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An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment.

Abstract：

:The world is entering a new era of the COVID-19 pandemic in which there is an increasing call for reliable antibody testing. To support decision making on the deployment of serology for either population screening or diagnostics, we present a detailed comparison of serological COVID-19 assays. We show that among the selected assays there is a wide diversity in assay performance in different scenarios and when correlated to virus neutralizing antibodies. The Wantai ELISA detecting total immunoglobulins against the receptor binding domain of SARS CoV-2, has the best overall characteristics to detect functional antibodies in different stages and severity of disease, including the potential to set a cut-off indicating the presence of protective antibodies. The large variety of available serological assays requires proper assay validation before deciding on deployment of assays for specific applications.

journal_name

Nat Commun

journal_title

Nature communications

authors

GeurtsvanKessel CH,Okba NMA,Igloi Z,Bogers S,Embregts CWE,Laksono BM,Leijten L,Rokx C,Rijnders B,Rahamat-Langendoen J,van den Akker JPC,van Kampen JJA,van der Eijk AA,van Binnendijk RS,Haagmans B,Koopmans M

doi

10.1038/s41467-020-17317-y

subject

Has Abstract

pub_date

2020-07-06 00:00:00

pages

3436

issue

1

issn

2041-1723

pii

10.1038/s41467-020-17317-y

journal_volume

11

pub_type

杂志文章

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