Calculating with light using a chip-scale all-optical abacus.

abstract：:Leptin stimulates the sympathetic nervous system (SNS), energy expenditure, and weight loss; however, the underlying molecular mechanism remains elusive. Here, we uncover Sh2b1 in leptin receptor (LepR) neurons as a critical component of a SNS/brown adipose tissue (BAT)/thermogenesis axis. LepR neuron-specific deletio...

journal_title：Nature communications

authors： Jiang L,Su H,Wu X,Shen H,Kim MH,Li Y,Myers MG Jr,Owyang C,Rui L

更新日期：2020-03-23 00:00:00

abstract：:Optical tracking is often combined with conventional flat panel solar cells to maximize electrical power generation over the course of a day. However, conventional trackers are complex and often require costly and cumbersome structural components to support system weight. Here we use kirigami (the art of paper cutting...

journal_title：Nature communications

authors： Lamoureux A,Lee K,Shlian M,Forrest SR,Shtein M

更新日期：2015-09-08 00:00:00

abstract：:Structural degradation and low conductivity of transition-metal oxides lead to severe capacity fading in lithium-ion batteries. Recent efforts to solve this issue have mainly focused on using nanocomposites or hybrids by integrating nanosized metal oxides with conducting additives. Here we design specific hierarchical...

journal_title：Nature communications

authors： Tan G,Wu F,Yuan Y,Chen R,Zhao T,Yao Y,Qian J,Liu J,Ye Y,Shahbazian-Yassar R,Lu J,Amine K

更新日期：2016-06-03 00:00:00

abstract：:Considering the synthetic value of introducing active alcoholic hydroxyl group, developing C-H functionalization of alcohols is of significance. Herein, we present a photochemical method that under visible light irradiation, selectfluor can effectively promote the oxidative cross-coupling between alcohols and heteroar...

journal_title：Nature communications

authors： Niu L,Liu J,Liang XA,Wang S,Lei A

更新日期：2019-01-28 00:00:00

abstract：:Myoblast fusion (MF) is required for muscle growth and repair, and its alteration contributes to muscle diseases. The mechanisms governing this process are incompletely understood, and no epigenetic regulator has been previously described. Ash1L is an epigenetic activator belonging to the Trithorax group of proteins a...

journal_title：Nature communications

authors： Castiglioni I,Caccia R,Garcia-Manteiga JM,Ferri G,Caretti G,Molineris I,Nishioka K,Gabellini D

更新日期：2018-11-28 00:00:00

abstract：:Neurotransmitter/sodium symporters (NSSs) are responsible for Na+-dependent reuptake of neurotransmitters and represent key targets for antidepressants and psychostimulants. LeuT, a prokaryotic NSS protein, constitutes a primary structural model for these transporters. Here we show that K+ inhibits Na+-dependent bindi...

journal_title：Nature communications

authors： Billesbølle CB,Mortensen JS,Sohail A,Schmidt SG,Shi L,Sitte HH,Gether U,Loland CJ

更新日期：2016-09-28 00:00:00

abstract：:The allotetraploid plant Nicotiana tabacum (common tobacco) is a major crop species and a model organism, for which only very fragmented genomic sequences are currently available. Here we report high-quality draft genomes for three main tobacco varieties. These genomes show both the low divergence of tobacco from its ...

journal_title：Nature communications

authors： Sierro N,Battey JN,Ouadi S,Bakaher N,Bovet L,Willig A,Goepfert S,Peitsch MC,Ivanov NV

更新日期：2014-05-08 00:00:00

abstract：:Modern computation relies crucially on modular architectures, breaking a complex algorithm into self-contained subroutines. A client can then call upon a remote server to implement parts of the computation independently via an application programming interface (API). Present APIs relay only classical information. Here...

journal_title：Nature communications

authors： Zhang K,Thompson J,Zhang X,Shen Y,Lu Y,Zhang S,Ma J,Vedral V,Gu M,Kim K

更新日期：2019-10-16 00:00:00

abstract：:In higher plants, the hormone auxin orchestrates a diverse array of developmental and environmental responses mainly exerted via transcriptional control. In its absence, auxin-mediated transcription is postulated to be repressed by histone deacetylases, which convert chromatin into a highly packed inactive state. Here...

journal_title：Nature communications

authors： Weiste C,Dröge-Laser W

更新日期：2014-05-27 00:00:00

abstract：:Invasive plant species threaten native biodiversity, ecosystems, agriculture, industry and human health worldwide, lending urgency to the search for predictors of plant invasiveness outside native ranges. There is much conflicting evidence about which plant characteristics best predict invasiveness. Here we use a glob...

journal_title：Nature communications

authors： Jelbert K,Buss D,McDonald J,Townley S,Franco M,Stott I,Jones O,Salguero-Gómez R,Buckley Y,Knight T,Silk M,Sargent F,Rolph S,Wilson P,Hodgson D

更新日期：2019-12-06 00:00:00

abstract：:In melanoma, therapies with inhibitors to oncogenic BRAFV600E are highly effective but responses are often short-lived due to the emergence of drug-resistant tumor subpopulations. We describe here a mechanism of acquired drug resistance through the tumor microenvironment, which is mediated by human tumor-associated B ...

journal_title：Nature communications

authors： Somasundaram R,Zhang G,Fukunaga-Kalabis M,Perego M,Krepler C,Xu X,Wagner C,Hristova D,Zhang J,Tian T,Wei Z,Liu Q,Garg K,Griss J,Hards R,Maurer M,Hafner C,Mayerhöfer M,Karanikas G,Jalili A,Bauer-Pohl V,Weihsengru

更新日期：2017-09-19 00:00:00

abstract：:Seed germination and young seedling establishment should be tightly regulated to maximize plant survival and thereby enable successful propagation. Plants have evolved developmental signalling networks to integrate environmental cues for proper control of these critical processes, in which brassinosteroids are known t...

journal_title：Nature communications

authors： Ryu H,Cho H,Bae W,Hwang I

更新日期：2014-06-18 00:00:00

abstract：:Bacterial infections and antibiotic resistance, particularly by Gram-negative pathogens, have become a global healthcare crisis. We report the design of a class of cationic antimicrobial polymers that cluster local facial amphiphilicity from repeating units to enhance interactions with bacterial membranes without requ...

journal_title：Nature communications

authors： Rahman MA,Bam M,Luat E,Jui MS,Ganewatta MS,Shokfai T,Nagarkatti M,Decho AW,Tang C

更新日期：2018-12-07 00:00:00

abstract：:Inbreeding typically reduces fitness. Related partners may fail to reproduce and any inbred offspring may die early or fail to reproduce themselves. Here we show that inbreeding causes early death in the zebra finch Taeniopygia guttata, and among inbred individuals of the same inbreeding coefficient (F), those that di...

journal_title：Nature communications

authors： Hemmings NL,Slate J,Birkhead TR

更新日期：2012-05-29 00:00:00

abstract：:Akin to single-site homogeneous catalysis, a long sought-after goal is to achieve reaction site precision in heterogeneous catalysis for chemical control over patterns of activity, selectivity and stability. Herein, we report on metal phosphides as a class of material capable of realizing these attributes and unlock t...

journal_title：Nature communications

authors： Xu YF,Duchesne PN,Wang L,Tavasoli A,Jelle AA,Xia M,Liao JF,Kuang DB,Ozin GA

更新日期：2020-10-13 00:00:00

abstract：:The ubiquitin receptors Rad23 and Dsk2 deliver polyubiquitylated substrates to the proteasome for destruction. The C-terminal ubiquitin-associated (UBA) domain of Rad23 functions as a cis-acting stabilization signal that protects this protein from proteasomal degradation. Here, we provide evidence that the C-terminal ...

journal_title：Nature communications

authors： Heinen C,Acs K,Hoogstraten D,Dantuma NP

更新日期：2011-02-08 00:00:00

abstract：:Grain rotation is a well-known phenomenon during high (homologous) temperature deformation and recrystallization of polycrystalline materials. In recent years, grain rotation has also been proposed as a plasticity mechanism at low temperatures (for example, room temperature for metals), especially for nanocrystalline ...

journal_title：Nature communications

authors： Wang L,Teng J,Liu P,Hirata A,Ma E,Zhang Z,Chen M,Han X

更新日期：2014-07-17 00:00:00

abstract：:In carrier multiplication, the absorption of a single photon results in two or more electron-hole pairs. Quantum dots are promising materials for implementing carrier multiplication principles in real-life technologies. So far, however, most of research in this area has focused on optical studies of solution samples w...

journal_title：Nature communications

authors： Gao J,Fidler AF,Klimov VI

更新日期：2015-09-08 00:00:00

abstract：:Nonsyndromic cleft lip with or without a cleft palate (NSCL/P) is among the most common human congenital birth defects and imposes a substantial physical and financial burden on affected individuals. Here, we conduct a case-control-based GWAS followed by two rounds of replication; we include six independent cohorts fr...

journal_title：Nature communications

authors： Sun Y,Huang Y,Yin A,Pan Y,Wang Y,Wang C,Du Y,Wang M,Lan F,Hu Z,Wang G,Jiang M,Ma J,Zhang X,Ma H,Ma J,Zhang W,Huang Q,Zhou Z,Ma L,Li Y,Jiang H,Xie L,Jiang Y,Shi B,Cheng J,Shen H,Wang L,Yang Y

更新日期：2015-03-16 00:00:00

abstract：:Highly pure semiconducting single-walled carbon nanotubes (SWNTs) are essential for the next generation of electronic devices, such as field-effect transistors and photovoltaic applications; however, contamination by metallic SWNTs reduces the efficiency of their associated devices. Here we report a simple and efficie...

journal_title：Nature communications

authors： Toshimitsu F,Nakashima N

更新日期：2014-10-03 00:00:00

abstract：:The initiation of heterogeneity within a population of phenotypically identical progenitors is a critical event for the onset of morphogenesis and differentiation patterning. Gap junction communication within multicellular systems produces complex networks of intercellular connectivity that result in heterogeneous dis...

journal_title：Nature communications

authors： Glen CM,McDevitt TC,Kemp ML

更新日期：2018-10-05 00:00:00

abstract：:In response to brain injury, microglia rapidly extend processes that isolate lesion sites and protect the brain from further injury. Here we report that microglia carrying a pathogenic mutation in the Parkinson's disease (PD)-associated gene, G2019S-LRRK2 (GS-Tg microglia), show retarded ADP-induced motility and delay...

journal_title：Nature communications

authors： Choi I,Kim B,Byun JW,Baik SH,Huh YH,Kim JH,Mook-Jung I,Song WK,Shin JH,Seo H,Suh YH,Jou I,Park SM,Kang HC,Joe EH

更新日期：2015-09-14 00:00:00

abstract：:Neuronal reward valuations provide the physiological basis for economic behaviour. Yet, how such valuations are converted to economic decisions remains unclear. Here we show that the dorsolateral prefrontal cortex (DLPFC) implements a flexible value code based on object-specific valuations by single neurons. As monkey...

journal_title：Nature communications

authors： Tsutsui KI,Grabenhorst F,Kobayashi S,Schultz W

更新日期：2016-09-13 00:00:00

abstract：:The magnetic excitations in the cuprate superconductors might be essential for an understanding of high-temperature superconductivity. In these cuprate superconductors the magnetic excitation spectrum resembles an hour-glass and certain resonant magnetic excitations within are believed to be connected to the pairing m...

journal_title：Nature communications

authors： Drees Y,Li ZW,Ricci A,Rotter M,Schmidt W,Lamago D,Sobolev O,Rütt U,Gutowski O,Sprung M,Piovano A,Castellan JP,Komarek AC

更新日期：2014-12-23 00:00:00

abstract：:Gfi1b is a transcriptional repressor expressed in hematopoietic stem cells (HSCs) and megakaryocytes (MKs). Gfi1b deficiency leads to expansion of both cell types and abrogates the ability of MKs to respond to integrin. Here we show that Gfi1b forms complexes with β-catenin, its co-factors Pontin52, CHD8, TLE3 and CtB...

journal_title：Nature communications

authors： Shooshtarizadeh P,Helness A,Vadnais C,Brouwer N,Beauchemin H,Chen R,Bagci H,Staal FJT,Coté JF,Möröy T

更新日期：2019-03-20 00:00:00

abstract：:The mega-diversity of herbivorous insects is attributed to their co-evolutionary associations with plants. Despite abundant studies on insect-plant interactions, we do not know whether host-plant shifts have impacted both genomic adaptation and species diversification over geological times. We show that the antagonist...

journal_title：Nature communications

authors： Allio R,Nabholz B,Wanke S,Chomicki G,Pérez-Escobar OA,Cotton AM,Clamens AL,Kergoat GJ,Sperling FAH,Condamine FL

更新日期：2021-01-13 00:00:00

abstract：:Many microorganisms, with phytoplankton and zooplankton as prominent examples, display phototactic behaviour, that is, the ability to perform directed motion within a light gradient. Here we experimentally demonstrate that sensing of light gradients can also be achieved in a system of synthetic photo-activated micropa...

journal_title：Nature communications

authors： Lozano C,Ten Hagen B,Löwen H,Bechinger C

更新日期：2016-09-30 00:00:00

abstract：:The concept of spin-torque-driven high-frequency magnetization dynamics, allows the potential construction of complex networks of non-linear dynamical nanoscale systems, combining the field of spintronics and the study of non-linear systems. In the few previous demonstrations of synchronization of several spin-torque ...

journal_title：Nature communications

authors： Lebrun R,Tsunegi S,Bortolotti P,Kubota H,Jenkins AS,Romera M,Yakushiji K,Fukushima A,Grollier J,Yuasa S,Cros V

更新日期：2017-06-12 00:00:00

abstract：:We propose the concept of universal fiducials based on a set of pre-made semi-synthetic antibodies (sABs) generated by customized phage display selections against the fusion protein BRIL, an engineered variant of apocytochrome b562a. These sABs can bind to BRIL fused either into the loops or termini of different GPCRs...

journal_title：Nature communications

authors： Mukherjee S,Erramilli SK,Ammirati M,Alvarez FJD,Fennell KF,Purdy MD,Skrobek BM,Radziwon K,Coukos J,Kang Y,Dutka P,Gao X,Qiu X,Yeager M,Eric Xu H,Han S,Kossiakoff AA

更新日期：2020-03-27 00:00:00

abstract：:Whole-genome sequencing using sequencing technologies such as Illumina enables the accurate detection of small-scale variants but provides limited information about haplotypes and variants in repetitive regions of the human genome. Single-molecule sequencing (SMS) technologies such as Pacific Biosciences and Oxford Na...

journal_title：Nature communications

authors： Edge P,Bansal V

更新日期：2019-10-11 00:00:00