39Ar dating with small samples provides new key constraints on ocean ventilation.

abstract：:Molecular shape recognition for larger guest molecules (typically over 1 nm) is a difficult task because it requires cooperativity within a wide three-dimensional nanospace coincidentally probing every molecular aspect (size, outline shape, flexibility and specific groups). Although the intelligent functions of protei...

journal_title：Nature communications

authors： Imaoka T,Kawana Y,Kurokawa T,Yamamoto K

更新日期：2013-01-01 00:00:00

abstract：:Researchers strive to produce nanoparticles with complexity in composition and structure. Although traditional spherical, cylindrical and membranous, or planar, nanostructures are ubiquitous, scientists seek more complicated geometries for potential functionality. Here we report the simple solution construction of mul...

journal_title：Nature communications

authors： Zhu J,Zhang S,Zhang K,Wang X,Mays JW,Wooley KL,Pochan DJ

更新日期：2013-01-01 00:00:00

abstract：:Tomography--cross-sectional imaging based on measuring radiation transmitted through an object along different directions--enables non-invasive imaging of hidden stationary objects, such as internal bodily organs, from their sequentially measured projections. Here we adapt tomographic methods to visualize--in one lase...

journal_title：Nature communications

authors： Li Z,Zgadzaj R,Wang X,Chang YY,Downer MC

更新日期：2014-01-01 00:00:00

abstract：:Anthropogenic CO2 emissions are causing ocean acidification, which can affect the physiology of marine organisms. Here we assess the possible effects of ocean acidification on the metabolic potential of sponge symbionts, inferred by metagenomic analyses of the microbiomes of two sponge species sampled at a shallow vol...

journal_title：Nature communications

authors： Botté ES,Nielsen S,Abdul Wahab MA,Webster J,Robbins S,Thomas T,Webster NS

更新日期：2019-09-12 00:00:00

abstract：:One of the primary contributors to forgetting is interference from overlapping memories. Intuitively, this suggests-and prominent theoretical models argue-that memory interference is best avoided by encoding overlapping memories as if they were unrelated. It is therefore surprising that reactivation of older memories ...

journal_title：Nature communications

authors： Chanales AJH,Dudukovic NM,Richter FR,Kuhl BA

更新日期：2019-11-25 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is a notoriously difficult-to-treat cancer and patients are in need of novel therapies. We have shown previously that these tumours have altered metabolic requirements, making them highly reliant on a number of adaptations including a non-canonical glutamine (Gln) metabolic pathway and...

journal_title：Nature communications

authors： Biancur DE,Paulo JA,Małachowska B,Quiles Del Rey M,Sousa CM,Wang X,Sohn ASW,Chu GC,Gygi SP,Harper JW,Fendler W,Mancias JD,Kimmelman AC

更新日期：2017-07-03 00:00:00

abstract：:WNTs are lipid-modified proteins that control multiple functions in development and disease via short- and long-range signaling. However, it is unclear how these hydrophobic molecules spread over long distances in the mammalian brain. Here we show that WNT5A is produced by the choroid plexus (ChP) of the developing hi...

journal_title：Nature communications

authors： Kaiser K,Gyllborg D,Procházka J,Salašová A,Kompaníková P,Molina FL,Laguna-Goya R,Radaszkiewicz T,Harnoš J,Procházková M,Potěšil D,Barker RA,Casado ÁG,Zdráhal Z,Sedláček R,Arenas E,Villaescusa JC,Bryja V

更新日期：2019-04-02 00:00:00

abstract：:Nonribosomal peptide synthetases containing starter condensation domains direct the biosynthesis of nonribosomal lipopeptides, which generally exhibit wide bioactivities. The acyl chain has strong impacts on bioactivity and toxicity, but the lack of an in-depth understanding of starter condensation domain-mediated lip...

journal_title：Nature communications

authors： Zhong L,Diao X,Zhang N,Li F,Zhou H,Chen H,Bai X,Ren X,Zhang Y,Wu D,Bian X

更新日期：2021-01-12 00:00:00

abstract：:Silicon dioxide is one of the most abundant natural compounds. Polymorphs of SiO₂ and their phase transitions have long been a focus of great interest and intense theoretical and experimental pursuits. Here, compressing single-crystal coesite SiO₂ under hydrostatic pressures of 26-53 GPa at room temperature, we discov...

journal_title：Nature communications

authors： Hu QY,Shu JF,Cadien A,Meng Y,Yang WG,Sheng HW,Mao HK

更新日期：2015-03-20 00:00:00

abstract：:The search for two-dimensional quantum spin liquids, exotic magnetic states remaining disordered down to zero temperature, has been a great challenge in frustrated magnetism over the last few decades. Recently, evidence for fractionalized excitations, called spinons, emerging from these states has been observed in kag...

journal_title：Nature communications

authors： Lhotel E,Petit S,Ciomaga Hatnean M,Ollivier J,Mutka H,Ressouche E,Lees MR,Balakrishnan G

更新日期：2018-09-17 00:00:00

abstract：:Single-atom catalysts (SACs) have sparked broad interest recently while the low metal loading poses a big challenge for further applications. Herein, a dual protection strategy has been developed to give high-content SACs by nanocasting SiO2 into porphyrinic metal-organic frameworks (MOFs). The pyrolysis of SiO2@MOF c...

journal_title：Nature communications

authors： Jiao L,Zhang R,Wan G,Yang W,Wan X,Zhou H,Shui J,Yu SH,Jiang HL

更新日期：2020-06-05 00:00:00

abstract：:Biological tissues have the remarkable ability to remodel and repair in response to disease, injury and mechanical stresses. Synthetic materials lack the complexity of biological tissues, and man-made materials that respond to external stresses through a permanent increase in stiffness are uncommon. Here we report tha...

journal_title：Nature communications

authors： Agrawal A,Chipara AC,Shamoo Y,Patra PK,Carey BJ,Ajayan PM,Chapman WG,Verduzco R

更新日期：2013-01-01 00:00:00

abstract：:Three-dimensional topological Dirac semimetals (TDSs) are a new kind of Dirac materials that exhibit linear energy dispersion in the bulk and can be viewed as three-dimensional graphene. It has been proposed that TDSs can be driven to other exotic phases like Weyl semimetals, topological insulators and topological sup...

journal_title：Nature communications

authors： Cao J,Liang S,Zhang C,Liu Y,Huang J,Jin Z,Chen ZG,Wang Z,Wang Q,Zhao J,Li S,Dai X,Zou J,Xia Z,Li L,Xiu F

更新日期：2015-07-13 00:00:00

abstract：:Health risk factors such as body mass index (BMI) and serum cholesterol are associated with many common diseases. It often remains unclear whether the risk factors are cause or consequence of disease, or whether the associations are the result of confounding. We develop and apply a method (called GSMR) that performs a...

journal_title：Nature communications

authors： Zhu Z,Zheng Z,Zhang F,Wu Y,Trzaskowski M,Maier R,Robinson MR,McGrath JJ,Visscher PM,Wray NR,Yang J

更新日期：2018-01-15 00:00:00

abstract：:Recent outbreaks of Zika, chikungunya and dengue highlight the importance of better understanding the spread of disease-carrying mosquitoes across multiple spatio-temporal scales. Traditional surveillance tools are limited by jurisdictional boundaries and cost constraints. Here we show how a scalable citizen science s...

journal_title：Nature communications

authors： Palmer JRB,Oltra A,Collantes F,Delgado JA,Lucientes J,Delacour S,Bengoa M,Eritja R,Bartumeus F

更新日期：2017-10-24 00:00:00

abstract：:The unique properties of ferroelectric materials enable a plethora of applications, which are hindered by the phenomenon known as ferroelectric fatigue that leads to the degradation of ferroelectric properties with polarization cycling. Multiple microscopic models explaining fatigue have been suggested; however, the c...

journal_title：Nature communications

authors： Ievlev AV,Kc S,Vasudevan RK,Kim Y,Lu X,Alexe M,Cooper VR,Kalinin SV,Ovchinnikova OS

更新日期：2019-07-11 00:00:00

abstract：:Zinc-finger nuclease, transcription activator-like effector nuclease and CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9) are becoming major tools for genome editing. Importantly, knock-in in several non-rodent species has been finally achieved thanks to these custo...

journal_title：Nature communications

authors： Song J,Yang D,Xu J,Zhu T,Chen YE,Zhang J

更新日期：2016-01-28 00:00:00

abstract：:Homologous recombination (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold containing protein that binds ssDNA, as a DNA repair factor involved in HR. MCM8IP-deficient cells exhibit HR defects, especially in long-tract gene c...

journal_title：Nature communications

authors： Huang JW,Acharya A,Taglialatela A,Nambiar TS,Cuella-Martin R,Leuzzi G,Hayward SB,Joseph SA,Brunette GJ,Anand R,Soni RK,Clark NL,Bernstein KA,Cejka P,Ciccia A

更新日期：2020-06-11 00:00:00

abstract：:The precise measurement of forces is one way to obtain deep insight into the fundamental interactions present in nature. In the context of neutral antimatter, the gravitational interaction is of high interest, potentially revealing new forces that violate the weak equivalence principle. Here we report on a successful ...

journal_title：Nature communications

authors： Aghion S,Ahlén O,Amsler C,Ariga A,Ariga T,Belov AS,Berggren K,Bonomi G,Bräunig P,Bremer J,Brusa RS,Cabaret L,Canali C,Caravita R,Castelli F,Cerchiari G,Cialdi S,Comparat D,Consolati G,Derking H,Di Domizio S,Di N

更新日期：2014-07-28 00:00:00

abstract：:While the antiandrogen enzalutamide (Enz) extends the castration resistant prostate cancer (CRPC) patients' survival an extra 4.8 months, it might also result in some adverse effects via inducing the neuroendocrine differentiation (NED). Here we found that lncRNA-p21 is highly expressed in the NEPC patients derived xe...

journal_title：Nature communications

authors： Luo J,Wang K,Yeh S,Sun Y,Liang L,Xiao Y,Xu W,Niu Y,Cheng L,Maity SN,Jiang R,Chang C

更新日期：2019-06-12 00:00:00

abstract：:Precise frequency discrimination is a hallmark of auditory function in birds and mammals and is required for distinguishing similar sounding words, like 'bat,' 'cat' and 'hat.' In the cochlea, tuning and spectral separation result from longitudinal differences in basilar membrane stiffness and numerous individual grad...

journal_title：Nature communications

authors： Thiede BR,Mann ZF,Chang W,Ku YC,Son YK,Lovett M,Kelley MW,Corwin JT

更新日期：2014-05-20 00:00:00

abstract：:The indisputable role of epigenetics in cancer and the fact that epigenetic alterations can be reversed have favoured development of epigenetic drugs. In this study, we design and synthesize potent novel, selective and reversible chemical probes that simultaneously inhibit the G9a and DNMTs methyltransferase activity....

journal_title：Nature communications

authors： San José-Enériz E,Agirre X,Rabal O,Vilas-Zornoza A,Sanchez-Arias JA,Miranda E,Ugarte A,Roa S,Paiva B,Estella-Hermoso de Mendoza A,Alvarez RM,Casares N,Segura V,Martín-Subero JI,Ogi FX,Soule P,Santiveri CM,Campos-Olivas

更新日期：2017-05-26 00:00:00

abstract：:Topological nodal line semimetals, a novel quantum state of materials, possess topologically nontrivial valence and conduction bands that touch at a line near the Fermi level. The exotic band structure can lead to various novel properties, such as long-range Coulomb interaction and flat Landau levels. Recently, topolo...

journal_title：Nature communications

authors： Feng B,Fu B,Kasamatsu S,Ito S,Cheng P,Liu CC,Feng Y,Wu S,Mahatha SK,Sheverdyaeva P,Moras P,Arita M,Sugino O,Chiang TC,Shimada K,Miyamoto K,Okuda T,Wu K,Chen L,Yao Y,Matsuda I

更新日期：2017-10-18 00:00:00

abstract：:The rapid development of scientific CMOS (sCMOS) technology has greatly advanced optical microscopy for biomedical research with superior sensitivity, resolution, field-of-view, and frame rates. However, for sCMOS sensors, the parallel charge-voltage conversion and different responsivity at each pixel induces extra re...

journal_title：Nature communications

authors： Mandracchia B,Hua X,Guo C,Son J,Urner T,Jia S

更新日期：2020-01-03 00:00:00

abstract：:Ferroportin is an iron exporter essential for releasing cellular iron into circulation. Ferroportin is inhibited by a peptide hormone, hepcidin. In humans, mutations in ferroportin lead to ferroportin diseases that are often associated with accumulation of iron in macrophages and symptoms of iron deficiency anemia. He...

journal_title：Nature communications

authors： Pan Y,Ren Z,Gao S,Shen J,Wang L,Xu Z,Yu Y,Bachina P,Zhang H,Fan X,Laganowsky A,Yan N,Zhou M

更新日期：2020-11-10 00:00:00

abstract：:During animal cell division, the central spindle, an anti-parallel microtubule bundle structure formed between segregating chromosomes during anaphase, cooperates with astral microtubules to position the cleavage furrow. Because the central spindle is the only structure linking the two halves of the mitotic spindle, i...

journal_title：Nature communications

authors： Lee KY,Esmaeili B,Zealley B,Mishima M

更新日期：2015-06-19 00:00:00

abstract：:Metal oxides with a tunnelled structure are attractive as charge storage materials for rechargeable batteries and supercapacitors, since the tunnels enable fast reversible insertion/extraction of charge carriers (for example, lithium ions). Common synthesis methods can introduce large cations such as potassium, barium...

journal_title：Nature communications

authors： Yuan Y,Zhan C,He K,Chen H,Yao W,Sharifi-Asl S,Song B,Yang Z,Nie A,Luo X,Wang H,Wood SM,Amine K,Islam MS,Lu J,Shahbazian-Yassar R

更新日期：2016-11-21 00:00:00

abstract：:T cells expressing CD19-targeting chimeric antigen receptors (CARs) reveal high efficacy in the treatment of B cell malignancies. Here, we report that T cell receptor fusion constructs (TRuCs) comprising an antibody-based binding domain fused to T cell receptor (TCR) subunits can effectively reprogram an intact TCR co...

journal_title：Nature communications

authors： Baeuerle PA,Ding J,Patel E,Thorausch N,Horton H,Gierut J,Scarfo I,Choudhary R,Kiner O,Krishnamurthy J,Le B,Morath A,Baldeviano GC,Quinn J,Tavares P,Wei Q,Weiler S,Maus MV,Getts D,Schamel WW,Hofmeister R

更新日期：2019-05-07 00:00:00

abstract：:Intracranial aneurysm is a common life-threatening disease. Computed tomography angiography is recommended as the standard diagnosis tool; yet, interpretation can be time-consuming and challenging. We present a specific deep-learning-based model trained on 1,177 digital subtraction angiography verified bone-removal co...

journal_title：Nature communications

authors： Shi Z,Miao C,Schoepf UJ,Savage RH,Dargis DM,Pan C,Chai X,Li XL,Xia S,Zhang X,Gu Y,Zhang Y,Hu B,Xu W,Zhou C,Luo S,Wang H,Mao L,Liang K,Wen L,Zhou L,Yu Y,Lu GM,Zhang LJ

更新日期：2020-11-30 00:00:00

abstract：:To fully exploit the microbial genome resources, a high-throughput experimental platform is needed to associate genes with phenotypes at the genome level. We present here a novel method that enables investigation of the cellular consequences of repressing individual transcripts based on the CRISPR interference (CRISPR...

journal_title：Nature communications

authors： Wang T,Guan C,Guo J,Liu B,Wu Y,Xie Z,Zhang C,Xing XH

更新日期：2018-06-26 00:00:00