TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts.

abstract：:We previously demonstrated that beta II protein kinase C (βIIPKC) activity is elevated in failing hearts and contributes to this pathology. Here we report that βIIPKC accumulates on the mitochondrial outer membrane and phosphorylates mitofusin 1 (Mfn1) at serine 86. Mfn1 phosphorylation results in partial loss of its ...

journal_title：Nature communications

authors： Ferreira JCB,Campos JC,Qvit N,Qi X,Bozi LHM,Bechara LRG,Lima VM,Queliconi BB,Disatnik MH,Dourado PMM,Kowaltowski AJ,Mochly-Rosen D

更新日期：2019-01-18 00:00:00

abstract：:In response to virus infection, RIG-I-like receptors (RLRs) sense virus RNA and induce MAVS to form prion-like aggregates to further propagate antiviral signalling. Although monomeric MAVS recombinant protein can assemble into prion-like filaments spontaneously in vitro, endogenous MAVS in cells is prevented from aggr...

journal_title：Nature communications

authors： Qi N,Shi Y,Zhang R,Zhu W,Yuan B,Li X,Wang C,Zhang X,Hou F

更新日期：2017-06-13 00:00:00

abstract：:Syngnathid fish (seahorses, pipefish and sea dragons) are slow swimmers yet capture evasive prey (copepods) using a technique known as the 'pivot' feeding, which involves rapid movement to overcome prey escape capabilities. However, this feeding mode functions only at short range and requires approaching very closely ...

journal_title：Nature communications

authors： Gemmell BJ,Sheng J,Buskey EJ

更新日期：2013-01-01 00:00:00

abstract：:Although chemically very simple, Fe2O3 is known to undergo a series of enigmatic structural, electronic and magnetic transformations at high pressures and high temperatures. So far, these transformations have neither been correctly described nor understood because of the lack of structural data. Here we report a syste...

journal_title：Nature communications

authors： Bykova E,Dubrovinsky L,Dubrovinskaia N,Bykov M,McCammon C,Ovsyannikov SV,Liermann HP,Kupenko I,Chumakov AI,Rüffer R,Hanfland M,Prakapenka V

更新日期：2016-02-11 00:00:00

abstract：:The practices of synthetic biology are being integrated into 'multiscale' designs enabling two-way communication across organic and inorganic information substrates in biological, digital and cyber-physical system integrations. Novel applications of 'bio-informational' engineering will arise in environmental monitorin...

journal_title：Nature communications

authors： Dixon TA,Williams TC,Pretorius IS

更新日期：2021-01-15 00:00:00

abstract：:Ligand-induced receptor dimerization has traditionally been viewed as the key event in transmembrane signalling by epidermal growth factor receptors (EGFRs). Here we show that the Caenorhabditis elegans EGFR orthologue LET-23 is constitutively dimeric, yet responds to its ligand LIN-3 without changing oligomerization ...

journal_title：Nature communications

authors： Freed DM,Alvarado D,Lemmon MA

更新日期：2015-06-10 00:00:00

abstract：:In eukaryotes, adventitious oxidation of erythrose-4-phosphate, an intermediate of the pentose phosphate pathway (PPP), generates 4-phosphoerythronate (4PE), which inhibits 6-phosphogluconate dehydrogenase. 4PE is detoxified by metabolite-proofreading phosphatases such as yeast Pho13. Here, we report that a similar fu...

journal_title：Nature communications

authors： Sachla AJ,Helmann JD

更新日期：2019-04-04 00:00:00

abstract：:Antiaromatic and open-shell molecules are attractive because of their distinct electronic and magnetic behaviour. However, their increased reactivity creates a challenge for probing their properties. Here, we describe the on-surface and in-solution generation and characterisation of a highly reactive antiaromatic mole...

journal_title：Nature communications

authors： Majzik Z,Pavliček N,Vilas-Varela M,Pérez D,Moll N,Guitián E,Meyer G,Peña D,Gross L

更新日期：2018-03-22 00:00:00

abstract：:The metazoan TREX complex is recruited to mRNA during nuclear RNA processing and functions in exporting mRNA to the cytoplasm. Nxf1 is an mRNA export receptor, which binds processed mRNA and transports it through the nuclear pore complex. At present, the relationship between TREX and Nxf1 is not understood. Here we sh...

journal_title：Nature communications

authors： Viphakone N,Hautbergue GM,Walsh M,Chang CT,Holland A,Folco EG,Reed R,Wilson SA

更新日期：2012-01-01 00:00:00

abstract：:Processing of interleukin RNAs must be tightly controlled during the immune response. Here we report that a subnuclear body called the interleukin-6 and -10 splicing activating compartment (InSAC) is a nuclear site of cytokine RNA production and stability. Tat-activating regulatory DNA-binding protein-43 (TDP-43) acts...

journal_title：Nature communications

authors： Lee S,Lee TA,Lee E,Kang S,Park A,Kim SW,Park HJ,Yoon JH,Ha SJ,Park T,Lee JS,Cheon JH,Park B

更新日期：2015-01-05 00:00:00

abstract：:Coupling vibrational transitions to resonant optical modes creates vibrational polaritons shifted from the uncoupled molecular resonances and provides a convenient way to modify the energetics of molecular vibrations. This approach is a viable method to explore controlling chemical reactivity. In this work, we report ...

journal_title：Nature communications

authors： Dunkelberger AD,Spann BT,Fears KP,Simpkins BS,Owrutsky JC

更新日期：2016-11-22 00:00:00

abstract：:Adoptive immunotherapy using chimeric antigen receptor (CAR) expressing T cells targeting the CD19 B lineage receptor has demonstrated marked success in relapsed pre-B-cell acute lymphoblastic leukaemia (ALL). Persisting CAR-T cells generate sustained pressure against CD19 that may drive unique mechanisms of resistanc...

journal_title：Nature communications

authors： Jacoby E,Nguyen SM,Fountaine TJ,Welp K,Gryder B,Qin H,Yang Y,Chien CD,Seif AE,Lei H,Song YK,Khan J,Lee DW,Mackall CL,Gardner RA,Jensen MC,Shern JF,Fry TJ

更新日期：2016-07-27 00:00:00

abstract：:Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in turn delivers FAs into adipocytes. During the process, binding of FAs to CD36 activates its downstream kinase LYN, which phosphorylates DH...

journal_title：Nature communications

authors： Hao JW,Wang J,Guo H,Zhao YY,Sun HH,Li YF,Lai XY,Zhao N,Wang X,Xie C,Hong L,Huang X,Wang HR,Li CB,Liang B,Chen S,Zhao TJ

更新日期：2020-09-21 00:00:00

abstract：:Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncy...

journal_title：Nature communications

authors： Ezzat K,Pernemalm M,Pålsson S,Roberts TC,Järver P,Dondalska A,Bestas B,Sobkowiak MJ,Levänen B,Sköld M,Thompson EA,Saher O,Kari OK,Lajunen T,Sverremark Ekström E,Nilsson C,Ishchenko Y,Malm T,Wood MJA,Power UF,Masic

更新日期：2019-05-27 00:00:00

abstract：:Nociceptors rely on cap-dependent translation to rapidly induce protein synthesis in response to pro-inflammatory signals. Comparatively little is known regarding the role of the regulatory factors bound to the 3' end of mRNA in nociceptor sensitization. Poly(A)-binding protein (PABP) stimulates translation initiation...

journal_title：Nature communications

authors： Barragán-Iglesias P,Lou TF,Bhat VD,Megat S,Burton MD,Price TJ,Campbell ZT

更新日期：2018-01-02 00:00:00

abstract：:Most estimates of the burden of malaria are based on its direct impacts; however, its true burden is likely to be greater because of its wider effects on overall health. Here we estimate the indirect impact of malaria on children's health in a case-control study, using the sickle cell trait (HbAS), a condition associa...

journal_title：Nature communications

authors： Uyoga S,Macharia AW,Ndila CM,Nyutu G,Shebe M,Awuondo KO,Mturi N,Peshu N,Tsofa B,Scott JAG,Maitland K,Williams TN

更新日期：2019-02-20 00:00:00

abstract：:Considerable progress in the fabrication of quasicrystals demonstrates that they can be realized in a broad range of materials. However, the development of chemistries enabling direct experimental observation of early quasicrystal growth pathways remains challenging. Here, we report the synthesis of four surfactant-di...

journal_title：Nature communications

authors： Sun Y,Ma K,Kao T,Spoth KA,Sai H,Zhang D,Kourkoutis LF,Elser V,Wiesner U

更新日期：2017-08-15 00:00:00

abstract：:The behavior of uranium in environments, ranging from those of natural systems responsible for the formation of uranium deposits to those of nuclear reactors providing 11% of the world's electricity, is governed by processes involving high-temperature aqueous solutions. It has been well documented that uranium is mobi...

journal_title：Nature communications

authors： Timofeev A,Migdisov AA,Williams-Jones AE,Roback R,Nelson AT,Xu H

更新日期：2018-04-16 00:00:00

abstract：:In photosystem II, light-induced water oxidation occurs at the Mn4CaO5 cluster. Here we demonstrate proton releases, dioxygen formation, and substrate water incorporation in response to Mn4CaO5 oxidation in the protein environment, using a quantum mechanical/molecular mechanical approach and molecular dynamics simulat...

journal_title：Nature communications

authors： Kawashima K,Takaoka T,Kimura H,Saito K,Ishikita H

更新日期：2018-03-28 00:00:00

abstract：:To perform their computational function, genetic circuits change states through a symphony of genetic parts that turn regulator expression on and off. Debugging is frustrated by an inability to characterize parts in the context of the circuit and identify the origins of failures. Here, we take snapshots of a large gen...

journal_title：Nature communications

authors： Espah Borujeni A,Zhang J,Doosthosseini H,Nielsen AAK,Voigt CA

更新日期：2020-10-05 00:00:00

abstract：:Plasma dynamics critically depends on density and temperature, thus well-controlled experimental realizations are essential benchmarks for theoretical models. The formation of an ultracold plasma can be triggered by ionizing a tunable number of atoms in a micrometer-sized volume of a 87Rb Bose-Einstein condensate (BEC...

journal_title：Nature communications

authors： Kroker T,Großmann M,Sengstock K,Drescher M,Wessels-Staarmann P,Simonet J

更新日期：2021-01-26 00:00:00

abstract：:In retinitis pigmentosa, loss of cone photoreceptors leads to blindness, and preservation of cone function is a major therapeutic goal. However, cone loss is thought to occur as a secondary event resulting from degeneration of rod photoreceptors. Here we report a genome editing approach in which adeno-associated virus...

journal_title：Nature communications

authors： Yu W,Mookherjee S,Chaitankar V,Hiriyanna S,Kim JW,Brooks M,Ataeijannati Y,Sun X,Dong L,Li T,Swaroop A,Wu Z

更新日期：2017-03-14 00:00:00

abstract：:One of the most dramatic events in river environments is the natural diversion, or avulsion, of a channel across its floodplain. Though rarely witnessed, avulsions can cause massive floods, and over geologic time they create most of the fluvial stratigraphic record. Avulsions exhibit behavior ranging from reoccupying ...

journal_title：Nature communications

authors： Valenza JM,Edmonds DA,Hwang T,Roy S

更新日期：2020-04-30 00:00:00

abstract：:Flicker or 1/f noise in metal-oxide-semiconductor field-effect transistors (MOSFETs) has been identified as the main source of noise at low frequency. It often originates from an ensemble of a huge number of charges becoming trapped and de-trapped. However, as a deviation from the well-known model of 1/f noise is obse...

journal_title：Nature communications

authors： Clément N,Nishiguchi K,Fujiwara A,Vuillaume D

更新日期：2010-10-19 00:00:00

abstract：:The unusual electronic properties of diamondoids, the nanoscale relatives of diamond, make them attractive for applications ranging from drug delivery to field emission displays. Identifying the fundamental origin of these properties has proven highly challenging, with even the most advanced quantum many-body calculat...

journal_title：Nature communications

authors： Patrick CE,Giustino F

更新日期：2013-01-01 00:00:00

abstract：:Breast cancer (BC) patients diagnosed between two screenings (interval cancers) are more likely than screen-detected patients to carry rare deleterious mutations in cancer genes potentially leading to increased risk for other non-breast cancer (non-BC) tumors. In this study, we include 14,846 women diagnosed with BC o...

journal_title：Nature communications

authors： Grassmann F,He W,Eriksson M,Gabrielson M,Hall P,Czene K

更新日期：2019-10-22 00:00:00

abstract：:Structural rearrangements govern the various properties of disordered systems and visualization of these dynamical processes can provide critical information on structural deformation and phase transformation of the systems. However, direct imaging of individual atoms or molecules in a disordered state is quite challe...

journal_title：Nature communications

authors： Choe J,Lee Y,Park J,Kim Y,Kim CU,Kim K

更新日期：2019-09-27 00:00:00

abstract：:When a thin film of active, nematic microtubules and kinesin motor clusters is confined on the surface of a vesicle, four +1/2 topological defects oscillate in a periodic manner between tetrahedral and planar arrangements. Here a theoretical description of nematics, coupled to the relevant hydrodynamic equations, is p...

journal_title：Nature communications

authors： Zhang R,Zhou Y,Rahimi M,de Pablo JJ

更新日期：2016-11-21 00:00:00

abstract：:Extensive efforts have been expended in developing hybrid quantum systems to overcome the short coherence time of superconducting circuits by introducing the naturally long-lived spin degree of freedom. Among all the possible materials, single-crystal yttrium iron garnet has shown up recently as a promising candidate ...

journal_title：Nature communications

authors： Zhang X,Zou CL,Zhu N,Marquardt F,Jiang L,Tang HX

更新日期：2015-11-16 00:00:00

abstract：:Emerging evidence suggests associations between the vaginal microbiota (VMB) composition, human papillomavirus (HPV) infection, and cervical intraepithelial neoplasia (CIN); however, causal inference remains uncertain. Here, we use bacterial DNA sequencing from serially collected vaginal samples from a cohort of 87 ad...

journal_title：Nature communications

authors： Mitra A,MacIntyre DA,Ntritsos G,Smith A,Tsilidis KK,Marchesi JR,Bennett PR,Moscicki AB,Kyrgiou M

更新日期：2020-04-24 00:00:00