Inbreeding causes early death in a passerine bird.

abstract：:Solid organic matter (OM) plays an essential role in the generation, migration, storage, and production of hydrocarbons from economically important shale rock formations. Electron microscopy images have documented spatial heterogeneity in the porosity of OM at nanoscale, and bulk spectroscopy measurements have documen...

journal_title：Nature communications

authors： Yang J,Hatcherian J,Hackley PC,Pomerantz AE

更新日期：2017-12-19 00:00:00

abstract：:There is increasing interest in transplantation of human stem cells for therapeutic purposes. It would benefit future application if one could achieve their long-term acceptance and functional differentiation in allogeneic hosts using minimal immunosuppression. Allogeneic stem cell transplants differ from conventional...

journal_title：Nature communications

authors： Lui KO,Howie D,Ng SW,Liu S,Chien KR,Waldmann H

更新日期：2014-12-01 00:00:00

abstract：:Quantum Hall edge channels offer an efficient and controllable platform to study quantum transport in one dimension. Such channels are a prospective tool for the efficient transfer of quantum information at the nanoscale, and play a vital role in exposing intriguing physics. Electric current along the edge carries ene...

journal_title：Nature communications

authors： Krähenmann T,Fischer SG,Röösli M,Ihn T,Reichl C,Wegscheider W,Ensslin K,Gefen Y,Meir Y

更新日期：2019-09-02 00:00:00

abstract：:Modern computation relies crucially on modular architectures, breaking a complex algorithm into self-contained subroutines. A client can then call upon a remote server to implement parts of the computation independently via an application programming interface (API). Present APIs relay only classical information. Here...

journal_title：Nature communications

authors： Zhang K,Thompson J,Zhang X,Shen Y,Lu Y,Zhang S,Ma J,Vedral V,Gu M,Kim K

更新日期：2019-10-16 00:00:00

abstract：:Protein homeostasis (proteostasis) is a potential mechanism that contributes to cancer cell survival and drug resistance. Constitutively active androgen receptor (AR) variants confer anti-androgen resistance in advanced prostate cancer. However, the role of proteostasis involved in next generation anti-androgen resist...

journal_title：Nature communications

authors： Liu C,Lou W,Yang JC,Liu L,Armstrong CM,Lombard AP,Zhao R,Noel ODV,Tepper CG,Chen HW,Dall'Era M,Evans CP,Gao AC

更新日期：2018-11-16 00:00:00

abstract：:Insulin regulates glycaemia, lipogenesis and increases mRNA translation. Cells with reduced eukaryotic initiation factor 6 (eIF6) do not increase translation in response to insulin. The role of insulin-regulated translation is unknown. Here we show that reduction of insulin-regulated translation in mice heterozygous f...

journal_title：Nature communications

authors： Brina D,Miluzio A,Ricciardi S,Clarke K,Davidsen PK,Viero G,Tebaldi T,Offenhäuser N,Rozman J,Rathkolb B,Neschen S,Klingenspor M,Wolf E,Gailus-Durner V,Fuchs H,Hrabe de Angelis M,Quattrone A,Falciani F,Biffo S

更新日期：2015-09-18 00:00:00

abstract：:Molecular machines carry out their function by equilibrium mechanical motions in environments that are far from thermodynamic equilibrium. The mechanically equilibrated character of the trajectories of the macromolecule has allowed development of a powerful theoretical description, reminiscent of Onsager's trajectory ...

journal_title：Nature communications

authors： Astumian RD

更新日期：2019-08-23 00:00:00

abstract：:6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). 6PGD is commonly upregulated and plays important roles in many human cancers, while the mechanism underlying such roles of 6PGD remains elusi...

journal_title：Nature communications

authors： Liu R,Li W,Tao B,Wang X,Yang Z,Zhang Y,Wang C,Liu R,Gao H,Liang J,Yang W

更新日期：2019-03-01 00:00:00

abstract：:Although many animals have evolved intrinsic transparency for the purpose of concealment, the development of dynamic, that is, controllable and reversible, transparency for living human cells and tissues has remained elusive to date. Here, by drawing inspiration from the structures and functionalities of adaptive ceph...

journal_title：Nature communications

authors： Chatterjee A,Cerna Sanchez JA,Yamauchi T,Taupin V,Couvrette J,Gorodetsky AA

更新日期：2020-06-02 00:00:00

abstract：:Electron motion in chemical bonds occurs on an attosecond timescale. This ultrafast motion can be driven by strong laser fields. Ultrashort asymmetric laser pulses are known to direct electrons to a certain direction. But do symmetric laser pulses destroy symmetry in breaking chemical bonds? Here we answer this questi...

journal_title：Nature communications

authors： Wu J,Magrakvelidze M,Schmidt LP,Kunitski M,Pfeifer T,Schöffler M,Pitzer M,Richter M,Voss S,Sann H,Kim H,Lower J,Jahnke T,Czasch A,Thumm U,Dörner R

更新日期：2013-01-01 00:00:00

abstract：:Electric eels (Electrophorus electricus) are legendary for their ability to incapacitate fish, humans, and horses with hundreds of volts of electricity. The function of this output as a weapon has been obvious for centuries but its potential role for electroreception has been overlooked. Here it is shown that electric...

journal_title：Nature communications

authors： Catania KC

更新日期：2015-10-20 00:00:00

abstract：:Long-range chromosomal interactions bring distal regulatory elements and promoters together to regulate gene expression in biological processes. By performing promoter capture Hi-C (PCHi-C) on human embryonic stem cell-derived cardiomyocytes (hESC-CMs), we show that such promoter interactions are a key mechanism by wh...

journal_title：Nature communications

authors： Choy MK,Javierre BM,Williams SG,Baross SL,Liu Y,Wingett SW,Akbarov A,Wallace C,Freire-Pritchett P,Rugg-Gunn PJ,Spivakov M,Fraser P,Keavney BD

更新日期：2018-06-28 00:00:00

abstract：:Synthetic genetic circuits allow us to modify the behavior of living cells. However, changes in environmental conditions and unforeseen interactions with the host cell can cause deviations from a desired function, resulting in the need for time-consuming reassembly to fix these issues. Here, we use a regulatory motif ...

journal_title：Nature communications

authors： Bartoli V,Meaker GA,di Bernardo M,Gorochowski TE

更新日期：2020-04-29 00:00:00

abstract：:Generation of periodic patterns is fundamental to the differentiation of multiple tissues during development. How such patterns form robustly is still unclear. The Drosophila eye comprises ∼750 units, whose crystalline order is set during differentiation of the eye imaginal disc: an activation wave sweeping across the...

journal_title：Nature communications

authors： Gavish A,Shwartz A,Weizman A,Schejter E,Shilo BZ,Barkai N

更新日期：2016-02-15 00:00:00

abstract：:Heterogeneous catalysis is an enabling technology that utilises transition metal nanoparticles (NPs) supported on oxides to promote chemical reactions. Structural mismatch at the NP-support interface generates lattice strain that could affect catalytic properties. However, detailed knowledge about strain in supported ...

journal_title：Nature communications

authors： Nilsson Pingel T,Jørgensen M,Yankovich AB,Grönbeck H,Olsson E

更新日期：2018-07-13 00:00:00

abstract：:The emergence of larger brains with large numbers of neurons is an evolutionary innovation in mammals and birds. However, the corresponding changes in cortical developmental programmes during amniote evolution are poorly understood. Here we examine the cortical development of Madagascar ground geckos, and report uniqu...

journal_title：Nature communications

authors： Nomura T,Gotoh H,Ono K

更新日期：2013-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause severe deficits in meningeal lymphatic drainage that begin within hours and last out to at least one month post-injury. To investigate a mechan...

journal_title：Nature communications

authors： Bolte AC,Dutta AB,Hurt ME,Smirnov I,Kovacs MA,McKee CA,Ennerfelt HE,Shapiro D,Nguyen BH,Frost EL,Lammert CR,Kipnis J,Lukens JR

更新日期：2020-09-10 00:00:00

abstract：:Anthropogenic mercury (Hg(0)) emissions oxidize to gaseous Hg(II) compounds, before deposition to Earth surface ecosystems. Atmospheric reduction of Hg(II) competes with deposition, thereby modifying the magnitude and pattern of Hg deposition. Global Hg models have postulated that Hg(II) reduction in the atmosphere oc...

journal_title：Nature communications

authors： Saiz-Lopez A,Sitkiewicz SP,Roca-Sanjuán D,Oliva-Enrich JM,Dávalos JZ,Notario R,Jiskra M,Xu Y,Wang F,Thackray CP,Sunderland EM,Jacob DJ,Travnikov O,Cuevas CA,Acuña AU,Rivero D,Plane JMC,Kinnison DE,Sonke JE

更新日期：2018-11-15 00:00:00

abstract：:Prolonged cell survival occurs through the expression of specific protein isoforms generated by alternate splicing of mRNA precursors in cancer cells. How alternate splicing regulates tumor development and resistance to targeted therapies in cancer remain poorly understood. Here we show that RNF113A, whose loss-of-fun...

journal_title：Nature communications

authors： Shostak K,Jiang Z,Charloteaux B,Mayer A,Habraken Y,Tharun L,Klein S,Xu X,Duong HQ,Vislovukh A,Close P,Florin A,Rambow F,Marine JC,Büttner R,Chariot A

更新日期：2020-03-09 00:00:00

abstract：:Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations. There is also clinical evidence for the utility of PARPi in breast and ovarian cancers without BRCA mutations, but the underlying mechanism is not clear...

journal_title：Nature communications

authors： Peng Y,Liao Q,Tan W,Peng C,Hu Z,Chen Y,Li Z,Li J,Zhen B,Zhu W,Li X,Yao Y,Song Q,Liu C,Qi X,He F,Pei H

更新日期：2019-03-15 00:00:00

abstract：:The separation of immiscible liquids has significant implications for magma evolution and the formation of magmatic ore deposits. We combine high-resolution imaging and electron probe microanalysis with the first use of atom probe tomography on tholeiitic basaltic glass from Hawaii, the Snake River Plain, and Iceland,...

journal_title：Nature communications

authors： Honour VC,Holness MB,Charlier B,Piazolo SC,Namur O,Prosa TJ,Martin I,Helz RT,Maclennan J,Jean MM

更新日期：2019-10-23 00:00:00

abstract：:The negative-capacitance field-effect transistor(NC-FET) has attracted tremendous research efforts. However, the lack of a clear physical picture and design rule for this device has led to numerous invalid fabrications. In this work, we address this issue based on an unexpectedly concise and insightful analytical form...

journal_title：Nature communications

authors： Cao W,Banerjee K

更新日期：2020-01-10 00:00:00

abstract：:Interfacial issues commonly exist in solid-state batteries, and the microstructural complexity combines with the chemical heterogeneity to govern the local interfacial chemistry. The conventional wisdom suggests that "point-to-point" ion diffusion at the interface determines the ion transport kinetics. Here, we show t...

journal_title：Nature communications

authors： Lou S,Liu Q,Zhang F,Liu Q,Yu Z,Mu T,Zhao Y,Borovilas J,Chen Y,Ge M,Xiao X,Lee WK,Yin G,Yang Y,Sun X,Wang J

更新日期：2020-11-11 00:00:00

abstract：:Non-aromatic nitrogen- and oxygen-containing heterocycles such as piperidines and pyrans are prevalent components of natural products and pharmaceutical drugs. Although it has been a workhorse as a synthetic method for assembling unsaturated sp(2)-hybridized substrates, transition metal-catalysed cross-coupling chemis...

journal_title：Nature communications

authors： Ding J,Rybak T,Hall DG

更新日期：2014-11-18 00:00:00

abstract：:Direct reciprocity is a mechanism for cooperation among humans. Many of our daily interactions are repeated. We interact repeatedly with our family, friends, colleagues, members of the local and even global community. In the theory of repeated games, it is a tacit assumption that the various games that a person plays ...

journal_title：Nature communications

authors： Reiter JG,Hilbe C,Rand DG,Chatterjee K,Nowak MA

更新日期：2018-02-07 00:00:00

abstract：:Omniphobic membranes are attractive for membrane distillation (MD) because of their superior wetting resistance. However, a design framework for MD membrane remains incomplete, due to the complexity of omniphobic membrane fabrication and the lack of fundamental relationship between wetting resistance and water vapor p...

journal_title：Nature communications

authors： Wang W,Du X,Vahabi H,Zhao S,Yin Y,Kota AK,Tong T

更新日期：2019-07-19 00:00:00

abstract：:Spectral domain optical coherence tomography (OCT) is a widely employed, minimally invasive bio-medical imaging technique, which requires a broadband light source, typically implemented by super-luminescent diodes. Recent advances in soliton based photonic integrated frequency combs (soliton microcombs) have enabled t...

journal_title：Nature communications

authors： Marchand PJ,Riemensberger J,Skehan JC,Ho JJ,Pfeiffer MHP,Liu J,Hauger C,Lasser T,Kippenberg TJ

更新日期：2021-01-18 00:00:00

abstract：:A gene is considered essential if loss of function results in loss of viability, fitness or in disease. This concept is well established for coding genes; however, non-coding regions are thought less likely to be determinants of critical functions. Here we train a machine learning model using functional, mutational an...

journal_title：Nature communications

authors： Wells A,Heckerman D,Torkamani A,Yin L,Sebat J,Ren B,Telenti A,di Iulio J

更新日期：2019-11-20 00:00:00

abstract：:Tenuazonic acid (TeA) is a well-known mycotoxin produced by various plant pathogenic fungi. However, its biosynthetic gene has been unknown to date. Here we identify the TeA biosynthetic gene from Magnaporthe oryzae by finding two TeA-inducing conditions of a low-producing strain. We demonstrate that TeA is synthesize...

journal_title：Nature communications

authors： Yun CS,Motoyama T,Osada H

更新日期：2015-10-27 00:00:00

abstract：:Many drugs bind to and activate human pregnane X receptor (hPXR) to upregulate drug-metabolizing enzymes, resulting in decreased drug efficacy and increased resistance. This suggests that hPXR antagonists have therapeutic value. Here we report that SPA70 is a potent and selective hPXR antagonist. SPA70 inhibits hPXR i...

journal_title：Nature communications

authors： Lin W,Wang YM,Chai SC,Lv L,Zheng J,Wu J,Zhang Q,Wang YD,Griffin PR,Chen T

更新日期：2017-09-29 00:00:00