Abstract:
:Experience-dependent plasticity of cell and tissue function is critical for survival by allowing organisms to dynamically adjust physiological processes in response to changing or harsh environmental conditions. Despite the conferred evolutionary advantage, it remains unknown whether emergent experience-dependent properties are present in cell populations organized as networks within endocrine tissues involved in regulating body-wide homeostasis. Here we show, using lactation to repeatedly activate a specific endocrine cell network in situ in the mammalian pituitary, that templates of prior demand are permanently stored through stimulus-evoked alterations to the extent and strength of cell-cell connectivity. Strikingly, following repeat stimulation, evolved population behaviour leads to improved tissue output. As such, long-lasting experience-dependent plasticity is an important feature of endocrine cell networks and underlies functional adaptation of hormone release.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Hodson DJ,Schaeffer M,Romanò N,Fontanaud P,Lafont C,Birkenstock J,Molino F,Christian H,Lockey J,Carmignac D,Fernandez-Fuente M,Le Tissier P,Mollard Pdoi
10.1038/ncomms1612subject
Has Abstractpub_date
2012-01-03 00:00:00pages
605issn
2041-1723pii
ncomms1612journal_volume
3pub_type
杂志文章abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-020-17555-0
更新日期:2020-07-28 00:00:00
abstract::Various viruses enter host cells via endocytosis, but the molecular mechanisms underlying the specific internalization pathways remain unclear. Here we show that influenza A viruses (IAVs) enter cells via redundant pathways of clathrin-mediated and clathrin-independent endocytosis, with intracellular Ca(2+) having a c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3763
更新日期:2013-01-01 00:00:00
abstract::Visualization and exploration of high-dimensional data is a ubiquitous challenge across disciplines. Widely used techniques such as principal component analysis (PCA) aim to identify dominant trends in one dataset. However, in many settings we have datasets collected under different conditions, e.g., a treatment and a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04608-8
更新日期:2018-05-30 00:00:00
abstract::Understanding the role of intermolecular interaction on through-space charge transfer characteristics in π-stacked molecular systems is central to the rational design of electronic materials. However, a quantitative study of charge transfer in such systems is often difficult because of poor control over molecular morp...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2083
更新日期:2012-01-01 00:00:00
abstract::The original version of this article contained an error in the spelling of Juan Pedro Martinez-Barbera, which was incorrectly given as Juan Pedro Martinez Barbera. This error has now been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-05718-z
更新日期:2018-08-02 00:00:00
abstract::Lipids and amphiphilic block copolymers spontaneously self-assemble in water to form a plethora of micelles and vesicles. They are typically fluidic in nature and often mechanically weak for applications such as drug delivery and gene therapeutics. Mechanical properties of polymeric materials could be improved by form...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10599
更新日期:2016-02-03 00:00:00
abstract::The dual role played by symmetry in many-body physics manifests itself through two fundamental mechanisms: spontaneous symmetry breaking and topological symmetry protection. These two concepts, ubiquitous in both condensed matter and high energy physics, have been applied successfully in the last decades to unravel a ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10796-8
更新日期:2019-06-19 00:00:00
abstract::We report the results from the first 5D tomographic diffraction imaging experiment of a complex Ni-Pd/CeO2-ZrO2/Al2O3 catalyst used for methane reforming. This five-dimensional (three spatial, one scattering and one dimension to denote time/imposed state) approach enabled us to track the chemical evolution of many par...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07046-8
更新日期:2018-11-12 00:00:00
abstract::Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4127
更新日期:2014-01-01 00:00:00
abstract::Batesian mimicry, in which harmless species (mimics) deter predators by deceitfully imitating the warning signals of noxious species (models), generates striking cases of phenotypic convergence that are classic examples of evolution by natural selection. However, mimicry of venomous coral snakes has remained controver...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11484
更新日期:2016-05-05 00:00:00
abstract::Antibodies against programmed cell death-1 (PD-1) have considerably changed the treatment for melanoma. However, many patients do not display therapeutic response or eventually relapse. Moreover, patients treated with anti-PD-1 develop immune-related adverse events that can be cured with anti-tumor necrosis factor α (...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02358-7
更新日期:2017-12-22 00:00:00
abstract::Nascent polypeptides can induce ribosome stalling, regulating downstream genes. Stalling of ErmBL peptide translation in the presence of the macrolide antibiotic erythromycin leads to resistance in Streptococcus sanguis. To reveal this stalling mechanism we obtained 3.6-Å-resolution cryo-EM structures of ErmBL-stalled...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12026
更新日期:2016-07-06 00:00:00
abstract::The expression and stabilization of recombinant proteins is fundamental to basic and applied biology. Here we have engineered a thermostable protein nanoparticle (tES) to improve both expression and stabilization of recombinant proteins using this technology. tES provides steric accommodation and charge complementatio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01585-2
更新日期:2017-11-13 00:00:00
abstract::How to move efficiently is an optimal control problem, whose computational complexity grows exponentially with the horizon of the planned trajectory. Breaking a compound movement into a series of chunks, each planned over a shorter horizon can thus reduce the overall computational complexity and associated costs while...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12176
更新日期:2016-07-11 00:00:00
abstract::Cambodia harbours a variety of aboriginal (and presumably ancient) populations that have largely been ignored in studies of genetic diversity. Here we investigate the matrilineal gene pool of 1,054 Cambodians from 14 geographic populations. Using mitochondrial whole-genome sequencing, we identify eight new mitochondri...
journal_title:Nature communications
pub_type: 历史文章,杂志文章
doi:10.1038/ncomms3599
更新日期:2013-01-01 00:00:00
abstract::Nano-sized metal particles are attracting much interest in industrial and biomedical applications due to the recent progress and development of nanotechnology, and the surface-modifications by appropriate polymers are key techniques to stably express their characteristics. Herein, we applied cyclic poly(ethylene glyco...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19947-8
更新日期:2020-11-30 00:00:00
abstract::Sunlight is the ultimate driver of biosynthesis but photochemical steps late in biosynthetic pathways are very rare. They appear to play a role in the formation of certain furanocembranoids isolated from Caribbean corals. One of these compounds, intricarene, has been suspected to arise from an intramolecular 1,3-dipol...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6597
更新日期:2014-12-03 00:00:00
abstract::Hybrid organic-inorganic perovskites have attractive optoelectronic properties including exceptional solar cell performance. The improved properties of perovskites have been attributed to polaronic effects involving stabilization of localized charge character by structural deformations and polarizations. Here we exami...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04946-7
更新日期:2018-06-28 00:00:00
abstract::To expand the toolbox of imaging in living cells, we have engineered a single-chain variable fragment binding the linear HA epitope with high affinity and specificity in vivo. The resulting probe, called the HA frankenbody, can light up in multiple colors HA-tagged nuclear, cytoplasmic, membrane, and mitochondrial pro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10846-1
更新日期:2019-07-03 00:00:00
abstract::β-Diguetoxin-Dc1a (Dc1a) is a toxin from the desert bush spider Diguetia canities that incapacitates insects at concentrations that are non-toxic to mammals. Dc1a promotes opening of German cockroach voltage-gated sodium (Nav) channels (BgNav1), whereas human Nav channels are insensitive. Here, by transplanting common...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5350
更新日期:2014-07-11 00:00:00
abstract::In the lead-up to the Cretaceous/Paleogene mass extinction, dinosaur diversity is argued to have been either in long-term decline, or thriving until their sudden demise. The latest Cretaceous (Campanian-Maastrichtian [83-66 Ma]) of North America provides the best record to address this debate, but even here diversity ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08997-2
更新日期:2019-03-06 00:00:00
abstract::Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-cells. Prognosis is strongly associated with molecular subgroup, although the driver mutations that distinguish the two main subgroups remain poorly defined. Through an integrative analysis of whole genomes, exomes, and transcripto...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06354-3
更新日期:2018-10-01 00:00:00
abstract::White light-emitting diodes (WLEDs) are candidates to revolutionize the lighting industry towards energy efficient and environmental friendly lighting and displays. The current challenges in WLEDs encompass high luminous efficiency, chromatic stability, high colour-rending index and price competitiveness. Recently, th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6702
更新日期:2014-12-08 00:00:00
abstract::Recently, stretchable electronics combined with wireless technology have been crucial for realizing efficient human-machine interaction. Here, we demonstrate highly stretchable transparent wireless electronics composed of Ag nanofibers coils and functional electronic components for power transfer and information commu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19367-8
更新日期:2020-11-06 00:00:00
abstract::Troodontid dinosaurs share a close ancestry with birds and were distributed widely across Laurasia during the Cretaceous. Hundreds of occurrences of troodontid bones, and their highly distinctive teeth, are known from North America, Europe and Asia. Thus far, however, they remain unknown from Gondwanan landmasses. Her...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2716
更新日期:2013-01-01 00:00:00
abstract::The original version of this Article contained an error in Figure 4. In panel a, the colour code for hot and cold clusters was inadvertently inverted. In the correct version of panel a, the hot clusters are blue and the cold clusters are yellow. This error has now been corrected in both the PDF and HTML versions of th...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-07155-4
更新日期:2018-11-02 00:00:00
abstract::Macrophages play crucial roles in host defence and tissue homoeostasis, processes in which both environmental stimuli and intracellularly generated metabolites influence activation of macrophages. Activated macrophages are classified into M1 and M2 macrophages. It remains unclear how intracellular nutrition sufficienc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13130
更新日期:2016-10-12 00:00:00
abstract::Addressing the intrinsic charge transport limitation of metal oxides has been of significance for pursuing viable PEC water splitting photoelectrodes. Growing a photoelectrode with conductive nanoobjects embedded in the matrix is promising for enhanced charge transport but remains a challenge technically. We herein sh...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10543-z
更新日期:2019-06-13 00:00:00
abstract::A recent review concluded that earthworm presence increases CO₂ emissions by 33% but does not affect soil organic carbon stocks. However, the findings are controversial and raise new questions. Here we hypothesize that neither an increase in CO₂ emission nor in stabilized carbon would entirely reflect the earthworms' ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3576
更新日期:2013-01-01 00:00:00
abstract::One of the most dramatic events in river environments is the natural diversion, or avulsion, of a channel across its floodplain. Though rarely witnessed, avulsions can cause massive floods, and over geologic time they create most of the fluvial stratigraphic record. Avulsions exhibit behavior ranging from reoccupying ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15859-9
更新日期:2020-04-30 00:00:00