Abstract:
:Antibodies against programmed cell death-1 (PD-1) have considerably changed the treatment for melanoma. However, many patients do not display therapeutic response or eventually relapse. Moreover, patients treated with anti-PD-1 develop immune-related adverse events that can be cured with anti-tumor necrosis factor α (TNF) antibodies. Whether anti-TNF antibodies affect the anti-cancer immune response remains unknown. Our recent work has highlighted that TNFR1-dependent TNF signalling impairs the accumulation of CD8+ tumor-infiltrating T lymphocytes (CD8+ TILs) in mouse melanoma. Herein, our results indicate that TNF or TNFR1 blockade synergizes with anti-PD-1 on anti-cancer immune responses towards solid cancers. Mechanistically, TNF blockade prevents anti-PD-1-induced TIL cell death as well as PD-L1 and TIM-3 expression. TNF expression positively correlates with expression of PD-L1 and TIM-3 in human melanoma specimens. This study provides a strong rationale to develop a combination therapy based on the use of anti-PD-1 and anti-TNF in cancer patients.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Bertrand F,Montfort A,Marcheteau E,Imbert C,Gilhodes J,Filleron T,Rochaix P,Andrieu-Abadie N,Levade T,Meyer N,Colacios C,Ségui Bdoi
10.1038/s41467-017-02358-7subject
Has Abstractpub_date
2017-12-22 00:00:00pages
2256issue
1issn
2041-1723pii
10.1038/s41467-017-02358-7journal_volume
8pub_type
杂志文章abstract::Transposons are known to participate in tissue aging, but their effects on aged stem cells remain unclear. Here, we report that in the Drosophila ovarian germline stem cell (GSC) niche, aging-related reductions in expression of Piwi (a transposon silencer) derepress retrotransposons and cause GSC loss. Suppression of ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16858-6
更新日期:2020-06-19 00:00:00
abstract::Both basal ganglia (BG) and orbitofrontal cortex (OFC) have been widely implicated in social and non-social decision-making. However, unlike OFC damage, BG pathology is not typically associated with disturbances in social functioning. Here we studied the behavior of patients with focal lesions to either BG or OFC in a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08766-1
更新日期:2019-02-18 00:00:00
abstract::Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease with features that vary by ethnicity. A systematic characterization of the genomic landscape of Chinese ccRCC is lacking, and features of ccRCC associated with tumor thrombus (ccRCC-TT) remain poorly understood. Here, we applied whole-exome sequencing ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14601-9
更新日期:2020-02-06 00:00:00
abstract::The original version of this Article contained an error in Fig. 3. The scale bars in Figs 3c and 3d were incorrectly labelled as 50 μA. In the correct version, the scale bars are labelled as 0.5 μA. This has now been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-03030-4
更新日期:2018-02-08 00:00:00
abstract::Orai channels are required for store-operated Ca(2+) entry (SOCE) in multiple cell types. Septins are a class of GTP-binding proteins that function as diffusion barriers in cells. Here we show that Septin 7 acts as a 'molecular brake' on activation of Orai channels in Drosophila neurons. Lowering Septin 7 levels resul...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11751
更新日期:2016-05-26 00:00:00
abstract::Metal ions at the active site of an enzyme act as cofactors, and their dynamic fluctuations can potentially influence enzyme activity. Here, we use λ-exonuclease as a model enzyme with two Mg2+ binding sites and probe activity at various concentrations of magnesium by single-molecule-FRET. We find that while MgA2+ and...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06750-9
更新日期:2018-10-23 00:00:00
abstract::The temporal resolution of ultrafast electron diffraction and microscopy experiments is currently limited by the available experimental techniques for the generation and characterization of electron bunches with single femtosecond or attosecond durations. Here, we present proof of principle experiments of an optical g...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14342
更新日期:2017-01-25 00:00:00
abstract::Strain engineering is widely used in material science to tune the (opto-)electronic properties of materials and enhance the performance of devices. Two-dimensional atomic crystals are a versatile playground to study the influence of strain, as they can sustain very large deformations without breaking. Various optical ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-02830-y
更新日期:2018-02-06 00:00:00
abstract::The prokaryotic chemotaxis system is arguably the best-understood signaling pathway in biology. In all previously described species, chemoreceptors organize into a hexagonal (P6 symmetry) extended array. Here, we report an alternative symmetry (P2) of the chemotaxis apparatus that emerges from a strict linear organiza...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19628-6
更新日期:2020-11-13 00:00:00
abstract::A major conundrum in climate science is how to account for dependence between climate models. This complicates interpretation of probabilistic projections derived from such models. Here we show that this problem can be addressed using a novel method to test multiple non-exclusive hypotheses, and to make predictions un...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10561-x
更新日期:2019-07-09 00:00:00
abstract::Kevin J. Cao and Richard H. Kramer, who developed extended release with beta cyclodextrin, were inadvertently omitted from the author list and author contributions section of this Article. These errors have now been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-03585-2
更新日期:2018-03-13 00:00:00
abstract::Recently, ferroelectric tunnel junctions have attracted much attention due to their potential applications in non-destructive readout non-volatile memories. Using a semiconductor electrode has been proven effective to enhance the tunnelling electroresistance in ferroelectric tunnel junctions. Here we report a systemat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15217
更新日期:2017-05-17 00:00:00
abstract::Recently, coherent control of the optical response of thin films in standing waves has attracted considerable attention, ranging from applications in excitation-selective spectroscopy and nonlinear optics to all-optical image processing. Here, we show that integration of metamaterial and optical fibre technologies all...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02434-y
更新日期:2018-01-12 00:00:00
abstract::Genetic noise together with genome duplication and volume changes during cell cycle are significant contributors to cell-to-cell heterogeneity. How can cells buffer the effects of these unavoidable epigenetic and genetic variations on phenotypes that are sensitive to such variations? Here we show that a simple network...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12959
更新日期:2016-10-03 00:00:00
abstract::Single-celled eukaryotes (protists) are critical players in global biogeochemical cycling of nutrients and energy in the oceans. While their roles as primary producers and grazers are well appreciated, other aspects of their life histories remain obscure due to challenges in culturing and sequencing their natural dive...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02235-3
更新日期:2018-01-22 00:00:00
abstract::Ever since the discovery of dye self-assemblies in nature, there have been tremendous efforts to exploit biomimetic supramolecular assemblies for tailored artificial photon processing materials. This feature necessarily has resulted in an increasing demand for understanding exciton dynamics in the dye self-assemblies....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9646
更新日期:2015-10-23 00:00:00
abstract::The discovery of quantum spin-Hall (QSH) insulators has brought topology to the forefront of condensed matter physics. While a QSH state from spin-orbit coupling can be fully understood in terms of band theory, fascinating many-body effects are expected if it instead results from spontaneous symmetry breaking. Here, w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10372-0
更新日期:2019-06-14 00:00:00
abstract::Multiple myeloma (MM) is a plasma-cell neoplasm that is treated with high-dose chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. The presence of somatic mutations in the peripheral blood is termed clonal hematopoiesis of indeterminate potential (CHIP) and is a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16805-5
更新日期:2020-06-12 00:00:00
abstract::X-chromosome inactivation (XCI), i.e., the inactivation of one of the female X chromosomes, restores equal expression of X-chromosomal genes between females and males. However, ~10% of genes show variable degrees of escape from XCI between females, although little is known about the causes of variable XCI. Using a dis...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05714-3
更新日期:2018-09-14 00:00:00
abstract::Incited by public fascination and engineering application, water-skipping of rigid stones and spheres has received considerable study. While these objects can be coaxed to ricochet, elastic spheres demonstrate superior water-skipping ability, but little is known about the effect of large material compliance on water i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10551
更新日期:2016-02-04 00:00:00
abstract::While many tools exist for identifying and quantifying individual cell types, few methods are available to assess the relationships between cell types in organs and tissues and how these relationships change during aging or disease states. We present a quantitative method for evaluating cellular organization, using th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15619
更新日期:2017-05-30 00:00:00
abstract::Several of the steps in protein synthesis on the ribosome utilize hydrolysis of guanosine triphosphate (GTP) as the driving force. This reaction is catalyzed by translation factors that become activated upon binding to the ribosome. The recently determined crystal structure of an elongation factor-Tu ternary complex b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2741
更新日期:2013-01-01 00:00:00
abstract::Insoluble protein aggregates are the hallmarks of many neurodegenerative diseases. For example, aggregates of TDP-43 occur in nearly all cases of amyotrophic lateral sclerosis (ALS). However, whether aggregates cause cellular toxicity is still not clear, even in simpler cellular systems. We reasoned that deep mutagene...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12101-z
更新日期:2019-09-13 00:00:00
abstract::Ubiquitous satellite communications are in a leading position for bridging the digital divide. Fulfilling such a mission will require satellite services on par with fibre services, both in bandwidth and cost. Achieving such a performance requires a new generation of communications payloads powered by large-scale proce...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10077-4
更新日期:2019-04-30 00:00:00
abstract::Single-photon counters are single-pixel binary devices that click upon the absorption of a photon but obscure its spectral information, whereas resolving the color of detected photons has been in critical demand for frontier astronomical observation, spectroscopic imaging and wavelength division multiplexed quantum co...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12149-x
更新日期:2019-09-10 00:00:00
abstract::Cell biologists generally consider that microtubules and actin play complementary roles in long- and short-distance transport in animal cells. On the contrary, using melanosomes of melanocytes as a model, we recently discovered that the motor protein myosin-Va works with dynamic actin tracks to drive long-range organe...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17212-6
更新日期:2020-07-13 00:00:00
abstract::Ultrasound sensors have wide applications across science and technology. However, improved sensitivity is required for both miniaturisation and increased spatial resolution. Here, we introduce cavity optomechanical ultrasound sensing, where dual optical and mechanical resonances enhance the ultrasound signal. We achie...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08038-4
更新日期:2019-01-10 00:00:00
abstract::Liquid crystalline network (LCN) actuator normally deforms upon thermally or optically induced order-disorder phase transition, switching once between two shapes (shape 1 in LC phase and shape 2 in isotropic state) for each stimulation on/off cycle. Herein, we report an LCN actuator that deforms from shape 1 to shape ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-021-20938-6
更新日期:2021-01-27 00:00:00
abstract::Mutations in BLM in Bloom Syndrome patients predispose them to multiple types of cancers. Here we report that BLM is recruited in a biphasic manner to annotated DSBs. BLM recruitment is dependent on the presence of NBS1, MRE11 and ATM. While ATM activity is essential for BLM recruitment in early phase, it is dispensab...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03393-8
更新日期:2018-03-09 00:00:00
abstract::The expansion of the white adipose tissue (WAT) in obesity goes along with increased mechanical, metabolic and inflammatory stress. How adipocytes resist this stress is still poorly understood. Both in human and mouse adipocytes, the transcriptional co-activators YAP/TAZ and YAP/TAZ target genes become activated durin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19229-3
更新日期:2020-10-28 00:00:00