Abstract:
:An amendment to this paper has been published and can be accessed via a link at the top of the paper.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Fryirs KA,Brierley GJ,Dixon Tdoi
10.1038/s41467-019-13141-1subject
Has Abstractpub_date
2019-11-08 00:00:00pages
5149issue
1issn
2041-1723pii
10.1038/s41467-019-13141-1journal_volume
10pub_type
已发布勘误abstract::5-Deoxyribose is formed from 5'-deoxyadenosine, a toxic byproduct of radical S-adenosylmethionine (SAM) enzymes. The degradative fate of 5-deoxyribose is unknown. Here, we define a salvage pathway for 5-deoxyribose in bacteria, consisting of phosphorylation, isomerization, and aldol cleavage steps. Analysis of bacteri...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05589-4
更新日期:2018-08-06 00:00:00
abstract::Fas induces apoptosis in activated T cell to maintain immune homeostasis, but the effects of non-apoptotic Fas signaling on T cells remain unclear. Here we show that Fas promotes TH9 cell differentiation by activating NF-κB via Ca2+-dependent PKC-β activation. In addition, PKC-β also phosphorylates p38 to inactivate N...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10889-4
更新日期:2019-07-02 00:00:00
abstract::To balance immunity and tolerance, the endogenous pool of Foxp3+ regulatory T (Treg) cells is tightly controlled, but the underlying mechanisms of this control remain poorly understood. Here we show that the number of Treg cells is negatively regulated by the kinase Lkb1 in dendritic cells (DCs). Conditional knockout ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07545-8
更新日期:2018-12-13 00:00:00
abstract::Oxygen vacancies, especially their distribution, are directly coupled to the electromagnetic properties of oxides and related emergent functionalities that have implications for device applications. Here using a homoepitaxial strontium titanate thin film, we demonstrate a controlled manipulation of the oxygen vacancy ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00710-5
更新日期:2017-09-20 00:00:00
abstract::Solid substrates often induce non-uniform strain and doping in graphene monolayer, therefore altering the intrinsic properties of graphene, reducing its charge carrier mobilities and, consequently, the overall electrical performance. Here, we exploit confocal Raman spectroscopy to study graphene directly free-floating...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14637-x
更新日期:2020-02-14 00:00:00
abstract::Lanthanide compounds show much higher energy barriers to magnetic relaxation than 3d-block compounds, and this has led to speculation that they could be used in molecular spintronic devices. Prototype molecular spin valves and molecular transistors have been reported, with remarkable experiments showing the influence ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6243
更新日期:2014-10-13 00:00:00
abstract::Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01297-7
更新日期:2017-11-03 00:00:00
abstract::Storage of chromatin in restricted nuclear space requires dense packing while ensuring DNA accessibility. Thus, different layers of chromatin organization and epigenetic control mechanisms exist. Genome-wide chromatin interaction maps revealed large interaction domains (TADs) and higher order A and B compartments, ref...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01724-9
更新日期:2017-11-21 00:00:00
abstract::Gas-sensing materials are becoming increasingly important in our society, requiring high sensitivity to differentiate similar gases like N2 and O2. For the design of such materials, the driving force of electronic host-guest interaction or host-framework changes during the sorption process has commonly been considered...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07889-1
更新日期:2018-12-21 00:00:00
abstract::The importance of the tumor-associated stroma in cancer progression is clear. However, it remains uncertain whether early events in the stroma are capable of initiating breast tumorigenesis. Here, we show that in the mammary glands of non-tumor bearing mice, stromal-specific phosphatase and tensin homolog (Pten) delet...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05266-6
更新日期:2018-07-17 00:00:00
abstract::Singlet oxygen has won a great deal of attention to catalysis and biological studies due to its strong oxidizing properties. However, the photosensitizers which require for the generation of singlet oxygen remain inadequate because of their lack of long-wavelength absorption, weak hydrophilicity, and poor biocompatibi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05223-3
更新日期:2018-07-18 00:00:00
abstract::The sigma-2 receptor, whose gene remains to be cloned, has been validated as a biomarker for tumour cell proliferation. Here we report the use of a novel photoaffinity probe, WC-21, to identify the sigma-2 receptor-binding site. WC-21, a sigma-2 ligand containing both a photoactive azide moiety and a fluorescein isoth...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1386
更新日期:2011-07-05 00:00:00
abstract::The original version of this Article contained an error in the author affiliations. Xiaochun Yu was incorrectly associated with College of Life Sciences, Hebei University, Baoding 071000 Hebei, China.This has now been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-08086-w
更新日期:2019-01-08 00:00:00
abstract::Metabolic reprogramming greatly contributes to the regulation of macrophage activation. However, the mechanism of lipid accumulation and the corresponding function in tumor-associated macrophages (TAMs) remain unclear. With primary investigation in colon cancer and confirmation in other cancer models, here we determin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04999-8
更新日期:2018-07-03 00:00:00
abstract::Inorganic perovskites such as CsPbX3 (X=Cl, Br, I) have attracted attention due to their excellent thermal stability and high photoluminescence quantum efficiency. However, the electroluminescence quantum efficiency of their light-emitting diodes was <1%. We posited that this low efficiency was a result of high leakag...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15640
更新日期:2017-06-07 00:00:00
abstract::Despite the maximized metal dispersion offered by single-atom catalysts, further improvement of intrinsic activity can be hindered by the lack of neighboring metal atoms in these systems. Here we report the use of isolated Pt1 atoms on ceria as "seeds" to develop a Pt-O-Pt ensemble, which is well-represented by a Pt8O...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11856-9
更新日期:2019-08-23 00:00:00
abstract::Soil microorganisms dominate terrestrial biogeochemical cycles; however, we know very little about their spatial distribution and how changes in the distributions of specific groups of microbes translate into landscape and global patterns of biogeochemical processes. In this paper, we use a nested sampling scheme at s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1055
更新日期:2010-08-10 00:00:00
abstract::Novel atherosclerosis models are needed to guide clinical therapy. Here, we report an in vitro model of early atherosclerosis by fabricating and perfusing multi-layer arteriole-scale human tissue-engineered blood vessels (TEBVs) by plastic compression. TEBVs maintain mechanical strength, vasoactivity, and nitric oxide...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19197-8
更新日期:2020-10-27 00:00:00
abstract::Malaria is a major public health problem that is actively being addressed in a global eradication campaign. Increased population mobility through international air travel has elevated the risk of re-introducing parasites to elimination areas and dispersing drug-resistant parasites to new regions. A simple genetic mark...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5052
更新日期:2014-06-13 00:00:00
abstract::Acoustic waves, capable of transmitting through optically opaque objects, have been widely used in biomedical imaging, industrial sensing and particle manipulation. High-fidelity wave front shaping is essential to further improve performance in these applications. An acoustic analog to the successful spatial light mod...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18347-2
更新日期:2020-09-10 00:00:00
abstract::The electronic properties of graphene are described by a Dirac Hamiltonian with a four-fold symmetry of spin and valley. This symmetry may yield novel fractional quantum Hall (FQH) states at high magnetic field depending on the relative strength of symmetry-breaking interactions. However, observing such states in tran...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6838
更新日期:2015-01-06 00:00:00
abstract::The leaf economics spectrum (LES) describes consistent correlations among a variety of leaf traits that reflect a gradient from conservative to acquisitive plant strategies. So far, whether the LES holds in wetland plants at a global scale has been unclear. Using data on 365 wetland species from 151 studies, we find t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18354-3
更新日期:2020-09-09 00:00:00
abstract::The insulin/IGF-1 signalling pathway is a key regulator of metabolism and the rate of ageing. We previously documented that systemic inactivation of phosphoinositide 3-kinase (PI3K) p110α, the principal PI3K isoform that positively regulates insulin signalling, results in a beneficial metabolic effect in aged mice. He...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09514-1
更新日期:2019-04-04 00:00:00
abstract::The contrast and sensitivity of in vivo fluorescence imaging has been revolutionized by molecular fluorophores operating in the second near-infrared window (NIR-II; 1000-1700 nm), but an ongoing challenge is the solvatochromism-caused quenching in aqueous solution for the long-wavelength absorbing fluorophores. Herein...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09043-x
更新日期:2019-03-05 00:00:00
abstract::Nervous systems exhibit myriad cell types, but understanding how this diversity arises is hampered by the difficulty to visualize and genetically-probe specific lineages, especially at early developmental stages prior to expression of unique molecular markers. Here, we use a genetic immortalization method to analyze t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08345-4
更新日期:2019-02-07 00:00:00
abstract::Covalent organic frameworks (COFs) have emerged as a promising light-harvesting module for artificial photosynthesis and photovoltaics. For efficient generation of free charge carriers, the donor-acceptor (D-A) conjugation has been adopted for two-dimensional (2D) COFs recently. In the 2D D-A COFs, photoexcitation wou...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09872-w
更新日期:2019-04-23 00:00:00
abstract::There is enormous interest in engineering topological photonic systems. Despite intense activity, most works on topological photonic states (and more generally bosonic states) amount in the end to replicating a well-known fermionic single-particle Hamiltonian. Here we show how the squeezing of light can lead to the fo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10779
更新日期:2016-03-02 00:00:00
abstract::Intrinsic apoptosis is critical to prevent tumor formation and is engaged by many anti-cancer agents to eliminate tumor cells. BAX and BAK, the two essential mediators of apoptosis, are thought to be regulated through similar mechanisms and act redundantly to drive apoptotic cell death. From an unbiased genome-wide CR...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07309-4
更新日期:2018-11-26 00:00:00
abstract::Chemical modifications on DNA molecules, such as 5-methylcytosine and 5-hydroxymethylcytosine, play important roles in the mammalian brain. A novel DNA adenine modification, N(6)-methyladenine (6mA), has recently been found in mammalian cells. However, the presence and function(s) of 6mA in the mammalian brain remain ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01195-y
更新日期:2017-10-24 00:00:00
abstract::Quasi-two-dimensional perovskites have emerged as a new material platform for optoelectronics on account of its intrinsic stability. A major bottleneck to device performance is the high charge injection barrier caused by organic molecular layers on its basal plane, thus the best performing device currently relies on e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19331-6
更新日期:2020-10-30 00:00:00