Probing nanoscale spatial distribution of plasmonically excited hot carriers.

abstract：:Mutant Huntingtin (mtHtt) causes neurodegeneration in Huntington's disease (HD) by evoking defects in the mitochondria, but the underlying mechanisms remains elusive. Our proteomic analysis identifies valosin-containing protein (VCP) as an mtHtt-binding protein on the mitochondria. Here we show that VCP is selectively...

journal_title：Nature communications

authors： Guo X,Sun X,Hu D,Wang YJ,Fujioka H,Vyas R,Chakrapani S,Joshi AU,Luo Y,Mochly-Rosen D,Qi X

更新日期：2016-08-26 00:00:00

abstract：:Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. TOP1 is also a major driver of endogenous genome instability, particularly when its catalytic intermediate-a covalent TOP1-DNA adduct known as a TOP1 cleavage complex (TOP1cc)-is stabilised. TOP1ccs are high...

journal_title：Nature communications

authors： Fielden J,Wiseman K,Torrecilla I,Li S,Hume S,Chiang SC,Ruggiano A,Narayan Singh A,Freire R,Hassanieh S,Domingo E,Vendrell I,Fischer R,Kessler BM,Maughan TS,El-Khamisy SF,Ramadan K

更新日期：2020-03-09 00:00:00

abstract：:Even a single-component liquid may have more than two liquid states. The transition between them is called a 'liquid-liquid transition' (LLT). Such LLTs have recently attracted considerable attention mainly because of the fundamental interest in the physical origin of this counter-intuitive phenomenon. In this study, ...

journal_title：Nature communications

authors： Murata K,Tanaka H

更新日期：2010-05-04 00:00:00

abstract：:Hybrid halide perovskite solar cells were first demonstrated in 2009 with cell efficiency quickly soaring from below 10% to more than 23% in a few years. Halide perovskites have the desirable processing simplicity but are very fragile when exposed to water and heat. This fragility represents a great challenge for the ...

journal_title：Nature communications

authors： Gao P,Bin Mohd Yusoff AR,Nazeeruddin MK

更新日期：2018-11-28 00:00:00

abstract：:Main group elements usually assume a typical oxidation state while forming compounds with other species. Group I elements are usually in the +1 state in inorganic materials. Our recent work reveals that pressure may make the inner shell 5p electrons of Cs reactive, causing Cs to expand beyond the +1 oxidation state. H...

journal_title：Nature communications

authors： Botana J,Miao MS

更新日期：2014-09-10 00:00:00

abstract：:Topological insulators represent a new quantum state of matter that are insulating in the bulk but metallic on the edge or surface. In the Dirac surface state, it is well-established that the electron spin is locked with the crystal momentum. Here we report a new phenomenon of the spin texture locking with the orbital...

journal_title：Nature communications

authors： Xie Z,He S,Chen C,Feng Y,Yi H,Liang A,Zhao L,Mou D,He J,Peng Y,Liu X,Liu Y,Liu G,Dong X,Yu L,Zhang J,Zhang S,Wang Z,Zhang F,Yang F,Peng Q,Wang X,Chen C,Xu Z,Zhou XJ

更新日期：2014-02-28 00:00:00

abstract：:FR171456 is a natural product with cholesterol-lowering properties in animal models, but its molecular target is unknown, which hinders further drug development. Here we show that FR171456 specifically targets the sterol-4-alpha-carboxylate-3-dehydrogenase (Saccharomyces cerevisiae--Erg26p, Homo sapiens--NSDHL (NAD(P)...

journal_title：Nature communications

authors： Helliwell SB,Karkare S,Bergdoll M,Rahier A,Leighton-Davis JR,Fioretto C,Aust T,Filipuzzi I,Frederiksen M,Gounarides J,Hoepfner D,Hofmann A,Imbert PE,Jeker R,Knochenmuss R,Krastel P,Margerit A,Memmert K,Miault CV,Rao

更新日期：2015-10-12 00:00:00

abstract：:Electric fields can transform materials with respect to their structure and properties, enabling various applications ranging from batteries to spintronics. Recently electrolytic gating, which can generate large electric fields and voltage-driven ion transfer, has been identified as a powerful means to achieve electri...

journal_title：Nature communications

authors： Yi D,Wang Y,van ʼt Erve OMJ,Xu L,Yuan H,Veit MJ,Balakrishnan PP,Choi Y,N'Diaye AT,Shafer P,Arenholz E,Grutter A,Xu H,Yu P,Jonker BT,Suzuki Y

更新日期：2020-02-14 00:00:00

abstract：:Protein-protein interactions featuring intricate binding epitopes remain challenging targets for synthetic inhibitors. Interactions of NEMO, a scaffolding protein central to NF-κB signaling, exemplify this challenge. Various regulators are known to interact with different coiled coil regions of NEMO, but the topologic...

journal_title：Nature communications

authors： Sadek J,Wuo MG,Rooklin D,Hauenstein A,Hong SH,Gautam A,Wu H,Zhang Y,Cesarman E,Arora PS

更新日期：2020-04-14 00:00:00

abstract：:MADS-domain transcription factors have been shown to act as key repressors or activators of the transition to flowering and as master regulators of reproductive organ identities. Despite their important roles in plant development, the origin of several MADS-box subfamilies has remained enigmatic so far. Here we demons...

journal_title：Nature communications

authors： Ruelens P,de Maagd RA,Proost S,Theißen G,Geuten K,Kaufmann K

更新日期：2013-01-01 00:00:00

abstract：:Quantum states induced by single-atomic impurities are at the frontier of physics and material science. While such states have been reported in high-temperature superconductors and dilute magnetic semiconductors, they are unexplored in topological magnets which can feature spin-orbit tunability. Here we use spin-polar...

journal_title：Nature communications

authors： Yin JX,Shumiya N,Jiang Y,Zhou H,Macam G,Sura HOM,Zhang SS,Cheng ZJ,Guguchia Z,Li Y,Wang Q,Litskevich M,Belopolski I,Yang XP,Cochran TA,Chang G,Zhang Q,Huang ZQ,Chuang FC,Lin H,Lei H,Andersen BM,Wang Z,Jia S

更新日期：2020-09-04 00:00:00

abstract：:Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. Here we investigate the relationship between joint pain and the gastrointestinal microbiome composition, and o...

journal_title：Nature communications

authors： Boer CG,Radjabzadeh D,Medina-Gomez C,Garmaeva S,Schiphof D,Arp P,Koet T,Kurilshikov A,Fu J,Ikram MA,Bierma-Zeinstra S,Uitterlinden AG,Kraaij R,Zhernakova A,van Meurs JBJ

更新日期：2019-10-25 00:00:00

abstract：:Antibiotic biosynthetic gene clusters (BGCs) produce bioactive metabolites that impart a fitness advantage to their producer, providing a mechanism for natural selection. This selection drives antibiotic evolution and adapts BGCs for expression in different organisms, potentially providing clues to improve heterologou...

journal_title：Nature communications

authors： Johnston CW,Badran AH,Collins JJ

更新日期：2020-08-21 00:00:00

abstract：:Stimulation of TNFR1 by TNFα can promote three distinct alternative mechanisms of cell death: necroptosis, RIPK1-independent and -dependent apoptosis. How cells decide which way to die is unclear. Here, we report that TNFα-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulati...

journal_title：Nature communications

authors： Geng J,Ito Y,Shi L,Amin P,Chu J,Ouchida AT,Mookhtiar AK,Zhao H,Xu D,Shan B,Najafov A,Gao G,Akira S,Yuan J

更新日期：2017-08-25 00:00:00

abstract：:Most estimates of the burden of malaria are based on its direct impacts; however, its true burden is likely to be greater because of its wider effects on overall health. Here we estimate the indirect impact of malaria on children's health in a case-control study, using the sickle cell trait (HbAS), a condition associa...

journal_title：Nature communications

authors： Uyoga S,Macharia AW,Ndila CM,Nyutu G,Shebe M,Awuondo KO,Mturi N,Peshu N,Tsofa B,Scott JAG,Maitland K,Williams TN

更新日期：2019-02-20 00:00:00

abstract：:Biocatalytic cyclization is highly desirable for efficient synthesis of biologically derived chemical substances, such as the commodity chemicals ε-caprolactam and δ-valerolactam. To identify biocatalysts in lactam biosynthesis, we develop a caprolactam-detecting genetic enzyme screening system (CL-GESS). The Alcalige...

journal_title：Nature communications

authors： Yeom SJ,Kim M,Kwon KK,Fu Y,Rha E,Park SH,Lee H,Kim H,Lee DH,Kim DM,Lee SG

更新日期：2018-11-29 00:00:00

abstract：:The magnetostructural coupling between the structural and the magnetic transition has a crucial role in magnetoresponsive effects in a martensitic-transition system. A combination of various magnetoresponsive effects based on this coupling may facilitate the multifunctional applications of a host material. Here we dem...

journal_title：Nature communications

authors： Liu E,Wang W,Feng L,Zhu W,Li G,Chen J,Zhang H,Wu G,Jiang C,Xu H,de Boer F

更新日期：2012-05-29 00:00:00

abstract：:Central insulin is thought to act at the neural interface between metabolic and hedonic drives to eat. Here, using pharmacological fMRI, we show that intranasal insulin (INI) changes the value of food cues through modulation of mesolimbic pathways. Overnight fasted participants rated the palatability of food pictures ...

journal_title：Nature communications

authors： Tiedemann LJ,Schmid SM,Hettel J,Giesen K,Francke P,Büchel C,Brassen S

更新日期：2017-07-18 00:00:00

abstract：:Cytokinetic abscission, the terminal step of cell division, crucially depends on the local constriction of ESCRT-III helices after cytoskeleton disassembly. While the microtubules of the intercellular bridge are cut by the ESCRT-associated enzyme Spastin, the mechanism that clears F-actin at the abscission site is unk...

journal_title：Nature communications

authors： Frémont S,Hammich H,Bai J,Wioland H,Klinkert K,Rocancourt M,Kikuti C,Stroebel D,Romet-Lemonne G,Pylypenko O,Houdusse A,Echard A

更新日期：2017-02-23 00:00:00

abstract：:Weyl semimetals (WSMs) are topological quantum states wherein the electronic bands disperse linearly around pairs of nodes with fixed chirality, the Weyl points. In WSMs, nonorthogonal electric and magnetic fields induce an exotic phenomenon known as the chiral anomaly, resulting in an unconventional negative longitud...

journal_title：Nature communications

authors： Arnold F,Shekhar C,Wu SC,Sun Y,Dos Reis RD,Kumar N,Naumann M,Ajeesh MO,Schmidt M,Grushin AG,Bardarson JH,Baenitz M,Sokolov D,Borrmann H,Nicklas M,Felser C,Hassinger E,Yan B

更新日期：2016-05-17 00:00:00

abstract：:In most metazoan nuclei, heterochromatin is located at the nuclear periphery in contact with the nuclear lamina, which provides mechanical stability to the nucleus. We show that in cultured cells, chromatin decompaction by the nucleosome binding protein HMGN5 decreases the sturdiness, elasticity and rigidity of the nu...

journal_title：Nature communications

authors： Furusawa T,Rochman M,Taher L,Dimitriadis EK,Nagashima K,Anderson S,Bustin M

更新日期：2015-01-22 00:00:00

abstract：:Tumour vessels have been studied extensively as they are critical sites for drug delivery, anti-angiogenic therapies and immunotherapy. As a preclinical tool, intravital microscopy (IVM) allows for in vivo real-time direct observation of vessels at the cellular level. However, to date there are no reports of intravita...

journal_title：Nature communications

authors： Fisher DT,Muhitch JB,Kim M,Doyen KC,Bogner PN,Evans SS,Skitzki JJ

更新日期：2016-02-17 00:00:00

abstract：:Hexanucleotide repeat expansion in C9ORF72 is the most frequent cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we demonstrate that the repeat-associated non-AUG (RAN) translation of (GGGGCC) n -containing RNAs into poly-dipeptides can initiate in vivo without a 5'-cap. The pr...

journal_title：Nature communications

authors： Cheng W,Wang S,Mestre AA,Fu C,Makarem A,Xian F,Hayes LR,Lopez-Gonzalez R,Drenner K,Jiang J,Cleveland DW,Sun S

更新日期：2018-01-04 00:00:00

abstract：:The developing CA3 hippocampus is comprised by highly connected hub neurons that are particularly effective in achieving network synchronization. Functional hub neurons were shown to be exclusively GABAergic, suggesting that the contribution of glutamatergic neurons to physiological synchronization processes at early ...

journal_title：Nature communications

authors： Marissal T,Bonifazi P,Picardo MA,Nardou R,Petit LF,Baude A,Fishell GJ,Ben-Ari Y,Cossart R

更新日期：2012-01-01 00:00:00

abstract：:Congenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare by RNA-Seq the NPCs derived from CZS-affected and CZS-unaffected twins. Prior to Zika virus (ZIKV) infection the...

journal_title：Nature communications

authors： Caires-Júnior LC,Goulart E,Melo US,Araujo BHS,Alvizi L,Soares-Schanoski A,de Oliveira DF,Kobayashi GS,Griesi-Oliveira K,Musso CM,Amaral MS,daSilva LF,Astray RM,Suárez-Patiño SF,Ventini DC,Gomes da Silva S,Yamamoto GL,Ez

更新日期：2018-02-02 00:00:00

abstract：:Supported gold (Au) nanocatalysts have attracted extensive interests in the past decades because of their unique catalytic properties for a number of key chemical reactions, especially in (selective) oxidations. The activation of O2 on Au nanocatalysts is crucial and remains a challenge because only small Au nanoparti...

journal_title：Nature communications

authors： Zhang Y,Zhang J,Zhang B,Si R,Han B,Hong F,Niu Y,Sun L,Li L,Qiao B,Sun K,Huang J,Haruta M

更新日期：2020-01-28 00:00:00

abstract：:Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in HGPS individuals, although the reason for such vulnerability remains poorly understood. In this work, we develop a microfluidic chip formed by HGPS-S...

journal_title：Nature communications

authors： Pitrez PR,Estronca L,Monteiro LM,Colell G,Vazão H,Santinha D,Harhouri K,Thornton D,Navarro C,Egesipe AL,Carvalho T,Dos Santos RL,Lévy N,Smith JC,de Magalhães JP,Ori A,Bernardo A,De Sandre-Giovannoli A,Nissan X,Rosel

更新日期：2020-08-17 00:00:00

abstract：:The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein depletion technology Trim-Away. This activity is dependent on formation of self-anchored, K63-linked ubiquitin chains by the heterodimeric E2 enzyme Ube2N/Ube2V2....

journal_title：Nature communications

authors： Kiss L,Zeng J,Dickson CF,Mallery DL,Yang JC,McLaughlin SH,Boland A,Neuhaus D,James LC

更新日期：2019-10-03 00:00:00

abstract：:Coupling vibrational transitions to resonant optical modes creates vibrational polaritons shifted from the uncoupled molecular resonances and provides a convenient way to modify the energetics of molecular vibrations. This approach is a viable method to explore controlling chemical reactivity. In this work, we report ...

journal_title：Nature communications

authors： Dunkelberger AD,Spann BT,Fears KP,Simpkins BS,Owrutsky JC

更新日期：2016-11-22 00:00:00

abstract：:The temperature-jump technique, in which the sample is rapidly heated by a powerful laser pulse, has been widely used to probe the fast dynamics of folding of proteins and nucleic acids. However, the existing temperature-jump setups tend to involve sophisticated and expensive instrumentation, while providing only mode...

journal_title：Nature communications

authors： Polinkovsky ME,Gambin Y,Banerjee PR,Erickstad MJ,Groisman A,Deniz AA

更新日期：2014-12-17 00:00:00