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Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons.

Abstract：

:Neurons maintain axonal homeostasis via employing a unique organization of the microtubule (MT) cytoskeleton, which supports axonal morphology and provides tracks for intracellular transport. Abnormal MT-based trafficking hallmarks the pathology of neurodegenerative diseases, but the exact mechanism regulating MT dynamics in axons remains enigmatic. Here we report on a regulation of MT dynamics by AuTophaGy(ATG)-related proteins, which previously have been linked to the autophagy pathway. We find that ATG proteins required for LC3 lipid conjugation are dispensable for survival of excitatory neurons and instead regulate MT stability via controlling the abundance of the MT-binding protein CLASP2. This function of ATGs is independent of their role in autophagy and requires the active zone protein ELKS1. Our results highlight a non-canonical role of ATG proteins in neurons and suggest that pharmacological activation of autophagy may not only promote the degradation of cytoplasmic material, but also impair axonal integrity via altering MT stability.

journal_name

Nat Commun

journal_title

Nature communications

authors

Negrete-Hurtado A,Overhoff M,Bera S,De Bruyckere E,Schätzmüller K,Kye MJ,Qin C,Lammers M,Kondylis V,Neundorf I,Kononenko NL

doi

10.1038/s41467-020-15287-9

subject

Has Abstract

pub_date

2020-03-24 00:00:00

pages

1535

issue

1

issn

2041-1723

pii

10.1038/s41467-020-15287-9

journal_volume

11

pub_type

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