Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis.

abstract：:In eukaryotes, DNA polymerase δ (Pol δ) bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. We present the high-resolution cryo-EM structure of the human processive Pol δ-DNA-PCNA comple...

journal_title：Nature communications

authors： Lancey C,Tehseen M,Raducanu VS,Rashid F,Merino N,Ragan TJ,Savva CG,Zaher MS,Shirbini A,Blanco FJ,Hamdan SM,De Biasio A

更新日期：2020-02-28 00:00:00

abstract：:Organic conjugated polymers demonstrate great potential in transistors, solar cells and light-emitting diodes, whose performances are fundamentally governed by charge transport. However, the morphology-property relationships and the underpinning charge transport mechanisms remain unclear. Particularly, whether the non...

journal_title：Nature communications

authors： Wang J,Niu J,Shao B,Yang G,Lu C,Li M,Zhou Z,Chuai X,Chen J,Lu N,Huang B,Wang Y,Li L,Liu M

更新日期：2021-01-04 00:00:00

abstract：:Piezo proteins are transmembrane ion channels which transduce many forms of mechanical stimuli into electrochemical signals. Their pore, formed by the assembly of three identical subunits, opens by an unknown mechanism. Here, to probe this mechanism, we investigate the interaction of Piezo1 with the small molecule ago...

journal_title：Nature communications

authors： Lacroix JJ,Botello-Smith WM,Luo Y

更新日期：2018-05-23 00:00:00

abstract：:Homeowners around the world elevate houses to manage flood risks. Deciding how high to elevate a house poses a nontrivial decision problem. The U.S. Federal Emergency Management Agency (FEMA) recommends elevating existing houses to the Base Flood Elevation (the elevation of the 100-year flood) plus a freeboard. This r...

journal_title：Nature communications

authors： Zarekarizi M,Srikrishnan V,Keller K

更新日期：2020-10-26 00:00:00

abstract：:Xylanolytic enzymes from glycoside hydrolase family 43 (GH43) are involved in the breakdown of hemicellulose, the second most abundant carbohydrate in plants. Here, we kinetically and mechanistically describe the non-reducing-end xylose-releasing exo-oligoxylanase activity and report the crystal structure of a native ...

journal_title：Nature communications

authors： Morais MAB,Coines J,Domingues MN,Pirolla RAS,Tonoli CCC,Santos CR,Correa JBL,Gozzo FC,Rovira C,Murakami MT

更新日期：2021-01-14 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Barlow JT,Bogatyrev SR,Ismagilov RF

更新日期：2020-07-06 00:00:00

abstract：:Avoiding repeated mistakes and learning to reinforce rewarding decisions is critical for human survival and adaptive actions. Yet, the neural underpinnings of the value systems that encode different decision-outcomes remain elusive. Here coupling single-trial electroencephalography with simultaneously acquired functio...

journal_title：Nature communications

authors： Fouragnan E,Retzler C,Mullinger K,Philiastides MG

更新日期：2015-09-08 00:00:00

abstract：:Alike materials in the solid state, the phase diagram of type-II superconductors exhibit crystalline, amorphous, liquid and spatially inhomogeneous phases. The multitude of different phases of vortex matter has thence proven to act as almost ideal model system for the study of both the underlying properties of superco...

journal_title：Nature communications

authors： Reimann T,Mühlbauer S,Schulz M,Betz B,Kaestner A,Pipich V,Böni P,Grünzweig C

更新日期：2015-11-02 00:00:00

abstract：:During neuronal differentiation, the transcriptional profile and the epigenetic context of neural committed cells is subject to significant rearrangements, but a systematic quantification of global histone modification changes is still missing. Here, we show that H3K79me2 increases and H3K27ac decreases globally durin...

journal_title：Nature communications

authors： Ferrari F,Arrigoni L,Franz H,Izzo A,Butenko L,Trompouki E,Vogel T,Manke T

更新日期：2020-10-15 00:00:00

abstract：:Soil surface temperature, an important driver of terrestrial biogeochemical processes, depends strongly on soil albedo, which can be significantly modified by factors such as plant cover. In sparsely vegetated lands, the soil surface can be colonized by photosynthetic microbes that build biocrust communities. Here we ...

journal_title：Nature communications

authors： Couradeau E,Karaoz U,Lim HC,Nunes da Rocha U,Northen T,Brodie E,Garcia-Pichel F

更新日期：2016-01-20 00:00:00

abstract：:Mammals have nine different homologues (ALKBH1-9) of the Escherichia coli DNA repair demethylase AlkB. ALKBH2 is a genuine DNA repair enzyme, but the in vivo function of the other ALKBH proteins has remained elusive. It was recently shown that ALKBH8 contains an additional transfer RNA (tRNA) methyltransferase domain,...

journal_title：Nature communications

authors： van den Born E,Vågbø CB,Songe-Møller L,Leihne V,Lien GF,Leszczynska G,Malkiewicz A,Krokan HE,Kirpekar F,Klungland A,Falnes PØ

更新日期：2011-02-01 00:00:00

abstract：:In the development of addiction, drug seeking becomes habitual and controlled by drug-associated cues, and the neural locus of control over behaviour shifts from the ventral to the dorsolateral striatum. The neural mechanisms underlying this functional transition from recreational drug use to drug-seeking habits are u...

journal_title：Nature communications

authors： Murray JE,Belin-Rauscent A,Simon M,Giuliano C,Benoit-Marand M,Everitt BJ,Belin D

更新日期：2015-12-14 00:00:00

abstract：:Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against SARS-CoV-2 in a random sample of HCW from a large hospital in Spain. Of the 578 participants recruited from 28 March to 9 April 2020, 54 (9.3%...

journal_title：Nature communications

authors： Garcia-Basteiro AL,Moncunill G,Tortajada M,Vidal M,Guinovart C,Jiménez A,Santano R,Sanz S,Méndez S,Llupià A,Aguilar R,Alonso S,Barrios D,Carolis C,Cisteró P,Chóliz E,Cruz A,Fochs S,Jairoce C,Hecht J,Lamoglia M,M

更新日期：2020-07-08 00:00:00

abstract：:Artificial molecules containing just one or two electrons provide a powerful platform for studies of orbital and spin quantum dynamics in nanoscale devices. A well-known example of these dynamics is tunnelling of electrons between two coupled quantum dots triggered by mi...

journal_title：Nature communications

authors： Schreiber LR,Braakman FR,Meunier T,Calado V,Danon J,Taylor JM,Wegscheider W,Vandersypen LM

更新日期：2011-11-22 00:00:00

abstract：:The word 'holography' means a drawing that contains all of the information for light-both amplitude and wavefront. However, because of the insufficient bandwidth of current electronics, the direct measurement of the wavefront of light has not yet been achieved. Though reference-field-assisted interferometric methods h...

journal_title：Nature communications

authors： Lee K,Park Y

更新日期：2016-10-31 00:00:00

abstract：:Despite significant advances in the fabrication and applications of graphene-like materials, it remains a challenge to prepare single-layered metallic materials, which have great potential applications in physics, chemistry and material science. Here we report the fabrication of poly(vinylpyrrolidone)-supported single...

journal_title：Nature communications

authors： Duan H,Yan N,Yu R,Chang CR,Zhou G,Hu HS,Rong H,Niu Z,Mao J,Asakura H,Tanaka T,Dyson PJ,Li J,Li Y

更新日期：2014-01-01 00:00:00

abstract：:The exploration of chemical space for new reactivity, reactions and molecules is limited by the need for separate work-up-separation steps searching for molecules rather than reactivity. Herein we present a system that can autonomously evaluate chemical reactivity within a network of 64 possible reaction combinations ...

journal_title：Nature communications

authors： Dragone V,Sans V,Henson AB,Granda JM,Cronin L

更新日期：2017-06-09 00:00:00

abstract：:Brain-inspired parallel computing, which is typically performed using a hardware neural-network platform consisting of numerous artificial synapses, is a promising technology for effectively handling large amounts of informational data. However, the reported nonlinear and asymmetric conductance-update characteristics ...

journal_title：Nature communications

authors： Seo S,Kang BS,Lee JJ,Ryu HJ,Kim S,Kim H,Oh S,Shim J,Heo K,Oh S,Park JH

更新日期：2020-08-07 00:00:00

abstract：:Human pre-implantation embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here, we report on LiCAT-seq, a technique that enables simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells, and map the chromatin accessibility an...

journal_title：Nature communications

authors： Liu L,Leng L,Liu C,Lu C,Yuan Y,Wu L,Gong F,Zhang S,Wei X,Wang M,Zhao L,Hu L,Wang J,Yang H,Zhu S,Chen F,Lu G,Shang Z,Lin G

更新日期：2019-01-21 00:00:00

abstract：:The possibility of measuring binding of small-molecule drugs to desired targets in live cells could provide a better understanding of drug action. However, current approaches mostly yield static data, require lysis or rely on indirect assays and thus often provide an incomplete understanding of drug action. Here, we p...

journal_title：Nature communications

authors： Dubach JM,Vinegoni C,Mazitschek R,Fumene Feruglio P,Cameron LA,Weissleder R

更新日期：2014-05-28 00:00:00

abstract：:Arriving rapidly to the hospital after a heart attack or stroke is critical for patients to be within time windows for treatment. Prior research in heart attacks has suggested a paradoxical role of the social environment: those who arrive early are surrounded by nonrelatives, while those who arrive late are surrounded...

journal_title：Nature communications

authors： Dhand A,Luke D,Lang C,Tsiaklides M,Feske S,Lee JM

更新日期：2019-03-14 00:00:00

abstract：:Cell-cell communication and interaction is critical during fertilization and triggers free cytosolic calcium ([Ca2+]cyto) as a key signal for egg activation and a polyspermy block in animal oocytes. Fertilization in flowering plants is more complex, involving interaction of a pollen tube with egg adjoining synergid ce...

journal_title：Nature communications

authors： Denninger P,Bleckmann A,Lausser A,Vogler F,Ott T,Ehrhardt DW,Frommer WB,Sprunck S,Dresselhaus T,Grossmann G

更新日期：2014-08-22 00:00:00

abstract：:On-surface chemical reactions hold the potential for manufacturing nanoscale structures directly onto surfaces by linking carbon atoms in a single-step reaction. To fabricate more complex and functionalized structures, the control of the on-surface chemical reactions must be developed significantly. Here, we present a...

journal_title：Nature communications

authors： Kawai S,Haapasilta V,Lindner BD,Tahara K,Spijker P,Buitendijk JA,Pawlak R,Meier T,Tobe Y,Foster AS,Meyer E

更新日期：2016-09-13 00:00:00

abstract：:The photon-like behavior of electrons in graphene causes unusual confinement properties that depend strongly on the geometry and strength of the surrounding potential. We report bottom-up synthesis of atomically-precise one-dimensional (1D) arrays of point charges on graphene that allow exploration of a new type of su...

journal_title：Nature communications

authors： Lu J,Tsai HZ,Tatan AN,Wickenburg S,Omrani AA,Wong D,Riss A,Piatti E,Watanabe K,Taniguchi T,Zettl A,Pereira VM,Crommie MF

更新日期：2019-01-29 00:00:00

abstract：:Heterozygous germline mutations in BRCA2 predispose to breast and ovarian cancer. Contrary to non-cancerous cells, where BRCA2 deletion causes cell cycle arrest or cell death, tumors carrying BRCA2 inactivation continue to proliferate. Here we set out to investigate adaptation to loss of BRCA2 focusing on genome-wide ...

journal_title：Nature communications

authors： Reisländer T,Lombardi EP,Groelly FJ,Miar A,Porru M,Di Vito S,Wright B,Lockstone H,Biroccio A,Harris A,Londoño-Vallejo A,Tarsounas M

更新日期：2019-07-17 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Wang X,Cao L,Fox AD,Fuller R,Griffin L,Mitchell C,Zhao Y,Moon OK,Cabot D,Xu Z,Batbayar N,Kölzsch A,van der Jeugd HP,Madsen J,Chen L,Nathan R

更新日期：2019-07-22 00:00:00

abstract：:Persistent exposure to man-made endocrine disrupting chemicals during fetal endocrine development may lead to disruption of metabolic homeostasis contributing to childhood obesity. Limited cellular platforms exist to test endocrine disrupting chemical-induced developmental abnormalities in human endocrine tissues. Her...

journal_title：Nature communications

authors： Rajamani U,Gross AR,Ocampo C,Andres AM,Gottlieb RA,Sareen D

更新日期：2017-08-09 00:00:00

abstract：:Comparisons of climate model hindcasts with independent proxy data are essential for assessing model performance in non-analogue situations. However, standardized palaeoclimate data sets for assessing the spatial pattern of past climatic change across continents are lacking for some of the most dynamic episodes of Ear...

journal_title：Nature communications

authors： Heiri O,Brooks SJ,Renssen H,Bedford A,Hazekamp M,Ilyashuk B,Jeffers ES,Lang B,Kirilova E,Kuiper S,Millet L,Samartin S,Toth M,Verbruggen F,Watson JE,van Asch N,Lammertsma E,Amon L,Birks HH,Birks HJ,Mortensen MF,H

更新日期：2014-09-11 00:00:00

abstract：:CD47 is a cell surface molecule that inhibits phagocytosis of cells that express it by binding to its receptor, SIRPα, on macrophages and other immune cells. CD47 is expressed at different levels by neoplastic and normal cells. Here, to reveal mechanisms by which different neoplastic cells generate this dominant 'don'...

journal_title：Nature communications

authors： Betancur PA,Abraham BJ,Yiu YY,Willingham SB,Khameneh F,Zarnegar M,Kuo AH,McKenna K,Kojima Y,Leeper NJ,Ho P,Gip P,Swigut T,Sherwood RI,Clarke MF,Somlo G,Young RA,Weissman IL

更新日期：2017-04-05 00:00:00

abstract：:Analysis of potentially interconnected residential water and energy demand is sparse. In a 1-in-10 random sample of Singapore households living in apartments, water use per capita declines over the socioeconomic distribution, whereas electricity use rises. Here I show that in this leading Asian city and tropical clima...

journal_title：Nature communications

authors： Salvo A

更新日期：2018-12-20 00:00:00