Abstract:
:The HIV Tat protein competes with the 7SK:HEXIM interaction to hijack pTEFb from 7SK snRNP and recruit it to the TAR motif on stalled viral transcripts. Here we solve structures of 7SK stemloop-1 and TAR in complex with Tat's RNA binding domain (RBD) to gain insights into this process. We find that 7SK is peppered with arginine sandwich motifs (ASM)-three classical and one with a pseudo configuration. Despite having similar RBDs, the presence of an additional arginine, R52, confers Tat the ability to remodel the pseudo configuration, required for HEXIM binding, into a classical sandwich, thus displacing HEXIM. Tat also uses R52 to remodel the TAR bulge into an ASM whose structure is identical to that of the remodeled ASM in 7SK. Together, our structures reveal a dual structural mimicry wherein viral Tat and TAR have co-opted structural motifs present in cellular HEXIM and 7SK for productive transcription of its genome.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Pham VV,Salguero C,Khan SN,Meagher JL,Brown WC,Humbert N,de Rocquigny H,Smith JL,D'Souza VMdoi
10.1038/s41467-018-06591-6subject
Has Abstractpub_date
2018-10-15 00:00:00pages
4266issue
1issn
2041-1723pii
10.1038/s41467-018-06591-6journal_volume
9pub_type
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