Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum.

abstract：:Circuit reactivations involve a stereotyped sequence of neuronal firing and have been behaviourally linked to memory consolidation. Here we use multiphoton imaging and patch-clamp recording, and observe sparse and stereotyped circuit reactivations that correspond to UP states within active neurons. To evaluate the eff...

journal_title：Nature communications

authors： Kruskal PB,Li L,MacLean JN

更新日期：2013-01-01 00:00:00

abstract：:Schwann cells (SCs) generate the myelin wrapping of peripheral nerve axons and are promising candidates for cell therapy. However, to date a renewable source of SCs is lacking. In this study, we show the conversion of skin fibroblasts into induced Schwann cells (iSCs) by driving the expression of two transcription fac...

journal_title：Nature communications

authors： Mazzara PG,Massimino L,Pellegatta M,Ronchi G,Ricca A,Iannielli A,Giannelli SG,Cursi M,Cancellieri C,Sessa A,Del Carro U,Quattrini A,Geuna S,Gritti A,Taveggia C,Broccoli V

更新日期：2017-02-07 00:00:00

abstract：:Genetic factors and mechanisms underlying food allergy are largely unknown. Due to heterogeneity of symptoms a reliable diagnosis is often difficult to make. Here, we report a genome-wide association study on food allergy diagnosed by oral food challenge in 497 cases and 2387 controls. We identify five loci at genome-...

journal_title：Nature communications

authors： Marenholz I,Grosche S,Kalb B,Rüschendorf F,Blümchen K,Schlags R,Harandi N,Price M,Hansen G,Seidenberg J,Röblitz H,Yürek S,Tschirner S,Hong X,Wang X,Homuth G,Schmidt CO,Nöthen MM,Hübner N,Niggemann B,Beyer K,Lee

更新日期：2017-10-20 00:00:00

abstract：:Preterm birth places infants in an adverse environment that leads to abnormal brain development and cerebral injury through a poorly understood mechanism known to involve neuroinflammation. In this study, we integrate human and mouse molecular and neuroimaging data to investigate the role of microglia in preterm white...

journal_title：Nature communications

authors： Krishnan ML,Van Steenwinckel J,Schang AL,Yan J,Arnadottir J,Le Charpentier T,Csaba Z,Dournaud P,Cipriani S,Auvynet C,Titomanlio L,Pansiot J,Ball G,Boardman JP,Walley AJ,Saxena A,Mirza G,Fleiss B,Edwards AD,Petretto

更新日期：2017-09-05 00:00:00

abstract：:Efficient crop improvement depends on the application of accurate genetic information contained in diverse germplasm resources. Here we report a reference-grade genome of wild soybean accession W05, with a final assembled genome size of 1013.2 Mb and a contig N50 of 3.3 Mb. The analytical power of the W05 genome is de...

journal_title：Nature communications

authors： Xie M,Chung CY,Li MW,Wong FL,Wang X,Liu A,Wang Z,Leung AK,Wong TH,Tong SW,Xiao Z,Fan K,Ng MS,Qi X,Yang L,Deng T,He L,Chen L,Fu A,Ding Q,He J,Chung G,Isobe S,Tanabata T,Valliyodan B,Nguyen HT,Cannon SB

更新日期：2019-03-14 00:00:00

abstract：:In genome editing with CRISPR-Cas9, transgene integration often remains challenging. Here, we present an approach for increasing the efficiency of transgene integration by homology-dependent repair (HDR). CtIP, a key protein in early steps of homologous recombination, is fused to Cas9 and stimulates transgene integrat...

journal_title：Nature communications

authors： Charpentier M,Khedher AHY,Menoret S,Brion A,Lamribet K,Dardillac E,Boix C,Perrouault L,Tesson L,Geny S,De Cian A,Itier JM,Anegon I,Lopez B,Giovannangeli C,Concordet JP

更新日期：2018-03-19 00:00:00

abstract：:The ontogeny of haematopoietic niches in vertebrates is essentially unknown. Here we show that the stromal cells of the caudal haematopoietic tissue (CHT), the first niche where definitive haematopoietic stem/progenitor cells (HSPCs) home in zebrafish development, derive from the caudal somites through an epithelial-m...

journal_title：Nature communications

authors： Murayama E,Sarris M,Redd M,Le Guyader D,Vivier C,Horsley W,Trede N,Herbomel P

更新日期：2015-09-28 00:00:00

abstract：:There has been much research on renewable energy-harvesting techniques. However, owing to increasing energy demands, significant energy-related issues remain to be solved. Efforts aimed at reducing the amount of energy loss in electric/electronic systems are essential for reducing energy consumption and protecting the...

journal_title：Nature communications

authors： Kim T,Yong H,Kim B,Kim D,Choi D,Park YT,Lee S

更新日期：2018-04-12 00:00:00

abstract：:Synthetic biology tools, such as modular parts and combinatorial DNA assembly, are routinely used to optimise the productivity of heterologous metabolic pathways for biosynthesis or substrate utilisation, yet it is well established that host strain background is just as important for determining productivity. Here we ...

journal_title：Nature communications

authors： Blount BA,Gowers GF,Ho JCH,Ledesma-Amaro R,Jovicevic D,McKiernan RM,Xie ZX,Li BZ,Yuan YJ,Ellis T

更新日期：2018-05-22 00:00:00

abstract：:Spinal motor neurons (MNs) control diverse motor tasks including respiration, posture and locomotion that are disrupted by neurodegenerative diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy. Methods directing MN differentiation from stem cells have been developed to enable disease modelling i...

journal_title：Nature communications

authors： Adams KL,Rousso DL,Umbach JA,Novitch BG

更新日期：2015-04-14 00:00:00

abstract：:Antibodies conjugated to bioactive compounds allow targeted delivery of therapeutics to cell types of choice based on that antibody's specificity. Here we develop a new type of conjugate that consists of a nanobody and a peptidic ligand for a G protein-coupled receptor (GPCR), fused via their C-termini. We address act...

journal_title：Nature communications

authors： Cheloha RW,Fischer FA,Woodham AW,Daley E,Suminski N,Gardella TJ,Ploegh HL

更新日期：2020-04-29 00:00:00

abstract：:The importance of the tumor-associated stroma in cancer progression is clear. However, it remains uncertain whether early events in the stroma are capable of initiating breast tumorigenesis. Here, we show that in the mammary glands of non-tumor bearing mice, stromal-specific phosphatase and tensin homolog (Pten) delet...

journal_title：Nature communications

authors： Sizemore GM,Balakrishnan S,Thies KA,Hammer AM,Sizemore ST,Trimboli AJ,Cuitiño MC,Steck SA,Tozbikian G,Kladney RD,Shinde N,Das M,Park D,Majumder S,Krishnan S,Yu L,Fernandez SA,Chakravarti A,Shields PG,White JR,Yee

更新日期：2018-07-17 00:00:00

abstract：:Understanding nanoscale thermal transport is of substantial importance for designing contemporary semiconductor technologies. Heat removal from small sources is well established to be severely impeded compared to diffusive predictions due to the ballistic nature of the dominant heat carriers. Experimental observations...

journal_title：Nature communications

authors： Ziabari A,Torres P,Vermeersch B,Xuan Y,Cartoixà X,Torelló A,Bahk JH,Koh YR,Parsa M,Ye PD,Alvarez FX,Shakouri A

更新日期：2018-01-17 00:00:00

abstract：:Cellular events that occur across the seminiferous epithelium in the mammalian testis during spermatogenesis are tightly coordinated by biologically active peptides released from laminin chains. Laminin-γ3 domain IV is released at the apical ectoplasmic specialization during spermiation and mediates restructuring of t...

journal_title：Nature communications

authors： Su L,Mruk DD,Lie PP,Silvestrini B,Cheng CY

更新日期：2012-01-01 00:00:00

abstract：:The Nuclear Pore Complex (NPC) has emerged as an important hub for processing various types of DNA damage. Here, we uncover that fusing a DNA binding domain to the NPC basket protein Nup1 reduces telomere relocalization to nuclear pores early after telomerase inactivation. This Nup1 modification also impairs the reloc...

journal_title：Nature communications

authors： Aguilera P,Whalen J,Minguet C,Churikov D,Freudenreich C,Simon MN,Géli V

更新日期：2020-01-09 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Ma X,Liang H,Cui X,Liu Y,Lu H,Ning W,Poon NY,Ho B,Zhou K

更新日期：2019-08-21 00:00:00

abstract：:During morphogenesis, remodelling of cell shape requires the expansion or contraction of plasma membrane domains. Here we identify a mechanism underlying the restructuring of the apical surface during epithelial morphogenesis in Drosophila. We show that the retraction of villous protrusions and subsequent apical plasm...

journal_title：Nature communications

authors： Fabrowski P,Necakov AS,Mumbauer S,Loeser E,Reversi A,Streichan S,Briggs JA,De Renzis S

更新日期：2013-01-01 00:00:00

abstract：:Approximately 30% of ERα breast cancer patients relapse with metastatic disease following adjuvant endocrine therapies. The connection between acquisition of drug resistance and invasive potential is poorly understood. In this study, we demonstrate that the type II keratin topological associating domain undergoes epig...

journal_title：Nature communications

authors： Perone Y,Farrugia AJ,Rodríguez-Meira A,Győrffy B,Ion C,Uggetti A,Chronopoulos A,Marrazzo P,Faronato M,Shousha S,Davies C,Steel JH,Patel N,Del Rio Hernandez A,Coombes C,Pruneri G,Lim A,Calvo F,Magnani L

更新日期：2019-05-09 00:00:00

abstract：:Remarkable breakthroughs have established the functionality of graphene and carbon nanotube transistors as replacements to silicon in conventional computing structures, and numerous spintronic logic gates have been presented. However, an efficient cascaded logic structure that exploits electron spin has not yet been d...

journal_title：Nature communications

authors： Friedman JS,Girdhar A,Gelfand RM,Memik G,Mohseni H,Taflove A,Wessels BW,Leburton JP,Sahakian AV

更新日期：2017-06-05 00:00:00

abstract：:Enhancers are DNA sequences that enable complex temporal and tissue-specific regulation of genes in higher eukaryotes. Although it is not entirely clear how enhancer-promoter interactions can increase gene expression, this proximity has been observed in multiple systems at multiple loci and is thought to be essential ...

journal_title：Nature communications

authors： Crump NT,Ballabio E,Godfrey L,Thorne R,Repapi E,Kerry J,Tapia M,Hua P,Lagerholm C,Filippakopoulos P,Davies JOJ,Milne TA

更新日期：2021-01-11 00:00:00

abstract：:Lungs resected for adenocarcinomas often harbour minute discrete foci of cytologically atypical pneumocyte proliferations designated as atypical adenomatous hyperplasia (AAH). Evidence suggests that AAH represents an initial step in the progression to adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MI...

journal_title：Nature communications

authors： Izumchenko E,Chang X,Brait M,Fertig E,Kagohara LT,Bedi A,Marchionni L,Agrawal N,Ravi R,Jones S,Hoque MO,Westra WH,Sidransky D

更新日期：2015-09-16 00:00:00

abstract：:Cold- and β3-adrenoceptor agonist-induced sympathetic activation leads to angiogenesis and UCP1-dependent thermogenesis in mouse brown and white adipose tissues. Here we show that endothelial production of PDGF-CC during white adipose tissue (WAT) angiogenesis regulates WAT browning. We find that genetic deletion of e...

journal_title：Nature communications

authors： Seki T,Hosaka K,Lim S,Fischer C,Honek J,Yang Y,Andersson P,Nakamura M,Näslund E,Ylä-Herttuala S,Sun M,Iwamoto H,Li X,Liu Y,Samani NJ,Cao Y

更新日期：2016-08-05 00:00:00

abstract：:Alkenes are fundamental functionalities in nature and highly useful intermediates in organic synthesis, medicinal chemistry and material sciences. Transition-metal-catalyzed Heck couplings with organic halides as electrophiles have been established as a powerful protocol for the synthesis of this valuable building blo...

journal_title：Nature communications

authors： Lv L,Zhu D,Li CJ

更新日期：2019-02-12 00:00:00

abstract：:Epigenetic control of enhancers alters neuronal functions and may be involved in Alzheimer's disease (AD). Here, we identify enhancers in neurons contributing to AD by comprehensive fine-mapping of DNA methylation at enhancers, genome-wide. We examine 1.2 million CpG and CpH sites in enhancers in prefrontal cortex neu...

journal_title：Nature communications

authors： Li P,Marshall L,Oh G,Jakubowski JL,Groot D,He Y,Wang T,Petronis A,Labrie V

更新日期：2019-05-21 00:00:00

abstract：:Cosmic rays interact with the Earth's atmosphere to produce 14C, which can be absorbed by trees. Therefore, rapid increases of 14C in tree rings can be used to probe previous cosmic-ray events. By this method, three 14C rapidly increasing events have been found. Plausible causes of these events include large solar pro...

journal_title：Nature communications

authors： Wang FY,Yu H,Zou YC,Dai ZG,Cheng KS

更新日期：2017-11-14 00:00:00

abstract：:Cancer persister cells tolerate anticancer drugs and serve as the founders of acquired resistance and cancer relapse. Here we show that a subpopulation of BRAFV600 mutant melanoma cells that tolerates exposure to BRAF and MEK inhibitors undergoes a reversible remodelling of mRNA translation that evolves in parallel wi...

journal_title：Nature communications

authors： Shen S,Faouzi S,Bastide A,Martineau S,Malka-Mahieu H,Fu Y,Sun X,Mateus C,Routier E,Roy S,Desaubry L,André F,Eggermont A,David A,Scoazec JY,Vagner S,Robert C

更新日期：2019-12-16 00:00:00

abstract：:Post-transcriptional RNA modifications play a critical role in the pathogenesis of human mitochondrial disorders, but the mechanisms by which specific modifications affect mitochondrial protein synthesis remain poorly understood. Here we used a quantitative RNA sequencing approach to investigate, at nucleotide resolut...

journal_title：Nature communications

authors： Richter U,Evans ME,Clark WC,Marttinen P,Shoubridge EA,Suomalainen A,Wredenberg A,Wedell A,Pan T,Battersby BJ

更新日期：2018-09-27 00:00:00

abstract：:The NASA MErcury Surface, Space ENvironment, GEochemistry and Ranging (MESSENGER) spacecraft entered orbital phase around Mercury on 18 March 2011. A surprising consistent feature in the data returned is large-scale vortices that form exclusively on the dusk side of the magnetosphere. Here we present global kinetic hy...

journal_title：Nature communications

authors： Paral J,Rankin R

更新日期：2013-01-01 00:00:00

abstract：:Nonbiaryl N-C atropisomer is an important structural scaffold, which is present in natural products, medicines and chiral ligands. However the direct enantioselective C-H amination to access optically pure N-C atropisomer is still difficult and rare. Here we report a π-π interaction and dual H-bond concerted control s...

journal_title：Nature communications

authors： Bai HY,Tan FX,Liu TQ,Zhu GD,Tian JM,Ding TM,Chen ZM,Zhang SY

更新日期：2019-07-11 00:00:00

abstract：:Polycyclic aromatic hydrocarbons as well as other organic molecules appear among the most abundant observed species in interstellar space and are key molecules to understanding the prebiotic roots of life. However, their existence and abundance in space remain a puzzle. Here we present a new top-down route to form pol...

journal_title：Nature communications

authors： Merino P,Švec M,Martinez JI,Jelinek P,Lacovig P,Dalmiglio M,Lizzit S,Soukiassian P,Cernicharo J,Martin-Gago JA

更新日期：2014-01-01 00:00:00