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Oscillatory integration windows in neurons.

Abstract：

:Oscillatory synchrony among neurons occurs in many species and brain areas, and has been proposed to help neural circuits process information. One hypothesis states that oscillatory input creates cyclic integration windows: specific times in each oscillatory cycle when postsynaptic neurons become especially responsive to inputs. With paired local field potential (LFP) and intracellular recordings and controlled stimulus manipulations we directly test this idea in the locust olfactory system. We find that inputs arriving in Kenyon cells (KCs) sum most effectively in a preferred window of the oscillation cycle. With a computational model, we show that the non-uniform structure of noise in the membrane potential helps mediate this process. Further experiments performed in vivo demonstrate that integration windows can form in the absence of inhibition and at a broad range of oscillation frequencies. Our results reveal how a fundamental coincidence-detection mechanism in a neural circuit functions to decode temporally organized spiking.

journal_name

Nat Commun

journal_title

Nature communications

authors

Gupta N,Singh SS,Stopfer M

doi

10.1038/ncomms13808

subject

Has Abstract

pub_date

2016-12-15 00:00:00

pages

13808

issn

2041-1723

pii

ncomms13808

journal_volume

7

pub_type

杂志文章

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