Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness.

abstract：:How to move efficiently is an optimal control problem, whose computational complexity grows exponentially with the horizon of the planned trajectory. Breaking a compound movement into a series of chunks, each planned over a shorter horizon can thus reduce the overall computational complexity and associated costs while...

journal_title：Nature communications

authors： Ramkumar P,Acuna DE,Berniker M,Grafton ST,Turner RS,Kording KP

更新日期：2016-07-11 00:00:00

abstract：:Osteoporosis is a devastating disease with an essential genetic component. GWAS have discovered genetic signals robustly associated with bone mineral density (BMD), but not the precise localization of effector genes. Here, we carry out physical and direct variant to gene mapping in human mesenchymal progenitor cell-de...

journal_title：Nature communications

authors： Chesi A,Wagley Y,Johnson ME,Manduchi E,Su C,Lu S,Leonard ME,Hodge KM,Pippin JA,Hankenson KD,Wells AD,Grant SFA

更新日期：2019-03-19 00:00:00

abstract：:Magnetic skyrmions are localized, topologically protected spin structures that have been proposed for storing or processing information due to their intriguing dynamical and transport properties. Important in terms of applications is the recent discovery of interface stabilized skyrmions as evidenced in ultra-thin tra...

journal_title：Nature communications

authors： Dupé B,Bihlmayer G,Böttcher M,Blügel S,Heinze S

更新日期：2016-06-03 00:00:00

abstract：:Elucidating the factors governing the functional compatibility of horizontally transferred genes is important to understand bacterial evolution, including the emergence and spread of antibiotic resistance, and to successfully engineer biological systems. In silico efforts and work using single-gene libraries have sugg...

journal_title：Nature communications

authors： Porse A,Schou TS,Munck C,Ellabaan MMH,Sommer MOA

更新日期：2018-02-06 00:00:00

abstract：:Understanding human mobility is crucial for applications such as forecasting epidemic spreading, planning transport infrastructure and urbanism in general. While, traditionally, mobility information has been collected via surveys, the pervasive adoption of mobile technologies has brought a wealth of (real time) data. ...

journal_title：Nature communications

authors： Mazzoli M,Molas A,Bassolas A,Lenormand M,Colet P,Ramasco JJ

更新日期：2019-08-29 00:00:00

abstract：:Accumulation of mutant p53 proteins is frequently found in a wide range of cancers. While conventional antibodies fail to target intracellular proteins, proteosomal degradation results in the presentation of p53-derived peptides on the tumour cell surface by class I molecules of the major histocompatibility complex (M...

journal_title：Nature communications

authors： Low L,Goh A,Koh J,Lim S,Wang CI

更新日期：2019-11-26 00:00:00

abstract：:The miniaturization of integrated optical circuits below the diffraction limit for high-speed manipulation of information is one of the cornerstones in plasmonics research. By coupling to surface plasmons supported on nanostructured metallic surfaces, light can be confined to the nanoscale, enabling the potential inte...

journal_title：Nature communications

authors： Raza S,Esfandyarpour M,Koh AL,Mortensen NA,Brongersma ML,Bozhevolnyi SI

更新日期：2016-12-16 00:00:00

abstract：:Legionella pneumophila is a bacterial pathogen that utilises a Type IV secretion (T4S) system to inject effector proteins into human macrophages. Essential to the recruitment and delivery of effectors to the T4S machinery is the membrane-embedded T4 coupling complex (T4CC). Here, we purify an intact T4CC from the Legi...

journal_title：Nature communications

authors： Meir A,Macé K,Lukoyanova N,Chetrit D,Hospenthal MK,Redzej A,Roy C,Waksman G

更新日期：2020-06-08 00:00:00

abstract：:The quiescent centre (QC) in the Arabidopsis root apical meristem is essential for stem cell organization. Here we show that the loss of REPRESSOR OF WUSCHEL1 (ROW1), a PHD domain-containing protein, leads to QC failure, defects in cell differentiation and ectopic expression of WUSCHEL-RELATED HOMEOBOX 5 (WOX5) in cel...

journal_title：Nature communications

authors： Zhang Y,Jiao Y,Liu Z,Zhu YX

更新日期：2015-01-29 00:00:00

abstract：:Chromatin remodeling is of crucial importance during brain development. Pathogenic alterations of several chromatin remodeling ATPases have been implicated in neurodevelopmental disorders. We describe an index case with a de novo missense mutation in CHD3, identified during whole genome sequencing of a cohort of child...

journal_title：Nature communications

authors： Snijders Blok L,Rousseau J,Twist J,Ehresmann S,Takaku M,Venselaar H,Rodan LH,Nowak CB,Douglas J,Swoboda KJ,Steeves MA,Sahai I,Stumpel CTRM,Stegmann APA,Wheeler P,Willing M,Fiala E,Kochhar A,Gibson WT,Cohen ASA,Agb

更新日期：2018-11-05 00:00:00

abstract：:Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is absent from most of central Africa due to the near fixation of a mutation that inhibits the expression of its receptor, the Duffy antigen, on human erythrocytes. The emergence of this protective allele is not understood because P. ...

journal_title：Nature communications

authors： Liu W,Li Y,Shaw KS,Learn GH,Plenderleith LJ,Malenke JA,Sundararaman SA,Ramirez MA,Crystal PA,Smith AG,Bibollet-Ruche F,Ayouba A,Locatelli S,Esteban A,Mouacha F,Guichet E,Butel C,Ahuka-Mundeke S,Inogwabini BI,Ndjango

更新日期：2014-01-01 00:00:00

abstract：:We propose the concept of universal fiducials based on a set of pre-made semi-synthetic antibodies (sABs) generated by customized phage display selections against the fusion protein BRIL, an engineered variant of apocytochrome b562a. These sABs can bind to BRIL fused either into the loops or termini of different GPCRs...

journal_title：Nature communications

authors： Mukherjee S,Erramilli SK,Ammirati M,Alvarez FJD,Fennell KF,Purdy MD,Skrobek BM,Radziwon K,Coukos J,Kang Y,Dutka P,Gao X,Qiu X,Yeager M,Eric Xu H,Han S,Kossiakoff AA

更新日期：2020-03-27 00:00:00

abstract：:In the Arctic, environmental factors governing microbial degradation of soil carbon (C) in active layer and permafrost are poorly understood. Here we determined the functional potential of soil microbiomes horizontally and vertically across a cryoperturbed polygonal landscape in Alaska. With comparative metagenomics, ...

journal_title：Nature communications

authors： Taş N,Prestat E,Wang S,Wu Y,Ulrich C,Kneafsey T,Tringe SG,Torn MS,Hubbard SS,Jansson JK

更新日期：2018-02-22 00:00:00

abstract：:Although, a number of pathogenic mutations have been found for Alzheimer's disease (AD), only one protective mutation has been identified so far in humans. Here we identify possible protective deletion mutations in the 3'-UTR of the amyloid precursor protein (App) gene in mice. We use an App knock-in mouse model carry...

journal_title：Nature communications

authors： Nagata K,Takahashi M,Matsuba Y,Okuyama-Uchimura F,Sato K,Hashimoto S,Saito T,Saido TC

更新日期：2018-05-04 00:00:00

abstract：:We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI study using whole exome sequencing. Here we identify mutations induced as a consequence of misdirected AID in the partner oncogenes of IGH translocations, which are activating and associated with impaired clinical outcome. An APOBEC mutat...

journal_title：Nature communications

authors： Walker BA,Wardell CP,Murison A,Boyle EM,Begum DB,Dahir NM,Proszek PZ,Melchor L,Pawlyn C,Kaiser MF,Johnson DC,Qiang YW,Jones JR,Cairns DA,Gregory WM,Owen RG,Cook G,Drayson MT,Jackson GH,Davies FE,Morgan GJ

更新日期：2015-04-23 00:00:00

abstract：:Advances in chemistry and massively parallel detection underlie DNA-sequencing platforms that are poised for application in personalized medicine. In stark contrast, systematic generation of protein-level data lags well behind genomics in virtually every aspect: depth of coverage, throughput, ease of sample preparatio...

journal_title：Nature communications

authors： Zhou F,Lu Y,Ficarro SB,Adelmant G,Jiang W,Luckey CJ,Marto JA

更新日期：2013-01-01 00:00:00

abstract：:Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations. There is also clinical evidence for the utility of PARPi in breast and ovarian cancers without BRCA mutations, but the underlying mechanism is not clear...

journal_title：Nature communications

authors： Peng Y,Liao Q,Tan W,Peng C,Hu Z,Chen Y,Li Z,Li J,Zhen B,Zhu W,Li X,Yao Y,Song Q,Liu C,Qi X,He F,Pei H

更新日期：2019-03-15 00:00:00

abstract：:Body temperature homoeostasis in mammals is governed centrally through the regulation of shivering and non-shivering thermogenesis and cutaneous vasomotion. Non-shivering thermogenesis in brown adipose tissue (BAT) is mediated by sympathetic activation, followed by PGC-1α induction, which drives UCP1. Here we identify...

journal_title：Nature communications

authors： Hiraoka Y,Matsuoka T,Ohno M,Nakamura K,Saijo S,Matsumura S,Nishi K,Sakamoto J,Chen PM,Inoue K,Fushiki T,Kita T,Kimura T,Nishi E

更新日期：2014-01-01 00:00:00

abstract：:Pulmonary disease increases the risk of developing abdominal aortic aneurysms (AAA). However, the mechanism underlying the pathological dialogue between the lungs and aorta is undefined. Here, we find that inflicting acute lung injury (ALI) to mice doubles their incidence of AAA and accelerates macrophage-driven prote...

journal_title：Nature communications

authors： Boytard L,Hadi T,Silvestro M,Qu H,Kumpfbeck A,Sleiman R,Fils KH,Alebrahim D,Boccalatte F,Kugler M,Corsica A,Gelb BE,Jacobowitz G,Miller G,Bellini C,Oakes J,Silvestre JS,Zangi L,Ramkhelawon B

更新日期：2020-08-27 00:00:00

abstract：:Cell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep in the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system to direct macrophages carrying an oncolytic ...

journal_title：Nature communications

authors： Muthana M,Kennerley AJ,Hughes R,Fagnano E,Richardson J,Paul M,Murdoch C,Wright F,Payne C,Lythgoe MF,Farrow N,Dobson J,Conner J,Wild JM,Lewis C

更新日期：2015-08-18 00:00:00

abstract：:Visualization of ion transport in electrolytes provides fundamental understandings of electrolyte dynamics and electrolyte-electrode interactions. However, this is challenging because existing techniques are hard to capture low ionic concentrations and fast electrolyte dynamics. Here we show that stimulated Raman scat...

journal_title：Nature communications

authors： Cheng Q,Wei L,Liu Z,Ni N,Sang Z,Zhu B,Xu W,Chen M,Miao Y,Chen LQ,Min W,Yang Y

更新日期：2018-07-30 00:00:00

abstract：:Microelectromechanical systems (MEMS) enable many modern-day technologies, including actuators, motion sensors, drug delivery systems, projection displays, etc. Currently, MEMS fabrication techniques are primarily based on silicon micromachining processes, resulting in rigid and low aspect ratio structures. In this st...

journal_title：Nature communications

authors： Khudiyev T,Clayton J,Levy E,Chocat N,Gumennik A,Stolyarov AM,Joannopoulos J,Fink Y

更新日期：2017-11-10 00:00:00

abstract：:The original version of this Article contained an error in the spelling of the author Woochul Song, which was incorrectly given as Woochul C. Song. This has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Shen YX,Song W,Barden DR,Ren T,Lang C,Feroz H,Henderson CB,Saboe PO,Tsai D,Yan H,Butler PJ,Bazan GC,Phillip WA,Hickey RJ,Cremer PS,Vashisth H,Kumar M

更新日期：2018-08-14 00:00:00

abstract：:Boron has become the principle proxy for the release of seawater-derived fluids into arc volcanics, linked to cross-arc variations in boron content and isotopic ratio. Because all ocean floor serpentinites so far analysed are strongly enriched in boron, it is generally assumed that if the uppermost slab mantle is hydr...

journal_title：Nature communications

authors： McCaig AM,Titarenko SS,Savov IP,Cliff RA,Banks D,Boyce A,Agostini S

更新日期：2018-11-02 00:00:00

abstract：:Quantum Hall edge channels offer an efficient and controllable platform to study quantum transport in one dimension. Such channels are a prospective tool for the efficient transfer of quantum information at the nanoscale, and play a vital role in exposing intriguing physics. Electric current along the edge carries ene...

journal_title：Nature communications

authors： Krähenmann T,Fischer SG,Röösli M,Ihn T,Reichl C,Wegscheider W,Ensslin K,Gefen Y,Meir Y

更新日期：2019-09-02 00:00:00

abstract：:Acanthamoeba are infected by a remarkable diversity of large dsDNA viruses, the infectious cycles of which have been characterized using genomics, transcriptomics and electron microscopy. Given their gene content and the persistence of the host nucleus throughout their infectious cycle, the Marseilleviridae were initi...

journal_title：Nature communications

authors： Fabre E,Jeudy S,Santini S,Legendre M,Trauchessec M,Couté Y,Claverie JM,Abergel C

更新日期：2017-04-21 00:00:00

abstract：:Heart failure (HF) is a leading cause of mortality. Inflammation is implicated in HF, yet clinical trials targeting pro-inflammatory cytokines in HF were unsuccessful, possibly due to redundant functions of individual cytokines. Searching for better cardiac inflammation targets, here we link T cells with HF developmen...

journal_title：Nature communications

authors： Kallikourdis M,Martini E,Carullo P,Sardi C,Roselli G,Greco CM,Vignali D,Riva F,Ormbostad Berre AM,Stølen TO,Fumero A,Faggian G,Di Pasquale E,Elia L,Rumio C,Catalucci D,Papait R,Condorelli G

更新日期：2017-03-06 00:00:00

abstract：:The development of stimulus-responsive polymeric materials is of great importance, especially for the development of remotely manipulated materials not in direct contact with an actuator. Here we design a photoresponsive supramolecular actuator by integrating host-guest interactions and photoswitching ability in a hyd...

journal_title：Nature communications

authors： Takashima Y,Hatanaka S,Otsubo M,Nakahata M,Kakuta T,Hashidzume A,Yamaguchi H,Harada A

更新日期：2012-01-01 00:00:00

abstract：:To fully exploit the microbial genome resources, a high-throughput experimental platform is needed to associate genes with phenotypes at the genome level. We present here a novel method that enables investigation of the cellular consequences of repressing individual transcripts based on the CRISPR interference (CRISPR...

journal_title：Nature communications

authors： Wang T,Guan C,Guo J,Liu B,Wu Y,Xie Z,Zhang C,Xing XH

更新日期：2018-06-26 00:00:00

abstract：:Anthropogenic CO2 emissions are causing ocean acidification, which can affect the physiology of marine organisms. Here we assess the possible effects of ocean acidification on the metabolic potential of sponge symbionts, inferred by metagenomic analyses of the microbiomes of two sponge species sampled at a shallow vol...

journal_title：Nature communications

authors： Botté ES,Nielsen S,Abdul Wahab MA,Webster J,Robbins S,Thomas T,Webster NS

更新日期：2019-09-12 00:00:00