Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma.

abstract：:Infection of specific pathogen-free mice with lymphocytic choriomeningitis virus (LCMV) is a widely used model to study antiviral T-cell immunity. Infections in the real world, however, are often accompanied by coinfections with unrelated pathogens. Here we show that in mice, systemic coinfection with E. coli suppress...

journal_title：Nature communications

authors： Straub T,Freudenberg MA,Schleicher U,Bogdan C,Gasteiger G,Pircher H

更新日期：2018-10-08 00:00:00

abstract：:In November 2013, a series of earthquakes began along a mapped ancient fault system near Azle, Texas. Here we assess whether it is plausible that human activity caused these earthquakes. Analysis of both lake and groundwater variations near Azle shows that no significant stress changes were associated with the shallow...

journal_title：Nature communications

authors： Hornbach MJ,DeShon HR,Ellsworth WL,Stump BW,Hayward C,Frohlich C,Oldham HR,Olson JE,Magnani MB,Brokaw C,Luetgert JH

更新日期：2015-04-21 00:00:00

abstract：:Land-atmosphere exchanges influence atmospheric CO2. Emphasis has been on describing photosynthetic CO2 uptake, but less on respiration losses. New global datasets describe upper canopy dark respiration (R d) and temperature dependencies. This allows characterisation of baseline R d, instantaneous temperature response...

journal_title：Nature communications

authors： Huntingford C,Atkin OK,Martinez-de la Torre A,Mercado LM,Heskel MA,Harper AB,Bloomfield KJ,O'Sullivan OS,Reich PB,Wythers KR,Butler EE,Chen M,Griffin KL,Meir P,Tjoelker MG,Turnbull MH,Sitch S,Wiltshire A,Malhi Y

更新日期：2017-11-17 00:00:00

abstract：:The immunosuppressive microenvironment that is shaped by hepatic metastatic pancreatic ductal adenocarcinoma (PDAC) is essential for tumor cell evasion of immune destruction. Neutrophils are important components of the metastatic tumor microenvironment and exhibit heterogeneity. However, the specific phenotypes, funct...

journal_title：Nature communications

authors： Wang X,Hu LP,Qin WT,Yang Q,Chen DY,Li Q,Zhou KX,Huang PQ,Xu CJ,Li J,Yao LL,Wang YH,Tian GA,Yang JY,Yang MW,Liu DJ,Sun YW,Jiang SH,Zhang XL,Zhang ZG

更新日期：2021-01-08 00:00:00

abstract：:Single chip integrated spectrometers are critical to bring chemical and biological sensing, spectroscopy, and spectral imaging into robust, compact and cost-effective devices. Existing on-chip spectrometer approaches fail to realize both high resolution and broad band. Here we demonstrate a microring resonator-assiste...

journal_title：Nature communications

authors： Zheng SN,Zou J,Cai H,Song JF,Chin LK,Liu PY,Lin ZP,Kwong DL,Liu AQ

更新日期：2019-05-28 00:00:00

abstract：:The human pathogen Helicobacter pylori displays extensive genetic diversity. While H. pylori is known to evolve during infection, population dynamics inside the gastric environment have not been extensively investigated. Here we obtained gastric biopsies from multiple stomach regions of 16 H. pylori-infected adults, a...

journal_title：Nature communications

authors： Ailloud F,Didelot X,Woltemate S,Pfaffinger G,Overmann J,Bader RC,Schulz C,Malfertheiner P,Suerbaum S

更新日期：2019-05-22 00:00:00

abstract：:Graphene is a single-atomic-layer material with excellent mechanical properties and has the potential to enhance the strength of composites. Its two-dimensional geometry, high intrinsic strength and modulus can effectively constrain dislocation motion, resulting in the significant strengthening of metals. Here we demo...

journal_title：Nature communications

authors： Kim Y,Lee J,Yeom MS,Shin JW,Kim H,Cui Y,Kysar JW,Hone J,Jung Y,Jeon S,Han SM

更新日期：2013-01-01 00:00:00

abstract：:Achieving and exceeding diversity of colloidal analogs of chemical elements and molecules as building blocks of matter has been the central goal and challenge of colloidal science ever since Einstein introduced the colloidal atom paradigm. Recent advances in colloids assembly have been achieved by exploiting the machi...

journal_title：Nature communications

authors： Senyuk B,Aplinc J,Ravnik M,Smalyukh II

更新日期：2019-04-23 00:00:00

abstract：:Alterations in the methylation of promoters of cancer-related genes are promising biomarkers for the early detection of disease. Compared with single methylation alteration, assessing combined methylation alterations can provide higher association with specific cancer. Here we use cationic conjugated polymer-based flu...

journal_title：Nature communications

authors： Yang Q,Dong Y,Wu W,Zhu C,Chong H,Lu J,Yu D,Liu L,Lv F,Wang S

更新日期：2012-01-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Temko D,Tomlinson IPM,Severini S,Schuster-Böckler B,Graham TA

更新日期：2020-04-20 00:00:00

abstract：:Multidrug resistance is a major challenge to cancer chemotherapy. The multidrug resistance phenotype is associated with the overexpression of the adenosine triphosphate (ATP)-driven transmembrane efflux pumps in cancer cells. Here, we report a lipid membrane-coated silica-carbon (LSC) hybrid nanoparticle that targets ...

journal_title：Nature communications

authors： Wang H,Gao Z,Liu X,Agarwal P,Zhao S,Conroy DW,Ji G,Yu J,Jaroniec CP,Liu Z,Lu X,Li X,He X

更新日期：2018-02-08 00:00:00

abstract：:Small interfering RNAs (siRNAs) conjugated to a trivalent N-acetylgalactosamine (GalNAc) ligand are being evaluated in investigational clinical studies for a variety of indications. The typical development candidate selection process includes evaluation of the most active compounds for toxicity in rats at pharmacologi...

journal_title：Nature communications

authors： Janas MM,Schlegel MK,Harbison CE,Yilmaz VO,Jiang Y,Parmar R,Zlatev I,Castoreno A,Xu H,Shulga-Morskaya S,Rajeev KG,Manoharan M,Keirstead ND,Maier MA,Jadhav V

更新日期：2018-02-19 00:00:00

abstract：:CD47 is a cell surface molecule that inhibits phagocytosis of cells that express it by binding to its receptor, SIRPα, on macrophages and other immune cells. CD47 is expressed at different levels by neoplastic and normal cells. Here, to reveal mechanisms by which different neoplastic cells generate this dominant 'don'...

journal_title：Nature communications

authors： Betancur PA,Abraham BJ,Yiu YY,Willingham SB,Khameneh F,Zarnegar M,Kuo AH,McKenna K,Kojima Y,Leeper NJ,Ho P,Gip P,Swigut T,Sherwood RI,Clarke MF,Somlo G,Young RA,Weissman IL

更新日期：2017-04-05 00:00:00

abstract：:The combined effects of anthropogenic and biological CO2 inputs may lead to more rapid acidification in coastal waters compared to the open ocean. It is less clear, however, how redox reactions would contribute to acidification. Here we report estuarine acidification dynamics based on oxygen, hydrogen sulfide (H2S), p...

journal_title：Nature communications

authors： Cai WJ,Huang WJ,Luther GW 3rd,Pierrot D,Li M,Testa J,Xue M,Joesoef A,Mann R,Brodeur J,Xu YY,Chen B,Hussain N,Waldbusser GG,Cornwell J,Kemp WM

更新日期：2017-08-28 00:00:00

abstract：:Cholesterol is a key component of cell membranes with a proven modulatory role on the function and ligand-binding properties of G-protein-coupled receptors (GPCRs). Crystal structures of prototypical GPCRs such as the adenosine A2A receptor (A2AR) have confirmed that cholesterol finds stable binding sites at the recep...

journal_title：Nature communications

authors： Guixà-González R,Albasanz JL,Rodriguez-Espigares I,Pastor M,Sanz F,Martí-Solano M,Manna M,Martinez-Seara H,Hildebrand PW,Martín M,Selent J

更新日期：2017-02-21 00:00:00

abstract：:WNTs are lipid-modified proteins that control multiple functions in development and disease via short- and long-range signaling. However, it is unclear how these hydrophobic molecules spread over long distances in the mammalian brain. Here we show that WNT5A is produced by the choroid plexus (ChP) of the developing hi...

journal_title：Nature communications

authors： Kaiser K,Gyllborg D,Procházka J,Salašová A,Kompaníková P,Molina FL,Laguna-Goya R,Radaszkiewicz T,Harnoš J,Procházková M,Potěšil D,Barker RA,Casado ÁG,Zdráhal Z,Sedláček R,Arenas E,Villaescusa JC,Bryja V

更新日期：2019-04-02 00:00:00

abstract：:Understanding the formation chemistry of metal halide perovskites is key to optimizing processing conditions and realizing enhanced optoelectronic properties. Here, we reveal the structure of the crystalline precursor in the formation of methylammonium lead iodide (MAPbI3) from the single-step deposition of lead chlor...

journal_title：Nature communications

authors： Stone KH,Gold-Parker A,Pool VL,Unger EL,Bowring AR,McGehee MD,Toney MF,Tassone CJ

更新日期：2018-08-27 00:00:00

abstract：:GABAB receptors (GBRs) are key regulators of synaptic release but little is known about trafficking mechanisms that control their presynaptic abundance. We now show that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic GBRs. Of the three in...

journal_title：Nature communications

authors： Dinamarca MC,Raveh A,Schneider A,Fritzius T,Früh S,Rem PD,Stawarski M,Lalanne T,Turecek R,Choo M,Besseyrias V,Bildl W,Bentrop D,Staufenbiel M,Gassmann M,Fakler B,Schwenk J,Bettler B

更新日期：2019-03-22 00:00:00

abstract：:The superconducting state is formed by the condensation of Cooper pairs and protected by the superconducting gap. The pairing interaction between the two electrons of a Cooper pair determines the gap function. Thus, it is pivotal to detect the gap structure for understanding the mechanism of superconductivity. In cupr...

journal_title：Nature communications

authors： Gu Q,Wan S,Tang Q,Du Z,Yang H,Wang QH,Zhong R,Wen J,Gu GD,Wen HH

更新日期：2019-04-08 00:00:00

abstract：:The original version of this Article contained an error in the third sentence of the penultimate paragraph of the 'Definition of the harmonic phase' section of the Results, which incorrectly read 'In the Coulomb phase the tensor S αβ (q) has one zero and two degenerate eigenvalues and it may be represented by an infin...

journal_title：Nature communications

authors： Bramwell ST

更新日期：2018-04-16 00:00:00

abstract：:It is difficult to achieve minimally invasive injectable cell delivery while maintaining high cell retention and animal survival for in vivo stem cell therapy of myocardial infarction. Here we show that pluripotent stem cell aggregates pre-differentiated into the early cardiac lineage and encapsulated in a biocompatib...

journal_title：Nature communications

authors： Zhao S,Xu Z,Wang H,Reese BE,Gushchina LV,Jiang M,Agarwal P,Xu J,Zhang M,Shen R,Liu Z,Weisleder N,He X

更新日期：2016-10-27 00:00:00

abstract：:The practices of synthetic biology are being integrated into 'multiscale' designs enabling two-way communication across organic and inorganic information substrates in biological, digital and cyber-physical system integrations. Novel applications of 'bio-informational' engineering will arise in environmental monitorin...

journal_title：Nature communications

authors： Dixon TA,Williams TC,Pretorius IS

更新日期：2021-01-15 00:00:00

abstract：:The originally published version of this Article contained errors in Figure 4. In panel b, the square and diamond labels associated with the uppermost survival curve were incorrectly displayed as 'n' and 'u', respectively. These errors have now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Wang P,Li X,Wang J,Gao D,Li Y,Li H,Chu Y,Zhang Z,Liu H,Jiang G,Cheng Z,Wang S,Dong J,Feng B,Chard LS,Lemoine NR,Wang Y

更新日期：2018-01-10 00:00:00

abstract：:Fibronectin fibrils within the extracellular matrix play central roles in physiological and pathological processes, yet many structural details about their hierarchical and molecular assembly remain unknown. Here we combine site-specific protein labelling with single-molecule localization by stepwise photobleaching or...

journal_title：Nature communications

authors： Früh SM,Schoen I,Ries J,Vogel V

更新日期：2015-06-04 00:00:00

abstract：:The force generated by the actomyosin cytoskeleton controls focal adhesion dynamics during cell migration. This process is thought to involve the mechanical unfolding of talin to expose cryptic vinculin-binding sites. However, the ability of the actomyosin cytoskeleton to directly control the formation of a talin-vinc...

journal_title：Nature communications

authors： Ciobanasu C,Faivre B,Le Clainche C

更新日期：2014-01-01 00:00:00

abstract：:Detection of Identical-By-Descent (IBD) segments provides a fundamental measure of genetic relatedness and plays a key role in a wide range of analyses. We develop FastSMC, an IBD detection algorithm that combines a fast heuristic search with accurate coalescent-based likelihood calculations. FastSMC enables biobank-s...

journal_title：Nature communications

authors： Nait Saada J,Kalantzis G,Shyr D,Cooper F,Robinson M,Gusev A,Palamara PF

更新日期：2020-11-30 00:00:00

abstract：:Glucagon promotes hepatic gluconeogenesis and maintains whole-body glucose levels during fasting. The regulatory factors that are involved in fasting glucagon response are not well understood. Here we report a role of p52, a key activator of the noncanonical nuclear factor-kappaB signaling, in hepatic glucagon respons...

journal_title：Nature communications

authors： Zhang WS,Pan A,Zhang X,Ying A,Ma G,Liu BL,Qi LW,Liu Q,Li P

更新日期：2019-09-20 00:00:00

abstract：:Topological insulators represent a new quantum state of matter that are insulating in the bulk but metallic on the edge or surface. In the Dirac surface state, it is well-established that the electron spin is locked with the crystal momentum. Here we report a new phenomenon of the spin texture locking with the orbital...

journal_title：Nature communications

authors： Xie Z,He S,Chen C,Feng Y,Yi H,Liang A,Zhao L,Mou D,He J,Peng Y,Liu X,Liu Y,Liu G,Dong X,Yu L,Zhang J,Zhang S,Wang Z,Zhang F,Yang F,Peng Q,Wang X,Chen C,Xu Z,Zhou XJ

更新日期：2014-02-28 00:00:00

abstract：:Approximately 30% of ERα breast cancer patients relapse with metastatic disease following adjuvant endocrine therapies. The connection between acquisition of drug resistance and invasive potential is poorly understood. In this study, we demonstrate that the type II keratin topological associating domain undergoes epig...

journal_title：Nature communications

authors： Perone Y,Farrugia AJ,Rodríguez-Meira A,Győrffy B,Ion C,Uggetti A,Chronopoulos A,Marrazzo P,Faronato M,Shousha S,Davies C,Steel JH,Patel N,Del Rio Hernandez A,Coombes C,Pruneri G,Lim A,Calvo F,Magnani L

更新日期：2019-05-09 00:00:00

abstract：:The realization that mitigation efforts to reduce carbon dioxide emissions have, until now, been relatively ineffective has led to an increasing interest in climate engineering as a possible means of preventing the potentially catastrophic consequences of climate change. While many studies have addressed the potential...

journal_title：Nature communications

authors： Keller DP,Feng EY,Oschlies A

更新日期：2014-02-25 00:00:00