A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages.

abstract：:The miniaturization of integrated optical circuits below the diffraction limit for high-speed manipulation of information is one of the cornerstones in plasmonics research. By coupling to surface plasmons supported on nanostructured metallic surfaces, light can be confined to the nanoscale, enabling the potential inte...

journal_title：Nature communications

authors： Raza S,Esfandyarpour M,Koh AL,Mortensen NA,Brongersma ML,Bozhevolnyi SI

更新日期：2016-12-16 00:00:00

abstract：:Bacterial vaginosis is a condition associated with adverse reproductive outcomes and characterized by a shift from a Lactobacillus-dominant vaginal microbiota to a polymicrobial microbiota, consistently colonized by strains of Gardnerella vaginalis. Metronidazole is the first-line treatment; however, treatment failure...

journal_title：Nature communications

authors： Lee CY,Cheu RK,Lemke MM,Gustin AT,France MT,Hampel B,Thurman AR,Doncel GF,Ravel J,Klatt NR,Arnold KB

更新日期：2020-12-01 00:00:00

abstract：:The virulence factor pyocyanin and the intracellular second messenger cyclic diguanylate monophosphate (c-di-GMP) play key roles in regulating biofilm formation and multi-drug efflux pump expression in Pseudomonas aeruginosa. However, the crosstalk between these two signaling pathways remains unclear. Here we show tha...

journal_title：Nature communications

authors： Wang F,He Q,Yin J,Xu S,Hu W,Gu L

更新日期：2018-07-02 00:00:00

abstract：:The emergence of personalized and stratified medicine requires label-free, low-cost diagnostic technology capable of monitoring multiple disease biomarkers in parallel. Silicon photonic biosensors combine high-sensitivity analysis with scalable, low-cost manufacturing, but they tend to measure only a single biomarker ...

journal_title：Nature communications

authors： Juan-Colás J,Parkin A,Dunn KE,Scullion MG,Krauss TF,Johnson SD

更新日期：2016-09-14 00:00:00

abstract：:Plant phytochromes are thought to transduce light signals by mediating the degradation of phytochrome-interacting transcription factors (PIFs) through the N-terminal photosensory module, while the C-terminal module, including a histidine kinase-related domain (HKRD), does not participate in signaling. Here we show tha...

journal_title：Nature communications

authors： Qiu Y,Pasoreck EK,Reddy AK,Nagatani A,Ma W,Chory J,Chen M

更新日期：2017-12-04 00:00:00

abstract：:Synonymous mutations have been viewed as silent mutations, since they only affect the DNA and mRNA, but not the amino acid sequence of the resulting protein. Nonetheless, recent studies suggest their significant impact on splicing, RNA stability, RNA folding, translation or co-translational protein folding. Hence, we ...

journal_title：Nature communications

authors： Sharma Y,Miladi M,Dukare S,Boulay K,Caudron-Herger M,Groß M,Backofen R,Diederichs S

更新日期：2019-06-12 00:00:00

abstract：:Immunotherapy is emerging as a new pillar of cancer treatment with potential to cure. However, many patients still fail to respond to these therapies. Among the underlying factors, an immunosuppressive tumor microenvironment (TME) plays a major role. Here we show that monocyte-mediated gene delivery of IFNα inhibits l...

journal_title：Nature communications

authors： Escobar G,Barbarossa L,Barbiera G,Norelli M,Genua M,Ranghetti A,Plati T,Camisa B,Brombin C,Cittaro D,Annoni A,Bondanza A,Ostuni R,Gentner B,Naldini L

更新日期：2018-07-24 00:00:00

abstract：:Directed self-assemblies in water are known as the most efficient means of forming complex higher ordered structures in nature. Here we show a straightforward and robust method for particle assembly which utilises the amphiphilic tri-block co-polymer poloxamer-188 and a hydrophobic fluorophore as the two designer comp...

journal_title：Nature communications

authors： Cheung S,O'Shea DF

更新日期：2017-12-01 00:00:00

abstract：:MicroRNAs play important roles in regulating tumour development, progression and metastasis. Here we show that one of the miR-200 family members, miR-141, is under-expressed in several prostate cancer (PCa) stem/progenitor cell populations in both xenograft and primary patient tumours. Enforced expression of miR-141 i...

journal_title：Nature communications

authors： Liu C,Liu R,Zhang D,Deng Q,Liu B,Chao HP,Rycaj K,Takata Y,Lin K,Lu Y,Zhong Y,Krolewski J,Shen J,Tang DG

更新日期：2017-01-23 00:00:00

abstract：:Acid-sensing ion channel 3 (ASIC3) is involved in acid nociception, but its possible role in neurosensory mechanotransduction is disputed. We report here the generation of Asic3-knockout/eGFPf-knockin mice and subsequent characterization of heterogeneous expression of ASIC3 in the dorsal root ganglion (DRG). ASIC3 is ...

journal_title：Nature communications

authors： Lin SH,Cheng YR,Banks RW,Min MY,Bewick GS,Chen CC

更新日期：2016-05-10 00:00:00

abstract：:Recent years have witnessed the growing interest in the remote functionalization of alkenes for it offers a strategy to activate the challenging C-H bonds distant from the initiation point via alkene isomerization/functionalization. However, the catalytic enantioselective isomerization/functionalization with one singl...

journal_title：Nature communications

authors： Chen X,Cheng Z,Guo J,Lu Z

更新日期：2018-09-26 00:00:00

abstract：:Glycans from microbial pathogens are well known pathogen-associated molecular patterns that are recognized by the host immunity; however, little is known about whether and how mammalian self-glycans activate the host immune response, especially in the context of autoimmune disease. Using biochemical fractionation and ...

journal_title：Nature communications

authors： Fermaintt CS,Sano K,Liu Z,Ishii N,Seino J,Dobbs N,Suzuki T,Fu YX,Lehrman MA,Matsuo I,Yan N

更新日期：2019-05-30 00:00:00

abstract：:Environmental metabolomes are fundamentally coupled to microbially-linked biogeochemical processes within ecosystems. However, significant gaps exist in our understanding of their spatiotemporal organization, limiting our ability to uncover transferrable principles and predict ecosystem function. We propose that a the...

journal_title：Nature communications

authors： Danczak RE,Chu RK,Fansler SJ,Goldman AE,Graham EB,Tfaily MM,Toyoda J,Stegen JC

更新日期：2020-12-11 00:00:00

abstract：:Deep long-period (DLP) earthquakes observed beneath active volcanoes are sometimes considered as precursors to eruptions. Their origin remains, however, unclear. Here, we present a possible DLP generating mechanism related to the rapid growth of gas bubbles in response to the slow decompression of over-saturated magma...

journal_title：Nature communications

authors： Melnik O,Lyakhovsky V,Shapiro NM,Galina N,Bergal-Kuvikas O

更新日期：2020-08-06 00:00:00

abstract：:The ubiquitin receptors Rad23 and Dsk2 deliver polyubiquitylated substrates to the proteasome for destruction. The C-terminal ubiquitin-associated (UBA) domain of Rad23 functions as a cis-acting stabilization signal that protects this protein from proteasomal degradation. Here, we provide evidence that the C-terminal ...

journal_title：Nature communications

authors： Heinen C,Acs K,Hoogstraten D,Dantuma NP

更新日期：2011-02-08 00:00:00

abstract：:Type I modular polyketide synthases assemble diverse bioactive natural products. Such multienzymes typically use malonyl and methylmalonyl-CoA building blocks for polyketide chain assembly. However, in several cases more exotic alkylmalonyl-CoA extender units are also known to be incorporated. In all examples studied ...

journal_title：Nature communications

authors： Ray L,Valentic TR,Miyazawa T,Withall DM,Song L,Milligan JC,Osada H,Takahashi S,Tsai SC,Challis GL

更新日期：2016-12-21 00:00:00

abstract：:An invisibility cloak should completely hide an object from an observer, ideally across the visible spectrum and for all angles of incidence and polarizations of light, in three dimensions. However, until now, all such devices have been limited to either small bandwidths or have disregarded the phase of the impinging ...

journal_title：Nature communications

authors： Tsakmakidis KL,Reshef O,Almpanis E,Zouros GP,Mohammadi E,Saadat D,Sohrabi F,Fahimi-Kashani N,Etezadi D,Boyd RW,Altug H

更新日期：2019-10-24 00:00:00

abstract：:The possibility of measuring binding of small-molecule drugs to desired targets in live cells could provide a better understanding of drug action. However, current approaches mostly yield static data, require lysis or rely on indirect assays and thus often provide an incomplete understanding of drug action. Here, we p...

journal_title：Nature communications

authors： Dubach JM,Vinegoni C,Mazitschek R,Fumene Feruglio P,Cameron LA,Weissleder R

更新日期：2014-05-28 00:00:00

abstract：:The continued convergence of electronics and photonics on the chip scale can benefit from the voltage control of optical polarization for applications in communications, signal processing and sensing. It is challenging, however, to electrically manipulate the polarization state of light in planar optical waveguides. H...

journal_title：Nature communications

authors： Xu Q,Chen L,Wood MG,Sun P,Reano RM

更新日期：2014-11-12 00:00:00

abstract：:Naturally-occurring thermal materials usually possess specific thermal conductivity (κ), forming a digital set of κ values. Emerging thermal metamaterials have been deployed to realize effective thermal conductivities unattainable in natural materials. However, the effective thermal conductivities of such mixing-based...

journal_title：Nature communications

authors： Xu G,Dong K,Li Y,Li H,Liu K,Li L,Wu J,Qiu CW

更新日期：2020-11-27 00:00:00

abstract：:Experience-dependent plasticity of cell and tissue function is critical for survival by allowing organisms to dynamically adjust physiological processes in response to changing or harsh environmental conditions. Despite the conferred evolutionary advantage, it remains unknown whether emergent experience-dependent prop...

journal_title：Nature communications

authors： Hodson DJ,Schaeffer M,Romanò N,Fontanaud P,Lafont C,Birkenstock J,Molino F,Christian H,Lockey J,Carmignac D,Fernandez-Fuente M,Le Tissier P,Mollard P

更新日期：2012-01-03 00:00:00

abstract：:Chemical cross-linking of proteins coupled with mass spectrometry analysis (CXMS) is widely used to study protein-protein interactions (PPI), protein structures, and even protein dynamics. However, structural information provided by CXMS is still limited, partly because most CXMS experiments use lysine-lysine (K-K) cr...

journal_title：Nature communications

authors： Jones AX,Cao Y,Tang YL,Wang JH,Ding YH,Tan H,Chen ZL,Fang RQ,Yin J,Chen RC,Zhu X,She Y,Huang N,Shao F,Ye K,Sun RX,He SM,Lei X,Dong MQ

更新日期：2019-09-02 00:00:00

abstract：:Affiliation 4 incorrectly read 'University of the Basque Country (Ikerbasque), University of the Basque Country and Donostia International Physics Center, San Sebastian 20018, Spain.'Also, the affiliations of Ignacio Arganda-Carreras with 'IKERBASQUE, Basque Foundation for Science, Bilbao, 48013, Spain' and 'Donostia ...

journal_title：Nature communications

authors： Abdeladim L,Matho KS,Clavreul S,Mahou P,Sintes JM,Solinas X,Arganda-Carreras I,Turney SG,Lichtman JW,Chessel A,Bemelmans AP,Loulier K,Supatto W,Livet J,Beaurepaire E

更新日期：2019-05-09 00:00:00

abstract：:Staphylococcal pathogens adhere to their human targets with exceptional resilience to mechanical stress, some propagating force to the bacterium via small, Ig-like folds called B domains. We examine the mechanical stability of these folds using atomic force microscopy-based single-molecule force spectroscopy. The forc...

journal_title：Nature communications

authors： Milles LF,Unterauer EM,Nicolaus T,Gaub HE

更新日期：2018-11-12 00:00:00

abstract：:In social species, the phenotype and fitness of an individual depend in part on the genotype of its social partners. However, how these indirect genetic effects affect genotype fitness in competitive situations is poorly understood in animal societies. We therefore studied phenotypic plasticity and fitness of two clon...

journal_title：Nature communications

authors： Teseo S,Châline N,Jaisson P,Kronauer DJ

更新日期：2014-01-01 00:00:00

abstract：:The allotetraploid plant Nicotiana tabacum (common tobacco) is a major crop species and a model organism, for which only very fragmented genomic sequences are currently available. Here we report high-quality draft genomes for three main tobacco varieties. These genomes show both the low divergence of tobacco from its ...

journal_title：Nature communications

authors： Sierro N,Battey JN,Ouadi S,Bakaher N,Bovet L,Willig A,Goepfert S,Peitsch MC,Ivanov NV

更新日期：2014-05-08 00:00:00

abstract：:Organic-inorganic hybrid perovskites are promising candidates for the next-generation solar cells. Many efforts have been made to study their structures in the search for a better mechanistic understanding to guide the materials optimization. Here, we investigate the structure instability of the single-crystalline CH3...

journal_title：Nature communications

authors： Chen S,Zhang X,Zhao J,Zhang Y,Kong G,Li Q,Li N,Yu Y,Xu N,Zhang J,Liu K,Zhao Q,Cao J,Feng J,Li X,Qi J,Yu D,Li J,Gao P

更新日期：2018-11-15 00:00:00

abstract：:R-loops are stable nucleic acid structures that have important physiological functions, but which also pose a significant threat to genomic stability. Increased R-loops cause replication stress and chromosome fragility and have been associated with diseases such as neurodegeneration and cancer. Although excessive R-lo...

journal_title：Nature communications

authors： Chakraborty P,Huang JTJ,Hiom K

更新日期：2018-10-19 00:00:00

abstract：:Signal regulatory protein α (SIRPα), an immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptor, is an essential negative regulator of leukocyte inflammatory responses. Here we report that SIRPα cytoplasmic signalling ITIMs in neutrophils are cleaved during active inflammation and that the loss of SI...

journal_title：Nature communications

authors： Zen K,Guo Y,Bian Z,Lv Z,Zhu D,Ohnishi H,Matozaki T,Liu Y

更新日期：2013-01-01 00:00:00

abstract：:Vortices in quantum condensates exist owing to a macroscopic phase coherence. Here we show, both experimentally and theoretically, that a quantum vortex with a well-defined core can exist in a rather thick normal metal, proximized with a superconductor. Using scanning tunneling spectroscopy we reveal a proximity vorte...

journal_title：Nature communications

authors： Stolyarov VS,Cren T,Brun C,Golovchanskiy IA,Skryabina OV,Kasatonov DI,Khapaev MM,Kupriyanov MY,Golubov AA,Roditchev D

更新日期：2018-06-11 00:00:00