The indirect health effects of malaria estimated from health advantages of the sickle cell trait.

abstract：:Niemann-Pick type C disease is a fatal, progressive neurodegenerative disorder caused by loss-of-function mutations in NPC1, a multipass transmembrane glycoprotein essential for intracellular lipid trafficking. We sought to define the cellular machinery controlling degradation of the most common disease-causing mutant...

journal_title：Nature communications

authors： Schultz ML,Krus KL,Kaushik S,Dang D,Chopra R,Qi L,Shakkottai VG,Cuervo AM,Lieberman AP

更新日期：2018-09-10 00:00:00

abstract：:Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations. There is also clinical evidence for the utility of PARPi in breast and ovarian cancers without BRCA mutations, but the underlying mechanism is not clear...

journal_title：Nature communications

authors： Peng Y,Liao Q,Tan W,Peng C,Hu Z,Chen Y,Li Z,Li J,Zhen B,Zhu W,Li X,Yao Y,Song Q,Liu C,Qi X,He F,Pei H

更新日期：2019-03-15 00:00:00

abstract：:Haematopoietic stem cells (HSCs) are produced during embryogenesis from the floor of the dorsal aorta. The localization of HSCs is dependent on the presence of instructive signals on the ventral side of the vessel. The nature of the extrinsic molecular signals that control the aortic haematopoietic niche is currently ...

journal_title：Nature communications

authors： Pouget C,Peterkin T,Simões FC,Lee Y,Traver D,Patient R

更新日期：2014-11-27 00:00:00

abstract：:A fundamental puzzle of human evolution is how we evolved to cooperate with genetically unrelated strangers in transient interactions. Group-level selection on culturally differentiated populations is one proposed explanation. We evaluate a central untested prediction of Cultural Group Selection theory, by assessing w...

journal_title：Nature communications

authors： Handley C,Mathew S

更新日期：2020-02-04 00:00:00

abstract：:Colloidal semiconductor nanocrystals have attracted significant interest for applications in solution-processable devices such as light-emitting diodes and solar cells. However, a poor understanding of charge transport in nanocrystal assemblies, specifically the relation between electrical conductance in dark and unde...

journal_title：Nature communications

authors： Nagpal P,Klimov VI

更新日期：2011-09-27 00:00:00

abstract：:The continued convergence of electronics and photonics on the chip scale can benefit from the voltage control of optical polarization for applications in communications, signal processing and sensing. It is challenging, however, to electrically manipulate the polarization state of light in planar optical waveguides. H...

journal_title：Nature communications

authors： Xu Q,Chen L,Wood MG,Sun P,Reano RM

更新日期：2014-11-12 00:00:00

abstract：:Invasive plant species threaten native biodiversity, ecosystems, agriculture, industry and human health worldwide, lending urgency to the search for predictors of plant invasiveness outside native ranges. There is much conflicting evidence about which plant characteristics best predict invasiveness. Here we use a glob...

journal_title：Nature communications

authors： Jelbert K,Buss D,McDonald J,Townley S,Franco M,Stott I,Jones O,Salguero-Gómez R,Buckley Y,Knight T,Silk M,Sargent F,Rolph S,Wilson P,Hodgson D

更新日期：2019-12-06 00:00:00

abstract：:Antibiotic resistance is ancient and widespread in environmental bacteria. These are therefore reservoirs of resistance elements and reflective of the natural history of antibiotics and resistance. In a previous study, we discovered that multi-drug resistance is common in bacteria isolated from Lechuguilla Cave, an un...

journal_title：Nature communications

authors： Pawlowski AC,Wang W,Koteva K,Barton HA,McArthur AG,Wright GD

更新日期：2016-12-08 00:00:00

abstract：:The energy band alignment in solar cell devices is critically important because it largely governs elementary photovoltaic processes, such as the generation, separation, transport, recombination and collection of charge carriers. Despite the expenditure of considerable effort, the measurement of energy band depth prof...

journal_title：Nature communications

authors： Chen Q,Mao L,Li Y,Kong T,Wu N,Ma C,Bai S,Jin Y,Wu D,Lu W,Wang B,Chen L

更新日期：2015-07-13 00:00:00

abstract：:Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by tracking individual tubular cells in conditional Pax8/Confetti mice that kidney function is  recovered after AKI despite substantial t...

journal_title：Nature communications

authors： Lazzeri E,Angelotti ML,Peired A,Conte C,Marschner JA,Maggi L,Mazzinghi B,Lombardi D,Melica ME,Nardi S,Ronconi E,Sisti A,Antonelli G,Becherucci F,De Chiara L,Guevara RR,Burger A,Schaefer B,Annunziato F,Anders HJ,La

更新日期：2018-04-09 00:00:00

abstract：:A primary function of the midbrain stimulus selection network is to compute the highest-priority location for attention and gaze. Here we report the contribution of a specific cholinergic circuit to this computation. We functionally disconnected the tegmental cholinergic nucleus isthmi pars parvocellularis (Ipc) from ...

journal_title：Nature communications

authors： Asadollahi A,Knudsen EI

更新日期：2016-11-17 00:00:00

abstract：:Nanocarrier administration has primarily been restricted to intermittent bolus injections with limited available options for sustained delivery in vivo. Here, we demonstrate that cylinder-to-sphere transitions of self-assembled filomicelle (FM) scaffolds can be employed for sustained delivery of monodisperse micellar ...

journal_title：Nature communications

authors： Karabin NB,Allen S,Kwon HK,Bobbala S,Firlar E,Shokuhfar T,Shull KR,Scott EA

更新日期：2018-02-12 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Chen S,Wang Q,Yu H,Capitano ML,Vemula S,Nabinger SC,Gao R,Yao C,Kobayashi M,Geng Z,Fahey A,Henley D,Liu SZ,Barajas S,Cai W,Wolf ER,Ramdas B,Cai Z,Gao H,Luo N,Sun Y,Wong TN,Link DC,Liu Y,Boswell HS,Mayo L

更新日期：2020-07-28 00:00:00

abstract：:Chiral magnets are an emerging class of topological matter harboring localized and topologically protected vortex-like magnetic textures called skyrmions, which are currently under intense scrutiny as an entity for information storage and processing. Here, on the level of micromagnetics we rigorously show that chiral ...

journal_title：Nature communications

authors： Hoffmann M,Zimmermann B,Müller GP,Schürhoff D,Kiselev NS,Melcher C,Blügel S

更新日期：2017-08-21 00:00:00

abstract：:Optical spectroscopy is a fundamental tool in numerous areas of science and technology. Much effort has focused on miniaturizing spectrometers, but thus far at the cost of spectral resolution and broad operating range. Here we describe a compact spectrometer that achieves both high spectral resolution and broad bandwi...

journal_title：Nature communications

authors： Wan NH,Meng F,Schröder T,Shiue RJ,Chen EH,Englund D

更新日期：2015-07-23 00:00:00

abstract：:Urbanisation is an important global driver of biodiversity change, negatively impacting some species groups whilst providing opportunities for others. Yet its impact on ecosystem services is poorly investigated. Here, using a replicated experimental design, we test how Central European cities impact flying insects and...

journal_title：Nature communications

authors： Theodorou P,Radzevičiūtė R,Lentendu G,Kahnt B,Husemann M,Bleidorn C,Settele J,Schweiger O,Grosse I,Wubet T,Murray TE,Paxton RJ

更新日期：2020-01-29 00:00:00

abstract：:We constructed an intelligent cloud lab that integrates lab automation with cloud servers and artificial intelligence (AI) to detect chirality in perovskites. Driven by the materials acceleration operating system in cloud (MAOSIC) platform, on-demand experimental design by remote users was enabled in this cloud lab. B...

journal_title：Nature communications

authors： Li J,Li J,Liu R,Tu Y,Li Y,Cheng J,He T,Zhu X

更新日期：2020-04-27 00:00:00

abstract：:The outcome of adult cochlear implantation is predicted positively by the involvement of visual cortex in speech processing, and negatively by the cross-modal recruitment of the right temporal cortex during and after deafness. How these two neurofunctional predictors concur to modulate cochlear implant (CI) performanc...

journal_title：Nature communications

authors： Lazard DS,Giraud AL

更新日期：2017-03-28 00:00:00

abstract：:Knowing which proteins and RNAs directly interact is essential for understanding cellular mechanisms. Unfortunately, discovering such interactions is costly and often unreliable. To overcome these limitations, we developed rec-YnH, a new yeast two and three-hybrid-based screening pipeline capable of detecting interact...

journal_title：Nature communications

authors： Yang JS,Garriga-Canut M,Link N,Carolis C,Broadbent K,Beltran-Sastre V,Serrano L,Maurer SP

更新日期：2018-09-14 00:00:00

abstract：:The COVID-19 epidemic hit Italy particularly hard, yielding the implementation of strict national lockdown rules. Previous modelling studies at the national level overlooked the fact that Italy is divided into administrative regions which can independently oversee their own share of the Italian National Health Service...

journal_title：Nature communications

authors： Della Rossa F,Salzano D,Di Meglio A,De Lellis F,Coraggio M,Calabrese C,Guarino A,Cardona-Rivera R,De Lellis P,Liuzza D,Lo Iudice F,Russo G,di Bernardo M

更新日期：2020-10-09 00:00:00

abstract：:Here, to overcome many limitations accompanying current available methods to detect protein-protein interactions (PPIs), we develop a live cell method called Split Intein-Mediated Protein Ligation (SIMPL). In this approach, bait and prey proteins are respectively fused to an intein N-terminal fragment (IN) and C-termi...

journal_title：Nature communications

authors： Yao Z,Aboualizadeh F,Kroll J,Akula I,Snider J,Lyakisheva A,Tang P,Kotlyar M,Jurisica I,Boxem M,Stagljar I

更新日期：2020-05-15 00:00:00

abstract：:Trafficking of mitochondria into dendrites and axons plays an important role in the physiology and pathophysiology of neurons. Mitochondrial outer membrane protein Miro and adaptor proteins TRAKs/Milton link mitochondria to molecular motors. Here we show that metaxins MTX-1 and MTX-2 contribute to mitochondrial transp...

journal_title：Nature communications

authors： Zhao Y,Song E,Wang W,Hsieh CH,Wang X,Feng W,Wang X,Shen K

更新日期：2021-01-04 00:00:00

abstract：:Generation of coherent light with desirable amplitude and phase profiles throughout the optical spectrum is a key issue in optical technologies. Nonlinear wavefront shaping offers an exceptional way to achieve this goal by converting an incident light beam into the beam (or beams) of different frequency with spatially...

journal_title：Nature communications

authors： Liu S,Switkowski K,Xu C,Tian J,Wang B,Lu P,Krolikowski W,Sheng Y

更新日期：2019-07-19 00:00:00

abstract：:Precise frequency discrimination is a hallmark of auditory function in birds and mammals and is required for distinguishing similar sounding words, like 'bat,' 'cat' and 'hat.' In the cochlea, tuning and spectral separation result from longitudinal differences in basilar membrane stiffness and numerous individual grad...

journal_title：Nature communications

authors： Thiede BR,Mann ZF,Chang W,Ku YC,Son YK,Lovett M,Kelley MW,Corwin JT

更新日期：2014-05-20 00:00:00

abstract：:Mutations in patatin-like phospholipase domain-containing 1 (PNPLA1) cause autosomal recessive congenital ichthyosis, but the mechanism involved remains unclear. Here we show that PNPLA1, an enzyme expressed in differentiated keratinocytes, plays a crucial role in the biosynthesis of ω-O-acylceramide, a lipid componen...

journal_title：Nature communications

authors： Hirabayashi T,Anjo T,Kaneko A,Senoo Y,Shibata A,Takama H,Yokoyama K,Nishito Y,Ono T,Taya C,Muramatsu K,Fukami K,Muñoz-Garcia A,Brash AR,Ikeda K,Arita M,Akiyama M,Murakami M

更新日期：2017-03-01 00:00:00

abstract：:All motile organisms use spatially distributed chemical features of their surroundings to guide their behaviors, but the neural mechanisms underlying such behaviors in mammals have been difficult to study, largely due to the technical challenges of controlling chemical concentrations in space and time during behaviora...

journal_title：Nature communications

authors： Radvansky BA,Dombeck DA

更新日期：2018-02-26 00:00:00

abstract：:Variability in dense shelf water formation can potentially impact Antarctic Bottom Water (AABW) production, a vital component of the global climate system. In East Antarctica, the George V Land polynya system (142-150°E) is structured by the local 'icescape', promoting sea ice formation that is driven by the offshore ...

journal_title：Nature communications

authors： Tamura T,Williams GD,Fraser AD,Ohshima KI

更新日期：2012-05-08 00:00:00

abstract：:The preparation of α-functionalized organic acids can be greatly simplified by adopting a protocol involving the catalytic assembly of achiral building blocks. However, the enzymatic assembly of small amino acids and aldehydes to form numerous α-functionalized organic acids is highly desired and remains a significant ...

journal_title：Nature communications

authors： Song W,Wang JH,Wu J,Liu J,Chen XL,Liu LM

更新日期：2018-09-19 00:00:00

abstract：:Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer. Here, we identify a lncRNA, DILA1, which interacts with Cyclin D1 and is overexpressed in tamoxifen-resistant breast cancer cells. Mechanistically, DILA1 inhibits the pho...

journal_title：Nature communications

authors： Shi Q,Li Y,Li S,Jin L,Lai H,Wu Y,Cai Z,Zhu M,Li Q,Li Y,Wang J,Liu Y,Wu Z,Song E,Liu Q

更新日期：2020-11-02 00:00:00

abstract：:Tunneling is a fundamental quantum process with no classical equivalent, which can compete with Coulomb interactions to give rise to complex phenomena. Phosphorus dopants in silicon can be placed with atomic precision to address the different regimes arising from this competition. However, they exploit wavefunctions r...

journal_title：Nature communications

authors： Voisin B,Bocquel J,Tankasala A,Usman M,Salfi J,Rahman R,Simmons MY,Hollenberg LCL,Rogge S

更新日期：2020-11-30 00:00:00