Spatial ultrasound modulation by digitally controlling microbubble arrays.

abstract：:Base editing tools with diversified editing scopes and minimized RNA off-target activities are required for broad applications. Nevertheless, current Streptococcus pyogenes Cas9 (SpCas9)-based adenine base editors (ABEs) with minimized RNA off-target activities display constrained editing scopes with efficient editing...

journal_title：Nature communications

authors： Li S,Yuan B,Cao J,Chen J,Chen J,Qiu J,Zhao XM,Wang X,Qiu Z,Cheng TL

更新日期：2020-11-17 00:00:00

abstract：:Amyloid supramolecular assemblies have found widespread exploitation as ordered nanomaterials in a range of applications from materials science to biotechnology. New strategies are, however, required for understanding and promoting mature fibril formation from simple monomer motifs through easy and scalable processes....

journal_title：Nature communications

authors： Bertolani A,Pirrie L,Stefan L,Houbenov N,Haataja JS,Catalano L,Terraneo G,Giancane G,Valli L,Milani R,Ikkala O,Resnati G,Metrangolo P

更新日期：2015-06-30 00:00:00

abstract：:Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative syndromes linked to deficiencies in the DNA-damage response. The role of ATM as a key regulator of signalling following DNA double-strand breaks (DSBs) has been dissected in extraordinary detai...

journal_title：Nature communications

authors： Álvarez-Quilón A,Serrano-Benítez A,Lieberman JA,Quintero C,Sánchez-Gutiérrez D,Escudero LM,Cortés-Ledesma F

更新日期：2014-02-27 00:00:00

abstract：:Coordination between osteoblasts and osteoclasts is required for bone health and homeostasis. Here we show that mice deficient in SMURF2 have severe osteoporosis in vivo. This low bone mass phenotype is accompanied by a pronounced increase in osteoclast numbers, although Smurf2-deficient osteoclasts have no intrinsic ...

journal_title：Nature communications

authors： Xu Z,Greenblatt MB,Yan G,Feng H,Sun J,Lotinun S,Brady N,Baron R,Glimcher LH,Zou W

更新日期：2017-02-20 00:00:00

abstract：:Antibiotic biosynthetic gene clusters (BGCs) produce bioactive metabolites that impart a fitness advantage to their producer, providing a mechanism for natural selection. This selection drives antibiotic evolution and adapts BGCs for expression in different organisms, potentially providing clues to improve heterologou...

journal_title：Nature communications

authors： Johnston CW,Badran AH,Collins JJ

更新日期：2020-08-21 00:00:00

abstract：:Gut microbiota composition influences the clinical benefit of immune checkpoints in patients with advanced cancer but mechanisms underlying this relationship remain unclear. Molecular mechanism whereby gut microbiota influences immune responses is mainly assigned to gut microbial metabolites. Short-chain fatty acids (...

journal_title：Nature communications

authors： Coutzac C,Jouniaux JM,Paci A,Schmidt J,Mallardo D,Seck A,Asvatourian V,Cassard L,Saulnier P,Lacroix L,Woerther PL,Vozy A,Naigeon M,Nebot-Bral L,Desbois M,Simeone E,Mateus C,Boselli L,Grivel J,Soularue E,Lepage P,

更新日期：2020-05-01 00:00:00

abstract：:Conventional interferometers usually utilize beam splitters for wave splitting and recombination. These interferometers are widely used for precision measurement. Their sensitivity for phase measurement is limited by the shot noise, which can be suppressed with squeezed states of light. Here we study a new type of int...

journal_title：Nature communications

authors： Hudelist F,Kong J,Liu C,Jing J,Ou ZY,Zhang W

更新日期：2014-01-01 00:00:00

abstract：:The diversity reflected by >100 different neural cell types fundamentally contributes to brain function and a central idea is that neuronal identity can be inferred from genetic information. Recent large-scale transcriptomic assays seem to confirm this hypothesis, but a lack of morphological information has limited th...

journal_title：Nature communications

authors： Que L,Lukacsovich D,Luo W,Földy C

更新日期：2021-01-04 00:00:00

abstract：:The space charge layer (SCL) is generally considered one of the origins of the sluggish interfacial lithium-ion transport in all-solid-state lithium-ion batteries (ASSLIBs). However, in-situ visualization of the SCL effect on the interfacial lithium-ion transport in sulfide-based ASSLIBs is still a great challenge. He...

journal_title：Nature communications

authors： Wang L,Xie R,Chen B,Yu X,Ma J,Li C,Hu Z,Sun X,Xu C,Dong S,Chan TS,Luo J,Cui G,Chen L

更新日期：2020-11-18 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome that elevates the risk of hepatocellular carcinoma (HCC). Although alteration of lipid metabolism has been increasingly recognized as a hallmark of cancer cells, the deregulated metabolic modulation of HCC cells in the NAF...

journal_title：Nature communications

authors： Tian Y,Yang B,Qiu W,Hao Y,Zhang Z,Yang B,Li N,Cheng S,Lin Z,Rui YC,Cheung OKW,Yang W,Wu WKK,Cheung YS,Lai PBS,Luo J,Sung JJY,Chen R,Wang HY,Cheng ASL,Yang P

更新日期：2019-07-29 00:00:00

abstract：:The phase diagram of BaPb(1-x)Bi(x)O3 exhibits a superconducting dome in the proximity of a charge density wave phase. For the superconducting compositions, the material coexists as two structural polymorphs. Here we show, via high-resolution transmission electron microscopy, that the structural dimorphism is accommod...

journal_title：Nature communications

authors： Giraldo-Gallo P,Zhang Y,Parra C,Manoharan HC,Beasley MR,Geballe TH,Kramer MJ,Fisher IR

更新日期：2015-09-16 00:00:00

abstract：:Thanks to the nature of strong programmability, field-programmable gate arrays (FPGAs) have been playing a significant role in signal processing and control. With the explosive growth in digital data, big data analytics becomes an important emerging field, in which FPGAs are a major player. However, the computational ...

journal_title：Nature communications

authors： Zhang W,Yao J

更新日期：2020-01-21 00:00:00

abstract：:Gold recovery using environmentally benign chemistry is imperative from an environmental perspective. Here we report the spontaneous assembly of a one-dimensional supramolecular complex with an extended {[K(OH₂)₆][AuBr₄](α-cyclodextrin)₂}n chain superstructure formed during the rapid co-precipitation of α-cyclodextrin...

journal_title：Nature communications

authors： Liu Z,Frasconi M,Lei J,Brown ZJ,Zhu Z,Cao D,Iehl J,Liu G,Fahrenbach AC,Botros YY,Farha OK,Hupp JT,Mirkin CA,Fraser Stoddart J

更新日期：2013-01-01 00:00:00

abstract：:Hypertension induces structural remodelling of arteries, which leads to arteriosclerosis and end-organ damage. Hyperplasia of vascular smooth muscle cells (VSMCs) and infiltration of immune cells are the hallmark of hypertensive arterial remodelling. However, the precise molecular mechanisms of arterial remodelling re...

journal_title：Nature communications

authors： Sumida T,Naito AT,Nomura S,Nakagawa A,Higo T,Hashimoto A,Okada K,Sakai T,Ito M,Yamaguchi T,Oka T,Akazawa H,Lee JK,Minamino T,Offermanns S,Noda T,Botto M,Kobayashi Y,Morita H,Manabe I,Nagai T,Shiojima I,Komuro

更新日期：2015-02-26 00:00:00

abstract：:Despite their energy-efficient merits as promising light-weight structural materials, magnesium (Mg) based alloys suffer from inadequate corrosion resistance. One primary reason is that the native surface film on Mg formed in air mainly consists of Mg(OH)2 and MgO, which is porous and unprotective, especially in humid...

journal_title：Nature communications

authors： Wang Y,Liu B,Zhao X,Zhang X,Miao Y,Yang N,Yang B,Zhang L,Kuang W,Li J,Ma E,Shan Z

更新日期：2018-10-03 00:00:00

abstract：:As children grow, they gradually learn how to make decisions independently. However, decisions like choosing healthy but less-tasty foods can be challenging for children whose self-regulation and executive cognitive functions are still maturing. We propose a computational decision-making process in which children esti...

journal_title：Nature communications

authors： Lim SL,Cherry JB,Davis AM,Balakrishnan SN,Ha OR,Bruce JM,Bruce AS

更新日期：2016-05-24 00:00:00

abstract：:Base editors (BEs) are RNA-guided CRISPR-Cas-derived genome editing tools that induce single-nucleotide changes. The limitations of current BEs lie in their low precision (especially when multiple target nucleotides of the deaminase are present within the activity window) and their restriction to targets that are in p...

journal_title：Nature communications

authors： Tan J,Zhang F,Karcher D,Bock R

更新日期：2020-01-31 00:00:00

abstract：:Complex behaviours may be viewed as sequences of modular actions, each elicited by specific sensory cues in their characteristic timescales. From this perspective, we can construct models in which unitary behavioural modules are hierarchically placed in context of related actions. Here, we analyse antennal positioning...

journal_title：Nature communications

authors： Natesan D,Saxena N,Ekeberg Ö,Sane SP

更新日期：2019-12-06 00:00:00

abstract：:The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes breast cancer cell proliferation, survival, migration and tumour growth. Here we show that, in breast cancer cells, KLF5 is stabilized by the deubiquitinase (DUB) BAP1. With a genome-wide siRNA library screen of DUBs, we identif...

journal_title：Nature communications

authors： Qin J,Zhou Z,Chen W,Wang C,Zhang H,Ge G,Shao M,You D,Fan Z,Xia H,Liu R,Chen C

更新日期：2015-09-30 00:00:00

abstract：:Rapid and accurate clinical diagnosis remains challenging. A component of diagnosis tool development is the design of effective classification models with Mass spectrometry (MS) data. Some Machine Learning approaches have been investigated but these models require time-consuming preprocessing steps to remove artifacts...

journal_title：Nature communications

authors： Seddiki K,Saudemont P,Precioso F,Ogrinc N,Wisztorski M,Salzet M,Fournier I,Droit A

更新日期：2020-11-05 00:00:00

abstract：:Cell-cell communication and interaction is critical during fertilization and triggers free cytosolic calcium ([Ca2+]cyto) as a key signal for egg activation and a polyspermy block in animal oocytes. Fertilization in flowering plants is more complex, involving interaction of a pollen tube with egg adjoining synergid ce...

journal_title：Nature communications

authors： Denninger P,Bleckmann A,Lausser A,Vogler F,Ott T,Ehrhardt DW,Frommer WB,Sprunck S,Dresselhaus T,Grossmann G

更新日期：2014-08-22 00:00:00

abstract：:Ryanodine receptors (RyRs) form calcium release channels located in the membranes of the sarcoplasmic and endoplasmic reticulum. RyRs play a major role in excitation-contraction coupling and other Ca(2+)-dependent signalling events, and consist of several globular domains that together form a large assembly. Here we d...

journal_title：Nature communications

authors： Yuchi Z,Yuen SM,Lau K,Underhill AQ,Cornea RL,Fessenden JD,Van Petegem F

更新日期：2015-08-06 00:00:00

abstract：:Global emergence of Gram-negative bacteria carrying the plasmid-borne resistance genes, blaMBL and mcr, raises a significant challenge to the treatment of life-threatening infections by the antibiotics, carbapenem and colistin (COL). Here, we identify an antirheumatic drug, auranofin (AUR) as a dual inhibitor of metal...

journal_title：Nature communications

authors： Sun H,Zhang Q,Wang R,Wang H,Wong YT,Wang M,Hao Q,Yan A,Kao RY,Ho PL,Li H

更新日期：2020-10-16 00:00:00

abstract：:Transition metal dichalcogenides have attracted research interest over the last few decades due to their interesting structural chemistry, unusual electronic properties, rich intercalation chemistry and wide spectrum of potential applications. Despite the fact that the majority of related research focuses on semicondu...

journal_title：Nature communications

authors： Qi Y,Naumov PG,Ali MN,Rajamathi CR,Schnelle W,Barkalov O,Hanfland M,Wu SC,Shekhar C,Sun Y,Süß V,Schmidt M,Schwarz U,Pippel E,Werner P,Hillebrand R,Förster T,Kampert E,Parkin S,Cava RJ,Felser C,Yan B,Medvedev S

更新日期：2016-03-14 00:00:00

abstract：:Antibiotics that interfere with translation, when combined, interact in diverse and difficult-to-predict ways. Here, we explain these interactions by "translation bottlenecks": points in the translation cycle where antibiotics block ribosomal progression. To elucidate the underlying mechanisms of drug interactions bet...

journal_title：Nature communications

authors： Kavčič B,Tkačik G,Bollenbach T

更新日期：2020-08-11 00:00:00

abstract：:To date, the vast preponderance of somatic variants observed in the cancer genome have been rare variants, and it is common in practice to encounter in a new tumor variants that have not been observed previously. Here we focus on probability estimation for encountering such hitherto unseen variants. We draw upon stati...

journal_title：Nature communications

authors： Chakraborty S,Arora A,Begg CB,Shen R

更新日期：2019-12-03 00:00:00

abstract：:The world is entering a new era of the COVID-19 pandemic in which there is an increasing call for reliable antibody testing. To support decision making on the deployment of serology for either population screening or diagnostics, we present a detailed comparison of serological COVID-19 assays. We show that among the s...

journal_title：Nature communications

authors： GeurtsvanKessel CH,Okba NMA,Igloi Z,Bogers S,Embregts CWE,Laksono BM,Leijten L,Rokx C,Rijnders B,Rahamat-Langendoen J,van den Akker JPC,van Kampen JJA,van der Eijk AA,van Binnendijk RS,Haagmans B,Koopmans M

更新日期：2020-07-06 00:00:00

abstract：:Spectral domain optical coherence tomography (OCT) is a widely employed, minimally invasive bio-medical imaging technique, which requires a broadband light source, typically implemented by super-luminescent diodes. Recent advances in soliton based photonic integrated frequency combs (soliton microcombs) have enabled t...

journal_title：Nature communications

authors： Marchand PJ,Riemensberger J,Skehan JC,Ho JJ,Pfeiffer MHP,Liu J,Hauger C,Lasser T,Kippenberg TJ

更新日期：2021-01-18 00:00:00

abstract：:A phase transition is often accompanied by the appearance of an order parameter and symmetry breaking. Certain magnetic materials exhibit exotic hidden-order phases, in which the order parameters are not directly accessible to conventional magnetic measurements. Thus, experimental identification and theoretical unders...

journal_title：Nature communications

authors： Shen Y,Liu C,Qin Y,Shen S,Li YD,Bewley R,Schneidewind A,Chen G,Zhao J

更新日期：2019-10-08 00:00:00

abstract：:Memories of experiences that occur around the same time are linked together by a shared temporal context, represented by shared patterns of neural activity. However, shared temporal context may be problematic for selective retrieval of specific memories. Here, we examine intracranial EEG (iEEG) in the human temporal l...

journal_title：Nature communications

authors： El-Kalliny MM,Wittig JH Jr,Sheehan TC,Sreekumar V,Inati SK,Zaghloul KA

更新日期：2019-01-14 00:00:00