Abstract:
:Processing within the anterior cingulate cortex (ACC) is crucial for the patterning of appropriate behavior, and ACC dysfunction following chronic drug use is thought to play a major role in drug addiction. However, cortical pyramidal projection neurons can be subdivided into two major types (intratelencephalic (IT) and pyramidal tract (PT)), with distinct inputs and projection targets, molecular and receptor profiles, morphologies and electrophysiological properties. Yet, how each of these cell populations modulate behavior related to addiction is unknown. We demonstrate that PT neurons regulate the positive features of a drug experience whereas IT neurons regulate the negative features. These findings support a revised theory of cortical function in addiction, with distinct cells and circuits mediating reward and aversion.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Garcia AF,Crummy EA,Webb IG,Nooney MN,Ferguson SMdoi
10.1038/s41467-020-20526-0subject
Has Abstractpub_date
2021-01-08 00:00:00pages
182issue
1issn
2041-1723pii
10.1038/s41467-020-20526-0journal_volume
12pub_type
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