XPC deficiency increases risk of hematologic malignancies through mutator phenotype and characteristic mutational signature.

abstract：:While distinct stages of natural killer (NK) cell development have been defined, the molecular interactions that shape human NK cell maturation are poorly understood. Here we define intercellular interactions between developing NK cells and stromal cells which, through contact-dependent mechanisms, promote the generat...

journal_title：Nature communications

authors： Mace EM,Gunesch JT,Dixon A,Orange JS

更新日期：2016-07-20 00:00:00

abstract：:The spatial scaling of stability is key to understanding ecological sustainability across scales and the sensitivity of ecosystems to habitat destruction. Here we propose the invariability-area relationship (IAR) as a novel approach to investigate the spatial scaling of stability. The shape and slope of IAR are largel...

journal_title：Nature communications

authors： Wang S,Loreau M,Arnoldi JF,Fang J,Rahman KA,Tao S,de Mazancourt C

更新日期：2017-05-19 00:00:00

abstract：:Quantum fluctuations give rise to van der Waals and Casimir forces that dominate the interaction between electrically neutral objects at sub-micron separations. Under the trend of miniaturization, such quantum electrodynamical effects are expected to play an important role in micro- and nano-mechanical devices. Nevert...

journal_title：Nature communications

authors： Zou J,Marcet Z,Rodriguez AW,Reid MT,McCauley AP,Kravchenko II,Lu T,Bao Y,Johnson SG,Chan HB

更新日期：2013-01-01 00:00:00

abstract：:Understanding the details of domain wall (DW) motion along magnetic racetracks has drawn considerable interest in the past few years for their applications in non-volatile memory devices. The propagation of the DW is dictated by the interplay between its driving force, either field or current, and the complex energy l...

journal_title：Nature communications

authors： Jiang X,Thomas L,Moriya R,Hayashi M,Bergman B,Rettner C,Parkin SS

更新日期：2010-06-15 00:00:00

abstract：:Invariant natural killer T cells have a distinct developmental pathway from conventional αβ T cells. Here we demonstrate that the transcriptional repressor NKAP is required for invariant natural killer T cell but not conventional T cell development. In CD4-cre NKAP conditional knockout mice, invariant natural killer T...

journal_title：Nature communications

authors： Thapa P,Das J,McWilliams D,Shapiro M,Sundsbak R,Nelson-Holte M,Tangen S,Anderson J,Desiderio S,Hiebert S,Sant'angelo DB,Shapiro VS

更新日期：2013-01-01 00:00:00

abstract：:With the development of ultrafast electron and X-ray sources it is becoming possible to study structural dynamics with atomic-level spatial and temporal resolution. Because of their short mean free path, electrons are particularly well suited for investigating surfaces and thin films, such as the challenging and impor...

journal_title：Nature communications

authors： Engelen WJ,van der Heijden MA,Bakker DJ,Vredenbregt EJ,Luiten OJ

更新日期：2013-01-01 00:00:00

abstract：:Bioorthogonal chemistry introduces affinity-labels into biomolecules with minimal disruption to the original system and is widely applicable in a range of contexts. In proteomics, immobilized metal affinity chromatography (IMAC) enables enrichment of phosphopeptides with extreme sensitivity and selectivity. Here, we a...

journal_title：Nature communications

authors： Kleinpenning F,Steigenberger B,Wu W,Heck AJR

更新日期：2020-06-26 00:00:00

abstract：:Formation of amyloid-beta (Aβ) oligomer pores in the membrane of neurons has been proposed to explain neurotoxicity in Alzheimer's disease (AD). Here, we present the three-dimensional structure of an Aβ oligomer formed in a membrane mimicking environment, namely an Aβ(1-42) tetramer, which comprises a six stranded β-s...

journal_title：Nature communications

authors： Ciudad S,Puig E,Botzanowski T,Meigooni M,Arango AS,Do J,Mayzel M,Bayoumi M,Chaignepain S,Maglia G,Cianferani S,Orekhov V,Tajkhorshid E,Bardiaux B,Carulla N

更新日期：2020-06-15 00:00:00

abstract：:Two-dimensional transition metal carbides (MXenes) have attracted a great interest of the research community as a relatively recently discovered large class of materials with unique electronic and optical properties. Understanding of adhesion between MXenes and various substrates is critically important for MXene devi...

journal_title：Nature communications

authors： Li Y,Huang S,Wei C,Wu C,Mochalin VN

更新日期：2019-07-08 00:00:00

abstract：:The mammary gland experiences substantial remodeling and regeneration during development and reproductive life, facilitated by stem cells and progenitors that act in concert with physiological stimuli. While studies have focused on deciphering regenerative cells within the parenchymal epithelium, cell lineages in the ...

journal_title：Nature communications

authors： Joshi PA,Waterhouse PD,Kasaian K,Fang H,Gulyaeva O,Sul HS,Boutros PC,Khokha R

更新日期：2019-04-15 00:00:00

abstract：:The survival of viruses partly relies on their ability to self-assemble inside host cells. Although coarse-grained simulations have identified different pathways leading to assembled virions from their components, experimental evidence is severely lacking. Here, we use time-resolved small-angle X-ray scattering to unc...

journal_title：Nature communications

authors： Chevreuil M,Law-Hine D,Chen J,Bressanelli S,Combet S,Constantin D,Degrouard J,Möller J,Zeghal M,Tresset G

更新日期：2018-08-06 00:00:00

abstract：:Controlling the domain size and degree of crystallization in organic films is highly important for electronic applications such as organic photovoltaics, but suitable nanoscale mapping is very difficult. Here we apply infrared-spectroscopic nano-imaging to directly determine the local crystallinity of organic thin fil...

journal_title：Nature communications

authors： Westermeier C,Cernescu A,Amarie S,Liewald C,Keilmann F,Nickel B

更新日期：2014-06-11 00:00:00

abstract：:Targeting of immunoglobulin E (IgE) represents an interesting approach for the treatment of allergic disorders. A high-affinity monoclonal anti-IgE antibody, ligelizumab, has recently been developed to overcome some of the limitations associated with the clinical use of the therapeutic anti-IgE antibody, omalizumab. H...

journal_title：Nature communications

authors： Gasser P,Tarchevskaya SS,Guntern P,Brigger D,Ruppli R,Zbären N,Kleinboelting S,Heusser C,Jardetzky TS,Eggel A

更新日期：2020-01-08 00:00:00

abstract：:We introduce a microfluidic platform that enables off-chip single-cell RNA-seq after multi-generational lineage tracking under controlled culture conditions. We use this platform to generate whole-transcriptome profiles of primary, activated murine CD8+ T-cell and lymphocytic leukemia cell line lineages. Here we repor...

journal_title：Nature communications

authors： Kimmerling RJ,Lee Szeto G,Li JW,Genshaft AS,Kazer SW,Payer KR,de Riba Borrajo J,Blainey PC,Irvine DJ,Shalek AK,Manalis SR

更新日期：2016-01-06 00:00:00

abstract：:Neuronal reward valuations provide the physiological basis for economic behaviour. Yet, how such valuations are converted to economic decisions remains unclear. Here we show that the dorsolateral prefrontal cortex (DLPFC) implements a flexible value code based on object-specific valuations by single neurons. As monkey...

journal_title：Nature communications

authors： Tsutsui KI,Grabenhorst F,Kobayashi S,Schultz W

更新日期：2016-09-13 00:00:00

abstract：:Despite the pursuit of quantum advantages in various applications, the power of quantum computers in executing neural network has mostly remained unknown, primarily due to a missing tool that effectively designs a neural network suitable for quantum circuit. Here, we present a neural network and quantum circuit co-des...

journal_title：Nature communications

authors： Jiang W,Xiong J,Shi Y

更新日期：2021-01-25 00:00:00

abstract：:Interest in manipulating the magnetic order by ultrashort laser pulses has thrived since it was observed that such pulses can be used to alter the magnetization on a sub-picosecond timescale. Usually this involves demagnetization by laser heating or, in rare cases, a transient increase of magnetization. Here we demons...

journal_title：Nature communications

authors： Matsubara M,Schroer A,Schmehl A,Melville A,Becher C,Trujillo-Martinez M,Schlom DG,Mannhart J,Kroha J,Fiebig M

更新日期：2015-04-02 00:00:00

abstract：:Because of the potential impact on agriculture and other key human activities, efforts have been dedicated to the local control of precipitation. The most common approach consists of dispersing small particles of dry ice, silver iodide, or other salts in the atmosphere. Here we show, using field experiments conducted ...

journal_title：Nature communications

authors： Henin S,Petit Y,Rohwetter P,Stelmaszczyk K,Hao ZQ,Nakaema WM,Vogel A,Pohl T,Schneider F,Kasparian J,Weber K,Wöste L,Wolf JP

更新日期：2011-08-30 00:00:00

abstract：:Antibodies conjugated to bioactive compounds allow targeted delivery of therapeutics to cell types of choice based on that antibody's specificity. Here we develop a new type of conjugate that consists of a nanobody and a peptidic ligand for a G protein-coupled receptor (GPCR), fused via their C-termini. We address act...

journal_title：Nature communications

authors： Cheloha RW,Fischer FA,Woodham AW,Daley E,Suminski N,Gardella TJ,Ploegh HL

更新日期：2020-04-29 00:00:00

abstract：:Cryptosporidiosis in an enteric infection caused by Cryptosporidium parasites and is a major cause of acute infant diarrhea in the developing world. A major bottleneck to research progress is the lack of methods to cryopreserve Cryptosporidium oocysts, thus requiring routine propagation in laboratory animals. Here, we...

journal_title：Nature communications

authors： Jaskiewicz JJ,Sandlin RD,Swei AA,Widmer G,Toner M,Tzipori S

更新日期：2018-07-23 00:00:00

abstract：:Here we benchmark device-to-device variation in field-effect transistors (FETs) based on monolayer MoS2 and WS2 films grown using metal-organic chemical vapor deposition process. Our study involves 230 MoS2 FETs and 160 WS2 FETs with channel lengths ranging from 5 μm down to 100 nm. We use statistical measures to eval...

journal_title：Nature communications

authors： Sebastian A,Pendurthi R,Choudhury TH,Redwing JM,Das S

更新日期：2021-01-29 00:00:00

abstract：:Recent developments in stem cell biology have enabled the study of cell fate decisions in early human development that are impossible to study in vivo. However, understanding how development varies across individuals and, in particular, the influence of common genetic variants during this process has not been characte...

journal_title：Nature communications

authors： Cuomo ASE,Seaton DD,McCarthy DJ,Martinez I,Bonder MJ,Garcia-Bernardo J,Amatya S,Madrigal P,Isaacson A,Buettner F,Knights A,Natarajan KN,HipSci Consortium.,Vallier L,Marioni JC,Chhatriwala M,Stegle O

更新日期：2020-02-10 00:00:00

abstract：:Novel atherosclerosis models are needed to guide clinical therapy. Here, we report an in vitro model of early atherosclerosis by fabricating and perfusing multi-layer arteriole-scale human tissue-engineered blood vessels (TEBVs) by plastic compression. TEBVs maintain mechanical strength, vasoactivity, and nitric oxide...

journal_title：Nature communications

authors： Zhang X,Bishawi M,Zhang G,Prasad V,Salmon E,Breithaupt JJ,Zhang Q,Truskey GA

更新日期：2020-10-27 00:00:00

abstract：:Understanding the role of intermolecular interaction on through-space charge transfer characteristics in π-stacked molecular systems is central to the rational design of electronic materials. However, a quantitative study of charge transfer in such systems is often difficult because of poor control over molecular morp...

journal_title：Nature communications

authors： Batra A,Kladnik G,Vázquez H,Meisner JS,Floreano L,Nuckolls C,Cvetko D,Morgante A,Venkataraman L

更新日期：2012-01-01 00:00:00

abstract：:A specific bone vessel subtype, strongly positive for CD31 and endomucin (CD31hiEmcnhi), is identified as coupling angiogenesis and osteogenesis. The abundance of type CD31hiEmcnhi vessels decrease during ageing. Here we show that expression of the miR-497∼195 cluster is high in CD31hiEmcnhi endothelium but gradually ...

journal_title：Nature communications

authors： Yang M,Li CJ,Sun X,Guo Q,Xiao Y,Su T,Tu ML,Peng H,Lu Q,Liu Q,He HB,Jiang TJ,Lei MX,Wan M,Cao X,Luo XH

更新日期：2017-07-07 00:00:00

abstract：:Locusts are one of the world's most destructive agricultural pests and represent a useful model system in entomology. Here we present a draft 6.5 Gb genome sequence of Locusta migratoria, which is the largest animal genome sequenced so far. Our findings indicate that the large genome size of L. migratoria is likely to...

journal_title：Nature communications

authors： Wang X,Fang X,Yang P,Jiang X,Jiang F,Zhao D,Li B,Cui F,Wei J,Ma C,Wang Y,He J,Luo Y,Wang Z,Guo X,Guo W,Wang X,Zhang Y,Yang M,Hao S,Chen B,Ma Z,Yu D,Xiong Z,Zhu Y,Fan D,Han L,Wang B,Chen Y,Wang J

更新日期：2014-01-01 00:00:00

abstract：:The phosphorylation of eIF4E1 at serine 209 by MNK1 or MNK2 has been shown to initiate oncogenic mRNA translation, a process that favours cancer development and maintenance. Here, we interrogate the MNK-eIF4E axis in diffuse large B-cell lymphoma (DLBCL) and show a distinct distribution of MNK1 and MNK2 in germinal ce...

journal_title：Nature communications

authors： Landon AL,Muniandy PA,Shetty AC,Lehrmann E,Volpon L,Houng S,Zhang Y,Dai B,Peroutka R,Mazan-Mamczarz K,Steinhardt J,Mahurkar A,Becker KG,Borden KL,Gartenhaus RB

更新日期：2014-11-18 00:00:00

abstract：:The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes breast cancer cell proliferation, survival, migration and tumour growth. Here we show that, in breast cancer cells, KLF5 is stabilized by the deubiquitinase (DUB) BAP1. With a genome-wide siRNA library screen of DUBs, we identif...

journal_title：Nature communications

authors： Qin J,Zhou Z,Chen W,Wang C,Zhang H,Ge G,Shao M,You D,Fan Z,Xia H,Liu R,Chen C

更新日期：2015-09-30 00:00:00

abstract：:Lipids and amphiphilic block copolymers spontaneously self-assemble in water to form a plethora of micelles and vesicles. They are typically fluidic in nature and often mechanically weak for applications such as drug delivery and gene therapeutics. Mechanical properties of polymeric materials could be improved by form...

journal_title：Nature communications

authors： Wang W,Qi H,Zhou T,Mei S,Han L,Higuchi T,Jinnai H,Li CY

更新日期：2016-02-03 00:00:00

abstract：:The atypical chemokine receptor 3 (ACKR3) plays a pivotal role in directing the migration of various cellular populations and its over-expression in tumors promotes cell proliferation and invasiveness. The intracellular signaling pathways transducing ACKR3-dependent effects remain poorly characterized, an issue we add...

journal_title：Nature communications

authors： Fumagalli A,Heuninck J,Pizzoccaro A,Moutin E,Koenen J,Séveno M,Durroux T,Junier MP,Schlecht-Louf G,Bachelerie F,Schütz D,Stumm R,Smit MJ,Guérineau NC,Chaumont-Dubel S,Marin P

更新日期：2020-09-25 00:00:00