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Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction.

Abstract：

:Members of the interleukin-1 (IL-1) family are important mediators of obesity and metabolic disease and have been described to often play opposing roles. Here we report that the interleukin-36 (IL-36) subfamily can play a protective role against the development of disease. Elevated IL-36 cytokine expression is found in the serum of obese patients and negatively correlates with blood glucose levels among those presenting with type 2 diabetes. Mice lacking IL-36Ra, an IL-36 family signalling antagonist, develop less diet-induced weight gain, hyperglycemia and insulin resistance. These protective effects correlate with increased abundance of the metabolically protective bacteria Akkermansia muciniphila in the intestinal microbiome. IL-36 cytokines promote its outgrowth as well as increased colonic mucus secretion. These findings identify a protective role for IL-36 cytokines in obesity and metabolic disease, adding to the current understanding of the role the broader IL-1 family plays in regulating disease pathogenesis.

journal_name

Nat Commun

journal_title

Nature communications

authors

Giannoudaki E,Hernandez-Santana YE,Mulfaul K,Doyle SL,Hams E,Fallon PG,Mat A,O'Shea D,Kopf M,Hogan AE,Walsh PT

doi

10.1038/s41467-019-11944-w

subject

Has Abstract

pub_date

2019-09-05 00:00:00

pages

4003

issue

1

issn

2041-1723

pii

10.1038/s41467-019-11944-w

journal_volume

10

pub_type

杂志文章

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