducials based on a set of pre-made semi-synthetic antibodies (sABs) generated by customized phage display selections against the fusion protein BRIL, an engineered variant of apocytochrome b562a. These sABs can bind to BRIL fused either into the loops or termini of different GPCRs...

journal_title：Nature communications

authors： Mukherjee S,Erramilli SK,Ammirati M,Alvarez FJD,Fennell KF,Purdy MD,Skrobek BM,Radziwon K,Coukos J,Kang Y,Dutka P,Gao X,Qiu X,Yeager M,Eric Xu H,Han S,Kossiakoff AA

更新日期：2020-03-27 00:00:00

abstract：:Digital polymers with precisely ordered units acting as the coded 0- or 1-bit, are introduced as a promising option for molecular data storage. However, the pursuit of better performance in terms of high storage capacity and useful functions never stops. Herein, we propose a concept of an information-coded 2D digital ...

journal_title：Nature communications

authors： Huang Z,Shi Q,Guo J,Meng F,Zhang Y,Lu Y,Qian Z,Li X,Zhou N,Zhang Z,Zhu X

更新日期：2019-04-23 00:00:00

abstract：:CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and memory T cells is necessary for resolution of acute inflammation. Failure of this neural circuit co...

journal_title：Nature communications

authors： Dubeykovskaya Z,Si Y,Chen X,Worthley DL,Renz BW,Urbanska AM,Hayakawa Y,Xu T,Westphalen CB,Dubeykovskiy A,Chen D,Friedman RA,Asfaha S,Nagar K,Tailor Y,Muthupalani S,Fox JG,Kitajewski J,Wang TC

更新日期：2016-02-04 00:00:00