当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations.

Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations.

Abstract：

:Gross chromosomal rearrangements (GCRs), such as translocations, deletions or inversions, are often generated by illegitimate repair between two DNA breakages at regions with nucleotide sequences that might potentially adopt a non-B DNA conformation. We previously established a plasmid-based model system that recapitulates palindrome-mediated recurrent chromosomal translocations in humans, and demonstrated that cruciform DNA conformation is required for the translocation-like rearrangements. Here we show that two sequential reactions that cleave the cruciform structures give rise to the translocation: GEN1-mediated resolution that cleaves diagonally at the four-way junction of the cruciform and Artemis-mediated opening of the subsequently formed hairpin ends. Indeed, translocation products in human sperm reveal the remnants of this two-step mechanism. These two intrinsic pathways that normally fulfil vital functions independently, Holliday-junction resolution in homologous recombination and coding joint formation in rearrangement of antigen-receptor genes, act upon the unusual DNA conformation in concert and lead to a subset of recurrent GCRs in humans.

journal_name

Nat Commun

journal_title

Nature communications

authors

Inagaki H,Ohye T,Kogo H,Tsutsumi M,Kato T,Tong M,Emanuel BS,Kurahashi H

doi

10.1038/ncomms2595

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

1592

issn

2041-1723

pii

ncomms2595

journal_volume

4

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Mechanically and biologically skin-like elastomers for bio-integrated electronics.

    abstract：:The bio-integrated electronics industry is booming and becoming more integrated with biological tissues. To successfully integrate with the soft tissues of the body (eg. skin), the material must possess many of the same properties including compliance, toughness, elasticity, and tear resistance. In this work, we prepa...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14446-2

    authors： Chen S,Sun L,Zhou X,Guo Y,Song J,Qian S,Liu Z,Guan Q,Meade Jeffries E,Liu W,Wang Y,He C,You Z

    更新日期：2020-02-27 00:00:00

  • Direct RNA sequencing on nanopore arrays redefines the transcriptional complexity of a viral pathogen.

    abstract：:Characterizing complex viral transcriptomes by conventional RNA sequencing approaches is complicated by high gene density, overlapping reading frames, and complex splicing patterns. Direct RNA sequencing (direct RNA-seq) using nanopore arrays offers an exciting alternative whereby individual polyadenylated RNAs are se...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-08734-9

    authors： Depledge DP,Srinivas KP,Sadaoka T,Bready D,Mori Y,Placantonakis DG,Mohr I,Wilson AC

    更新日期：2019-02-14 00:00:00

  • Directing reaction pathways by catalyst active-site selection using self-assembled monolayers.

    abstract：:One key route for controlling reaction selectivity in heterogeneous catalysis is to prepare catalysts that exhibit only specific types of sites required for desired product formation. Here we show that alkanethiolate self-assembled monolayers with varying surface densities can be used to tune selectivity to desired hy...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3448

    authors： Pang SH,Schoenbaum CA,Schwartz DK,Medlin JW

    更新日期：2013-01-01 00:00:00

  • Overcoming evanescent field decay using 3D-tapered nanocavities for on-chip targeted molecular analysis.

    abstract：:Enhancement of optical emission on plasmonic nanostructures is intrinsically limited by the distance between the emitter and nanostructure surface, owing to a tightly-confined and exponentially-decaying electromagnetic field. This fundamental limitation prevents efficient application of plasmonic fluorescence enhancem...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16813-5

    authors： Kumar S,Park H,Cho H,Siddique RH,Narasimhan V,Yang D,Choo H

    更新日期：2020-06-10 00:00:00

  • Quantum Hall states observed in thin films of Dirac semimetal Cd3As2.

    abstract：:A well known semiconductor Cd3As2 has reentered the spotlight due to its unique electronic structure and quantum transport phenomena as a topological Dirac semimetal. For elucidating and controlling its topological quantum state, high-quality Cd3As2 thin films have been highly desired. Here we report the development o...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02423-1

    authors： Uchida M,Nakazawa Y,Nishihaya S,Akiba K,Kriener M,Kozuka Y,Miyake A,Taguchi Y,Tokunaga M,Nagaosa N,Tokura Y,Kawasaki M

    更新日期：2017-12-22 00:00:00

  • Surface plasmon resonance extension through two-block metal-conducting polymer nanorods.

    abstract：:Research on surface plasmon resonance coupling of metallic nanostructures is an important area in the field of plasmonics because distinctive collective optical properties can be realized that are different from the individual constituents. Here we report the localized surface plasmon resonance of hybrid metal-organic...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03453-z

    authors： Jung I,Kim M,Kwak M,Kim G,Jang M,Kim SM,Park DJ,Park S

    更新日期：2018-03-08 00:00:00

  • Hollow organic capsules assemble into cellular semiconductors.

    abstract：:Self-assembly of electroactive molecules is a promising route to new types of functional semiconductors. Here we report a capsule-shaped molecule that assembles itself into a cellular semiconducting material. The interior space of the capsule with a volume of ~415 Å3 is a nanoenvironment that can accommodate a guest. ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04246-0

    authors： Zhang B,Hernández Sánchez R,Zhong Y,Ball M,Terban MW,Paley D,Billinge SJL,Ng F,Steigerwald ML,Nuckolls C

    更新日期：2018-05-16 00:00:00

  • Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine.

    abstract：:Mycobacterium tuberculosis is a pathogen with a unique cell envelope including very long fatty acids, implicated in bacterial resistance and host immune modulation. FasR is a TetR-like transcriptional activator that plays a central role in sensing mycobacterial long-chain fatty acids and regulating lipid biosynthesis....

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17504-x

    authors： Lara J,Diacovich L,Trajtenberg F,Larrieux N,Malchiodi EL,Fernández MM,Gago G,Gramajo H,Buschiazzo A

    更新日期：2020-07-24 00:00:00

  • A programmable epidermal microfluidic valving system for wearable biofluid management and contextual biomarker analysis.

    abstract：:Active biofluid management is central to the realization of wearable bioanalytical platforms that are poised to autonomously provide frequent, real-time, and accurate measures of biomarkers in epidermally-retrievable biofluids (e.g., sweat). Accordingly, here, a programmable epidermal microfluidic valving system is de...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18238-6

    authors： Lin H,Tan J,Zhu J,Lin S,Zhao Y,Yu W,Hojaiji H,Wang B,Yang S,Cheng X,Wang Z,Tang E,Yeung C,Emaminejad S

    更新日期：2020-09-02 00:00:00

  • Negative magnetoresistance without well-defined chirality in the Weyl semimetal TaP.

    abstract：:Weyl semimetals (WSMs) are topological quantum states wherein the electronic bands disperse linearly around pairs of nodes with fixed chirality, the Weyl points. In WSMs, nonorthogonal electric and magnetic fields induce an exotic phenomenon known as the chiral anomaly, resulting in an unconventional negative longitud...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11615

    authors： Arnold F,Shekhar C,Wu SC,Sun Y,Dos Reis RD,Kumar N,Naumann M,Ajeesh MO,Schmidt M,Grushin AG,Bardarson JH,Baenitz M,Sokolov D,Borrmann H,Nicklas M,Felser C,Hassinger E,Yan B

    更新日期：2016-05-17 00:00:00

  • Early-warning signals for Dansgaard-Oeschger events in a high-resolution ice core record.

    abstract：:The Dansgaard-Oeschger (DO) events, as observed in oxygen isotope ratios from the North Greenland Ice Core Project (NGRIP) record, are an outstanding example of past abrupt climate transitions. Their physical cause remains debated, and previous research indicated that they are not preceded by classical early-warning s...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04881-7

    authors： Boers N

    更新日期：2018-07-02 00:00:00

  • Dual loss of human POLQ and LIG4 abolishes random integration.

    abstract：:Homologous recombination-mediated gene targeting has greatly contributed to genetic analysis in a wide range of species, but is highly inefficient in human cells because of overwhelmingly frequent random integration events, whose molecular mechanism remains elusive. Here we show that DNA polymerase θ, despite its mino...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms16112

    authors： Saito S,Maeda R,Adachi N

    更新日期：2017-07-11 00:00:00

  • Tuneable reflexes control antennal positioning in flying hawkmoths.

    abstract：:Complex behaviours may be viewed as sequences of modular actions, each elicited by specific sensory cues in their characteristic timescales. From this perspective, we can construct models in which unitary behavioural modules are hierarchically placed in context of related actions. Here, we analyse antennal positioning...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13595-3

    authors： Natesan D,Saxena N,Ekeberg Ö,Sane SP

    更新日期：2019-12-06 00:00:00

  • Bi- and uniciliated ependymal cells define continuous floor-plate-derived tanycytic territories.

    abstract：:Multiciliated ependymal (E1) cells line the brain ventricles and are essential for brain homeostasis. We previously identified in the lateral ventricles a rare ependymal subpopulation (E2) with only two cilia and unique basal bodies. Here we show that E2 cells form a distinct biciliated epithelium extending along the ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13759

    authors： Mirzadeh Z,Kusne Y,Duran-Moreno M,Cabrales E,Gil-Perotin S,Ortiz C,Chen B,Garcia-Verdugo JM,Sanai N,Alvarez-Buylla A

    更新日期：2017-01-09 00:00:00

  • Size-dependent strong metal-support interaction in TiO2 supported Au nanocatalysts.

    abstract：:The strong metal-support interaction (SMSI) has long been studied in heterogonous catalysis on account of its importance in stabilizing active metals and tuning catalytic performance. As a dynamic process taking place at the metal-support interface, the SMSI is closely related to the metal surface properties which are...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19484-4

    authors： Du X,Huang Y,Pan X,Han B,Su Y,Jiang Q,Li M,Tang H,Li G,Qiao B

    更新日期：2020-11-16 00:00:00

  • The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models.

    abstract：:Arterial networks enlarge in response to increase in tissue metabolism to facilitate flow and nutrient delivery. Typically, the transition of a growing artery with a small diameter into a large caliber artery with a sizeable diameter occurs upon the blood flow driven change in number and shape of endothelial cells lin...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19008-0

    authors： Klems A,van Rijssel J,Ramms AS,Wild R,Hammer J,Merkel M,Derenbach L,Préau L,Hinkel R,Suarez-Martinez I,Schulte-Merker S,Vidal R,Sauer S,Kivelä R,Alitalo K,Kupatt C,van Buul JD,le Noble F

    更新日期：2020-10-21 00:00:00

  • Coexistence of distinct skyrmion phases observed in hybrid ferromagnetic/ferrimagnetic multilayers.

    abstract：:Materials hosting magnetic skyrmions at room temperature could enable compact and energetically-efficient storage such as racetrack memories, where information is coded by the presence/absence of skyrmions forming a moving chain through the device. The skyrmion Hall effect leading to their annihilation at the racetrac...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20025-2

    authors： Mandru AO,Yıldırım O,Tomasello R,Heistracher P,Penedo M,Giordano A,Suess D,Finocchio G,Hug HJ

    更新日期：2020-12-11 00:00:00

  • Reagent-controlled regiodivergent ring expansions of steroids.

    abstract：:Ring expansion provides a powerful way of introducing a heteroatom substituent into a carbocyclic framework. However, such reactions are often limited by the tendency of a given substrate to afford only one of the two rearrangement products or fail to achieve high selectivity at all. These limitations are particularly...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03248-2

    authors： Charaschanya M,Aubé J

    更新日期：2018-03-05 00:00:00

  • Short-term reward experience biases inference despite dissociable neural correlates.

    abstract：:Optimal decision-making employs short-term rewards and abstract long-term information based on which of these is deemed relevant. Employing short- vs. long-term information is associated with different learning mechanisms, yet neural evidence showing that these two are dissociable is lacking. Here we demonstrate that ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01703-0

    authors： Fischer AG,Bourgeois-Gironde S,Ullsperger M

    更新日期：2017-11-22 00:00:00

  • Phosphatidylserine exposure is required for ADAM17 sheddase function.

    abstract：:ADAM17, a prominent member of the 'Disintegrin and Metalloproteinase' (ADAM) family, controls vital cellular functions through cleavage of transmembrane substrates. Here we present evidence that surface exposure of phosphatidylserine (PS) is pivotal for ADAM17 to exert sheddase activity. PS exposure is tightly coupled...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11523

    authors： Sommer A,Kordowski F,Büch J,Maretzky T,Evers A,Andrä J,Düsterhöft S,Michalek M,Lorenzen I,Somasundaram P,Tholey A,Sönnichsen FD,Kunzelmann K,Heinbockel L,Nehls C,Gutsmann T,Grötzinger J,Bhakdi S,Reiss K

    更新日期：2016-05-10 00:00:00

  • Highly efficient oxygen evolution reaction via facile bubble transport realized by three-dimensionally stack-printed catalysts.

    abstract：:Despite highly promising characteristics of three-dimensionally (3D) nanostructured catalysts for the oxygen evolution reaction (OER) in polymer electrolyte membrane water electrolyzers (PEMWEs), universal design rules for maximizing their performance have not been explored. Here we show that woodpile (WP)-structured ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18686-0

    authors： Kim YJ,Lim A,Kim JM,Lim D,Chae KH,Cho EN,Han HJ,Jeon KU,Kim M,Lee GH,Lee GR,Ahn HS,Park HS,Kim H,Kim JY,Jung YS

    更新日期：2020-10-01 00:00:00

  • Noble gases confirm plume-related mantle degassing beneath Southern Africa.

    abstract：:Southern Africa is characterised by unusually elevated topography and abnormal heat flow. This can be explained by thermal perturbation of the mantle, but the origin of this is unclear. Geophysics has not detected a thermal anomaly in the upper mantle and there is no geochemical evidence of an asthenosphere mantle con...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12944-6

    authors： Gilfillan SMV,Györe D,Flude S,Johnson G,Bond CE,Hicks N,Lister R,Jones DG,Kremer Y,Haszeldine RS,Stuart FM

    更新日期：2019-11-05 00:00:00

  • Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction.

    abstract：:Glucagon promotes hepatic gluconeogenesis and maintains whole-body glucose levels during fasting. The regulatory factors that are involved in fasting glucagon response are not well understood. Here we report a role of p52, a key activator of the noncanonical nuclear factor-kappaB signaling, in hepatic glucagon respons...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12351-x

    authors： Zhang WS,Pan A,Zhang X,Ying A,Ma G,Liu BL,Qi LW,Liu Q,Li P

    更新日期：2019-09-20 00:00:00

  • Extreme-ultraviolet high-harmonic generation in liquids.

    abstract：:High-harmonic generation (HHG) in gases has been the main enabling technology of attosecond science since its discovery. Recently, HHG from solids has been demonstrated, opening a lively area of research. In contrast, harmonic generation from liquids has so far remained restricted to low harmonics in the visible regim...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06040-4

    authors： Luu TT,Yin Z,Jain A,Gaumnitz T,Pertot Y,Ma J,Wörner HJ

    更新日期：2018-09-13 00:00:00

  • Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors.

    abstract：:Hydride transfers play a crucial role in a multitude of biological redox reactions and are mediated by flavin, deazaflavin or nicotinamide adenine dinucleotide cofactors at standard redox potentials ranging from 0 to -340 mV. 2-Naphthoyl-CoA reductase, a key enzyme of oxygen-independent bacterial naphthalene degradati...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10078-3

    authors： Willistein M,Bechtel DF,Müller CS,Demmer U,Heimann L,Kayastha K,Schünemann V,Pierik AJ,Ullmann GM,Ermler U,Boll M

    更新日期：2019-05-06 00:00:00

  • The Capsaspora genome reveals a complex unicellular prehistory of animals.

    abstract：:To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. However, only the genome of the choanoflagellate Monosiga brevicollis has been reported to date. Here we completely sequence the genome of the filastere...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3325

    authors： Suga H,Chen Z,de Mendoza A,Sebé-Pedrós A,Brown MW,Kramer E,Carr M,Kerner P,Vervoort M,Sánchez-Pons N,Torruella G,Derelle R,Manning G,Lang BF,Russ C,Haas BJ,Roger AJ,Nusbaum C,Ruiz-Trillo I

    更新日期：2013-01-01 00:00:00

  • Imaging and controlling plasmonic interference fields at buried interfaces.

    abstract：:Capturing and controlling plasmons at buried interfaces with nanometre and femtosecond resolution has yet to be achieved and is critical for next generation plasmonic devices. Here we use light to excite plasmonic interference patterns at a buried metal-dielectric interface in a nanostructured thin film. Plasmons are ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13156

    authors： Lummen TTA,Lamb RJ,Berruto G,LaGrange T,Dal Negro L,García de Abajo FJ,McGrouther D,Barwick B,Carbone F

    更新日期：2016-10-11 00:00:00

  • Field-programmable silicon temporal cloak.

    abstract：:Temporal cloaks have aroused tremendous research interest in both optical physics and optical communications, unfolding a distinct approach to conceal temporal events from an interrogating optical field. The state-of-the-art temporal cloaks exhibit picosecond-scale and static cloaking window, owing to significantly li...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10521-5

    authors： Zhou F,Yan S,Zhou H,Wang X,Qiu H,Dong J,Zhou L,Ding Y,Qiu CW,Zhang X

    更新日期：2019-06-20 00:00:00

  • Disease risk scores for skin cancers.

    abstract：:We trained and validated risk prediction models for the three major types of skin cancer- basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma-on a cross-sectional and longitudinal dataset of 210,000 consented research participants who responded to an online survey covering personal and family histo...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20246-5

    authors： Fontanillas P,Alipanahi B,Furlotte NA,Johnson M,Wilson CH,23andMe Research Team.,Pitts SJ,Gentleman R,Auton A

    更新日期：2021-01-08 00:00:00

  • Patterns of genomic evolution in advanced melanoma.

    abstract：:Genomic alterations occurring during melanoma progression and the resulting genomic heterogeneity between metastatic deposits remain incompletely understood. Analyzing 86 metastatic melanoma deposits from 53 patients with whole-exome sequencing (WES), we show a low branch to trunk mutation ratio and little intermetast...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05063-1

    authors： Birkeland E,Zhang S,Poduval D,Geisler J,Nakken S,Vodak D,Meza-Zepeda LA,Hovig E,Myklebost O,Knappskog S,Lønning PE

    更新日期：2018-07-10 00:00:00