当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Epigenome-wide association studies identify DNA methylation associated with kidney function.

Epigenome-wide association studies identify DNA methylation associated with kidney function.

Abstract：

:Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham Heart Study participants to identify epigenetic signatures of kidney function. Of 19 CpG sites significantly associated (P < 1e-07) with eGFR/CKD and replicated, five also associate with renal fibrosis in biopsies from CKD patients and show concordant DNA methylation changes in kidney cortex. Lead CpGs at PTPN6/PHB2, ANKRD11, and TNRC18 map to active enhancers in kidney cortex. At PTPN6/PHB2 cg19942083, methylation in kidney cortex associates with lower renal PTPN6 expression, higher eGFR, and less renal fibrosis. The regions containing the 243 eGFR-associated (P < 1e-05) CpGs are significantly enriched for transcription factor binding sites of EBF1, EP300, and CEBPB (P < 5e-6). Our findings highlight kidney function associated epigenetic variation.

journal_name

Nat Commun

journal_title

Nature communications

authors

Chu AY,Tin A,Schlosser P,Ko YA,Qiu C,Yao C,Joehanes R,Grams ME,Liang L,Gluck CA,Liu C,Coresh J,Hwang SJ,Levy D,Boerwinkle E,Pankow JS,Yang Q,Fornage M,Fox CS,Susztak K,Köttgen A

doi

10.1038/s41467-017-01297-7

subject

Has Abstract

pub_date

2017-11-03 00:00:00

pages

1286

issue

1

issn

2041-1723

pii

10.1038/s41467-017-01297-7

journal_volume

8

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • The role of water in fault lubrication.

    abstract：:The friction between two adjacent tectonic plates under shear loading may dictate seismic activities. To advance the understanding of mechanisms underlying fault strength, we investigate the frictional characteristics of calcite in an aqueous environment. By conducting single-asperity friction experiments using an ato...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04782-9

    authors： Diao Y,Espinosa-Marzal RM

    更新日期：2018-06-13 00:00:00

  • Effect of hydrogen on the integrity of aluminium-oxide interface at elevated temperatures.

    abstract：:Hydrogen can facilitate the detachment of protective oxide layer off metals and alloys. The degradation is usually exacerbated at elevated temperatures in many industrial applications; however, its origin remains poorly understood. Here by heating hydrogenated aluminium inside an environmental transmission electron mi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14564

    authors： Li M,Xie DG,Ma E,Li J,Zhang XX,Shan ZW

    更新日期：2017-02-20 00:00:00

  • Rapid laccolith intrusion driven by explosive volcanic eruption.

    abstract：:Magmatic intrusions and volcanic eruptions are intimately related phenomena. Shallow magma intrusion builds subsurface reservoirs that are drained by volcanic eruptions. Thus, the long-held view is that intrusions must precede and feed eruptions. Here we show that explosive eruptions can also cause magma intrusion. We...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13585

    authors： Castro JM,Cordonnier B,Schipper CI,Tuffen H,Baumann TS,Feisel Y

    更新日期：2016-11-23 00:00:00

  • 21st Century drought-related fires counteract the decline of Amazon deforestation carbon emissions.

    abstract：:Tropical carbon emissions are largely derived from direct forest clearing processes. Yet, emissions from drought-induced forest fires are, usually, not included in national-level carbon emission inventories. Here we examine Brazilian Amazon drought impacts on fire incidence and associated forest fire carbon emissions ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02771-y

    authors： Aragão LEOC,Anderson LO,Fonseca MG,Rosan TM,Vedovato LB,Wagner FH,Silva CVJ,Silva Junior CHL,Arai E,Aguiar AP,Barlow J,Berenguer E,Deeter MN,Domingues LG,Gatti L,Gloor M,Malhi Y,Marengo JA,Miller JB,Phillips OL,Sa

    更新日期：2018-02-13 00:00:00

  • NHC-Ni catalyzed enantioselective synthesis of 1,4-dienes by cross-hydroalkenylation of cyclic 1,3-dienes and heterosubstituted terminal olefins.

    abstract：:Enantioenriched 1,4-dienes are versatile building blocks in asymmetric synthesis, therefore their efficient synthesis directly from chemical feedstock is highly sought after. Here, we show an enantioselective cross-hydroalkenylation of cyclic 1,3-diene and hetero-substituted terminal olefin by using a chiral [NHC-Ni(a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16139-2

    authors： Chen Y,Dang L,Ho CY

    更新日期：2020-05-08 00:00:00

  • Assembly of complex viruses exemplified by a halophilic euryarchaeal virus.

    abstract：:Many of the largest known viruses belong to the PRD1-adeno structural lineage characterised by conserved pseudo-hexameric capsomers composed of three copies of a single major capsid protein (MCP). Here, by high-resolution cryo-EM analysis, we show that a class of archaeal viruses possess hetero-hexameric MCPs which mi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09451-z

    authors： De Colibus L,Roine E,Walter TS,Ilca SL,Wang X,Wang N,Roseman AM,Bamford D,Huiskonen JT,Stuart DI

    更新日期：2019-03-29 00:00:00

  • Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics.

    abstract：:Identification of the complete set of translated genes of viruses is important to understand viral replication and pathogenesis as well as for therapeutic approaches to control viral infection. Here, we use chemical proteomics, integrating bio-orthogonal non-canonical amino acid tagging and high-resolution mass spectr...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18718-9

    authors： Kato A,Adachi S,Kawano S,Takeshima K,Watanabe M,Kitazume S,Sato R,Kusano H,Koyanagi N,Maruzuru Y,Arii J,Hatta T,Natsume T,Kawaguchi Y

    更新日期：2020-09-29 00:00:00

  • The locust genome provides insight into swarm formation and long-distance flight.

    abstract：:Locusts are one of the world's most destructive agricultural pests and represent a useful model system in entomology. Here we present a draft 6.5 Gb genome sequence of Locusta migratoria, which is the largest animal genome sequenced so far. Our findings indicate that the large genome size of L. migratoria is likely to...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3957

    authors： Wang X,Fang X,Yang P,Jiang X,Jiang F,Zhao D,Li B,Cui F,Wei J,Ma C,Wang Y,He J,Luo Y,Wang Z,Guo X,Guo W,Wang X,Zhang Y,Yang M,Hao S,Chen B,Ma Z,Yu D,Xiong Z,Zhu Y,Fan D,Han L,Wang B,Chen Y,Wang J

    更新日期：2014-01-01 00:00:00

  • Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank.

    abstract：:Although snoring is common in the general population, its aetiology has been largely understudied. Here we report a genetic study on snoring (n ~ 408,000; snorers ~ 152,000) using data from the UK Biobank. We identify 42 genome-wide significant loci, with an SNP-based heritability estimate of ~10% on the liability sca...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14625-1

    authors： Campos AI,García-Marín LM,Byrne EM,Martin NG,Cuéllar-Partida G,Rentería ME

    更新日期：2020-02-14 00:00:00

  • Optical sinc-shaped Nyquist pulses of exceptional quality.

    abstract：:Sinc-shaped Nyquist pulses possess a rectangular spectrum, enabling data to be encoded in a minimum spectral bandwidth and satisfying by essence the Nyquist criterion of zero inter-symbol interference (ISI). This property makes them very attractive for communication systems since data transmission rates can be maximiz...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3898

    authors： Soto MA,Alem M,Amin Shoaie M,Vedadi A,Brès CS,Thévenaz L,Schneider T

    更新日期：2013-01-01 00:00:00

  • Ballistic interferences in suspended graphene.

    abstract：:The low-energy electronic excitations in graphene are described by massless Dirac fermions that have a linear dispersion relation. Taking advantage of this 'optics-like' electron dynamics, generic optical elements like lenses and wave guides have been proposed for electrons in graphene. Tuning of these elements relies...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3342

    authors： Rickhaus P,Maurand R,Liu MH,Weiss M,Richter K,Schönenberger C

    更新日期：2013-01-01 00:00:00

  • Task complexity interacts with state-space uncertainty in the arbitration between model-based and model-free learning.

    abstract：:It has previously been shown that the relative reliability of model-based and model-free reinforcement-learning (RL) systems plays a role in the allocation of behavioral control between them. However, the role of task complexity in the arbitration between these two strategies remains largely unknown. Here, using a com...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13632-1

    authors： Kim D,Park GY,O Doherty JP,Lee SW

    更新日期：2019-12-16 00:00:00

  • A new tool called DISSECT for analysing large genomic data sets using a Big Data approach.

    abstract：:Large-scale genetic and genomic data are increasingly available and the major bottleneck in their analysis is a lack of sufficiently scalable computational tools. To address this problem in the context of complex traits analysis, we present DISSECT. DISSECT is a new and freely available software that is able to exploi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10162

    authors： Canela-Xandri O,Law A,Gray A,Woolliams JA,Tenesa A

    更新日期：2015-12-11 00:00:00

  • Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits.

    abstract：:In the development of addiction, drug seeking becomes habitual and controlled by drug-associated cues, and the neural locus of control over behaviour shifts from the ventral to the dorsolateral striatum. The neural mechanisms underlying this functional transition from recreational drug use to drug-seeking habits are u...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10088

    authors： Murray JE,Belin-Rauscent A,Simon M,Giuliano C,Benoit-Marand M,Everitt BJ,Belin D

    更新日期：2015-12-14 00:00:00

  • TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice.

    abstract：:Pachytene piRNAs are the most abundant piRNAs in mammalian adult testes. They are generated from long precursor transcripts by the primary piRNA biogenesis pathway but the factors involved in pachytene piRNA precursors processing are poorly understood. Here we show that the Tudor domain-containing 5 (TDRD5) protein is...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02622-w

    authors： Ding D,Liu J,Midic U,Wu Y,Dong K,Melnick A,Latham KE,Chen C

    更新日期：2018-01-09 00:00:00

  • Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats.

    abstract：:Adolescence is a developmental period in which the mesolimbic dopaminergic "reward" circuitry of the brain, including the nucleus accumbens (NAc), undergoes significant plasticity. Dopamine D1 receptors (D1rs) in the NAc are critical for social behavior, but how these receptors are regulated during adolescence is not ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06118-z

    authors： Kopec AM,Smith CJ,Ayre NR,Sweat SC,Bilbo SD

    更新日期：2018-09-25 00:00:00

  • Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction.

    abstract：:Members of the interleukin-1 (IL-1) family are important mediators of obesity and metabolic disease and have been described to often play opposing roles. Here we report that the interleukin-36 (IL-36) subfamily can play a protective role against the development of disease. Elevated IL-36 cytokine expression is found i...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11944-w

    authors： Giannoudaki E,Hernandez-Santana YE,Mulfaul K,Doyle SL,Hams E,Fallon PG,Mat A,O'Shea D,Kopf M,Hogan AE,Walsh PT

    更新日期：2019-09-05 00:00:00

  • Clustering of arc volcanoes caused by temperature perturbations in the back-arc mantle.

    abstract：:Clustering of arc volcanoes in subduction zones indicates along-arc variation in the physical condition of the underlying mantle where majority of arc magmas are generated. The sub-arc mantle is brought in from the back-arc largely by slab-driven mantle wedge flow. Dynamic processes in the back-arc, such as small-scal...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15753

    authors： Lee C,Wada I

    更新日期：2017-06-29 00:00:00

  • Publisher Correction: Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers.

    abstract：:The original version of this Article contained an error in Fig. 2f, in which the phospholipid was incorrectly labelled 'PE' rather than the correct 'PC'. This has now been corrected in the PDF and HTML versions of the Article. ...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-019-08907-6

    authors： Zhang W,Zhang D,Chen Q,Wu J,Ouyang Z,Xia Y

    更新日期：2019-02-19 00:00:00

  • Reverse transduction measured in the living cochlea by low-coherence heterodyne interferometry.

    abstract：:It is generally believed that the remarkable sensitivity and frequency selectivity of mammalian hearing depend on outer hair cell-generated force, which amplifies sound-induced vibrations inside the cochlea. This 'reverse transduction' force production has never been demonstrated experimentally, however, in the living...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10282

    authors： Ren T,He W,Barr-Gillespie PG

    更新日期：2016-01-06 00:00:00

  • Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling.

    abstract：:In response to virus infection, RIG-I-like receptors (RLRs) sense virus RNA and induce MAVS to form prion-like aggregates to further propagate antiviral signalling. Although monomeric MAVS recombinant protein can assemble into prion-like filaments spontaneously in vitro, endogenous MAVS in cells is prevented from aggr...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15676

    authors： Qi N,Shi Y,Zhang R,Zhu W,Yuan B,Li X,Wang C,Zhang X,Hou F

    更新日期：2017-06-13 00:00:00

  • Dynamical observations on the crack tip zone and stress corrosion of two-dimensional MoS2.

    abstract：:Whether and how fracture mechanics needs to be modified for small length scales and in systems of reduced dimensionality remains an open debate. Here, employing in situ transmission electron microscopy, atomic structures and dislocation dynamics in the crack tip zone of a propagating crack in two-dimensional (2D) mono...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14116

    authors： Ly TH,Zhao J,Cichocka MO,Li LJ,Lee YH

    更新日期：2017-01-18 00:00:00

  • Inhibition of Ebola virus glycoprotein-mediated cytotoxicity by targeting its transmembrane domain and cholesterol.

    abstract：:The high pathogenicity of the Ebola virus reflects multiple concurrent processes on infection. Among other important determinants, Ebola fusogenic glycoprotein (GP) has been associated with the detachment of infected cells and eventually leads to vascular leakage and haemorrhagic fever. Here we report that the membran...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms8688

    authors： Hacke M,Björkholm P,Hellwig A,Himmels P,Ruiz de Almodóvar C,Brügger B,Wieland F,Ernst AM

    更新日期：2015-07-09 00:00:00

  • Self-cleaning and surface chemical reactions during hafnium dioxide atomic layer deposition on indium arsenide.

    abstract：:Atomic layer deposition (ALD) enables the ultrathin high-quality oxide layers that are central to all modern metal-oxide-semiconductor circuits. Crucial to achieving superior device performance are the chemical reactions during the first deposition cycle, which could ultimately result in atomic-scale perfection of the...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03855-z

    authors： Timm R,Head AR,Yngman S,Knutsson JV,Hjort M,McKibbin SR,Troian A,Persson O,Urpelainen S,Knudsen J,Schnadt J,Mikkelsen A

    更新日期：2018-04-12 00:00:00

  • Exploring the hidden interior of the Earth with directional neutrino measurements.

    abstract：:Roughly 40% of the Earth's total heat flow is powered by radioactive decays in the crust and mantle. Geo-neutrinos produced by these decays provide important clues about the origin, formation and thermal evolution of our planet, as well as the composition of its interior. Previous measurements of geo-neutrinos have al...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15989

    authors： Leyton M,Dye S,Monroe J

    更新日期：2017-07-10 00:00:00

  • Nonlinear XUV signal generation probed by transient grating spectroscopy with attosecond pulses.

    abstract：:Nonlinear spectroscopies are utilized extensively for selective measurements of chemical dynamics in the optical, infrared, and radio-frequency regimes. The development of these techniques for extreme ultraviolet (XUV) light sources facilitates measurements of electronic dynamics on attosecond timescales. Here, we elu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09317-4

    authors： Fidler AP,Camp SJ,Warrick ER,Bloch E,Marroux HJB,Neumark DM,Schafer KJ,Gaarde MB,Leone SR

    更新日期：2019-03-27 00:00:00

  • Cellobiohydrolase 1 from Trichoderma reesei degrades cellulose in single cellobiose steps.

    abstract：:Cellobiohydrolase 1 from Trichoderma reesei (TrCel7A) processively hydrolyses cellulose into cellobiose. Although enzymatic techniques have been established as promising tools in biofuel production, a clear understanding of the motor's mechanistic action has yet to be revealed. Here, we develop an optical tweezers-bas...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10149

    authors： Brady SK,Sreelatha S,Feng Y,Chundawat SP,Lang MJ

    更新日期：2015-12-10 00:00:00

  • Signature of coexistence of superconductivity and ferromagnetism in two-dimensional NbSe2 triggered by surface molecular adsorption.

    abstract：:Ferromagnetism is usually deemed incompatible with superconductivity. Consequently, the coexistence of superconductivity and ferromagnetism is usually observed only in elegantly designed multi-ingredient structures in which the two competing electronic states originate from separate structural components. Here we repo...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11210

    authors： Zhu X,Guo Y,Cheng H,Dai J,An X,Zhao J,Tian K,Wei S,Cheng Zeng X,Wu C,Xie Y

    更新日期：2016-04-04 00:00:00

  • Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.

    abstract：:Complex tissue-specific and cell-specific signaling by the estrogen receptor (ER) frequently leads to the development of resistance to endocrine therapy for breast cancer. Pure ER antagonists, which completely lack tissue-specific agonist activity, hold promise for preventing and treating endocrine resistance, however...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04413-3

    authors： Fanning SW,Hodges-Gallagher L,Myles DC,Sun R,Fowler CE,Plant IN,Green BD,Harmon CL,Greene GL,Kushner PJ

    更新日期：2018-06-18 00:00:00

  • Publisher Correction: Cellular adaptation to oxygen deficiency beyond the Nobel award.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-020-15018-0

    authors： López-Barneo J,Simon MC

    更新日期：2020-02-25 00:00:00