A Ca(2+)-dependent signalling circuit regulates influenza A virus internalization and infection.

abstract：:Colorectal cancer (CRC) transcriptional subtypes have been recently identified by gene expression profiling. Here we describe an analytical pipeline, microRNA master regulator analysis (MMRA), developed to search for microRNAs potentially driving CRC subtypes. Starting from a microRNA-mRNA tumour expression data set, ...

journal_title：Nature communications

authors： Cantini L,Isella C,Petti C,Picco G,Chiola S,Ficarra E,Caselle M,Medico E

更新日期：2015-11-17 00:00:00

abstract：:In response to brain injury, microglia rapidly extend processes that isolate lesion sites and protect the brain from further injury. Here we report that microglia carrying a pathogenic mutation in the Parkinson's disease (PD)-associated gene, G2019S-LRRK2 (GS-Tg microglia), show retarded ADP-induced motility and delay...

journal_title：Nature communications

authors： Choi I,Kim B,Byun JW,Baik SH,Huh YH,Kim JH,Mook-Jung I,Song WK,Shin JH,Seo H,Suh YH,Jou I,Park SM,Kang HC,Joe EH

更新日期：2015-09-14 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Kremer M,Petrides I,Meyer E,Heinrich M,Zilberberg O,Szameit A

更新日期：2020-04-08 00:00:00

abstract：:Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1R) mediate distinct cellular and physiological functions. Here, we demonstrate how domain differences between IR and IGF1R contribute to the distinct functions of these receptors using chimeric and site-mutated receptors. Receptors with t...

journal_title：Nature communications

authors： Cai W,Sakaguchi M,Kleinridders A,Gonzalez-Del Pino G,Dreyfuss JM,O'Neill BT,Ramirez AK,Pan H,Winnay JN,Boucher J,Eck MJ,Kahn CR

更新日期：2017-03-27 00:00:00

abstract：:The importance of the tumor-associated stroma in cancer progression is clear. However, it remains uncertain whether early events in the stroma are capable of initiating breast tumorigenesis. Here, we show that in the mammary glands of non-tumor bearing mice, stromal-specific phosphatase and tensin homolog (Pten) delet...

journal_title：Nature communications

authors： Sizemore GM,Balakrishnan S,Thies KA,Hammer AM,Sizemore ST,Trimboli AJ,Cuitiño MC,Steck SA,Tozbikian G,Kladney RD,Shinde N,Das M,Park D,Majumder S,Krishnan S,Yu L,Fernandez SA,Chakravarti A,Shields PG,White JR,Yee

更新日期：2018-07-17 00:00:00

abstract：:Transition-metal dissolution from cathode materials, manganese in particular, has been held responsible for severe capacity fading in lithium-ion batteries, with the deposition of the transition-metal cations on anode surface, in elemental form or as chelated-complexes, as the main contributor for such degradations. I...

journal_title：Nature communications

authors： Wang C,Xing L,Vatamanu J,Chen Z,Lan G,Li W,Xu K

更新日期：2019-07-31 00:00:00

abstract：:The gating mechanism of transmembrane ion channels is crucial for understanding how these proteins control ion flow across membranes in various physiological processes. Big potassium (BK) channels are particularly interesting with large single-channel conductance and dual regulation by membrane voltage and intracellul...

journal_title：Nature communications

authors： Jia Z,Yazdani M,Zhang G,Cui J,Chen J

更新日期：2018-08-24 00:00:00

abstract：:Calcareous microplankton shells form the dominant components of ancient and modern pelagic sea-floor carbonates and are widely used in palaeoenvironmental reconstructions. The efficacy of these applications, however, is dependent upon minimal geochemical alteration during diagenesis, but these modifying processes are ...

journal_title：Nature communications

authors： Wendler JE,Bown P

更新日期：2013-01-01 00:00:00

abstract：:Rapid growth in size and complexity of biological data sets has led to the 'Big Data to Knowledge' challenge. We develop advanced data integration methods for multi-level analysis of genomic, transcriptomic, ribosomal profiling, proteomic and fluxomic data. First, we show that pairwise integration of primary omics dat...

journal_title：Nature communications

authors： Ebrahim A,Brunk E,Tan J,O'Brien EJ,Kim D,Szubin R,Lerman JA,Lechner A,Sastry A,Bordbar A,Feist AM,Palsson BO

更新日期：2016-10-26 00:00:00

abstract：:Soft particulate media include a wide range of systems involving athermal dissipative particles both in non-living and biological materials. Characterization of flows of particulate media is of great practical and theoretical importance. A fascinating feature of these systems is the existence of a critical rigidity tr...

journal_title：Nature communications

authors： Rahbari SHE,Saberi AA,Park H,Vollmer J

更新日期：2017-04-10 00:00:00

abstract：:A variety of flexible and stretchable electronics have been reported for use in flexible electronic devices or biomedical applications. The practical and wider application of such flexible electronics has been limited because commercial electronic components are difficult to be directly integrated into flexible stretc...

journal_title：Nature communications

authors： Jeong GS,Baek DH,Jung HC,Song JH,Moon JH,Hong SW,Kim IY,Lee SH

更新日期：2012-01-01 00:00:00

abstract：:Herpes simplex encephalitis (HSE) is the most common form of acute viral encephalitis in industrialized countries. Type I interferon (IFN) is important for control of herpes simplex virus (HSV-1) in the central nervous system (CNS). Here we show that microglia are the main source of HSV-induced type I IFN expression i...

journal_title：Nature communications

authors： Reinert LS,Lopušná K,Winther H,Sun C,Thomsen MK,Nandakumar R,Mogensen TH,Meyer M,Vægter C,Nyengaard JR,Fitzgerald KA,Paludan SR

更新日期：2016-11-10 00:00:00

abstract：:Oxygen vacancies in proximity to surfaces and heterointerfaces in oxide thin film heterostructures have major effects on properties, resulting, for example, in emergent conduction behaviour, large changes in metal-insulator transition temperatures or enhanced catalytic activity. Here we report the discovery of a means...

journal_title：Nature communications

authors： Veal BW,Kim SK,Zapol P,Iddir H,Baldo PM,Eastman JA

更新日期：2016-06-10 00:00:00

abstract：:Amyloid β (Aβ) oligomer-induced aberrant neurotransmitter release is proposed to be a crucial early event leading to synapse dysfunction in Alzheimer's disease (AD). In the present study, we report that the release probability (Pr) at the synapse between the Schaffer collateral (SC) and CA1 pyramidal neurons is signif...

journal_title：Nature communications

authors： He Y,Wei M,Wu Y,Qin H,Li W,Ma X,Cheng J,Ren J,Shen Y,Chen Z,Sun B,Huang FD,Shen Y,Zhou YD

更新日期：2019-03-13 00:00:00

abstract：:CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and memory T cells is necessary for resolution of acute inflammation. Failure of this neural circuit co...

journal_title：Nature communications

authors： Dubeykovskaya Z,Si Y,Chen X,Worthley DL,Renz BW,Urbanska AM,Hayakawa Y,Xu T,Westphalen CB,Dubeykovskiy A,Chen D,Friedman RA,Asfaha S,Nagar K,Tailor Y,Muthupalani S,Fox JG,Kitajewski J,Wang TC

更新日期：2016-02-04 00:00:00

abstract：:The Peer Review File associated with this Article was updated shortly after publication to redact from the authors' point-by-point response a description of unpublished work describing how Speed OPIOM may in future be used to facilitate discrimination between FRET and direct excitation. ...

journal_title：Nature communications

authors： Quérard J,Zhang R,Kelemen Z,Plamont MA,Xie X,Chouket R,Roemgens I,Korepina Y,Albright S,Ipendey E,Volovitch M,Sladitschek HL,Neveu P,Gissot L,Gautier A,Faure JD,Croquette V,Le Saux T,Jullien L

更新日期：2017-12-14 00:00:00

abstract：:OPCML, a tumor suppressor gene, is frequently silenced epigenetically in ovarian and other cancers. Here we report, by analysis of databases of tumor sequences, the observation of OPCML somatic missense mutations from various tumor types and the impact of these mutations on OPCML function, by solving the X-ray crystal...

journal_title：Nature communications

authors： Birtley JR,Alomary M,Zanini E,Antony J,Maben Z,Weaver GC,Von Arx C,Mura M,Marinho AT,Lu H,Morecroft EVN,Karali E,Chayen NE,Tate EW,Jurewicz M,Stern LJ,Recchi C,Gabra H

更新日期：2019-07-17 00:00:00

abstract：:G-protein-coupled receptor (GPCR) expression is extensively studied in bulk cDNA, but heterogeneity and functional patterning of GPCR expression in individual vascular cells is poorly understood. Here, we perform a microfluidic-based single-cell GPCR expression analysis in primary smooth muscle cells (SMC) and endothe...

journal_title：Nature communications

authors： Kaur H,Carvalho J,Looso M,Singh P,Chennupati R,Preussner J,Günther S,Albarrán-Juárez J,Tischner D,Classen S,Offermanns S,Wettschureck N

更新日期：2017-06-16 00:00:00

abstract：:The proliferative and functional heterogeneity among seemingly uniform cells is a universal phenomenon. Identifying the underlying factors requires single-cell analysis of function and proliferation. Here we show that the pancreatic beta-cells in zebrafish exhibit different growth-promoting and functional properties, ...

journal_title：Nature communications

authors： Singh SP,Janjuha S,Hartmann T,Kayisoglu Ö,Konantz J,Birke S,Murawala P,Alfar EA,Murata K,Eugster A,Tsuji N,Morrissey ER,Brand M,Ninov N

更新日期：2017-09-22 00:00:00

abstract：:Identifying genes regulating the pace of epigenetic ageing represents a new frontier in genome-wide association studies (GWASs). Here using 1,796 brain samples from 1,163 individuals, we carry out a GWAS of two DNA methylation-based biomarkers of brain age: the epigenetic ageing rate and estimated proportion of neuron...

journal_title：Nature communications

authors： Lu AT,Hannon E,Levine ME,Crimmins EM,Lunnon K,Mill J,Geschwind DH,Horvath S

更新日期：2017-05-18 00:00:00

abstract：:A cloak that can hide living creatures from sight is a common feature of mythology but still remains unrealized as a practical device. To preserve the wave phase, the previous cloaking solution proposed by Pendry and colleagues required transformation of the electromagnetic space around the hidden object in such a way...

journal_title：Nature communications

authors： Chen H,Zheng B,Shen L,Wang H,Zhang X,Zheludev NI,Zhang B

更新日期：2013-01-01 00:00:00

abstract：:The removal of dying neurons by microglia has a key role during both development and in several diseases. To date, little is known about the cellular and molecular processes underlying neuronal engulfment in the brain. Here we took a live imaging approach to quantify neuronal cell death progression in embryonic zebraf...

journal_title：Nature communications

authors： Mazaheri F,Breus O,Durdu S,Haas P,Wittbrodt J,Gilmour D,Peri F

更新日期：2014-06-05 00:00:00

abstract：:Iron (Fe) is essential for life, but in excess can cause oxidative cytotoxicity through the generation of Fe-catalyzed reactive oxygen species. It is yet unknown which genes and mechanisms can provide Fe-toxicity tolerance. Here, we identify S-nitrosoglutathione-reductase (GSNOR) variants underlying a major quantitati...

journal_title：Nature communications

authors： Li B,Sun L,Huang J,Göschl C,Shi W,Chory J,Busch W

更新日期：2019-08-29 00:00:00

abstract：:The gut-derived orexigenic peptide hormone ghrelin enhances neuronal firing in the substantia nigra pars compacta, where dopaminergic neurons modulate the function of the nigrostriatal system for motor coordination. Here we describe a novel mechanism by which ghrelin enhances firing of nigral dopaminergic neurons by i...

journal_title：Nature communications

authors： Shi L,Bian X,Qu Z,Ma Z,Zhou Y,Wang K,Jiang H,Xie J

更新日期：2013-01-01 00:00:00

abstract：:Laryngeal squamous cell carcinoma is a frequent and significant cause of morbidity and mortality. Here we explore the biological basis of this aggressive tumour, and identify two cell-cell adhesion genes as recurrently mutated in this malignancy. We first perform exome sequencing of four laryngeal carcinomas and their...

journal_title：Nature communications

authors： Fanjul-Fernández M,Quesada V,Cabanillas R,Cadiñanos J,Fontanil T,Obaya A,Ramsay AJ,Llorente JL,Astudillo A,Cal S,López-Otín C

更新日期：2013-01-01 00:00:00

abstract：:Quantum dots (QDs) are an excellent single-photon source that can be combined with a spin quantum memory. Many quantum technologies require increased control over the characteristics of emitted photons. A powerful approach is to trigger coherent Raman photons from QDs with a Λ energy-level system, such as the spin sin...

journal_title：Nature communications

authors： Pursley BC,Carter SG,Yakes MK,Bracker AS,Gammon D

更新日期：2018-01-09 00:00:00

abstract：:Recent density-functional theory calculations suggest that codoping TiO2 with donor-acceptor pairs is more effective than monodoping for improving photoelectrochemical water-splitting performance because codoping can reduce charge recombination, improve material quality, enhance light absorption and increase solubilit...

journal_title：Nature communications

authors： Cho IS,Lee CH,Feng Y,Logar M,Rao PM,Cai L,Kim DR,Sinclair R,Zheng X

更新日期：2013-01-01 00:00:00

abstract：:The success of protein evolution campaigns is strongly dependent on the sequence context in which mutations are introduced, stemming from pervasive non-additive interactions between a protein's amino acids ('intra-gene epistasis'). Our limited understanding of such epistasis hinders the correct prediction of the funct...

journal_title：Nature communications

authors： Zurek PJ,Knyphausen P,Neufeld K,Pushpanath A,Hollfelder F

更新日期：2020-11-26 00:00:00

abstract：:Janus, patchy, stripe-like, or random arrangements of molecules within the ligand shell of nanoparticles affect many properties. Among all existing ligand shell morphology characterization methods, the one based on mass spectroscopy is arguably the simplest. Its greatest limitation is that the results are qualitative....

journal_title：Nature communications

authors： Luo Z,Zhao Y,Darwish T,Wang Y,Hou J,Stellacci F

更新日期：2018-10-26 00:00:00

abstract：:Assembly and maturation of synapses at the Drosophila neuromuscular junction (NMJ) depend on trans-synaptic neurexin/neuroligin signalling, which is promoted by the scaffolding protein Syd-1 binding to neurexin. Here we report that the scaffold protein spinophilin binds to the C-terminal portion of neurexin and is nee...

journal_title：Nature communications

authors： Muhammad K,Reddy-Alla S,Driller JH,Schreiner D,Rey U,Böhme MA,Hollmann C,Ramesh N,Depner H,Lützkendorf J,Matkovic T,Götz T,Bergeron DD,Schmoranzer J,Goettfert F,Holt M,Wahl MC,Hell SW,Scheiffele P,Walter AM,Loll B

更新日期：2015-10-16 00:00:00