Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens.

abstract：:Ultrafast photoinduced electron transfer preceding energy equilibration still poses many experimental and conceptual challenges to the optimization of photoconversion since an atomic-scale description has so far been beyond reach. Here we combine femtosecond transient optical absorption spectroscopy with ultrafast X-r...

journal_title：Nature communications

authors： Canton SE,Kjær KS,Vankó G,van Driel TB,Adachi S,Bordage A,Bressler C,Chabera P,Christensen M,Dohn AO,Galler A,Gawelda W,Gosztola D,Haldrup K,Harlang T,Liu Y,Møller KB,Németh Z,Nozawa S,Pápai M,Sato T,Sato T,Su

更新日期：2015-03-02 00:00:00

abstract：:Free-electron lasers providing ultra-short high-brightness pulses of X-ray radiation have great potential for a wide impact on science, and are a critical element for unravelling the structural dynamics of matter. To fully harness this potential, we must accurately know the X-ray properties: intensity, spectrum and te...

journal_title：Nature communications

authors： Sanchez-Gonzalez A,Micaelli P,Olivier C,Barillot TR,Ilchen M,Lutman AA,Marinelli A,Maxwell T,Achner A,Agåker M,Berrah N,Bostedt C,Bozek JD,Buck J,Bucksbaum PH,Montero SC,Cooper B,Cryan JP,Dong M,Feifel R,Frasinski

更新日期：2017-06-05 00:00:00

abstract：:Plasmacytoid dendritic cells (pDC) are type I interferon-producing cells with critical functions in a number of human illnesses; however, their molecular regulation is incompletely understood. Here we show the role of Src family kinases (SFK) in mouse and human pDCs. pDCs express Fyn and Lyn and their activating resid...

journal_title：Nature communications

authors： Dallari S,Macal M,Loureiro ME,Jo Y,Swanson L,Hesser C,Ghosh P,Zuniga EI

更新日期：2017-04-03 00:00:00

abstract：:Charge/discharge of lithium-ion battery cathode material LiFePO4 is mediated by the structure and properties of the interface between delithiated and lithiated phases. Direct observations of the interface in a partially delithiated single crystal as a function of time using scanning transmission electron microscopy an...

journal_title：Nature communications

authors： Kobayashi S,Kuwabara A,Fisher CAJ,Ukyo Y,Ikuhara Y

更新日期：2018-07-20 00:00:00

abstract：:Spinal cord injury (SCI) often causes severe and permanent disabilities due to the regenerative failure of severed axons. Here we report significant locomotor recovery of both hindlimbs after a complete spinal cord crush. This is achieved by the unilateral transduction of cortical motoneurons with an AAV expressing hy...

journal_title：Nature communications

authors： Leibinger M,Zeitler C,Gobrecht P,Andreadaki A,Gisselmann G,Fischer D

更新日期：2021-01-15 00:00:00

abstract：:Fusion proteins containing blue-light-activable protein domains possess great potential as molecular switches in cell signalling. This has recently been impressively demonstrated by connecting the light oxygen voltage LOV2-Jα-protein domain of A. sativa (AsLOV2-Jα) with the Rac1-GTPase, responsible for regulating the ...

journal_title：Nature communications

authors： Peter E,Dick B,Baeurle SA

更新日期：2010-11-16 00:00:00

abstract：:Knowledge of cell type composition in disease relevant tissues is an important step towards the identification of cellular targets of disease. We present MuSiC, a method that utilizes cell-type specific gene expression from single-cell RNA sequencing (RNA-seq) data to characterize cell type compositions from bulk RNA-...

journal_title：Nature communications

authors： Wang X,Park J,Susztak K,Zhang NR,Li M

更新日期：2019-01-22 00:00:00

abstract：:Epigenomic data sets provide critical information about the dynamic role of chromatin states in gene regulation, but a key question of how chromatin state segmentations vary under different conditions across the genome has remained unaddressed. Here we present ChromDiff, a group-wise chromatin state comparison method ...

journal_title：Nature communications

authors： Yen A,Kellis M

更新日期：2015-08-18 00:00:00

abstract：:The development of atomic-scale structures revealing novel transport phenomena is a major goal of nanotechnology. Examples include chains of atoms that form while stretching a transition metal contact or the predicted formation of magnetic order in these chains, the existence of which is still debated. Here we report ...

journal_title：Nature communications

authors： Strigl F,Espy C,Bückle M,Scheer E,Pietsch T

更新日期：2015-02-04 00:00:00

abstract：:Tropical south-western Pacific temperatures are of vital importance to the Great Barrier Reef (GBR), but the role of sea surface temperatures (SSTs) in the growth of the GBR since the Last Glacial Maximum remains largely unknown. Here we present records of Sr/Ca and δ(18)O for Last Glacial Maximum and deglacial corals...

journal_title：Nature communications

authors： Felis T,McGregor HV,Linsley BK,Tudhope AW,Gagan MK,Suzuki A,Inoue M,Thomas AL,Esat TM,Thompson WG,Tiwari M,Potts DC,Mudelsee M,Yokoyama Y,Webster JM

更新日期：2014-06-17 00:00:00

abstract：:Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1R) mediate distinct cellular and physiological functions. Here, we demonstrate how domain differences between IR and IGF1R contribute to the distinct functions of these receptors using chimeric and site-mutated receptors. Receptors with t...

journal_title：Nature communications

authors： Cai W,Sakaguchi M,Kleinridders A,Gonzalez-Del Pino G,Dreyfuss JM,O'Neill BT,Ramirez AK,Pan H,Winnay JN,Boucher J,Eck MJ,Kahn CR

更新日期：2017-03-27 00:00:00

abstract：:Acute myeloid leukaemia (AML) affects children and adults of all ages. AML remains one of the major causes of death in children with cancer and for children with AML relapse is the most common cause of death. Here, by modelling AML in vivo we demonstrate that AML is discriminated by the age of the cell of origin. Youn...

journal_title：Nature communications

authors： Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K

更新日期：2018-12-11 00:00:00

abstract：:While main group elements have four valence orbitals accessible for bonding, quadruple bonding to main group elements is extremely rare. Here we report that main group element boron is able to form quadruple bonding interactions with iron in the BFe(CO)3- anion complex, which has been revealed by quantum chemical inve...

journal_title：Nature communications

authors： Chi C,Wang JQ,Hu HS,Zhang YY,Li WL,Meng L,Luo M,Zhou M,Li J

更新日期：2019-10-17 00:00:00

abstract：:Activation of innate immunity by membrane-localized receptors is conserved across eukaryotes. Plant genomes contain hundreds of such receptor-like genes and those encoding proteins with an extracellular leucine-rich repeat (LRR) domain represent the largest family. Here, we develop a high-throughput approach to study ...

journal_title：Nature communications

authors： Wang Y,Xu Y,Sun Y,Wang H,Qi J,Wan B,Ye W,Lin Y,Shao Y,Dong S,Tyler BM,Wang Y

更新日期：2018-02-09 00:00:00

abstract：:Tornadoes cause loss of life and damage to property each year in the United States and around the world. The largest impacts come from 'outbreaks' consisting of multiple tornadoes closely spaced in time. Here we find an upward trend in the annual mean number of tornadoes per US tornado outbreak for the period 1954-201...

journal_title：Nature communications

authors： Tippett MK,Cohen JE

更新日期：2016-02-29 00:00:00

abstract：:Networks of natural protein nanofibrils, such as cytoskeletal filaments, control the shape and the division of cells, yet mimicking this functionality in a synthetic setting has proved challenging. Here, we demonstrate that artificial networks of protein nanofibrils can induce controlled deformation and division of al...

journal_title：Nature communications

authors： Song Y,Michaels TCT,Ma Q,Liu Z,Yuan H,Takayama S,Knowles TPJ,Shum HC

更新日期：2018-05-29 00:00:00

abstract：:Accumulating evidence suggests that transcriptional regulation is required for maintenance of long-term memories (LTMs). Here we characterize global transcriptional and epigenetic changes that occur during LTM storage in the Drosophila mushroom bodies (MBs), structures important for memory. Although LTM formation requ...

journal_title：Nature communications

authors： Hirano Y,Ihara K,Masuda T,Yamamoto T,Iwata I,Takahashi A,Awata H,Nakamura N,Takakura M,Suzuki Y,Horiuchi J,Okuno H,Saitoe M

更新日期：2016-11-14 00:00:00

abstract：:Muscle-resident PDGFRβ(+) cells, which include pericytes and PW1(+) interstitial cells (PICs), play a dual role in muscular dystrophy. They can either undergo myogenesis to promote muscle regeneration or differentiate into adipocytes and other cells to compromise regeneration. How the differentiation and fate determin...

journal_title：Nature communications

authors： Yao Y,Norris EH,Mason CE,Strickland S

更新日期：2016-05-03 00:00:00

abstract：:Maintaining DNA integrity is vital for all cells and organisms. Defective DNA repair may contribute to neurological disorders, including Alzheimer's disease (AD). We found reduced levels of BRCA1, but not of other DNA repair factors, in the brains of AD patients and human amyloid precursor protein (hAPP) transgenic mi...

journal_title：Nature communications

authors： Suberbielle E,Djukic B,Evans M,Kim DH,Taneja P,Wang X,Finucane M,Knox J,Ho K,Devidze N,Masliah E,Mucke L

更新日期：2015-11-30 00:00:00

abstract：:The antiquity and global abundance of the enzyme, RuBisCO, attests to the crucial and longstanding role it has played in the biogeochemical cycles of Earth over billions of years. The counterproductive oxygenase activity of RuBisCO has persisted over billions of years of evolution, despite its competition with the car...

journal_title：Nature communications

authors： Shih PM,Occhialini A,Cameron JC,Andralojc PJ,Parry MA,Kerfeld CA

更新日期：2016-01-21 00:00:00

abstract：:Metal-support interaction is of great significance for catalysis as it can induce charge transfer between metal and support, tame electronic structure of supported metals, impact adsorption energy of reaction intermediates, and eventually change the catalytic performance. Here, we report the metal size-dependent charg...

journal_title：Nature communications

authors： Yan QQ,Wu DX,Chu SQ,Chen ZQ,Lin Y,Chen MX,Zhang J,Wu XJ,Liang HW

更新日期：2019-10-31 00:00:00

abstract：:In carrier multiplication, the absorption of a single photon results in two or more electron-hole pairs. Quantum dots are promising materials for implementing carrier multiplication principles in real-life technologies. So far, however, most of research in this area has focused on optical studies of solution samples w...

journal_title：Nature communications

authors： Gao J,Fidler AF,Klimov VI

更新日期：2015-09-08 00:00:00

abstract：:Crosstalk between liver and skeletal muscle is vital for glucose homeostasis. Hepatokines, liver-derived proteins that play an important role in regulating muscle metabolism, are important to this communication. Here we identify apolipoprotein J (ApoJ) as a novel hepatokine targeting muscle glucose metabolism and insu...

journal_title：Nature communications

authors： Seo JA,Kang MC,Yang WM,Hwang WM,Kim SS,Hong SH,Heo JI,Vijyakumar A,Pereira de Moura L,Uner A,Huang H,Lee SH,Lima IS,Park KS,Kim MS,Dagon Y,Willnow TE,Aroda V,Ciaraldi TP,Henry RR,Kim YB

更新日期：2020-04-24 00:00:00

abstract：:Symmetry-breaking phase transitions are an example of non-equilibrium processes that require real-time treatment, a major challenge in strongly coupled systems without long-lived quasiparticles. Holographic duality provides such an approach by mapping strongly coupled field theories in D dimensions into weakly coupled...

journal_title：Nature communications

authors： Sonner J,Del Campo A,Zurek WH

更新日期：2015-06-23 00:00:00

abstract：:Glucocorticoids are among the most commonly used anti-inflammatory agents. Despite the enormous efforts in elucidating the glucocorticoid-mediated anti-inflammatory actions, how glucocorticoids tightly control overactive inflammatory response is not fully understood. Here we show that glucocorticoids suppress bacteria...

journal_title：Nature communications

authors： Miyata M,Lee JY,Susuki-Miyata S,Wang WY,Xu H,Kai H,Kobayashi KS,Flavell RA,Li JD

更新日期：2015-01-14 00:00:00

abstract：:The ubiquitin receptors Rad23 and Dsk2 deliver polyubiquitylated substrates to the proteasome for destruction. The C-terminal ubiquitin-associated (UBA) domain of Rad23 functions as a cis-acting stabilization signal that protects this protein from proteasomal degradation. Here, we provide evidence that the C-terminal ...

journal_title：Nature communications

authors： Heinen C,Acs K,Hoogstraten D,Dantuma NP

更新日期：2011-02-08 00:00:00

abstract：:Immunotherapy is emerging as a new pillar of cancer treatment with potential to cure. However, many patients still fail to respond to these therapies. Among the underlying factors, an immunosuppressive tumor microenvironment (TME) plays a major role. Here we show that monocyte-mediated gene delivery of IFNα inhibits l...

journal_title：Nature communications

authors： Escobar G,Barbarossa L,Barbiera G,Norelli M,Genua M,Ranghetti A,Plati T,Camisa B,Brombin C,Cittaro D,Annoni A,Bondanza A,Ostuni R,Gentner B,Naldini L

更新日期：2018-07-24 00:00:00

abstract：:Recent crystal structures of G-protein-coupled receptors (GPCRs) have revealed ordered internal water molecules, raising questions about the functional role of those waters for receptor activation that could not be answered by the static structures. Here, we used molecular dynamics simulations to monitor--at atomic an...

journal_title：Nature communications

authors： Yuan S,Filipek S,Palczewski K,Vogel H

更新日期：2014-09-09 00:00:00

abstract：:Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV...

journal_title：Nature communications

authors： Pérez-Guzmán EX,Pantoja P,Serrano-Collazo C,Hassert MA,Ortiz-Rosa A,Rodríguez IV,Giavedoni L,Hodara V,Parodi L,Cruz L,Arana T,White LJ,Martínez MI,Weiskopf D,Brien JD,de Silva A,Pinto AK,Sariol CA

更新日期：2019-09-20 00:00:00

abstract：:Signalling pathways that control endothelial cell (EC) permeability, leukocyte adhesion and inflammation are pivotal for atherosclerosis initiation and progression. Here we demonstrate that the Sterile-20-like mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), which has been implicated in inflammation, ...

journal_title：Nature communications

authors： Roth Flach RJ,Skoura A,Matevossian A,Danai LV,Zheng W,Cortes C,Bhattacharya SK,Aouadi M,Hagan N,Yawe JC,Vangala P,Menendez LG,Cooper MP,Fitzgibbons TP,Buckbinder L,Czech MP

更新日期：2015-12-21 00:00:00