Lithium lanthanum titanate perovskite as an anode for lithium ion batteries.

abstract：:Recent efforts to evaluate the contribution of neonicotinoid insecticides to worldwide pollinator declines have focused on honey bees and the chronic levels of exposure experienced when foraging on crops grown from neonicotinoid-treated seeds. However, few studies address non-crop plants as a potential route of pollin...

journal_title：Nature communications

authors： Long EY,Krupke CH

更新日期：2016-05-31 00:00:00

abstract：:Following uncontrolled proliferation, a subset of primary tumour cells acquires additional traits/mutations to trigger phenotypic changes that enhance migration and are hypothesized to be the initiators of metastasis. This study reveals an adaptive mechanism that harnesses synergistic paracrine signalling via IL-6/8, ...

journal_title：Nature communications

authors： Jayatilaka H,Tyle P,Chen JJ,Kwak M,Ju J,Kim HJ,Lee JSH,Wu PH,Gilkes DM,Fan R,Wirtz D

更新日期：2017-05-26 00:00:00

abstract：:Roughly 40% of the Earth's total heat flow is powered by radioactive decays in the crust and mantle. Geo-neutrinos produced by these decays provide important clues about the origin, formation and thermal evolution of our planet, as well as the composition of its interior. Previous measurements of geo-neutrinos have al...

journal_title：Nature communications

authors： Leyton M,Dye S,Monroe J

更新日期：2017-07-10 00:00:00

abstract：:Plant halogenated natural products are rare and harbor various interesting bioactivities, yet the biochemical basis for the involved halogenation chemistry is unknown. While a handful of Fe(II)- and 2-oxoglutarate-dependent halogenases (2ODHs) have been found to catalyze regioselective halogenation of unactivated C-H ...

journal_title：Nature communications

authors： Kim CY,Mitchell AJ,Glinkerman CM,Li FS,Pluskal T,Weng JK

更新日期：2020-04-20 00:00:00

abstract：:Early detection has the potential to reduce cancer mortality, but an effective screening test must demonstrate asymptomatic cancer detection years before conventional diagnosis in a longitudinal study. In the Taizhou Longitudinal Study (TZL), 123,115 healthy subjects provided plasma samples for long-term storage and w...

journal_title：Nature communications

authors： Chen X,Gole J,Gore A,He Q,Lu M,Min J,Yuan Z,Yang X,Jiang Y,Zhang T,Suo C,Li X,Cheng L,Zhang Z,Niu H,Li Z,Xie Z,Shi H,Zhang X,Fan M,Wang X,Yang Y,Dang J,McConnell C,Zhang J,Wang J,Yu S,Ye W,Gao Y,

更新日期：2020-07-21 00:00:00

abstract：:Post-transcriptional RNA modifications play a critical role in the pathogenesis of human mitochondrial disorders, but the mechanisms by which specific modifications affect mitochondrial protein synthesis remain poorly understood. Here we used a quantitative RNA sequencing approach to investigate, at nucleotide resolut...

journal_title：Nature communications

authors： Richter U,Evans ME,Clark WC,Marttinen P,Shoubridge EA,Suomalainen A,Wredenberg A,Wedell A,Pan T,Battersby BJ

更新日期：2018-09-27 00:00:00

abstract：:Gold recovery using environmentally benign chemistry is imperative from an environmental perspective. Here we report the spontaneous assembly of a one-dimensional supramolecular complex with an extended {[K(OH₂)₆][AuBr₄](α-cyclodextrin)₂}n chain superstructure formed during the rapid co-precipitation of α-cyclodextrin...

journal_title：Nature communications

authors： Liu Z,Frasconi M,Lei J,Brown ZJ,Zhu Z,Cao D,Iehl J,Liu G,Fahrenbach AC,Botros YY,Farha OK,Hupp JT,Mirkin CA,Fraser Stoddart J

更新日期：2013-01-01 00:00:00

abstract：:Recent advances in nonlinear optics have revolutionized integrated photonics, providing on-chip solutions to a wide range of new applications. Currently, state of the art integrated nonlinear photonic devices are mainly based on dielectric material platforms, such as Si3N4 and SiO2. While semiconductor materials featu...

journal_title：Nature communications

authors： Chang L,Xie W,Shu H,Yang QF,Shen B,Boes A,Peters JD,Jin W,Xiang C,Liu S,Moille G,Yu SP,Wang X,Srinivasan K,Papp SB,Vahala K,Bowers JE

更新日期：2020-03-12 00:00:00

abstract：:FAM46C is one of the most frequently mutated genes in multiple myeloma. Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene expression. Reintroduction of active FAM46C into multiple myeloma ce...

journal_title：Nature communications

authors： Mroczek S,Chlebowska J,Kuliński TM,Gewartowska O,Gruchota J,Cysewski D,Liudkovska V,Borsuk E,Nowis D,Dziembowski A

更新日期：2017-09-20 00:00:00

abstract：:Gene deletion-induced autophagy deficiency leads to neural tube defects (NTDs), similar to those in diabetic pregnancy. Here we report the key autophagy regulators modulated by diabetes in the murine developing neuroepithelium. Diabetes predominantly leads to exencephaly, induces neuroepithelial cell apoptosis and sup...

journal_title：Nature communications

authors： Wang F,Xu C,Reece EA,Li X,Wu Y,Harman C,Yu J,Dong D,Wang C,Yang P,Zhong J,Yang P

更新日期：2017-05-05 00:00:00

abstract：:The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response. The SUMO-targeted ubiquitin ligase RNF4 engages with SUMO chains on linked substrates and catalyses their ubiquitination, which targets substrates...

journal_title：Nature communications

authors： Xu Y,Plechanovová A,Simpson P,Marchant J,Leidecker O,Kraatz S,Hay RT,Matthews SJ

更新日期：2014-06-27 00:00:00

abstract：:Mucosal associated invariant T (MAIT) cells recognise conserved microbial metabolites from riboflavin synthesis. Striking evolutionary conservation and pulmonary abundance implicate them in antibacterial host defence, yet their functions in protection against clinically important pathogens are unknown. Here we show th...

journal_title：Nature communications

authors： Wang H,D'Souza C,Lim XY,Kostenko L,Pediongco TJ,Eckle SBG,Meehan BS,Shi M,Wang N,Li S,Liu L,Mak JYW,Fairlie DP,Iwakura Y,Gunnersen JM,Stent AW,Godfrey DI,Rossjohn J,Westall GP,Kjer-Nielsen L,Strugnell RA,McClusk

更新日期：2018-08-22 00:00:00

abstract：:During homologous recombination, eukaryotic RecA homologue Rad51 assembles into a nucleoprotein filament on single-stranded DNA to catalyse homologous pairing and DNA-strand exchange with a homologous template. Rad51 nucleoprotein filaments are highly dynamic and regulated via the coordinated actions of various access...

journal_title：Nature communications

authors： Sasanuma H,Tawaramoto MS,Lao JP,Hosaka H,Sanda E,Suzuki M,Yamashita E,Hunter N,Shinohara M,Nakagawa A,Shinohara A

更新日期：2013-01-01 00:00:00

abstract：:Imaging the optical properties of individual nanosystems beyond fluorescence can provide a wealth of information. However, the minute signals for absorption and dispersion are challenging to observe, and only specialized techniques requiring sophisticated noise rejection are available. Here we use signal enhancement i...

journal_title：Nature communications

authors： Mader M,Reichel J,Hänsch TW,Hunger D

更新日期：2015-06-24 00:00:00

abstract：:Taxanes are the only chemotherapies used to treat patients with metastatic castration-resistant prostate cancer (CRPC). Despite the initial efficacy of taxanes in treating CRPC, all patients ultimately fail due to the development of drug resistance. In this study, we show that ERG overexpression in in vitro and in viv...

journal_title：Nature communications

authors： Galletti G,Matov A,Beltran H,Fontugne J,Miguel Mosquera J,Cheung C,MacDonald TY,Sung M,O'Toole S,Kench JG,Suk Chae S,Kimovski D,Tagawa ST,Nanus DM,Rubin MA,Horvath LG,Giannakakou P,Rickman DS

更新日期：2014-11-25 00:00:00

abstract：:Heartbeat is required for normal development of the heart, and perturbation of intracardiac flow leads to morphological defects resembling congenital heart diseases. These observations implicate intracardiac haemodynamics in cardiogenesis, but the signalling cascades connecting physical forces, gene expression and mor...

journal_title：Nature communications

authors： Banjo T,Grajcarek J,Yoshino D,Osada H,Miyasaka KY,Kida YS,Ueki Y,Nagayama K,Kawakami K,Matsumoto T,Sato M,Ogura T

更新日期：2013-01-01 00:00:00

abstract：:Accumulation of nucleotide building blocks prior to and during S phase facilitates DNA duplication. Herein, we find that the anaphase-promoting complex/cyclosome (APC/C) synchronizes ribose-5-phosphate levels and DNA synthesis during the cell cycle. In late G1 and S phases, transketolase-like 1 (TKTL1) is overexpresse...

journal_title：Nature communications

authors： Li Y,Yao CF,Xu FJ,Qu YY,Li JT,Lin Y,Cao ZL,Lin PC,Xu W,Zhao SM,Zhao JY

更新日期：2019-06-07 00:00:00

abstract：:Genomic instability pathways in colorectal cancer (CRC) have been extensively studied, but the role of retrotransposition in colorectal carcinogenesis remains poorly understood. Although retrotransposons are usually repressed, they become active in several human cancers, in particular those of the gastrointestinal tra...

journal_title：Nature communications

authors： Cajuso T,Sulo P,Tanskanen T,Katainen R,Taira A,Hänninen UA,Kondelin J,Forsström L,Välimäki N,Aavikko M,Kaasinen E,Ristimäki A,Koskensalo S,Lepistö A,Renkonen-Sinisalo L,Seppälä T,Kuopio T,Böhm J,Mecklin JP,Kilpivaar

更新日期：2019-09-06 00:00:00

abstract：:During apoptosis, Bak and Bax are activated by BH3-only proteins binding to the α2-α5 hydrophobic groove; Bax is also activated via a rear pocket. Here we report that antibodies can directly activate Bak and mitochondrial Bax by binding to the α1-α2 loop. A monoclonal antibody (clone 7D10) binds close to α1 in non-act...

journal_title：Nature communications

authors： Iyer S,Anwari K,Alsop AE,Yuen WS,Huang DC,Carroll J,Smith NA,Smith BJ,Dewson G,Kluck RM

更新日期：2016-05-24 00:00:00

abstract：:Parkinson's disease-associated kinase LRRK2 has been linked to IFN type II (IFN-γ) response in infections and to dopaminergic neuronal loss. However, whether and how LRRK2 synergizes with IFN-γ remains unclear. In this study, we employed dopaminergic neurons and microglia differentiated from patient-derived induced pl...

journal_title：Nature communications

authors： Panagiotakopoulou V,Ivanyuk D,De Cicco S,Haq W,Arsić A,Yu C,Messelodi D,Oldrati M,Schöndorf DC,Perez MJ,Cassatella RP,Jakobi M,Schneiderhan-Marra N,Gasser T,Nikić-Spiegel I,Deleidi M

更新日期：2020-10-14 00:00:00

abstract：:Cerebral cavernous malformations (CCMs) are vascular abnormalities that primarily occur in adulthood and cause cerebral hemorrhage, stroke, and seizures. CCMs are thought to be initiated by endothelial cell (EC) loss of any one of the three Ccm genes: CCM1 (KRIT1), CCM2 (OSM), or CCM3 (PDCD10). Here we report that mic...

journal_title：Nature communications

authors： Zhou HJ,Qin L,Jiang Q,Murray KN,Zhang H,Li B,Lin Q,Graham M,Liu X,Grutzendler J,Min W

更新日期：2021-01-25 00:00:00

abstract：:HPV16 causes half of cervical cancers worldwide; for unknown reasons, most infections resolve within two years. Here, we analyze the viral genomes of 5,328 HPV16-positive case-control samples to investigate mutational signatures and the role of human APOBEC3-induced mutations in viral clearance and cervical carcinogen...

journal_title：Nature communications

authors： Zhu B,Xiao Y,Yeager M,Clifford G,Wentzensen N,Cullen M,Boland JF,Bass S,Steinberg MK,Raine-Bennett T,Lee D,Burk RD,Pinheiro M,Song L,Dean M,Nelson CW,Burdett L,Yu K,Roberson D,Lorey T,Franceschi S,Castle PE,Wa

更新日期：2020-02-14 00:00:00

abstract：:With the rapidly growing global air traffic, the impacts of the black carbon (BC) in the aviation exhaust on climate, environment and public health are likely rising. The particle number and size distribution are crucial metrics for toxicological analysis and aerosol-cloud interactions. Here, a size-resolved BC partic...

journal_title：Nature communications

authors： Zhang X,Chen X,Wang J

更新日期：2019-02-01 00:00:00

abstract：:Inspired by biological neural systems, neuromorphic devices may open up new computing paradigms to explore cognition, learning and limits of parallel computation. Here we report the demonstration of a synaptic transistor with SmNiO₃, a correlated electron system with insulator-metal transition temperature at 130°C in ...

journal_title：Nature communications

authors： Shi J,Ha SD,Zhou Y,Schoofs F,Ramanathan S

更新日期：2013-01-01 00:00:00

abstract：:During mitosis, duplicated sister chromatids attach to microtubules emanating from opposing sides of the bipolar spindle through large protein complexes called kinetochores. In the absence of stable kinetochore-microtubule attachments, a cell surveillance mechanism known as the spindle assembly checkpoint (SAC) produc...

journal_title：Nature communications

authors： Tauchman EC,Boehm FJ,DeLuca JG

更新日期：2015-12-01 00:00:00

abstract：:Generally, a homogeneous catalyst exhibits good activity and defined active sites but it is difficult to recycle. Meanwhile, a heterogeneous catalyst can easily be reused but its active site is difficult to reveal. It is interesting to bridge the gap between homogeneous and heterogeneous catalysis via controllable con...

journal_title：Nature communications

authors： Zhang Y,Pang S,Wei Z,Jiao H,Dai X,Wang H,Shi F

更新日期：2018-04-13 00:00:00

abstract：:Osteosarcoma is the most frequent primary bone tumor with poor prognosis. Through RNA-sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic osteosarcoma lesions, 11 major cell clusters are identified based on unbiased clustering of gene expression profiles and canonical markers. The...

journal_title：Nature communications

authors： Zhou Y,Yang D,Yang Q,Lv X,Huang W,Zhou Z,Wang Y,Zhang Z,Yuan T,Ding X,Tang L,Zhang J,Yin J,Huang Y,Yu W,Wang Y,Zhou C,Su Y,He A,Sun Y,Shen Z,Qian B,Meng W,Fei J,Yao Y,Pan X,Chen P,Hu H

更新日期：2020-12-10 00:00:00

abstract：:The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. We infer detailed reconstructions of tumor phylogenies in ten prostate cancer patients with fatal disease, and investigate them in conjunction with histopathology and tum...

journal_title：Nature communications

authors： Woodcock DJ,Riabchenko E,Taavitsainen S,Kankainen M,Gundem G,Brewer DS,Ellonen P,Lepistö M,Golubeva YA,Warner AC,Tolonen T,Jasu J,Isaacs WB,Emmert-Buck MR,Nykter M,Visakorpi T,Bova GS,Wedge DC

更新日期：2020-10-08 00:00:00

abstract：:Activation of the NLRP3 inflammasome and subsequent maturation of IL-1β have been implicated in acute lung injury (ALI), resulting in inflammation and fibrosis. We investigated the role of vimentin, a type III intermediate filament, in this process using three well-characterized murine models of ALI known to require N...

journal_title：Nature communications

authors： dos Santos G,Rogel MR,Baker MA,Troken JR,Urich D,Morales-Nebreda L,Sennello JA,Kutuzov MA,Sitikov A,Davis JM,Lam AP,Cheresh P,Kamp D,Shumaker DK,Budinger GR,Ridge KM

更新日期：2015-03-12 00:00:00

abstract：:Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and heterogeneity of hepatocellular carcinoma (HCC). However, the biology of hepatic CSCs remains largely undefined. Through analysis of transcriptome microarray data, we identify a long noncoding RNA (lncRNA) called lncBRM, which is highly e...

journal_title：Nature communications

authors： Zhu P,Wang Y,Wu J,Huang G,Liu B,Ye B,Du Y,Gao G,Tian Y,He L,Fan Z

更新日期：2016-12-01 00:00:00