Abstract:
:Storage of chromatin in restricted nuclear space requires dense packing while ensuring DNA accessibility. Thus, different layers of chromatin organization and epigenetic control mechanisms exist. Genome-wide chromatin interaction maps revealed large interaction domains (TADs) and higher order A and B compartments, reflecting active and inactive chromatin, respectively. The mutual dependencies between chromatin organization and patterns of epigenetic marks, including DNA methylation, remain poorly understood. Here, we demonstrate that establishment of A/B compartments precedes and defines DNA methylation signatures during differentiation and maturation of cardiac myocytes. Remarkably, dynamic CpG and non-CpG methylation in cardiac myocytes is confined to A compartments. Furthermore, genetic ablation or reduction of DNA methylation in embryonic stem cells or cardiac myocytes, respectively, does not alter genome-wide chromatin organization. Thus, DNA methylation appears to be established in preformed chromatin compartments and may be dispensable for the formation of higher order chromatin organization.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Nothjunge S,Nührenberg TG,Grüning BA,Doppler SA,Preissl S,Schwaderer M,Rommel C,Krane M,Hein L,Gilsbach Rdoi
10.1038/s41467-017-01724-9subject
Has Abstractpub_date
2017-11-21 00:00:00pages
1667issue
1issn
2041-1723pii
10.1038/s41467-017-01724-9journal_volume
8pub_type
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